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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Pharmacological recruitment of the GABAergic tail of the ventral tegmental area by acute drug exposure</title><author><name sortKey="Kaufling, Jennifer" sort="Kaufling, Jennifer" uniqKey="Kaufling J" first="Jennifer" last="Kaufling">Jennifer Kaufling</name><affiliation><nlm:aff id="au1"><institution>Institut des Neurosciences Cellulaires et Intégratives, Centre National de la Recherche Scientifique</institution><addr-line>Strasbourg, France</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="au2"><institution>Université de Strasbourg</institution><addr-line>Strasbourg, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Waltisperger, Elisabeth" sort="Waltisperger, Elisabeth" uniqKey="Waltisperger E" first="Elisabeth" last="Waltisperger">Elisabeth Waltisperger</name><affiliation><nlm:aff id="au1"><institution>Institut des Neurosciences Cellulaires et Intégratives, Centre National de la Recherche Scientifique</institution><addr-line>Strasbourg, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Bourdy, Romain" sort="Bourdy, Romain" uniqKey="Bourdy R" first="Romain" last="Bourdy">Romain Bourdy</name><affiliation><nlm:aff id="au1"><institution>Institut des Neurosciences Cellulaires et Intégratives, Centre National de la Recherche Scientifique</institution><addr-line>Strasbourg, France</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="au2"><institution>Université de Strasbourg</institution><addr-line>Strasbourg, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Valera, Antoine" sort="Valera, Antoine" uniqKey="Valera A" first="Antoine" last="Valera">Antoine Valera</name><affiliation><nlm:aff id="au2"><institution>Université de Strasbourg</institution><addr-line>Strasbourg, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Veinante, Pierre" sort="Veinante, Pierre" uniqKey="Veinante P" first="Pierre" last="Veinante">Pierre Veinante</name><affiliation><nlm:aff id="au1"><institution>Institut des Neurosciences Cellulaires et Intégratives, Centre National de la Recherche Scientifique</institution><addr-line>Strasbourg, France</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="au2"><institution>Université de Strasbourg</institution><addr-line>Strasbourg, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Freund Mercier, Marie Jose" sort="Freund Mercier, Marie Jose" uniqKey="Freund Mercier M" first="Marie-José" last="Freund-Mercier">Marie-José Freund-Mercier</name><affiliation><nlm:aff id="au1"><institution>Institut des Neurosciences Cellulaires et Intégratives, Centre National de la Recherche Scientifique</institution><addr-line>Strasbourg, France</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="au2"><institution>Université de Strasbourg</institution><addr-line>Strasbourg, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Barrot, Michel" sort="Barrot, Michel" uniqKey="Barrot M" first="Michel" last="Barrot">Michel Barrot</name><affiliation><nlm:aff id="au1"><institution>Institut des Neurosciences Cellulaires et Intégratives, Centre National de la Recherche Scientifique</institution><addr-line>Strasbourg, France</addr-line></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">21087442</idno><idno type="pmc">3010575</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3010575</idno><idno type="RBID">PMC:3010575</idno><idno type="doi">10.1111/j.1476-5381.2010.00984.x</idno><date when="2010">2010</date><idno type="wicri:Area/Pmc/Corpus">000436</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000436</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Pharmacological recruitment of the GABAergic tail of the ventral tegmental area by acute drug exposure</title><author><name sortKey="Kaufling, Jennifer" sort="Kaufling, Jennifer" uniqKey="Kaufling J" first="Jennifer" last="Kaufling">Jennifer Kaufling</name><affiliation><nlm:aff id="au1"><institution>Institut des Neurosciences Cellulaires et Intégratives, Centre National de la Recherche Scientifique</institution><addr-line>Strasbourg, France</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="au2"><institution>Université de Strasbourg</institution><addr-line>Strasbourg, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Waltisperger, Elisabeth" sort="Waltisperger, Elisabeth" uniqKey="Waltisperger E" first="Elisabeth" last="Waltisperger">Elisabeth Waltisperger</name><affiliation><nlm:aff id="au1"><institution>Institut des Neurosciences Cellulaires et Intégratives, Centre National de la Recherche Scientifique</institution><addr-line>Strasbourg, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Bourdy, Romain" sort="Bourdy, Romain" uniqKey="Bourdy R" first="Romain" last="Bourdy">Romain Bourdy</name><affiliation><nlm:aff