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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Liver X receptors alpha and beta promote myelination and remyelination in the cerebellum</title><author><name sortKey="Meffre, Delphine" sort="Meffre, Delphine" uniqKey="Meffre D" first="Delphine" last="Meffre">Delphine Meffre</name><affiliation><nlm:aff id="aff1">UMR-S 1124 INSERM, Paris Descartes University, Sorbonne Paris Cité University,<institution>Centre Interdisciplinaire Chimie Biologie-Paris (FR 3567, CNRS)</institution>, 75270 Paris Cedex 6,<country>France</country>;</nlm:aff></affiliation></author><author><name sortKey="Shackleford, Ghjuvan Hjacumu" sort="Shackleford, Ghjuvan Hjacumu" uniqKey="Shackleford G" first="Ghjuvan Hjacumu" last="Shackleford">Ghjuvan Hjacumu Shackleford</name><affiliation><nlm:aff id="aff1">UMR-S 1124 INSERM, Paris Descartes University, Sorbonne Paris Cité University,<institution>Centre Interdisciplinaire Chimie Biologie-Paris (FR 3567, CNRS)</institution>, 75270 Paris Cedex 6,<country>France</country>;</nlm:aff></affiliation></author><author><name sortKey="Hichor, Mehdi" sort="Hichor, Mehdi" uniqKey="Hichor M" first="Mehdi" last="Hichor">Mehdi Hichor</name><affiliation><nlm:aff id="aff1">UMR-S 1124 INSERM, Paris Descartes University, Sorbonne Paris Cité University,<institution>Centre Interdisciplinaire Chimie Biologie-Paris (FR 3567, CNRS)</institution>, 75270 Paris Cedex 6,<country>France</country>;</nlm:aff></affiliation></author><author><name sortKey="Gorgievski, Victor" sort="Gorgievski, Victor" uniqKey="Gorgievski V" first="Victor" last="Gorgievski">Victor Gorgievski</name><affiliation><nlm:aff wicri:cut=", and" id="aff2">U-1130 INSERM, CNRS 8246<institution>Pierre and Marie Curie University</institution>, 75005 Paris,<country>France</country>;</nlm:aff></affiliation></author><author><name sortKey="Tzavara, Eleni T" sort="Tzavara, Eleni T" uniqKey="Tzavara E" first="Eleni T." last="Tzavara">Eleni T. Tzavara</name><affiliation><nlm:aff wicri:cut=", and" id="aff2">U-1130 INSERM, CNRS 8246<institution>Pierre and Marie Curie University</institution>, 75005 Paris,<country>France</country>;</nlm:aff></affiliation></author><author><name sortKey="Trousson, Amalia" sort="Trousson, Amalia" uniqKey="Trousson A" first="Amalia" last="Trousson">Amalia Trousson</name><affiliation><nlm:aff id="aff1">UMR-S 1124 INSERM, Paris Descartes University, Sorbonne Paris Cité University,<institution>Centre Interdisciplinaire Chimie Biologie-Paris (FR 3567, CNRS)</institution>, 75270 Paris Cedex 6,<country>France</country>;</nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=", and" id="aff3">UMR-6547, CNRS, and Blaise Pascal University<institution>Centre de Recherche en Nutrition Humaine d’Auvergne</institution>, 63177 Aubière,<country>France</country>;</nlm:aff></affiliation></author><author><name sortKey="Ghoumari, Abdel M" sort="Ghoumari, Abdel M" uniqKey="Ghoumari A" first="Abdel M." last="Ghoumari">Abdel M. Ghoumari</name><affiliation><nlm:aff wicri:cut=", and" id="aff4">UMR-788, INSERM<institution>Paris-Sud University</institution>, 94276 Le Kremlin-Bicêtre Cedex,<country>France</country>;</nlm:aff></affiliation></author><author><name sortKey="Deboux, Cyrille" sort="Deboux, Cyrille" uniqKey="Deboux C" first="Cyrille" last="Deboux">Cyrille Deboux</name><affiliation><nlm:aff id="aff5">U-1127 INSERM, Institut du Cerveau et de la Moelle Epinière, Université Pierre et Marie Curie, Paris Sorbonne Universités UMR-S1127,<institution>CNRS UMR 7225</institution>, 75013 Paris,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Nait Oumesmar, Brahim" sort="Nait Oumesmar, Brahim" uniqKey="Nait Oumesmar B" first="Brahim" last="Nait Oumesmar">Brahim Nait Oumesmar</name><affiliation><nlm:aff id="aff5">U-1127 INSERM, Institut du Cerveau et de la Moelle Epinière, Université