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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Functions of autophagy in normal and diseased liver</title><author><name sortKey="Czaja, Mark J" sort="Czaja, Mark J" uniqKey="Czaja M" first="Mark J." last="Czaja">Mark J. Czaja</name><affiliation><nlm:aff id="A1">Department of Medicine; Marion Bessin Liver Research Center; Albert Einstein College of Medicine; Bronx, NY USA</nlm:aff></affiliation></author><author><name sortKey="Ding, Wen Xing" sort="Ding, Wen Xing" uniqKey="Ding W" first="Wen-Xing" last="Ding">Wen-Xing Ding</name><affiliation><nlm:aff id="A2">Department of Pharmacology, Toxicology and Therapeutics; University of Kansas Medical Center; Kansas City, KS USA</nlm:aff></affiliation></author><author><name sortKey="Donohue, Terrence M" sort="Donohue, Terrence M" uniqKey="Donohue T" first="Terrence M." last="Donohue">Terrence M. Donohue</name><affiliation><nlm:aff id="A3">Liver Study Unit; Department of Veterans Affairs; VA Nebraska-Western Iowa Health Care System; Omaha, NE USA</nlm:aff></affiliation></author><author><name sortKey="Friedman, Scott L" sort="Friedman, Scott L" uniqKey="Friedman S" first="Scott L." last="Friedman">Scott L. Friedman</name><affiliation><nlm:aff id="A4">Division of Liver Diseases; Icahn School of Medicine at Mt. Sinai; New York, NY USA</nlm:aff></affiliation></author><author><name sortKey="Kim, Jae Sung" sort="Kim, Jae Sung" uniqKey="Kim J" first="Jae-Sung" last="Kim">Jae-Sung Kim</name><affiliation><nlm:aff id="A5">Department of Surgery; University of Florida College of Medicine; Gainesville, FL USA</nlm:aff></affiliation></author><author><name sortKey="Komatsu, Masaaki" sort="Komatsu, Masaaki" uniqKey="Komatsu M" first="Masaaki" last="Komatsu">Masaaki Komatsu</name><affiliation><nlm:aff id="A6">Protein Metabolism Project; Tokyo Metropolitan Institute of Medical Science; Tokyo, Japan</nlm:aff></affiliation></author><author><name sortKey="Lemasters, John J" sort="Lemasters, John J" uniqKey="Lemasters J" first="John J." last="Lemasters">John J. Lemasters</name><affiliation><nlm:aff id="A7">Center for Cell Death, Injury and Regeneration, Departments of Drug Discovery and Biomedical Sciences and Biochemistry and Molecular Biology; Medical University of South Carolina; Charleston, SC USA</nlm:aff></affiliation></author><author><name sortKey="Lemoine, Antoinette" sort="Lemoine, Antoinette" uniqKey="Lemoine A" first="Antoinette" last="Lemoine">Antoinette Lemoine</name><affiliation><nlm:aff id="A8">AP-HP; Hôpital Paul Brousse; Service de Biochimie et Biologie Moléculaire; Villejuif, France</nlm:aff></affiliation></author><author><name sortKey="Lin, Jiandie D" sort="Lin, Jiandie D" uniqKey="Lin J" first="Jiandie D." last="Lin">Jiandie D. Lin</name><affiliation><nlm:aff id="A9">Life Sciences Institute and Department of Cell and Developmental Biology; University of Michigan Medical Center; Ann Arbor, MI USA</nlm:aff></affiliation></author><author><name sortKey="Ou, Jing Hsiung James" sort="Ou, Jing Hsiung James" uniqKey="Ou J" first="Jing-Hsiung James" last="Ou">Jing-Hsiung James Ou</name><affiliation><nlm:aff id="A10">Department of Molecular Microbiology and Immunology; University of Southern California Keck School of Medicine; Los Angeles, CA USA</nlm:aff></affiliation></author><author><name sortKey="Perlmutter, David H" sort="Perlmutter, David H" uniqKey="Perlmutter D" first="David H." last="Perlmutter">David H. Perlmutter</name><affiliation><nlm:aff id="A11">Departments of Pediatrics and Cell Biology; University of Pittsburgh School of Medicine; and Children’s Hospital of Pittsburgh of UPMC; Pittsburgh, PA USA</nlm:aff></affiliation></author><author><name sortKey="Randall, Glenn" sort="Randall, Glenn" uniqKey="Randall G" first="Glenn" last="Randall">Glenn Randall</name><affiliation><nlm:aff id="A12">Department of Microbiology; Biological Sciences Division; The