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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Are cyclooxygenase-2 and nitric oxide involved in the dyskinesia of Parkinson's disease induced by <sc>l</sc>-DOPA?<sup><xref ref-type="author-notes" rid="AN1">†</xref></sup></title><author><name sortKey="Bortolanza, Mariza" sort="Bortolanza, Mariza" uniqKey="Bortolanza M" first="Mariza" last="Bortolanza">Mariza Bortolanza</name><affiliation><nlm:aff id="af1"><addr-line>School of Odontology of Ribeirão Preto, Department of Morphology</addr-line>,<institution>University of São Paulo (USP)</institution>,<addr-line>Physiology and Basic Pathology, Av. Café S/N, 14040-904, Ribeirão Preto, São Paulo</addr-line>,<country>Brazil</country></nlm:aff></affiliation><affiliation><nlm:aff id="af2"><addr-line>Center for Interdisciplinary Research on Applied Neurosciences (NAPNA)</addr-line>,<institution>University of Sao Paulo</institution>,<addr-line>São Paulo</addr-line>,<country>Brazil</country></nlm:aff></affiliation></author><author><name sortKey="Padovan Neto, Fernando E" sort="Padovan Neto, Fernando E" uniqKey="Padovan Neto F" first="Fernando E." last="Padovan-Neto">Fernando E. Padovan-Neto</name><affiliation><nlm:aff id="af2"><addr-line>Center for Interdisciplinary Research on Applied Neurosciences (NAPNA)</addr-line>,<institution>University of Sao Paulo</institution>,<addr-line>São Paulo</addr-line>,<country>Brazil</country></nlm:aff></affiliation><affiliation><nlm:aff id="af3"><addr-line>Department of Behavioural Neurosciences, Av. Bandeirantes 3900, 14049-900 Ribeirão Preto, São Paulo</addr-line>,<country>Brazil</country></nlm:aff></affiliation></author><author><name sortKey="Cavalcanti Kiwiatkoski, Roberta" sort="Cavalcanti Kiwiatkoski, Roberta" uniqKey="Cavalcanti Kiwiatkoski R" first="Roberta" last="Cavalcanti-Kiwiatkoski">Roberta Cavalcanti-Kiwiatkoski</name><affiliation><nlm:aff id="af2"><addr-line>Center for Interdisciplinary Research on Applied Neurosciences (NAPNA)</addr-line>,<institution>University of Sao Paulo</institution>,<addr-line>São Paulo</addr-line>,<country>Brazil</country></nlm:aff></affiliation><affiliation><nlm:aff id="af4"><addr-line>Medical School, Department of Physiology</addr-line>,<institution>University of Sao Paulo</institution>,<addr-line>São Paulo</addr-line>,<country>Brazil</country></nlm:aff></affiliation></author><author><name sortKey="Dos Santos Pereira, Mauricio" sort="Dos Santos Pereira, Mauricio" uniqKey="Dos Santos Pereira M" first="Maurício" last="Dos Santos-Pereira">Maurício Dos Santos-Pereira</name><affiliation><nlm:aff id="af2"><addr-line>Center for Interdisciplinary Research on Applied Neurosciences (NAPNA)</addr-line>,<institution>University of Sao Paulo</institution>,<addr-line>São Paulo</addr-line>,<country>Brazil</country></nlm:aff></affiliation><affiliation><nlm:aff id="af4"><addr-line>Medical School, Department of Physiology</addr-line>,<institution>University of Sao Paulo</institution>,<addr-line>São Paulo</addr-line>,<country>Brazil</country></nlm:aff></affiliation></author><author><name sortKey="Mitkovski, Miso" sort="Mitkovski, Miso" uniqKey="Mitkovski M" first="Miso" last="Mitkovski">Miso Mitkovski</name><affiliation><nlm:aff id="af6"><institution>Light Microscopy Facility, Max Planck Institute of Experimental Medicine, Hermann-Rein-Str.