id="au1"><institution>Institut des Neurosciences Cellulaires et Intégratives, Centre National de la Recherche Scientifique</institution><addr-line>Strasbourg, France</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="au2"><institution>Université de Strasbourg</institution><addr-line>Strasbourg, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Valera, Antoine" sort="Valera, Antoine" uniqKey="Valera A" first="Antoine" last="Valera">Antoine Valera</name><affiliation><nlm:aff id="au2"><institution>Université de Strasbourg</institution><addr-line>Strasbourg, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Veinante, Pierre" sort="Veinante, Pierre" uniqKey="Veinante P" first="Pierre" last="Veinante">Pierre Veinante</name><affiliation><nlm:aff id="au1"><institution>Institut des Neurosciences Cellulaires et Intégratives, Centre National de la Recherche Scientifique</institution><addr-line>Strasbourg, France</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="au2"><institution>Université de Strasbourg</institution><addr-line>Strasbourg, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Freund Mercier, Marie Jose" sort="Freund Mercier, Marie Jose" uniqKey="Freund Mercier M" first="Marie-José" last="Freund-Mercier">Marie-José Freund-Mercier</name><affiliation><nlm:aff id="au1"><institution>Institut des Neurosciences Cellulaires et Intégratives, Centre National de la Recherche Scientifique</institution><addr-line>Strasbourg, France</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="au2"><institution>Université de Strasbourg</institution><addr-line>Strasbourg, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Barrot, Michel" sort="Barrot, Michel" uniqKey="Barrot M" first="Michel" last="Barrot">Michel Barrot</name><affiliation><nlm:aff id="au1"><institution>Institut des Neurosciences Cellulaires et Intégratives, Centre National de la Recherche Scientifique</institution><addr-line>Strasbourg, France</addr-line></nlm:aff></affiliation></author></analytic><series><title level="j">British Journal of Pharmacology</title><idno type="ISSN">0007-1188</idno><idno type="eISSN">1476-5381</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>BACKGROUND AND PURPOSE</title><p>The tail of the ventral tegmental area (tVTA), also called the rostromedial tegmental nucleus, is a newly defined brain structure and a potential control centre for dopaminergic activity. It was identified by the induction of DeltaFosB following chronic cocaine exposure. In this work, we screened 20 drugs for their ability to induce FosB/DeltaFosB in the tVTA.</p></sec><sec><title>EXPERIMENTAL APPROACH</title><p>Immunohistochemistry following systemic drug administration was used to study FosB/DeltaFosB induction in the tVTA of adult rats. Double-staining was used to determine whether dopamine or GABA neurones are involved in this induction.</p></sec><sec><title>KEY RESULTS</title><p>The acute injection of the psychostimulant drugs cocaine, D-amphetamine, (+/−)-3,4-methylenedioxymethamphetamine (MDMA), methylphenidate or caffeine, induced the expression of FosB/DeltaFosB in the tVTA GABAergic cells. No induction was observed following exposure to ethanol, diazepam, γ-hydroxybutyric acid (GHB), morphine, ketamine, phencyclidine (PCP), Δ<sup>9</sup>-tetrahydrocannabinol (THC), sodium valproic acid or gabapentin. To evaluate the role of monoamine transporters in the psychostimulant-induced expression of FosB/DeltaFosB, we tested the antidepressant drugs reboxetine, nortriptyline, fluoxetine and venlafaxine (which target the noradrenaline and/or the 5-hydroxytryptamine transporters), the 5-hydroxytryptamine releasing agent dexfenfluramine, and the dopamine transporter inhibitor GBR12909. Only GBR12909 was able to induce FosB/DeltaFosB expression in the tVTA, showing that this induction is mediated by dopamine.</p></sec><sec><title>CONCLUSIONS AND IMPLICATIONS</title><p>Newly described brain structures may help to increase our knowledge of brain function, pathology and targets for treatments. FosB/DeltaFosB induction in the tVTA is a common feature of drugs sharing psychostimulant properties but not of drugs sharing risk of abuse.