University of Chicago; Chicago, IL USA</nlm:aff></affiliation></author><author><name sortKey="Ray, Ratna B" sort="Ray, Ratna B" uniqKey="Ray R" first="Ratna B." last="Ray">Ratna B. Ray</name><affiliation><nlm:aff id="A13">Department of Pathology; Doisy Research Center; Saint Louis University; St. Louis, MO USA</nlm:aff></affiliation></author><author><name sortKey="Tsung, Allan" sort="Tsung, Allan" uniqKey="Tsung A" first="Allan" last="Tsung">Allan Tsung</name><affiliation><nlm:aff id="A14">Division of Hepatobiliary and Pancreatic Surgery; University of Pittsburgh Medical Center; Pittsburgh, PA USA</nlm:aff></affiliation></author><author><name sortKey="Yin, Xiao Ming" sort="Yin, Xiao Ming" uniqKey="Yin X" first="Xiao-Ming" last="Yin">Xiao-Ming Yin</name><affiliation><nlm:aff id="A15">Department of Pathology and Laboratory Medicine; Indiana University School of Medicine; Indianapolis, IN USA</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23774882</idno><idno type="pmc">3748187</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3748187</idno><idno type="RBID">PMC:3748187</idno><idno type="doi">10.4161/auto.25063</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">000899</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000899</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Functions of autophagy in normal and diseased liver</title><author><name sortKey="Czaja, Mark J" sort="Czaja, Mark J" uniqKey="Czaja M" first="Mark J." last="Czaja">Mark J. Czaja</name><affiliation><nlm:aff id="A1">Department of Medicine; Marion Bessin Liver Research Center; Albert Einstein College of Medicine; Bronx, NY USA</nlm:aff></affiliation></author><author><name sortKey="Ding, Wen Xing" sort="Ding, Wen Xing" uniqKey="Ding W" first="Wen-Xing" last="Ding">Wen-Xing Ding</name><affiliation><nlm:aff id="A2">Department of Pharmacology, Toxicology and Therapeutics; University of Kansas Medical Center; Kansas City, KS USA</nlm:aff></affiliation></author><author><name sortKey="Donohue, Terrence M" sort="Donohue, Terrence M" uniqKey="Donohue T" first="Terrence M." last="Donohue">Terrence M. Donohue</name><affiliation><nlm:aff id="A3">Liver Study Unit; Department of Veterans Affairs; VA Nebraska-Western Iowa Health Care System; Omaha, NE USA</nlm:aff></affiliation></author><author><name sortKey="Friedman, Scott L" sort="Friedman, Scott L" uniqKey="Friedman S" first="Scott L." last="Friedman">Scott L. Friedman</name><affiliation><nlm:aff id="A4">Division of Liver Diseases; Icahn School of Medicine at Mt. Sinai; New York, NY USA</nlm:aff></affiliation></author><author><name sortKey="Kim, Jae Sung" sort="Kim, Jae Sung" uniqKey="Kim J" first="Jae-Sung" last="Kim">Jae-Sung Kim</name><affiliation><nlm:aff id="A5">Department of Surgery; University of Florida College of Medicine; Gainesville, FL USA</nlm:aff></affiliation></author><author><name sortKey="Komatsu, Masaaki" sort="Komatsu, Masaaki" uniqKey="Komatsu M" first="Masaaki" last="Komatsu">Masaaki Komatsu</name><affiliation><nlm:aff id="A6">Protein Metabolism Project; Tokyo Metropolitan Institute of Medical Science; Tokyo, Japan</nlm:aff></affiliation></author><author><name sortKey="Lemasters, John J" sort="Lemasters, John J" uniqKey="Lemasters J" first="John J." last="Lemasters">John J. Lemasters</name><affiliation><nlm:aff id="A7">Center for Cell Death, Injury and Regeneration, Departments of Drug Discovery and Biomedical Sciences and Biochemistry and Molecular Biology; Medical University of South Carolina; Charleston, SC USA</nlm:aff></affiliation></author><author><name sortKey="Lemoine, Antoinette" sort="Lemoine, Antoinette" uniqKey="Lemoine A" first="Antoinette" last="Lemoine">Antoinette Lemoine</name><affiliation><nlm:aff id="A8">AP-HP; Hôpital Paul Brousse; Service de Biochimie et Biologie Moléculaire; Villejuif, France</nlm:aff></affiliation></author><author><name sortKey="Lin, Jiandie