Pierre et Marie Curie, Paris Sorbonne Universités UMR-S1127,<institution>CNRS UMR 7225</institution>, 75013 Paris,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Liere, Philippe" sort="Liere, Philippe" uniqKey="Liere P" first="Philippe" last="Liere">Philippe Liere</name><affiliation><nlm:aff wicri:cut=", and" id="aff4">UMR-788, INSERM<institution>Paris-Sud University</institution>, 94276 Le Kremlin-Bicêtre Cedex,<country>France</country>;</nlm:aff></affiliation></author><author><name sortKey="Schumacher, Michael" sort="Schumacher, Michael" uniqKey="Schumacher M" first="Michael" last="Schumacher">Michael Schumacher</name><affiliation><nlm:aff wicri:cut=", and" id="aff4">UMR-788, INSERM<institution>Paris-Sud University</institution>, 94276 Le Kremlin-Bicêtre Cedex,<country>France</country>;</nlm:aff></affiliation></author><author><name sortKey="Baulieu, Etienne Emile" sort="Baulieu, Etienne Emile" uniqKey="Baulieu E" first="Etienne-Emile" last="Baulieu">Etienne-Emile Baulieu</name><affiliation><nlm:aff wicri:cut=", and" id="aff4">UMR-788, INSERM<institution>Paris-Sud University</institution>, 94276 Le Kremlin-Bicêtre Cedex,<country>France</country>;</nlm:aff></affiliation></author><author><name sortKey="Charbonnier, Frederic" sort="Charbonnier, Frederic" uniqKey="Charbonnier F" first="Frédéric" last="Charbonnier">Frédéric Charbonnier</name><affiliation><nlm:aff id="aff1">UMR-S 1124 INSERM, Paris Descartes University, Sorbonne Paris Cité University,<institution>Centre Interdisciplinaire Chimie Biologie-Paris (FR 3567, CNRS)</institution>, 75270 Paris Cedex 6,<country>France</country>;</nlm:aff></affiliation></author><author><name sortKey="Grenier, Julien" sort="Grenier, Julien" uniqKey="Grenier J" first="Julien" last="Grenier">Julien Grenier</name><affiliation><nlm:aff id="aff1">UMR-S 1124 INSERM, Paris Descartes University, Sorbonne Paris Cité University,<institution>Centre Interdisciplinaire Chimie Biologie-Paris (FR 3567, CNRS)</institution>, 75270 Paris Cedex 6,<country>France</country>;</nlm:aff></affiliation></author><author><name sortKey="Massaad, Charbel" sort="Massaad, Charbel" uniqKey="Massaad C" first="Charbel" last="Massaad">Charbel Massaad</name><affiliation><nlm:aff id="aff1">UMR-S 1124 INSERM, Paris Descartes University, Sorbonne Paris Cité University,<institution>Centre Interdisciplinaire Chimie Biologie-Paris (FR 3567, CNRS)</institution>, 75270 Paris Cedex 6,<country>France</country>;</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26023184</idno><idno type="pmc">4475952</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4475952</idno><idno type="RBID">PMC:4475952</idno><idno type="doi">10.1073/pnas.1424951112</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000051</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000051</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Liver X receptors alpha and beta promote myelination and remyelination in the cerebellum</title><author><name sortKey="Meffre, Delphine" sort="Meffre, Delphine" uniqKey="Meffre D" first="Delphine" last="Meffre">Delphine Meffre</name><affiliation><nlm:aff id="aff1">UMR-S 1124 INSERM, Paris Descartes University, Sorbonne Paris Cité University,<institution>Centre Interdisciplinaire Chimie Biologie-Paris (FR 3567, CNRS)</institution>, 75270 Paris Cedex 6,<country>France</country>;</nlm:aff></affiliation></author><author><name sortKey="Shackleford, Ghjuvan Hjacumu" sort="Shackleford, Ghjuvan Hjacumu" uniqKey="Shackleford G" first="Ghjuvan Hjacumu" last="Shackleford">Ghjuvan Hjacumu Shackleford</name><affiliation><nlm:aff id="aff1">UMR-S 1124 INSERM, Paris Descartes University, Sorbonne Paris Cité University,<institution>Centre Interdisciplinaire Chimie Biologie-Paris (FR 3567, CNRS)</institution>, 75270 Paris Cedex 6,<country>France</country>;</nlm:aff></affiliation></author><author><name