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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Effect of food on the pharmacokinetics of ropinirole in parkinsonian patients</title>
<author><name sortKey="Brefel, C" sort="Brefel, C" uniqKey="Brefel C" first="C" last="Brefel">C. Brefel</name>
<affiliation><nlm:aff id="au1"><institution>Service de Pharmacologie Médicale et Clinique, INSERM U 455 et U 317, Faculté de Medecine</institution>
<addr-line>37 allées Jules Guesde, 31073 Toulouse Cedex, France</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Thalamas, C" sort="Thalamas, C" uniqKey="Thalamas C" first="C" last="Thalamas">C. Thalamas</name>
<affiliation><nlm:aff id="au2"><institution>Centre d’Investigation Clinique, hôpital Purpan</institution>
<addr-line>place du Docteur Baylac, 31059 Toulouse Cedex, France</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Rayet, S" sort="Rayet, S" uniqKey="Rayet S" first="S" last="Rayet">S. Rayet</name>
<affiliation><nlm:aff id="au2"><institution>Centre d’Investigation Clinique, hôpital Purpan</institution>
<addr-line>place du Docteur Baylac, 31059 Toulouse Cedex, France</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Lopez Gil, A" sort="Lopez Gil, A" uniqKey="Lopez Gil A" first="A" last="Lopez-Gil">A. Lopez-Gil</name>
<affiliation><nlm:aff id="au3"><institution>Clinical Pharmacology Unit, SmithKline Beecham Pharmaceuticals</institution>
<addr-line>Harlow, Essex, CM19 5AW UK</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Fitzpatrick, K" sort="Fitzpatrick, K" uniqKey="Fitzpatrick K" first="K" last="Fitzpatrick">K. Fitzpatrick</name>
<affiliation><nlm:aff id="au3"><institution>Clinical Pharmacology Unit, SmithKline Beecham Pharmaceuticals</institution>
<addr-line>Harlow, Essex, CM19 5AW UK</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Bullman, S" sort="Bullman, S" uniqKey="Bullman S" first="S" last="Bullman">S. Bullman</name>
<affiliation><nlm:aff id="au4"><institution>Drug Metabolism and Pharmacokinetics, SmithKline Beecham Pharmaceuticals</institution>
<addr-line>The Frythe, Welwyn, Herts, AL6 9AR, UK</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Citerone, D R" sort="Citerone, D R" uniqKey="Citerone D" first="D R" last="Citerone">D R Citerone</name>
<affiliation><nlm:aff id="au4"><institution>Drug Metabolism and Pharmacokinetics, SmithKline Beecham Pharmaceuticals</institution>
<addr-line>The Frythe, Welwyn, Herts, AL6 9AR, UK</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Taylor, A C" sort="Taylor, A C" uniqKey="Taylor A" first="A C" last="Taylor">A C Taylor</name>
<affiliation><nlm:aff id="au4"><institution>Drug Metabolism and Pharmacokinetics, SmithKline Beecham Pharmaceuticals</institution>
<addr-line>The Frythe, Welwyn, Herts, AL6 9AR, UK</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Montastruc, J L" sort="Montastruc, J L" uniqKey="Montastruc J" first="J L" last="Montastruc">J L Montastruc</name>
<affiliation><nlm:aff id="au1"><institution>Service de Pharmacologie Médicale et Clinique, INSERM U 455 et U 317, Faculté de Medecine</institution>
<addr-line>37 allées Jules Guesde, 31073 Toulouse Cedex, France</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Rascol, O" sort="Rascol, O" uniqKey="Rascol O" first="O" last="Rascol">O. Rascol</name>
<affiliation><nlm:aff id="au1"><institution>Service de Pharmacologie Médicale et Clinique, INSERM U 455 et U 317, Faculté de Medecine</institution>
<addr-line>37 allées Jules Guesde, 31073 Toulouse Cedex, France</addr-line>
</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="au2"><institution>Centre d’Investigation Clinique, hôpital Purpan</institution>
<addr-line>place du Docteur Baylac, 31059 Toulouse Cedex, France</addr-line>
</nlm:aff>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">9578193</idno>
<idno type="pmc">1873962</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1873962</idno>
<idno type="RBID">PMC:1873962</idno>
<idno type="doi">10.1046/j.1365-2125.1998.t01-1-00704.x</idno>
<date when="1998">1998</date>
<idno type="wicri:Area/Pmc/Corpus">000431</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000431</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Effect of food on the pharmacokinetics of ropinirole in parkinsonian patients</title>
<author><name sortKey="Brefel, C" sort="Brefel, C" uniqKey="Brefel C" first="C" last="Brefel">C. Brefel</name>
<affiliation><nlm:aff id="au1"><institution>Service de Pharmacologie Médicale et Clinique, INSERM U 455 et U 317, Faculté de Medecine</institution>
<addr-line>37 allées Jules Guesde, 31073 Toulouse Cedex, France</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Thalamas, C" sort="Thalamas, C" uniqKey="Thalamas C" first="C" last="Thalamas">C. Thalamas</name>