D" sort="Lin, Jiandie D" uniqKey="Lin J" first="Jiandie D." last="Lin">Jiandie D. Lin</name><affiliation><nlm:aff id="A9">Life Sciences Institute and Department of Cell and Developmental Biology; University of Michigan Medical Center; Ann Arbor, MI USA</nlm:aff></affiliation></author><author><name sortKey="Ou, Jing Hsiung James" sort="Ou, Jing Hsiung James" uniqKey="Ou J" first="Jing-Hsiung James" last="Ou">Jing-Hsiung James Ou</name><affiliation><nlm:aff id="A10">Department of Molecular Microbiology and Immunology; University of Southern California Keck School of Medicine; Los Angeles, CA USA</nlm:aff></affiliation></author><author><name sortKey="Perlmutter, David H" sort="Perlmutter, David H" uniqKey="Perlmutter D" first="David H." last="Perlmutter">David H. Perlmutter</name><affiliation><nlm:aff id="A11">Departments of Pediatrics and Cell Biology; University of Pittsburgh School of Medicine; and Children’s Hospital of Pittsburgh of UPMC; Pittsburgh, PA USA</nlm:aff></affiliation></author><author><name sortKey="Randall, Glenn" sort="Randall, Glenn" uniqKey="Randall G" first="Glenn" last="Randall">Glenn Randall</name><affiliation><nlm:aff id="A12">Department of Microbiology; Biological Sciences Division; The University of Chicago; Chicago, IL USA</nlm:aff></affiliation></author><author><name sortKey="Ray, Ratna B" sort="Ray, Ratna B" uniqKey="Ray R" first="Ratna B." last="Ray">Ratna B. Ray</name><affiliation><nlm:aff id="A13">Department of Pathology; Doisy Research Center; Saint Louis University; St. Louis, MO USA</nlm:aff></affiliation></author><author><name sortKey="Tsung, Allan" sort="Tsung, Allan" uniqKey="Tsung A" first="Allan" last="Tsung">Allan Tsung</name><affiliation><nlm:aff id="A14">Division of Hepatobiliary and Pancreatic Surgery; University of Pittsburgh Medical Center; Pittsburgh, PA USA</nlm:aff></affiliation></author><author><name sortKey="Yin, Xiao Ming" sort="Yin, Xiao Ming" uniqKey="Yin X" first="Xiao-Ming" last="Yin">Xiao-Ming Yin</name><affiliation><nlm:aff id="A15">Department of Pathology and Laboratory Medicine; Indiana University School of Medicine; Indianapolis, IN USA</nlm:aff></affiliation></author></analytic><series><title level="j">Autophagy</title><idno type="ISSN">1554-8627</idno><idno type="eISSN">1554-8635</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Autophagy has emerged as a critical lysosomal pathway that maintains cell function and survival through the degradation of cellular components such as organelles and proteins. Investigations specifically employing the liver or hepatocytes as experimental models have contributed significantly to our current knowledge of autophagic regulation and function. The diverse cellular functions of autophagy, along with unique features of the liver and its principal cell type the hepatocyte, suggest that the liver is highly dependent on autophagy for both normal function and to prevent the development of disease states. However, instances have also been identified in which autophagy promotes pathological changes such as the development of hepatic fibrosis. Considerable evidence has accumulated that alterations in autophagy are an underlying mechanism of a number of common hepatic diseases including toxin-, drug- and ischemia/reperfusion-induced liver injury, fatty liver, viral hepatitis and hepatocellular carcinoma. This review summarizes recent advances in understanding the roles that autophagy plays in normal hepatic physiology and pathophysiology with the intent of furthering the development of autophagy-based therapies for human liver diseases.