sortKey="Hichor, Mehdi" sort="Hichor, Mehdi" uniqKey="Hichor M" first="Mehdi" last="Hichor">Mehdi Hichor</name><affiliation><nlm:aff id="aff1">UMR-S 1124 INSERM, Paris Descartes University, Sorbonne Paris Cité University,<institution>Centre Interdisciplinaire Chimie Biologie-Paris (FR 3567, CNRS)</institution>, 75270 Paris Cedex 6,<country>France</country>;</nlm:aff></affiliation></author><author><name sortKey="Gorgievski, Victor" sort="Gorgievski, Victor" uniqKey="Gorgievski V" first="Victor" last="Gorgievski">Victor Gorgievski</name><affiliation><nlm:aff wicri:cut=", and" id="aff2">U-1130 INSERM, CNRS 8246<institution>Pierre and Marie Curie University</institution>, 75005 Paris,<country>France</country>;</nlm:aff></affiliation></author><author><name sortKey="Tzavara, Eleni T" sort="Tzavara, Eleni T" uniqKey="Tzavara E" first="Eleni T." last="Tzavara">Eleni T. Tzavara</name><affiliation><nlm:aff wicri:cut=", and" id="aff2">U-1130 INSERM, CNRS 8246<institution>Pierre and Marie Curie University</institution>, 75005 Paris,<country>France</country>;</nlm:aff></affiliation></author><author><name sortKey="Trousson, Amalia" sort="Trousson, Amalia" uniqKey="Trousson A" first="Amalia" last="Trousson">Amalia Trousson</name><affiliation><nlm:aff id="aff1">UMR-S 1124 INSERM, Paris Descartes University, Sorbonne Paris Cité University,<institution>Centre Interdisciplinaire Chimie Biologie-Paris (FR 3567, CNRS)</institution>, 75270 Paris Cedex 6,<country>France</country>;</nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=", and" id="aff3">UMR-6547, CNRS, and Blaise Pascal University<institution>Centre de Recherche en Nutrition Humaine d’Auvergne</institution>, 63177 Aubière,<country>France</country>;</nlm:aff></affiliation></author><author><name sortKey="Ghoumari, Abdel M" sort="Ghoumari, Abdel M" uniqKey="Ghoumari A" first="Abdel M." last="Ghoumari">Abdel M. Ghoumari</name><affiliation><nlm:aff wicri:cut=", and" id="aff4">UMR-788, INSERM<institution>Paris-Sud University</institution>, 94276 Le Kremlin-Bicêtre Cedex,<country>France</country>;</nlm:aff></affiliation></author><author><name sortKey="Deboux, Cyrille" sort="Deboux, Cyrille" uniqKey="Deboux C" first="Cyrille" last="Deboux">Cyrille Deboux</name><affiliation><nlm:aff id="aff5">U-1127 INSERM, Institut du Cerveau et de la Moelle Epinière, Université Pierre et Marie Curie, Paris Sorbonne Universités UMR-S1127,<institution>CNRS UMR 7225</institution>, 75013 Paris,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Nait Oumesmar, Brahim" sort="Nait Oumesmar, Brahim" uniqKey="Nait Oumesmar B" first="Brahim" last="Nait Oumesmar">Brahim Nait Oumesmar</name><affiliation><nlm:aff id="aff5">U-1127 INSERM, Institut du Cerveau et de la Moelle Epinière, Université Pierre et Marie Curie, Paris Sorbonne Universités UMR-S1127,<institution>CNRS UMR 7225</institution>, 75013 Paris,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Liere, Philippe" sort="Liere, Philippe" uniqKey="Liere P" first="Philippe" last="Liere">Philippe Liere</name><affiliation><nlm:aff wicri:cut=", and" id="aff4">UMR-788, INSERM<institution>Paris-Sud University</institution>, 94276 Le Kremlin-Bicêtre Cedex,<country>France</country>;</nlm:aff></affiliation></author><author><name sortKey="Schumacher, Michael" sort="Schumacher, Michael" uniqKey="Schumacher M" first="Michael" last="Schumacher">Michael Schumacher</name><affiliation><nlm:aff wicri:cut=", and" id="aff4">UMR-788, INSERM<institution>Paris-Sud University</institution>, 94276 Le Kremlin-Bicêtre Cedex,<country>France</country>;</nlm:aff></affiliation></author><author><name sortKey="Baulieu, Etienne Emile" sort="Baulieu, Etienne Emile" uniqKey="Baulieu E" first="Etienne-Emile" last="Baulieu">Etienne-Emile Baulieu</name><affiliation><nlm:aff wicri:cut=", and" id="aff4">UMR-788, INSERM<institution>Paris-Sud