</institution><addr-line>3, 37075 Göttingen</addr-line>,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Raisman Vozari, Rita" sort="Raisman Vozari, Rita" uniqKey="Raisman Vozari R" first="Rita" last="Raisman-Vozari">Rita Raisman-Vozari</name><affiliation><nlm:aff id="af5"><addr-line>Institut de Cerveau et de la Moelle Epinière</addr-line>,<institution>Sorbonne Université UPMC UM75 INSERM U1127, CNRS UMR 7225</institution>,<addr-line>Paris</addr-line>,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Del Bel, Elaine" sort="Del Bel, Elaine" uniqKey="Del Bel E" first="Elaine" last="Del-Bel">Elaine Del-Bel</name><affiliation><nlm:aff id="af1"><addr-line>School of Odontology of Ribeirão Preto, Department of Morphology</addr-line>,<institution>University of São Paulo (USP)</institution>,<addr-line>Physiology and Basic Pathology, Av. Café S/N, 14040-904, Ribeirão Preto, São Paulo</addr-line>,<country>Brazil</country></nlm:aff></affiliation><affiliation><nlm:aff id="af2"><addr-line>Center for Interdisciplinary Research on Applied Neurosciences (NAPNA)</addr-line>,<institution>University of Sao Paulo</institution>,<addr-line>São Paulo</addr-line>,<country>Brazil</country></nlm:aff></affiliation><affiliation><nlm:aff id="af3"><addr-line>Department of Behavioural Neurosciences, Av. Bandeirantes 3900, 14049-900 Ribeirão Preto, São Paulo</addr-line>,<country>Brazil</country></nlm:aff></affiliation><affiliation><nlm:aff id="af4"><addr-line>Medical School, Department of Physiology</addr-line>,<institution>University of Sao Paulo</institution>,<addr-line>São Paulo</addr-line>,<country>Brazil</country></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26009769</idno><idno type="pmc">4455759</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4455759</idno><idno type="RBID">PMC:4455759</idno><idno type="doi">10.1098/rstb.2014.0190</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000049</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000049</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Are cyclooxygenase-2 and nitric oxide involved in the dyskinesia of Parkinson's disease induced by <sc>l</sc>-DOPA?<sup><xref ref-type="author-notes" rid="AN1">†</xref></sup></title><author><name sortKey="Bortolanza, Mariza" sort="Bortolanza, Mariza" uniqKey="Bortolanza M" first="Mariza" last="Bortolanza">Mariza Bortolanza</name><affiliation><nlm:aff id="af1"><addr-line>School of Odontology of Ribeirão Preto, Department of Morphology</addr-line>,<institution>University of São Paulo (USP)</institution>,<addr-line>Physiology and Basic Pathology, Av. Café S/N, 14040-904, Ribeirão Preto, São Paulo</addr-line>,<country>Brazil</country></nlm:aff></affiliation><affiliation><nlm:aff id="af2"><addr-line>Center for Interdisciplinary Research on Applied Neurosciences (NAPNA)</addr-line>,<institution>University of Sao Paulo</institution>,<addr-line>São Paulo</addr-line>,<country>Brazil</country></nlm:aff></affiliation></author><author><name sortKey="Padovan Neto, Fernando E" sort="Padovan Neto, Fernando E" uniqKey="Padovan Neto F" first="Fernando E." last="Padovan-Neto">Fernando E. Padovan-Neto</name><affiliation><nlm:aff id="af2"><addr-line>Center for Interdisciplinary Research on Applied Neurosciences (NAPNA)</addr-line>,<institution>University of Sao Paulo</institution>,<addr-line>São Paulo</addr-line>,<country>Brazil</country></nlm:aff></affiliation><affiliation><nlm:aff id="af3"><addr-line>Department of Behavioural Neurosciences, Av. Bandeirantes 3900, 14049-900 Ribeirão Preto, São Paulo</addr-line>,<country>Brazil</country></nlm:aff></affiliation></author><author><name sortKey="Cavalcanti Kiwiatkoski, Roberta" sort="Cavalcanti Kiwiatkoski, Roberta" uniqKey="Cavalcanti Kiwiatkoski R" first="Roberta" last="Cavalcanti-Kiwiatkoski">Roberta Cavalcanti-Kiwiatkoski</name><affiliation><nlm:aff id="af2"><addr-line>Center for Interdisciplinary Research on Applied Neurosciences (NAPNA)</addr-line>,<institution>University of Sao Paulo</institution>,<addr-line>São Paulo</addr-line>,<country>Brazil</country></nlm:aff></affiliation><affiliation><nlm:aff id="af4"><addr-line>Medical School, Department of Physiology</addr-line>,<institution>University of Sao Paulo</institution>,<addr-line>São Paulo</addr-line>,<country>Brazil</country></nlm:aff></affiliation></author><author><name sortKey="Dos Santos Pereira, Mauricio" sort="Dos