<affiliation><nlm:aff id="au2"><institution>Centre d’Investigation Clinique, hôpital Purpan</institution>
<addr-line>place du Docteur Baylac, 31059 Toulouse Cedex, France</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Rayet, S" sort="Rayet, S" uniqKey="Rayet S" first="S" last="Rayet">S. Rayet</name>
<affiliation><nlm:aff id="au2"><institution>Centre d’Investigation Clinique, hôpital Purpan</institution>
<addr-line>place du Docteur Baylac, 31059 Toulouse Cedex, France</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Lopez Gil, A" sort="Lopez Gil, A" uniqKey="Lopez Gil A" first="A" last="Lopez-Gil">A. Lopez-Gil</name>
<affiliation><nlm:aff id="au3"><institution>Clinical Pharmacology Unit, SmithKline Beecham Pharmaceuticals</institution>
<addr-line>Harlow, Essex, CM19 5AW UK</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Fitzpatrick, K" sort="Fitzpatrick, K" uniqKey="Fitzpatrick K" first="K" last="Fitzpatrick">K. Fitzpatrick</name>
<affiliation><nlm:aff id="au3"><institution>Clinical Pharmacology Unit, SmithKline Beecham Pharmaceuticals</institution>
<addr-line>Harlow, Essex, CM19 5AW UK</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Bullman, S" sort="Bullman, S" uniqKey="Bullman S" first="S" last="Bullman">S. Bullman</name>
<affiliation><nlm:aff id="au4"><institution>Drug Metabolism and Pharmacokinetics, SmithKline Beecham Pharmaceuticals</institution>
<addr-line>The Frythe, Welwyn, Herts, AL6 9AR, UK</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Citerone, D R" sort="Citerone, D R" uniqKey="Citerone D" first="D R" last="Citerone">D R Citerone</name>
<affiliation><nlm:aff id="au4"><institution>Drug Metabolism and Pharmacokinetics, SmithKline Beecham Pharmaceuticals</institution>
<addr-line>The Frythe, Welwyn, Herts, AL6 9AR, UK</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Taylor, A C" sort="Taylor, A C" uniqKey="Taylor A" first="A C" last="Taylor">A C Taylor</name>
<affiliation><nlm:aff id="au4"><institution>Drug Metabolism and Pharmacokinetics, SmithKline Beecham Pharmaceuticals</institution>
<addr-line>The Frythe, Welwyn, Herts, AL6 9AR, UK</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Montastruc, J L" sort="Montastruc, J L" uniqKey="Montastruc J" first="J L" last="Montastruc">J L Montastruc</name>
<affiliation><nlm:aff id="au1"><institution>Service de Pharmacologie Médicale et Clinique, INSERM U 455 et U 317, Faculté de Medecine</institution>
<addr-line>37 allées Jules Guesde, 31073 Toulouse Cedex, France</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Rascol, O" sort="Rascol, O" uniqKey="Rascol O" first="O" last="Rascol">O. Rascol</name>
<affiliation><nlm:aff id="au1"><institution>Service de Pharmacologie Médicale et Clinique, INSERM U 455 et U 317, Faculté de Medecine</institution>
<addr-line>37 allées Jules Guesde, 31073 Toulouse Cedex, France</addr-line>
</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="au2"><institution>Centre d’Investigation Clinique, hôpital Purpan</institution>
<addr-line>place du Docteur Baylac, 31059 Toulouse Cedex, France</addr-line>
</nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">British Journal of Clinical Pharmacology</title>
<idno type="ISSN">0306-5251</idno>
<idno type="eISSN">1365-2125</idno>
<imprint><date when="1998">1998</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec><title>Aims</title>
<p>Ropinirole is a specific non-ergoline dopamine D<sub>2</sub>
-receptor agonist with antiparkinsonian properties. The pharmacokinetic parameters of ropinirole taken in the fasted condition were compared with those when it was co-administered with food.</p>
</sec>
<sec sec-type="methods"><title>Methods</title>
<p>This was an open, randomized, two sessions cross over study in 12 patients with Parkinson’s disease, comparing the steady-state pharmacokinetic profiles of ropinirole on two different study days: ‘fasted’ and ‘fed’.</p>
</sec>
<sec><title>Results</title>
<p>The mean <italic>C</italic>
<sub>max</sub>
was lower in the ‘fed’ regimen than in the ‘fasted’ one (−25%, <italic>P</italic>
= 0.002). The median <italic>t</italic>
<sub>max</sub>
was observed 2.6 h later in the ‘fed’ regimen than in the ‘fasted’ regimen (<italic>P</italic>
<0.05). There was a slight but significant decrease in AUC(0,8 h) in the ‘fed’ regimen (<italic>P</italic>
= 0.03).</p>
</sec>
<sec><title>Conclusions</title>
<p>Food decreases the rate of absorption of ropinirole, but has little effect on the extent of absorption.</p>
</sec>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Br J Clin Pharmacol</journal-id>
<journal-id journal-id-type="publisher-id">bcp</journal-id>
<journal-title>British Journal of Clinical Pharmacology</journal-title>
<issn pub-type="ppub">0306-5251</issn>
<issn pub-type="epub">1365-2125</issn>