University</institution>, 94276 Le Kremlin-Bicêtre Cedex,<country>France</country>;</nlm:aff></affiliation></author><author><name sortKey="Charbonnier, Frederic" sort="Charbonnier, Frederic" uniqKey="Charbonnier F" first="Frédéric" last="Charbonnier">Frédéric Charbonnier</name><affiliation><nlm:aff id="aff1">UMR-S 1124 INSERM, Paris Descartes University, Sorbonne Paris Cité University,<institution>Centre Interdisciplinaire Chimie Biologie-Paris (FR 3567, CNRS)</institution>, 75270 Paris Cedex 6,<country>France</country>;</nlm:aff></affiliation></author><author><name sortKey="Grenier, Julien" sort="Grenier, Julien" uniqKey="Grenier J" first="Julien" last="Grenier">Julien Grenier</name><affiliation><nlm:aff id="aff1">UMR-S 1124 INSERM, Paris Descartes University, Sorbonne Paris Cité University,<institution>Centre Interdisciplinaire Chimie Biologie-Paris (FR 3567, CNRS)</institution>, 75270 Paris Cedex 6,<country>France</country>;</nlm:aff></affiliation></author><author><name sortKey="Massaad, Charbel" sort="Massaad, Charbel" uniqKey="Massaad C" first="Charbel" last="Massaad">Charbel Massaad</name><affiliation><nlm:aff id="aff1">UMR-S 1124 INSERM, Paris Descartes University, Sorbonne Paris Cité University,<institution>Centre Interdisciplinaire Chimie Biologie-Paris (FR 3567, CNRS)</institution>, 75270 Paris Cedex 6,<country>France</country>;</nlm:aff></affiliation></author></analytic><series><title level="j">Proceedings of the National Academy of Sciences of the United States of America</title><idno type="ISSN">0027-8424</idno><idno type="eISSN">1091-6490</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Significance</title><p>Liver X receptors (LXRs) α and β are the two major receptors of oxysterols, oxygenated derivatives of cholesterol. They control the homeostasis of cholesterol, an important lipid constituent of myelin sheaths. In the central nervous system, these insulating structures are generated by oligodendrocytes and are stabilized by myelin proteins. Here, we provide evidence of a new role of LXRs in the myelin physiology of the cerebellum. Mice invalidated for both LXRs exhibit alteration in motor coordination and spatial learning linked with myelination deficits. We demonstrated that LXRs intervene both in oligodendroglial cell maturation and in the transcriptional control of myelin gene expression during (re)myelination processes.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Proc Natl Acad Sci U S A</journal-id><journal-id journal-id-type="iso-abbrev">Proc. Natl. Acad. Sci. U.S.A</journal-id><journal-id journal-id-type="hwp">pnas</journal-id><journal-id journal-id-type="pmc">pnas</journal-id><journal-id journal-id-type="publisher-id">PNAS</journal-id><journal-title-group><journal-title>Proceedings of the National Academy of Sciences of the United States of America</journal-title></journal-title-group><issn pub-type="ppub">0027-8424</issn><issn pub-type="epub">1091-6490</issn><publisher><publisher-name>National Academy of Sciences</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">26023184</article-id><article-id pub-id-type="pmc">4475952</article-id><article-id pub-id-type="publisher-id">201424951</article-id><article-id pub-id-type="doi">10.1073/pnas.1424951112</article-id><article-categories><subj-group subj-group-type="heading"><subject>Biological Sciences</subject><subj-group><subject>Neuroscience</subject></subj-group></subj-group></article-categories><title-group><article-title>Liver X receptors alpha and beta promote myelination and remyelination in the cerebellum</article-title><alt-title alt-title-type="short">LXRα/β promote (re)myelination in the cerebellum</alt-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Meffre</surname><given-names>Delphine</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref></contrib><contrib contrib-type="author"><name><surname>Shackleford</surname><given-names>Ghjuvan’Ghjacumu</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref></contrib><contrib contrib-type="author"><name><surname>Hichor</surname><given-names>Mehdi</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref></contrib><contrib contrib-type="author"><name><surname>Gorgievski</surname><given-names>Victor</given-names></name><xref ref-type="aff" rid="aff2"><sup>b</sup></xref></contrib><contrib contrib-type="author"><name><surname>Tzavara</surname><given-names>Eleni T.