Santos Pereira, Mauricio" uniqKey="Dos Santos Pereira M" first="Maurício" last="Dos Santos-Pereira">Maurício Dos Santos-Pereira</name><affiliation><nlm:aff id="af2"><addr-line>Center for Interdisciplinary Research on Applied Neurosciences (NAPNA)</addr-line>,<institution>University of Sao Paulo</institution>,<addr-line>São Paulo</addr-line>,<country>Brazil</country></nlm:aff></affiliation><affiliation><nlm:aff id="af4"><addr-line>Medical School, Department of Physiology</addr-line>,<institution>University of Sao Paulo</institution>,<addr-line>São Paulo</addr-line>,<country>Brazil</country></nlm:aff></affiliation></author><author><name sortKey="Mitkovski, Miso" sort="Mitkovski, Miso" uniqKey="Mitkovski M" first="Miso" last="Mitkovski">Miso Mitkovski</name><affiliation><nlm:aff id="af6"><institution>Light Microscopy Facility, Max Planck Institute of Experimental Medicine, Hermann-Rein-Str.</institution><addr-line>3, 37075 Göttingen</addr-line>,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Raisman Vozari, Rita" sort="Raisman Vozari, Rita" uniqKey="Raisman Vozari R" first="Rita" last="Raisman-Vozari">Rita Raisman-Vozari</name><affiliation><nlm:aff id="af5"><addr-line>Institut de Cerveau et de la Moelle Epinière</addr-line>,<institution>Sorbonne Université UPMC UM75 INSERM U1127, CNRS UMR 7225</institution>,<addr-line>Paris</addr-line>,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Del Bel, Elaine" sort="Del Bel, Elaine" uniqKey="Del Bel E" first="Elaine" last="Del-Bel">Elaine Del-Bel</name><affiliation><nlm:aff id="af1"><addr-line>School of Odontology of Ribeirão Preto, Department of Morphology</addr-line>,<institution>University of São Paulo (USP)</institution>,<addr-line>Physiology and Basic Pathology, Av. Café S/N, 14040-904, Ribeirão Preto, São Paulo</addr-line>,<country>Brazil</country></nlm:aff></affiliation><affiliation><nlm:aff id="af2"><addr-line>Center for Interdisciplinary Research on Applied Neurosciences (NAPNA)</addr-line>,<institution>University of Sao Paulo</institution>,<addr-line>São Paulo</addr-line>,<country>Brazil</country></nlm:aff></affiliation><affiliation><nlm:aff id="af3"><addr-line>Department of Behavioural Neurosciences, Av. Bandeirantes 3900, 14049-900 Ribeirão Preto, São Paulo</addr-line>,<country>Brazil</country></nlm:aff></affiliation><affiliation><nlm:aff id="af4"><addr-line>Medical School, Department of Physiology</addr-line>,<institution>University of Sao Paulo</institution>,<addr-line>São Paulo</addr-line>,<country>Brazil</country></nlm:aff></affiliation></author></analytic><series><title level="j">Philosophical Transactions of the Royal Society B: Biological Sciences</title><idno type="ISSN">0962-8436</idno><idno type="eISSN">1471-2970</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Inflammatory mechanisms are proposed to play a role in <sc>l</sc>-DOPA-induced dyskinesia. Cyclooxygenase-2 (COX2) contributes to inflammation pathways in the periphery and is constitutively expressed in the central nervous system. Considering that inhibition of nitric oxide (NO) formation attenuates <sc>l</sc>-DOPA-induced dyskinesia, this study aimed at investigating if a NO synthase (NOS) inhibitor would change COX2 brain expression in animals with <sc>l</sc>-DOPA-induced dyskinesia. To this aim, male Wistar rats received unilateral 6-hydroxydopamine microinjection into the medial forebrain bundle were treated daily with <sc>l</sc>-DOPA (21 days) combined with 7-nitroindazole or vehicle. All hemi-Parkinsonian rats receiving <sc>l</sc>-DOPA showed dyskinesia. They also presented increased neuronal COX2 immunoreactivity in the dopamine-depleted dorsal striatum that was directly correlated with dyskinesia severity. Striatal COX2 co-localized with choline-acetyltransferase, calbindin and DARPP-32 (dopamine-cAMP-regulated phosphoprotein-32), neuronal markers of GABAergic neurons. NOS inhibition prevented <sc>l</sc>-DOPA-induced dyskinesia and COX2 increased expression in the dorsal striatum. These results suggest that increased COX2 expression after <sc>l</sc>-DOPA long-term treatment in Parkinsonian-like rats could contribute to the development of dyskinesia.