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Br J Pharmacol</journal-id><journal-id journal-id-type="publisher-id">bph</journal-id><journal-title-group><journal-title>British Journal of Pharmacology</journal-title></journal-title-group><issn pub-type="ppub">0007-1188</issn><issn pub-type="epub">1476-5381</issn><publisher><publisher-name>Blackwell Publishing Ltd</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">21087442</article-id><article-id pub-id-type="pmc">3010575</article-id><article-id pub-id-type="doi">10.1111/j.1476-5381.2010.00984.x</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Papers</subject></subj-group></article-categories><title-group><article-title>Pharmacological recruitment of the GABAergic tail of the ventral tegmental area by acute drug exposure</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Kaufling</surname><given-names>Jennifer</given-names></name><xref ref-type="aff" rid="au1">1</xref><xref ref-type="aff" rid="au2">2</xref></contrib><contrib contrib-type="author"><name><surname>Waltisperger</surname><given-names>Elisabeth</given-names></name><xref ref-type="aff" rid="au1">1</xref></contrib><contrib contrib-type="author"><name><surname>Bourdy</surname><given-names>Romain</given-names></name><xref ref-type="aff" rid="au1">1</xref><xref ref-type="aff" rid="au2">2</xref></contrib><contrib contrib-type="author"><name><surname>Valera</surname><given-names>Antoine</given-names></name><xref ref-type="aff" rid="au2">2</xref></contrib><contrib contrib-type="author"><name><surname>Veinante</surname><given-names>Pierre</given-names></name><xref ref-type="aff" rid="au1">1</xref><xref ref-type="aff" rid="au2">2</xref></contrib><contrib contrib-type="author"><name><surname>Freund-Mercier</surname><given-names>Marie-José</given-names></name><xref ref-type="aff" rid="au1">1</xref><xref ref-type="aff" rid="au2">2</xref></contrib><contrib contrib-type="author"><name><surname>Barrot</surname><given-names>Michel</given-names></name><xref ref-type="aff" rid="au1">1</xref></contrib><aff id="au1"><label>1</label><institution>Institut des Neurosciences Cellulaires et Intégratives, Centre National de la Recherche Scientifique</institution><addr-line>Strasbourg, France</addr-line></aff><aff id="au2"><label>2</label><institution>Université de Strasbourg</institution><addr-line>Strasbourg, France</addr-line></aff></contrib-group><author-notes><corresp id="cor1">Dr Michel Barrot, Institut des Neurosciences Cellulaires et Intégratives, 21 rue René Descartes, 67084 Strasbourg Cedex, France. E-mail: <email>mbarrot@inci-cnrs.unistra.fr</email></corresp></author-notes><pub-date pub-type="ppub"><month>12</month><year>2010</year></pub-date><volume>161</volume><issue>8</issue><fpage>1677</fpage><lpage>1691</lpage><history><date date-type="received"><day>03</day><month>2</month><year>2010</year></date><date date-type="rev-recd"><day>02</day><month>7</month><year>2010</year></date><date date-type="accepted"><day>11</day><month>7</month><year>2010</year></date></history><permissions><copyright-statement>Copyright © 2010 The British Pharmacological Society</copyright-statement></permissions><abstract><sec><title>BACKGROUND AND PURPOSE</title><p>The tail of the ventral tegmental area (tVTA), also called the rostromedial tegmental nucleus, is a newly defined brain structure and a potential control centre for dopaminergic activity. It was identified by the induction of DeltaFosB following chronic cocaine exposure. In this work, we screened 20 drugs for their ability to induce FosB/DeltaFosB in the tVTA.</p></sec><sec><title>EXPERIMENTAL APPROACH</title><p>Immunohistochemistry following systemic drug administration was used to study FosB/DeltaFosB induction in the tVTA of adult rats. Double-staining was used to determine whether dopamine or GABA neurones are involved in this induction.</p></sec><sec><title>KEY RESULTS</title><p>The acute injection of the psychostimulant drugs cocaine, D-amphetamine, (+/−)-3,4-methylenedioxymethamphetamine (MDMA), methylphenidate or caffeine, induced the expression of FosB/DeltaFosB in the tVTA GABAergic cells. No induction was observed following exposure to ethanol, diazepam, γ-hydroxybutyric acid (GHB), morphine, ketamine, phencyclidine (PCP), Δ<sup>9</sup>-tetrahydrocannabinol (THC), sodium valproic acid or gabapentin. To evaluate the role of monoamine transporters in the psychostimulant-induced expression of FosB/DeltaFosB, we tested the antidepressant drugs reboxetine, nortriptyline, fluoxetine and venlafaxine (which target the noradrenaline and/or the 5-hydroxytryptamine transporters), the 5-hydroxytryptamine releasing agent dexfenfluramine, and the dopamine transporter inhibitor GBR12909. Only GBR12909 was able to induce FosB/DeltaFosB expression in the tVTA, showing that this induction is mediated by dopamine.</p></sec><sec><title>CONCLUSIONS AND IMPLICATIONS</title><p>Newly described brain structures may help to increase our knowledge of brain function, pathology and targets for treatments. FosB/DeltaFosB induction in the tVTA is a common feature of drugs sharing psychostimulant properties but not of drugs sharing risk of abuse.</p></sec></abstract><kwd-group><kwd>psychostimulant</kwd><kwd>DeltaFosB</kwd><kwd>VTA</kwd><kwd>dopamine</kwd><kwd>GABA</kwd><kwd>tVTA</kwd><kwd>RMTg</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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