<publisher><publisher-name>Blackwell Science Inc</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">9578193</article-id>
<article-id pub-id-type="pmc">1873962</article-id>
<article-id pub-id-type="doi">10.1046/j.1365-2125.1998.t01-1-00704.x</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Original Articles</subject>
</subj-group>
</article-categories>
<title-group><article-title>Effect of food on the pharmacokinetics of ropinirole in parkinsonian patients</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Brefel</surname>
<given-names>C</given-names>
</name>
<xref rid="au1" ref-type="aff">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Thalamas</surname>
<given-names>C</given-names>
</name>
<xref rid="au2" ref-type="aff">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Rayet</surname>
<given-names>S</given-names>
</name>
<xref rid="au2" ref-type="aff">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lopez-Gil</surname>
<given-names>A</given-names>
</name>
<xref rid="au3" ref-type="aff">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Fitzpatrick</surname>
<given-names>K</given-names>
</name>
<xref rid="au3" ref-type="aff">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Bullman</surname>
<given-names>S</given-names>
</name>
<xref rid="au4" ref-type="aff">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Citerone</surname>
<given-names>D R</given-names>
</name>
<xref rid="au4" ref-type="aff">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Taylor</surname>
<given-names>A C</given-names>
</name>
<xref rid="au4" ref-type="aff">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Montastruc</surname>
<given-names>J L</given-names>
</name>
<xref rid="au1" ref-type="aff">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Rascol</surname>
<given-names>O</given-names>
</name>
<xref rid="au1" ref-type="aff">1</xref>
<xref rid="au2" ref-type="aff">2</xref>
</contrib>
<aff id="au1"><label>1</label>
<institution>Service de Pharmacologie Médicale et Clinique, INSERM U 455 et U 317, Faculté de Medecine</institution>
<addr-line>37 allées Jules Guesde, 31073 Toulouse Cedex, France</addr-line>
</aff>
<aff id="au2"><label>2</label>
<institution>Centre d’Investigation Clinique, hôpital Purpan</institution>
<addr-line>place du Docteur Baylac, 31059 Toulouse Cedex, France</addr-line>
</aff>
<aff id="au3"><label>3</label>
<institution>Clinical Pharmacology Unit, SmithKline Beecham Pharmaceuticals</institution>
<addr-line>Harlow, Essex, CM19 5AW UK</addr-line>
</aff>
<aff id="au4"><label>4</label>
<institution>Drug Metabolism and Pharmacokinetics, SmithKline Beecham Pharmaceuticals</institution>
<addr-line>The Frythe, Welwyn, Herts, AL6 9AR, UK</addr-line>
</aff>
</contrib-group>
<author-notes><corresp id="cor1">Correspondence: Professor O. Rascol, Service de Pharmacologie Médicale et Clinique, INSERM U 455, Faculté de Medecine, 37 allées Jules Guesde, 31073 Toulouse Cedex, France.</corresp>
</author-notes>
<pub-date pub-type="ppub"><month>4</month>
<year>1998</year>
</pub-date>
<volume>45</volume>
<issue>4</issue>
<fpage>412</fpage>
<lpage>415</lpage>
<history><date date-type="received"><day>07</day>
<month>4</month>
<year>1997</year>
</date>
<date date-type="accepted"><day>04</day>
<month>12</month>
<year>1997</year>
</date>
</history>
<copyright-statement>© 1998 Blackwell Science Ltd</copyright-statement>
<copyright-year>1998</copyright-year>
<abstract><sec><title>Aims</title>
<p>Ropinirole is a specific non-ergoline dopamine D<sub>2</sub>
-receptor agonist with antiparkinsonian properties. The pharmacokinetic parameters of ropinirole taken in the fasted condition were compared with those when it was co-administered with food.</p>
</sec>
<sec sec-type="methods"><title>Methods</title>
<p>This was an open, randomized, two sessions cross over study in 12 patients with Parkinson’s disease, comparing the steady-state pharmacokinetic profiles of ropinirole on two different study days: ‘fasted’ and ‘fed’.</p>
</sec>
<sec><title>Results</title>
<p>The mean <italic>C</italic>
<sub>max</sub>
was lower in the ‘fed’ regimen than in the ‘fasted’ one (−25%, <italic>P</italic>
= 0.002). The median <italic>t</italic>
<sub>max</sub>
was observed 2.6 h later in the ‘fed’ regimen than in the ‘fasted’ regimen (<italic>P</italic>
<0.05). There was a slight but significant decrease in AUC(0,8 h) in the ‘fed’ regimen (<italic>P</italic>
= 0.03).</p>
</sec>
<sec><title>Conclusions</title>
<p>Food decreases the rate of absorption of ropinirole, but has little effect on the extent of absorption.</p>
</sec>
</abstract>
<kwd-group><kwd>dopaminergic agonist</kwd>
<kwd>ropinirole</kwd>
<kwd>pharmacokinetics</kwd>
<kwd>food interaction</kwd>
<kwd>Parkinson’s disease</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
</record>
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