</given-names></name><xref ref-type="aff" rid="aff2"><sup>b</sup></xref></contrib><contrib contrib-type="author"><name><surname>Trousson</surname><given-names>Amalia</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref><xref ref-type="aff" rid="aff3"><sup>c</sup></xref></contrib><contrib contrib-type="author"><name><surname>Ghoumari</surname><given-names>Abdel M.</given-names></name><xref ref-type="aff" rid="aff4"><sup>d</sup></xref></contrib><contrib contrib-type="author"><name><surname>Deboux</surname><given-names>Cyrille</given-names></name><xref ref-type="aff" rid="aff5"><sup>e</sup></xref></contrib><contrib contrib-type="author"><name><surname>Nait Oumesmar</surname><given-names>Brahim</given-names></name><xref ref-type="aff" rid="aff5"><sup>e</sup></xref></contrib><contrib contrib-type="author"><name><surname>Liere</surname><given-names>Philippe</given-names></name><xref ref-type="aff" rid="aff4"><sup>d</sup></xref></contrib><contrib contrib-type="author"><name><surname>Schumacher</surname><given-names>Michael</given-names></name><xref ref-type="aff" rid="aff4"><sup>d</sup></xref></contrib><contrib contrib-type="author"><name><surname>Baulieu</surname><given-names>Etienne-Emile</given-names></name><xref ref-type="aff" rid="aff4"><sup>d</sup></xref><xref ref-type="corresp" rid="cor1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Charbonnier</surname><given-names>Frédéric</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref></contrib><contrib contrib-type="author"><name><surname>Grenier</surname><given-names>Julien</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref></contrib><contrib contrib-type="author"><name><surname>Massaad</surname><given-names>Charbel</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref><xref ref-type="corresp" rid="cor1"><sup>1</sup></xref></contrib><aff id="aff1"><sup>a</sup>UMR-S 1124 INSERM, Paris Descartes University, Sorbonne Paris Cité University,<institution>Centre Interdisciplinaire Chimie Biologie-Paris (FR 3567, CNRS)</institution>, 75270 Paris Cedex 6,<country>France</country>;</aff><aff id="aff2"><sup>b</sup>U-1130 INSERM, CNRS 8246, and<institution>Pierre and Marie Curie University</institution>, 75005 Paris,<country>France</country>;</aff><aff id="aff3"><sup>c</sup>UMR-6547, CNRS, and Blaise Pascal University, and<institution>Centre de Recherche en Nutrition Humaine d’Auvergne</institution>, 63177 Aubière,<country>France</country>;</aff><aff id="aff4"><sup>d</sup>UMR-788, INSERM, and<institution>Paris-Sud University</institution>, 94276 Le Kremlin-Bicêtre Cedex,<country>France</country>;</aff><aff id="aff5"><sup>e</sup>U-1127 INSERM, Institut du Cerveau et de la Moelle Epinière, Université Pierre et Marie Curie, Paris Sorbonne Universités UMR-S1127,<institution>CNRS UMR 7225</institution>, 75013 Paris,<country>France</country></aff></contrib-group><author-notes><corresp id="cor1"><sup>1</sup>To whom correspondence may be addressed. Email: <email>charbel.massaad@parisdescartes.fr</email> or <email>etienne.baulieu@inserm.fr</email>.</corresp><fn fn-type="edited-by"><p>Contributed by Etienne-Emile Baulieu, January 6, 2015 (sent for review December 12, 2014)</p></fn><fn fn-type="con"><p>Author contributions: D.M., E.T.T., and C.M. designed research; D.M., A.T., G.S., M.H., V.G., A.T., C.D., P.L., and J.G. performed research; D.M., E.T.T., A.M.G., B.N.O., M.S., E.