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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">A Combined Measure of Cognition and Function for Clinical Trials: The Integrated Alzheimer’s Disease Rating Scale (iADRS)</title><author><name sortKey="Wessels, A M" sort="Wessels, A M" uniqKey="Wessels A" first="A. M." last="Wessels">A. M. Wessels</name><affiliation><nlm:aff id="A1">Eli Lilly and Company, Indianapolis, IN, USA</nlm:aff></affiliation></author><author><name sortKey="Siemers, E R" sort="Siemers, E R" uniqKey="Siemers E" first="E. R." last="Siemers">E. R. Siemers</name><affiliation><nlm:aff id="A1">Eli Lilly and Company, Indianapolis, IN, USA</nlm:aff></affiliation></author><author><name sortKey="Yu, P" sort="Yu, P" uniqKey="Yu P" first="P." last="Yu">P. Yu</name><affiliation><nlm:aff id="A1">Eli Lilly and Company, Indianapolis, IN, USA</nlm:aff></affiliation></author><author><name sortKey="Andersen, S W" sort="Andersen, S W" uniqKey="Andersen S" first="S. W." last="Andersen">S. W. Andersen</name><affiliation><nlm:aff id="A1">Eli Lilly and Company, Indianapolis, IN, USA</nlm:aff></affiliation></author><author><name sortKey="Holdridge, K C" sort="Holdridge, K C" uniqKey="Holdridge K" first="K. C." last="Holdridge">K. C. Holdridge</name><affiliation><nlm:aff id="A1">Eli Lilly and Company, Indianapolis, IN, USA</nlm:aff></affiliation></author><author><name sortKey="Sims, J R" sort="Sims, J R" uniqKey="Sims J" first="J. R." last="Sims">J. R. Sims</name><affiliation><nlm:aff id="A1">Eli Lilly and Company, Indianapolis, IN, USA</nlm:aff></affiliation></author><author><name sortKey="Sundell, K" sort="Sundell, K" uniqKey="Sundell K" first="K." last="Sundell">K. Sundell</name><affiliation><nlm:aff id="A1">Eli Lilly and Company, Indianapolis, IN, USA</nlm:aff></affiliation></author><author><name sortKey="Stern, Y" sort="Stern, Y" uniqKey="Stern Y" first="Y." last="Stern">Y. Stern</name><affiliation><nlm:aff id="A2">Department of Neurology, Columbia University Medical Center, New York, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Rentz, D M" sort="Rentz, D M" uniqKey="Rentz D" first="D. M." last="Rentz">D. M. Rentz</name><affiliation><nlm:aff id="A3">Departments of Neurology, Brigham and Women’s Hospital, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Dubois, B" sort="Dubois, B" uniqKey="Dubois B" first="B." last="Dubois">B. Dubois</name><affiliation><nlm:aff id="A4">Centre des Maladies Cognitives et Comportementales (IM2A), Institut du Cerveau et de la Moelle épinière (ICM), UMR-S975, Université Pierre et Marie Curie- Paris6, AP-HP, Hôpital de la Salpêtrière, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Jones, R W" sort="Jones, R W" uniqKey="Jones R" first="R. W." last="Jones">R. W. Jones</name><affiliation><nlm:aff id="A5">RICE (The Research Institute for the Care of Older People), Royal United Hospital, Bath, UK</nlm:aff></affiliation></author><author><name sortKey="Cummings, J" sort="Cummings, J" uniqKey="Cummings J" first="J." last="Cummings">J. Cummings</name><affiliation><nlm:aff id="A6">Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, Nevada, USA</nlm:aff></affiliation></author><author><name sortKey="Aisen, P S" sort="Aisen, P S" uniqKey="Aisen P" first="P. S." last="Aisen">P. S. Aisen</name><affiliation><nlm:aff id="A7">University of Southern California, CA, USA</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27019841</idno><idno type="pmc">4806404</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4806404</idno><idno type="RBID">PMC:4806404</idno><idno type="doi">10.14283/jpad.2015.82</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000613</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000613</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">A Combined Measure of Cognition and Function for Clinical Trials: The Integrated Alzheimer’s Disease Rating Scale (iADRS)</title><author><name sortKey="Wessels, A M" sort="Wessels, A M" uniqKey="Wessels A" first="A. M." last="Wessels">A. M. Wessels</name><affiliation><nlm:aff id="A1">Eli Lilly and Company, Indianapolis, IN, USA</nlm:aff></affiliation></author><author><name sortKey="Siemers, E R" sort="Siemers, E R" uniqKey="Siemers E" first="E. R." last="Siemers">E. R. Siemers</name><affiliation><nlm:aff id="A1">Eli Lilly and Company, Indianapolis, IN, USA</nlm:aff></affiliation></author><author><name sortKey="Yu, P" sort="Yu, P" uniqKey="Yu P" first="P." last="Yu">P. Yu</name><affiliation><nlm:aff id="A1">Eli Lilly and Company, Indianapolis, IN, USA</nlm:aff></affiliation></author><author><name sortKey="Andersen, S W" sort="Andersen, S W" uniqKey="Andersen S" first="S. W." last="Andersen">S. W. Andersen</name><affiliation><nlm:aff id="A1">Eli Lilly and Company, Indianapolis, IN, USA</nlm:aff></affiliation></author><author><name sortKey="Holdridge, K C" sort="Holdridge, K C" uniqKey="Holdridge K" first="K. C." last="Holdridge">K. C. Holdridge</name><affiliation><nlm:aff