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Philos Trans R Soc Lond B Biol Sci</journal-id><journal-id journal-id-type="iso-abbrev">Philos. Trans. R. Soc. Lond., B, Biol. Sci</journal-id><journal-id journal-id-type="publisher-id">RSTB</journal-id><journal-id journal-id-type="hwp">royptb</journal-id><journal-title-group><journal-title>Philosophical Transactions of the Royal Society B: Biological Sciences</journal-title></journal-title-group><issn pub-type="ppub">0962-8436</issn><issn pub-type="epub">1471-2970</issn><publisher><publisher-name>The Royal Society</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">26009769</article-id><article-id pub-id-type="pmc">4455759</article-id><article-id pub-id-type="doi">10.1098/rstb.2014.0190</article-id><article-id pub-id-type="publisher-id">rstb20140190</article-id><article-categories><subj-group subj-group-type="hwp-journal-coll"><subject>1001</subject><subject>14</subject><subject>133</subject><subject>202</subject></subj-group><subj-group subj-group-type="heading"><subject>Articles</subject></subj-group><subj-group subj-group-type="leader"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title>Are cyclooxygenase-2 and nitric oxide involved in the dyskinesia of Parkinson's disease induced by <sc>l</sc>-DOPA?<sup><xref ref-type="author-notes" rid="AN1">†</xref></sup></article-title><alt-title alt-title-type="short">L-DOPA dyskinesia and Cyclooxigenase-2</alt-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Bortolanza</surname><given-names>Mariza</given-names></name><xref ref-type="aff" rid="af1">1</xref><xref ref-type="aff" rid="af2">2</xref></contrib><contrib contrib-type="author"><name><surname>Padovan-Neto</surname><given-names>Fernando E.</given-names></name><xref ref-type="aff" rid="af2">2</xref><xref ref-type="aff" rid="af3">3</xref></contrib><contrib contrib-type="author"><name><surname>Cavalcanti-Kiwiatkoski</surname><given-names>Roberta</given-names></name><xref ref-type="aff" rid="af2">2</xref><xref ref-type="aff" rid="af4">4</xref></contrib><contrib contrib-type="author"><name><surname>dos Santos-Pereira</surname><given-names>Maurício</given-names></name><xref ref-type="aff" rid="af2">2</xref><xref ref-type="aff" rid="af4">4</xref></contrib><contrib contrib-type="author"><name><surname>Mitkovski</surname><given-names>Miso</given-names></name><xref ref-type="aff" rid="af6">6</xref></contrib><contrib contrib-type="author"><name><surname>Raisman-Vozari</surname><given-names>Rita</given-names></name><xref ref-type="aff" rid="af5">5</xref></contrib><contrib contrib-type="author"><name><surname>Del-Bel</surname><given-names>Elaine</given-names></name><xref ref-type="aff" rid="af1">1</xref><xref ref-type="aff" rid="af2">2</xref><xref ref-type="aff" rid="af3">3</xref><xref ref-type="aff" rid="af4">4</xref><xref ref-type="corresp" rid="cor1"></xref></contrib></contrib-group><aff id="af1"><label>1</label><addr-line>School of Odontology of Ribeirão Preto, Department of Morphology</addr-line>,<institution>University of São Paulo (USP)</institution>,<addr-line>Physiology and Basic Pathology, Av. Café S/N, 14040-904, Ribeirão Preto, São Paulo</addr-line>,<country>Brazil</country></aff><aff id="af2"><label>2</label><addr-line>Center for Interdisciplinary Research on Applied Neurosciences (NAPNA)</addr-line>,<institution>University of Sao Paulo</institution>,<addr-line>São Paulo</addr-line>,<country>Brazil</country></aff><aff id="af3"><label>3</label><addr-line>Department of Behavioural Neurosciences, Av. Bandeirantes 3900, 14049-900 