-E.B., F.C., J.G., and C.M. analyzed data; and D.M., E.T.T., M.S., E.-E.B., J.G., and C.M. wrote the paper.</p></fn></author-notes><pub-date pub-type="ppub"><day>16</day><month>6</month><year>2015</year></pub-date><pub-date pub-type="epub"><day>28</day><month>5</month><year>2015</year></pub-date><volume>112</volume><issue>24</issue><fpage>7587</fpage><lpage>7592</lpage><self-uri xlink:title="pdf" xlink:href="pnas.201424951.pdf"></self-uri><abstract abstract-type="executive-summary"><title>Significance</title><p>Liver X receptors (LXRs) α and β are the two major receptors of oxysterols, oxygenated derivatives of cholesterol. They control the homeostasis of cholesterol, an important lipid constituent of myelin sheaths. In the central nervous system, these insulating structures are generated by oligodendrocytes and are stabilized by myelin proteins. Here, we provide evidence of a new role of LXRs in the myelin physiology of the cerebellum. Mice invalidated for both LXRs exhibit alteration in motor coordination and spatial learning linked with myelination deficits. We demonstrated that LXRs intervene both in oligodendroglial cell maturation and in the transcriptional control of myelin gene expression during (re)myelination processes.</p></abstract><abstract><p>The identification of new pathways governing myelination provides innovative avenues for remyelination. Liver X receptors (LXRs) α and β are nuclear receptors activated by oxysterols that originated from the oxidation of cholesterol. They are crucial for cholesterol homeostasis, a major lipid constituent of myelin sheaths that are formed by oligodendrocytes. However, the role of LXRs in myelin generation and maintenance is poorly understood. Here, we show that LXRs are involved in myelination and remyelination processes. LXRs and their ligands are present in oligodendrocytes. We found that mice invalidated for LXRs exhibit altered motor coordination and spatial learning, thinner myelin sheaths, and reduced myelin gene expression. Conversely, activation of LXRs by either 25-hydroxycholesterol or synthetic TO901317 stimulates myelin gene expression at the promoter, mRNA, and protein levels, directly implicating LXRα/β in the transcriptional control of myelin gene expression. Interestingly, activation of LXRs also promotes oligodendroglial cell maturation and remyelination after lysolecithin-induced demyelination of organotypic cerebellar slice cultures. Together, our findings represent a conceptual advance in the transcriptional control of myelin gene expression and strongly support a new role of LXRs as positive modulators in central (re)myelination processes.</p></abstract><kwd-group><kwd>LXR alpha and beta</kwd><kwd>oligodendrocytes</kwd><kwd>cerebellum</kwd><kwd>myelination</kwd><kwd>oxysterols</kwd></kwd-group><funding-group><award-group id="gs1"><funding-source id="sp1">AFM-Téléthon (French Muscular Dystrophy Association)<named-content content-type="funder-id">501100004923</named-content></funding-source><award-id rid="sp1">AO2012</award-id></award-group><award-group id="gs2"><funding-source id="sp2">Fondation d'Aide pour la Recherche sur la Sclerose en Plaques (Fondation ARSEP)<named-content content-type="funder-id">100007379</named-content></funding-source><award-id rid="sp2">AO2014</award-id></award-group><award-group id="gs3"><funding-source id="sp3">Agence Nationale de la Recherche (L' Agence Nationale de la Recherche)<named-content content-type="funder-id">501100001665</named-content></funding-source><award-id rid="sp3">ERA-NET</award-id></award-group></funding-group><counts><page-count count="6"></page-count></counts></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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