CDK5
Identifieur interne : 000442 ( Pmc/Corpus ); précédent : 000441; suivant : 000443CDK5
Auteurs : Tobias Albert ; Monika Saxena ; Vincent LelievreSource :
- Cell Adhesion & Migration [ 1933-6918 ] ; 2009.
Abstract
Neurogenesis takes place in the mammalian hippocampus throughout the whole life and deficient adult hippocampal neurogenesis has been related to neurological conditions like Alzheimer disease (AD), Parkinson disease (PD) and epilepsy. The molecular mechanisms by which immature neurons and their extending neurites find their appropriate position and target area remain largely unknown. Recent work by Jessberger et al.
Url:
PubMed: 19855173
PubMed Central: 2802738
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PMC:2802738Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">CDK5</title>
<author><name sortKey="Albert, Tobias" sort="Albert, Tobias" uniqKey="Albert T" first="Tobias" last="Albert">Tobias Albert</name>
</author>
<author><name sortKey="Saxena, Monika" sort="Saxena, Monika" uniqKey="Saxena M" first="Monika" last="Saxena">Monika Saxena</name>
</author>
<author><name sortKey="Lelievre, Vincent" sort="Lelievre, Vincent" uniqKey="Lelievre V" first="Vincent" last="Lelievre">Vincent Lelievre</name>
</author>
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<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">19855173</idno>
<idno type="pmc">2802738</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2802738</idno>
<idno type="RBID">PMC:2802738</idno>
<date when="2009">2009</date>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">CDK5</title>
<author><name sortKey="Albert, Tobias" sort="Albert, Tobias" uniqKey="Albert T" first="Tobias" last="Albert">Tobias Albert</name>
</author>
<author><name sortKey="Saxena, Monika" sort="Saxena, Monika" uniqKey="Saxena M" first="Monika" last="Saxena">Monika Saxena</name>
</author>
<author><name sortKey="Lelievre, Vincent" sort="Lelievre, Vincent" uniqKey="Lelievre V" first="Vincent" last="Lelievre">Vincent Lelievre</name>
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<series><title level="j">Cell Adhesion & Migration</title>
<idno type="ISSN">1933-6918</idno>
<idno type="eISSN">1933-6926</idno>
<imprint><date when="2009">2009</date>
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<front><div type="abstract" xml:lang="en"><p>Neurogenesis takes place in the mammalian hippocampus throughout the whole life and deficient adult hippocampal neurogenesis has been related to neurological conditions like Alzheimer disease (AD), Parkinson disease (PD) and epilepsy. The molecular mechanisms by which immature neurons and their extending neurites find their appropriate position and target area remain largely unknown. Recent work by Jessberger et al.<xref ref-type="bibr" rid="R1">1</xref>
examines the role of Cdk5 in normal adult neurogenesis by a retroviral knock-down approach. Cdk5 is shown to be implicated in the migration of newborn neurons into the granule cell layer (GCL), as well as, in correct targeting of dendrites from newborn granule cells (GC) into the molecular layer (ML) of the dentate gyrus (DG). The study also shows that aberrant dendrites still seem to become synaptically integrated into the existing circuitry thereby suggesting a mechanistic dissociation between accurate dendritic targeting and subsequent synapse formation. The finding of Cdk5 guiding this integration of new born neurons at the physiologically appropriate place is an important step towards understanding adult neurogenesis that may help to overcome problems with the restorative use of neural stem cells in present grafting approaches in neurological diseases.</p>
</div>
</front>
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<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Cell Adh Migr</journal-id>
<journal-id journal-id-type="publisher-id">CAM</journal-id>
<journal-title-group><journal-title>Cell Adhesion & Migration</journal-title>
</journal-title-group>
<issn pub-type="ppub">1933-6918</issn>
<issn pub-type="epub">1933-6926</issn>
<publisher><publisher-name>Landes Bioscience</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">19855173</article-id>
<article-id pub-id-type="pmc">2802738</article-id>
<article-id pub-id-type="publisher-id">1933-6918-3-4-3</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Journal Club</subject>
</subj-group>
</article-categories>
<title-group><article-title>CDK5</article-title>
<subtitle>The “pathfinder” for new born neurons in adult hippocampus?</subtitle>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Albert</surname>
<given-names>Tobias</given-names>
</name>
<xref ref-type="author-notes" rid="FN1">†</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Saxena</surname>
<given-names>Monika</given-names>
</name>
<xref ref-type="author-notes" rid="FN1">†</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Lelievre</surname>
<given-names>Vincent</given-names>
</name>
</contrib>
</contrib-group>
<aff>Joint Master in Neuroscience; Faculté des Sciences de la Vie; Unìversité de Strasbourg; Strasbourg, France</aff>
<author-notes><corresp>Correspondence to: Lelievre Vincent; Institut des Neurosciences Cellulaires et Intégratives; CNRS UPR-3212-Université de Strasbourg Bâtiment Neurochimie; 5 rue Blaise Pascal; Strasbourg F-67084 France; Tel.: +33.38.845.6659; Fax: +33.38.860.1664; Email: <email>lelievre@neurochem.u-strasbg.fr</email>
</corresp>
<fn fn-type="equal" id="FN1"><label>†</label>
<p>These authors contributed equally to this work.</p>
</fn>
</author-notes>
<pub-date pub-type="ppub"><season>Oct-Dec</season>
<year>2009</year>
</pub-date>
<volume>3</volume>
<issue>4</issue>
<fpage>319</fpage>
<lpage>321</lpage>
<history><date date-type="received"><day>5</day>
<month>8</month>
<year>2009</year>
</date>
<date date-type="accepted"><day>31</day>
<month>8</month>
<year>2009</year>
</date>
</history>
<permissions><copyright-statement>Copyright © 2009 Landes Bioscience</copyright-statement>
<copyright-year>2009</copyright-year>
</permissions>
<abstract><p>Neurogenesis takes place in the mammalian hippocampus throughout the whole life and deficient adult hippocampal neurogenesis has been related to neurological conditions like Alzheimer disease (AD), Parkinson disease (PD) and epilepsy. The molecular mechanisms by which immature neurons and their extending neurites find their appropriate position and target area remain largely unknown. Recent work by Jessberger et al.<xref ref-type="bibr" rid="R1">1</xref>
examines the role of Cdk5 in normal adult neurogenesis by a retroviral knock-down approach. Cdk5 is shown to be implicated in the migration of newborn neurons into the granule cell layer (GCL), as well as, in correct targeting of dendrites from newborn granule cells (GC) into the molecular layer (ML) of the dentate gyrus (DG). The study also shows that aberrant dendrites still seem to become synaptically integrated into the existing circuitry thereby suggesting a mechanistic dissociation between accurate dendritic targeting and subsequent synapse formation. The finding of Cdk5 guiding this integration of new born neurons at the physiologically appropriate place is an important step towards understanding adult neurogenesis that may help to overcome problems with the restorative use of neural stem cells in present grafting approaches in neurological diseases.</p>
</abstract>
<kwd-group><title>Key words</title>
<kwd>cyclin-dependent kinase 5 (cdk5)</kwd>
<kwd>adult neurogenesis</kwd>
<kwd>dentate gyrus</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
</record>
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