id="A1">Eli Lilly and Company, Indianapolis, IN, USA</nlm:aff></affiliation></author><author><name sortKey="Sims, J R" sort="Sims, J R" uniqKey="Sims J" first="J. R." last="Sims">J. R. Sims</name><affiliation><nlm:aff id="A1">Eli Lilly and Company, Indianapolis, IN, USA</nlm:aff></affiliation></author><author><name sortKey="Sundell, K" sort="Sundell, K" uniqKey="Sundell K" first="K." last="Sundell">K. Sundell</name><affiliation><nlm:aff id="A1">Eli Lilly and Company, Indianapolis, IN, USA</nlm:aff></affiliation></author><author><name sortKey="Stern, Y" sort="Stern, Y" uniqKey="Stern Y" first="Y." last="Stern">Y. Stern</name><affiliation><nlm:aff id="A2">Department of Neurology, Columbia University Medical Center, New York, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Rentz, D M" sort="Rentz, D M" uniqKey="Rentz D" first="D. M." last="Rentz">D. M. Rentz</name><affiliation><nlm:aff id="A3">Departments of Neurology, Brigham and Women’s Hospital, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Dubois, B" sort="Dubois, B" uniqKey="Dubois B" first="B." last="Dubois">B. Dubois</name><affiliation><nlm:aff id="A4">Centre des Maladies Cognitives et Comportementales (IM2A), Institut du Cerveau et de la Moelle épinière (ICM), UMR-S975, Université Pierre et Marie Curie- Paris6, AP-HP, Hôpital de la Salpêtrière, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Jones, R W" sort="Jones, R W" uniqKey="Jones R" first="R. W." last="Jones">R. W. Jones</name><affiliation><nlm:aff id="A5">RICE (The Research Institute for the Care of Older People), Royal United Hospital, Bath, UK</nlm:aff></affiliation></author><author><name sortKey="Cummings, J" sort="Cummings, J" uniqKey="Cummings J" first="J." last="Cummings">J. Cummings</name><affiliation><nlm:aff id="A6">Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, Nevada, USA</nlm:aff></affiliation></author><author><name sortKey="Aisen, P S" sort="Aisen, P S" uniqKey="Aisen P" first="P. S." last="Aisen">P. S. Aisen</name><affiliation><nlm:aff id="A7">University of Southern California, CA, USA</nlm:aff></affiliation></author></analytic><series><title level="j">The journal of prevention of Alzheimer's disease</title><idno type="ISSN">2274-5807</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">It is generally recognized that more sensitive instruments for the earliest stages of Alzheimer’s disease (AD) are needed. The integrated Alzheimer’s Disease Rating Scale (iADRS) combines scores from 2 widely accepted measures, the Alzheimer’s Disease Assessment Scale-Cognitive subscale (ADAS-Cog) and the Alzheimer’s Disease Cooperative Study – instrumental Activities of Daily Living (ADCS-iADL). Disease progression and treatment differences as measured by the iADRS were analyzed using data from solanezumab EXPEDITION, EXPEDITION2, and EXPEDITION-EXT Studies; semagacestat IDENTITY Study; and donepezil ADCS – mild cognitive impairment (ADCS-MCI) Study. Psychometric properties of the iADRS were established through principal component analysis (PCA) and estimation of contributions of subscores and individual item scores to the iADRS total score. The iADRS performed better than most composites and scales in detecting disease progression and comparably or better than individual scales in detecting treatment differences. PCA demonstrated the iADRS can be divided into two principal components primarily representing cognitive items and instrumental ADLs. Dynamic ranges of the subscales were similar across all studies, reflecting approximately equal contributions from both subscales to the iADRS total score. In item analyses, every item contributed to the total score, with varying strength of contributions by item and across data sets. The iADRS demonstrated acceptable psychometric properties and was effective in capturing disease progression from MCI through moderate AD and treatment effects across the early disease spectrum. These findings suggest the iADRS can be used in studies of mixed populations, ensuring sensitivity to treatment effects as subjects progress during studies of putative disease-modifying agents.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">101638820</journal-id><journal-id journal-id-type="pubmed-jr-id">42950</journal-id><journal-id journal-id-type="nlm-ta">J Prev Alzheimers Dis</journal-id><journal-id journal-id-type="iso-abbrev">J Prev Alzheimers Dis</journal-id><journal-title-group><journal-title>The journal of prevention of Alzheimer's disease</journal-title></journal-title-group><issn pub-type="ppub">2274-5807</issn></journal-meta><article-meta><article-id pub-id-type="pmid">27019841</article-id><article-id pub-id-type="pmc">4806404</article-id><article-id pub-id-type="doi">10.14283/jpad.2015.82</article-id><article-id pub-id-type="manuscript">NIHMS745948</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>A Combined Measure of Cognition and Function for Clinical Trials: The Integrated Alzheimer’s Disease Rating Scale (iADRS)</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Wessels</surname><given-names>A.M.