</p></div></front></TEI><pmc article-type="review-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Autophagy</journal-id><journal-id journal-id-type="iso-abbrev">Autophagy</journal-id><journal-id journal-id-type="publisher-id">AUTO</journal-id><journal-title-group><journal-title>Autophagy</journal-title></journal-title-group><issn pub-type="ppub">1554-8627</issn><issn pub-type="epub">1554-8635</issn><publisher><publisher-name>Landes Bioscience</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">23774882</article-id><article-id pub-id-type="pmc">3748187</article-id><article-id pub-id-type="publisher-id">2013AUTO0146R1</article-id><article-id pub-id-type="doi">10.4161/auto.25063</article-id><article-id pub-id-type="pii">25063</article-id><article-categories><subj-group subj-group-type="heading"><subject>Review</subject></subj-group></article-categories><title-group><article-title>Functions of autophagy in normal and diseased liver</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Czaja</surname><given-names>Mark J.</given-names></name><xref ref-type="aff" rid="A1"><sup>1</sup></xref><xref ref-type="corresp" rid="cor1">*</xref></contrib><contrib contrib-type="author"><name><surname>Ding</surname><given-names>Wen-Xing</given-names></name><xref ref-type="aff" rid="A2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Donohue</surname><given-names>Terrence M.</given-names></name><xref ref-type="aff" rid="A3"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Friedman</surname><given-names>Scott L.</given-names></name><xref ref-type="aff" rid="A4"><sup>4</sup></xref></contrib><contrib contrib-type="author"><name><surname>Kim</surname><given-names>Jae-Sung</given-names></name><xref ref-type="aff" rid="A5"><sup>5</sup></xref></contrib><contrib contrib-type="author"><name><surname>Komatsu</surname><given-names>Masaaki</given-names></name><xref ref-type="aff" rid="A6"><sup>6</sup></xref></contrib><contrib contrib-type="author"><name><surname>Lemasters</surname><given-names>John J.</given-names></name><xref ref-type="aff" rid="A7"><sup>7</sup></xref></contrib><contrib contrib-type="author"><name><surname>Lemoine</surname><given-names>Antoinette</given-names></name><xref ref-type="aff" rid="A8"><sup>8</sup></xref></contrib><contrib contrib-type="author"><name><surname>Lin</surname><given-names>Jiandie D.</given-names></name><xref ref-type="aff" rid="A9"><sup>9</sup></xref></contrib><contrib contrib-type="author"><name><surname>Ou</surname><given-names>Jing-hsiung James</given-names></name><xref ref-type="aff" rid="A10"><sup>10</sup></xref></contrib><contrib contrib-type="author"><name><surname>Perlmutter</surname><given-names>David H.</given-names></name><xref ref-type="aff" rid="A11"><sup>11</sup></xref></contrib><contrib contrib-type="author"><name><surname>Randall</surname><given-names>Glenn</given-names></name><xref ref-type="aff" rid="A12"><sup>12</sup></xref></contrib><contrib contrib-type="author"><name><surname>Ray</surname><given-names>Ratna B.</given-names></name><xref ref-type="aff" rid="A13"><sup>13</sup></xref></contrib><contrib contrib-type="author"><name><surname>Tsung</surname><given-names>Allan</given-names></name><xref ref-type="aff" rid="A14"><sup>14</sup></xref></contrib><contrib contrib-type="author"><name><surname>Yin</surname><given-names>Xiao-Ming</given-names></name><xref ref-type="aff" rid="A15"><sup>15</sup></xref></contrib><aff id="A1"><label>1</label>Department of Medicine; Marion Bessin Liver Research Center; Albert Einstein College of Medicine; Bronx, NY USA</aff><aff id="A2"><label>2</label>Department of Pharmacology, Toxicology and Therapeutics; University of Kansas Medical Center; Kansas City, KS USA</aff><aff id="A3"><label>3</label>Liver Study Unit; Department of Veterans Affairs; VA Nebraska-Western Iowa Health Care System; Omaha, NE USA</aff><aff id="A4"><label>4</label>Division of Liver Diseases; Icahn School of Medicine at Mt. Sinai; New York, NY USA</aff><aff id="A5"><label>5</label>Department of Surgery; University of Florida College of Medicine; Gainesville, FL USA</aff><aff id="A6"><label>6</label>Protein Metabolism Project; Tokyo Metropolitan Institute of Medical Science; Tokyo, Japan</aff><aff id="A7"><label>7</label>Center