Ribeirão Preto, São Paulo</addr-line>,<country>Brazil</country></aff><aff id="af4"><label>4</label><addr-line>Medical School, Department of Physiology</addr-line>,<institution>University of Sao Paulo</institution>,<addr-line>São Paulo</addr-line>,<country>Brazil</country></aff><aff id="af5"><label>5</label><addr-line>Institut de Cerveau et de la Moelle Epinière</addr-line>,<institution>Sorbonne Université UPMC UM75 INSERM U1127, CNRS UMR 7225</institution>,<addr-line>Paris</addr-line>,<country>France</country></aff><aff id="af6"><label>6</label><institution>Light Microscopy Facility, Max Planck Institute of Experimental Medicine, Hermann-Rein-Str.</institution><addr-line>3, 37075 Göttingen</addr-line>,<country>Germany</country></aff><author-notes><corresp id="cor1">e-mail: <email>eadelbel@forp.usp.br</email></corresp><fn id="AN1" fn-type="other"><label>†</label><p>This work is dedicated to Prof. John Nicholls and Prof. Francisco Fernandez De Miguel for their dedication to science and their faithful encouragement.</p></fn><fn fn-type="other"><p>One contribution of 16 to a discussion meeting issue ‘<ext-link ext-link-type="uri" xlink:href="http://rstb.royalsocietypublishing.org/content/370/1672.toc">Release of chemical transmitters from cell bodies and dendrites of nerve cells</ext-link>’.</p></fn></author-notes><pub-date pub-type="ppub"><day>5</day><month>7</month><year>2015</year></pub-date><volume>370</volume><issue>1672</issue><issue-title>Discussion meeting issue ‘Release of chemical transmitters from cell bodies and dendrites of nerve cells’ organized and edited by Francisco F. De-Miguel and John G. Nicholls</issue-title><elocation-id>20140190</elocation-id><history><date date-type="accepted"><day>13</day><month>4</month><year>2015</year></date></history><permissions><copyright-statement>© 2015 The Author(s) Published by the Royal Society. All rights reserved.</copyright-statement><copyright-year>2015</copyright-year></permissions><self-uri content-type="pdf" xlink:type="simple" xlink:href="rstb20140190.pdf"></self-uri><abstract><p>Inflammatory mechanisms are proposed to play a role in <sc>l</sc>-DOPA-induced dyskinesia. Cyclooxygenase-2 (COX2) contributes to inflammation pathways in the periphery and is constitutively expressed in the central nervous system. Considering that inhibition of nitric oxide (NO) formation attenuates <sc>l</sc>-DOPA-induced dyskinesia, this study aimed at investigating if a NO synthase (NOS) inhibitor would change COX2 brain expression in animals with <sc>l</sc>-DOPA-induced dyskinesia. To this aim, male Wistar rats received unilateral 6-hydroxydopamine microinjection into the medial forebrain bundle were treated daily with <sc>l</sc>-DOPA (21 days) combined with 7-nitroindazole or vehicle. All hemi-Parkinsonian rats receiving <sc>l</sc>-DOPA showed dyskinesia. They also presented increased neuronal COX2 immunoreactivity in the dopamine-depleted dorsal striatum that was directly correlated with dyskinesia severity. Striatal COX2 co-localized with choline-acetyltransferase, calbindin and DARPP-32 (dopamine-cAMP-regulated phosphoprotein-32), neuronal markers of GABAergic neurons. NOS inhibition prevented <sc>l</sc>-DOPA-induced dyskinesia and COX2 increased expression in the dorsal striatum. These results suggest that increased COX2 expression after <sc>l</sc>-DOPA long-term treatment in Parkinsonian-like rats could contribute to the development of dyskinesia.</p></abstract><kwd-group><kwd>COX2</kwd><kwd>prostaglandin H-synthase</kwd><kwd>neuroinflammation</kwd><kwd>striatum interneurons</kwd><kwd>volume transmission</kwd><kwd>extrasynaptic signalling</kwd></kwd-group><custom-meta-group><custom-meta><meta-name>cover-date</meta-name><meta-value>July 5, 2015</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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