</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Siemers</surname><given-names>E.R.</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Yu</surname><given-names>P.</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Andersen</surname><given-names>S.W.</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Holdridge</surname><given-names>K.C.</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Sims</surname><given-names>J.R.</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Sundell</surname><given-names>K.</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Stern</surname><given-names>Y.</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Rentz</surname><given-names>D.M.</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Dubois</surname><given-names>B.</given-names></name><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Jones</surname><given-names>R.W.</given-names></name><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Cummings</surname><given-names>J.</given-names></name><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>Aisen</surname><given-names>P.S.</given-names></name><xref ref-type="aff" rid="A7">7</xref></contrib></contrib-group><aff id="A1"><label>1</label>Eli Lilly and Company, Indianapolis, IN, USA</aff><aff id="A2"><label>2</label>Department of Neurology, Columbia University Medical Center, New York, NY, USA</aff><aff id="A3"><label>3</label>Departments of Neurology, Brigham and Women’s Hospital, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA</aff><aff id="A4"><label>4</label>Centre des Maladies Cognitives et Comportementales (IM2A), Institut du Cerveau et de la Moelle épinière (ICM), UMR-S975, Université Pierre et Marie Curie- Paris6, AP-HP, Hôpital de la Salpêtrière, Paris, France</aff><aff id="A5"><label>5</label>RICE (The Research Institute for the Care of Older People), Royal United Hospital, Bath, UK</aff><aff id="A6"><label>6</label>Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, Nevada, USA</aff><aff id="A7"><label>7</label>University of Southern California, CA, USA</aff><author-notes><corresp id="cor1"><italic>Corresponding Author:</italic> Alette M Wessels, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA, <email>wesselsal@lilly.com</email>, Telephone: +1 (317) 276-9502, fax: +1 276-5791</corresp></author-notes><pub-date pub-type="nihms-submitted"><day>21</day><month>12</month><year>2015</year></pub-date><pub-date pub-type="ppub"><day>1</day><month>12</month><year>2015</year></pub-date><pub-date pub-type="pmc-release"><day>24</day><month>3</month><year>2016</year></pub-date><volume>2</volume><issue>4</issue><fpage>227</fpage><lpage>241</lpage><pmc-comment>elocation-id from pubmed: 10.14283/jpad.2015.82</pmc-comment>
<abstract><p id="P1">It is generally recognized that more sensitive instruments for the earliest stages of Alzheimer’s disease (AD) are needed. The integrated Alzheimer’s Disease Rating Scale (iADRS) combines scores from 2 widely accepted measures, the Alzheimer’s Disease Assessment Scale-Cognitive subscale (ADAS-Cog) and the Alzheimer’s Disease Cooperative Study – instrumental Activities of Daily Living (ADCS-iADL). Disease progression and treatment differences as measured by the iADRS were analyzed using data from solanezumab EXPEDITION, EXPEDITION2, and EXPEDITION-EXT Studies; semagacestat IDENTITY Study; and donepezil ADCS – mild cognitive impairment (ADCS-MCI) Study. Psychometric properties of the iADRS were established through principal component analysis (PCA) and estimation of contributions of subscores and individual item scores to the iADRS total score. The iADRS performed better than most composites and scales in detecting disease progression and comparably or better than individual scales in detecting treatment differences. PCA demonstrated the iADRS can be divided into two principal components primarily representing cognitive items and instrumental ADLs. Dynamic ranges of the subscales were similar across all studies, reflecting approximately equal contributions from both subscales to the iADRS total score. In item analyses, every item contributed to the total score, with varying strength of contributions by item and across data sets. The iADRS demonstrated acceptable psychometric properties and was effective in capturing disease progression from MCI through moderate AD and treatment effects across the early disease spectrum. These findings suggest the iADRS can be used in studies of mixed populations, ensuring sensitivity to treatment effects as subjects progress during studies of putative disease-modifying agents.</p></abstract><kwd-group><kwd>iADRS</kwd><kwd>Alzheimer’s disease</kwd><kwd>clinical trials</kwd><kwd>outcome measure</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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