for Cell Death, Injury and Regeneration, Departments of Drug Discovery and Biomedical Sciences and Biochemistry and Molecular Biology; Medical University of South Carolina; Charleston, SC USA</aff><aff id="A8"><label>8</label>AP-HP; Hôpital Paul Brousse; Service de Biochimie et Biologie Moléculaire; Villejuif, France</aff><aff id="A9"><label>9</label>Life Sciences Institute and Department of Cell and Developmental Biology; University of Michigan Medical Center; Ann Arbor, MI USA</aff><aff id="A10"><label>10</label>Department of Molecular Microbiology and Immunology; University of Southern California Keck School of Medicine; Los Angeles, CA USA</aff><aff id="A11"><label>11</label>Departments of Pediatrics and Cell Biology; University of Pittsburgh School of Medicine; and Children’s Hospital of Pittsburgh of UPMC; Pittsburgh, PA USA</aff><aff id="A12"><label>12</label>Department of Microbiology; Biological Sciences Division; The University of Chicago; Chicago, IL USA</aff><aff id="A13"><label>13</label>Department of Pathology; Doisy Research Center; Saint Louis University; St. Louis, MO USA</aff><aff id="A14"><label>14</label>Division of Hepatobiliary and Pancreatic Surgery; University of Pittsburgh Medical Center; Pittsburgh, PA USA</aff><aff id="A15"><label>15</label>Department of Pathology and Laboratory Medicine; Indiana University School of Medicine; Indianapolis, IN USA</aff></contrib-group><author-notes><corresp id="cor1"><label>*</label>Correspondence to: Mark J. Czaja, Email: <email xlink:href="mark.czaja@einstein.yu.edu">mark.czaja@einstein.yu.edu</email></corresp></author-notes><pub-date pub-type="ppub"><day>01</day><month>8</month><year>2013</year></pub-date><pub-date pub-type="epub"><day>22</day><month>5</month><year>2013</year></pub-date><volume>9</volume><issue>8</issue><fpage>1131</fpage><lpage>1158</lpage><history><date date-type="received"><day>06</day><month>3</month><year>2013</year></date><date date-type="rev-recd"><day>05</day><month>5</month><year>2013</year></date><date date-type="accepted"><day>16</day><month>5</month><year>2013</year></date></history><permissions><copyright-statement>Copyright © 2013 Landes Bioscience</copyright-statement><copyright-year>2013</copyright-year></permissions><abstract><p>Autophagy has emerged as a critical lysosomal pathway that maintains cell function and survival through the degradation of cellular components such as organelles and proteins. Investigations specifically employing the liver or hepatocytes as experimental models have contributed significantly to our current knowledge of autophagic regulation and function. The diverse cellular functions of autophagy, along with unique features of the liver and its principal cell type the hepatocyte, suggest that the liver is highly dependent on autophagy for both normal function and to prevent the development of disease states. However, instances have also been identified in which autophagy promotes pathological changes such as the development of hepatic fibrosis. Considerable evidence has accumulated that alterations in autophagy are an underlying mechanism of a number of common hepatic diseases including toxin-, drug- and ischemia/reperfusion-induced liver injury, fatty liver, viral hepatitis and hepatocellular carcinoma. This review summarizes recent advances in understanding the roles that autophagy plays in normal hepatic physiology and pathophysiology with the intent of furthering the development of autophagy-based therapies for human liver diseases.</p></abstract><kwd-group kwd-group-type="author"><title>Keywords: </title><kwd>autophagy</kwd><kwd>liver</kwd><kwd>hepatocyte</kwd><kwd>hepatitis</kwd><kwd>ischemia/reperfusion</kwd><kwd>liver injury</kwd><kwd>hepatotoxin</kwd><kwd>hepatocellular carcinoma</kwd><kwd>drug toxicity</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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