Normal activation of the supplementary motor area in patients with Parkinson's disease undergoing long-term treatment with levodopa.
Identifieur interne : 000969 ( Pmc/Checkpoint ); précédent : 000968; suivant : 000970Normal activation of the supplementary motor area in patients with Parkinson's disease undergoing long-term treatment with levodopa.
Auteurs : O. Rascol ; U. Sabatini ; F. Chollet ; N. Fabre ; J M Senard ; J L Montastruc ; P. Celsis ; J P Marc-Vergnes ; A. RascolSource :
- Journal of Neurology, Neurosurgery, and Psychiatry [ 0022-3050 ] ; 1994.
Abstract
Regional cerebral blood flow (rCBF) changes in cortical motor areas were measured during a movement of the dominant right hand in 15 patients with Parkinson's disease deprived of their usual levodopa treatment, in 11 patients with Parkinson's disease undergoing long-term treatment with levodopa, and in 15 normal volunteers. The supplementary motor areas were significantly activated in the normal subjects and in the patients receiving levodopa but not in the patients deprived of levodopa. The contralateral primary sensory motor area was significantly activated in all three groups. The ipsilateral primary sensory motor cortex was not activated in the normal subjects and the non-treated patients but was in the patients treated with levodopa. It is concluded that the supplementary motor area hypoactivation which is observed in akinetic non-treated patients with Parkinson's disease is not present in patients undergoing long-term treatment with levodopa. This result suggests that (a) levodopa improves the functional activity of supplementary motor areas in Parkinson's disease and (b) there is no pharmacological tolerance to this effect. The ipsilateral primary motor cortex activation observed in the patients treated with levodopa could be related to levodopa-induced abnormal involuntary movements.
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PubMed: 8201325
PubMed Central: 1072916
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Rascol</name></author><author><name sortKey="Sabatini, U" sort="Sabatini, U" uniqKey="Sabatini U" first="U" last="Sabatini">U. Sabatini</name></author><author><name sortKey="Chollet, F" sort="Chollet, F" uniqKey="Chollet F" first="F" last="Chollet">F. Chollet</name></author><author><name sortKey="Fabre, N" sort="Fabre, N" uniqKey="Fabre N" first="N" last="Fabre">N. Fabre</name></author><author><name sortKey="Senard, J M" sort="Senard, J M" uniqKey="Senard J" first="J M" last="Senard">J M Senard</name></author><author><name sortKey="Montastruc, J L" sort="Montastruc, J L" uniqKey="Montastruc J" first="J L" last="Montastruc">J L Montastruc</name></author><author><name sortKey="Celsis, P" sort="Celsis, P" uniqKey="Celsis P" first="P" last="Celsis">P. Celsis</name></author><author><name sortKey="Marc Vergnes, J P" sort="Marc Vergnes, J P" uniqKey="Marc Vergnes J" first="J P" last="Marc-Vergnes">J P Marc-Vergnes</name></author><author><name sortKey="Rascol, A" sort="Rascol, A" uniqKey="Rascol A" first="A" last="Rascol">A. Rascol</name></author></analytic><series><title level="j">Journal of Neurology, Neurosurgery, and Psychiatry</title><idno type="ISSN">0022-3050</idno><idno type="eISSN">1468-330X</idno><imprint><date when="1994">1994</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Regional cerebral blood flow (rCBF) changes in cortical motor areas were measured during a movement of the dominant right hand in 15 patients with Parkinson's disease deprived of their usual levodopa treatment, in 11 patients with Parkinson's disease undergoing long-term treatment with levodopa, and in 15 normal volunteers. The supplementary motor areas were significantly activated in the normal subjects and in the patients receiving levodopa but not in the patients deprived of levodopa. The contralateral primary sensory motor area was significantly activated in all three groups. The ipsilateral primary sensory motor cortex was not activated in the normal subjects and the non-treated patients but was in the patients treated with levodopa. It is concluded that the supplementary motor area hypoactivation which is observed in akinetic non-treated patients with Parkinson's disease is not present in patients undergoing long-term treatment with levodopa. This result suggests that (a) levodopa improves the functional activity of supplementary motor areas in Parkinson's disease and (b) there is no pharmacological tolerance to this effect. The ipsilateral primary motor cortex activation observed in the patients treated with levodopa could be related to levodopa-induced abnormal involuntary movements.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Neurol Neurosurg Psychiatry</journal-id><journal-title>Journal of Neurology, Neurosurgery, and Psychiatry</journal-title><issn pub-type="ppub">0022-3050</issn><issn pub-type="epub">1468-330X</issn></journal-meta><article-meta><article-id pub-id-type="pmid">8201325</article-id><article-id pub-id-type="pmc">1072916</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title>Normal activation of the supplementary motor area in patients with Parkinson's disease undergoing long-term treatment with levodopa.</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Rascol</surname><given-names>O</given-names></name></contrib><contrib contrib-type="author"><name><surname>Sabatini</surname><given-names>U</given-names></name></contrib><contrib contrib-type="author"><name><surname>Chollet</surname><given-names>F</given-names></name></contrib><contrib contrib-type="author"><name><surname>Fabre</surname><given-names>N</given-names></name></contrib><contrib contrib-type="author"><name><surname>Senard</surname><given-names>J M</given-names></name></contrib><contrib contrib-type="author"><name><surname>Montastruc</surname><given-names>J L</given-names></name></contrib><contrib contrib-type="author"><name><surname>Celsis</surname><given-names>P</given-names></name></contrib><contrib contrib-type="author"><name><surname>Marc-Vergnes</surname><given-names>J P</given-names></name></contrib><contrib contrib-type="author"><name><surname>Rascol</surname><given-names>A</given-names></name></contrib></contrib-group><aff>Laboratory of Medical and Clinical Pharmacology, Faculty of Medicine, National Institute of Health and Medical Research, Toulouse, France.</aff><pub-date pub-type="ppub"><month>5</month><year>1994</year></pub-date><volume>57</volume><issue>5</issue><fpage>567</fpage><lpage>571</lpage><abstract><p>Regional cerebral blood flow (rCBF) changes in cortical motor areas were measured during a movement of the dominant right hand in 15 patients with Parkinson's disease deprived of their usual levodopa treatment, in 11 patients with Parkinson's disease undergoing long-term treatment with levodopa, and in 15 normal volunteers. The supplementary motor areas were significantly activated in the normal subjects and in the patients receiving levodopa but not in the patients deprived of levodopa. The contralateral primary sensory motor area was significantly activated in all three groups. The ipsilateral primary sensory motor cortex was not activated in the normal subjects and the non-treated patients but was in the patients treated with levodopa. It is concluded that the supplementary motor area hypoactivation which is observed in akinetic non-treated patients with Parkinson's disease is not present in patients undergoing long-term treatment with levodopa. This result suggests that (a) levodopa improves the functional activity of supplementary motor areas in Parkinson's disease and (b) there is no pharmacological tolerance to this effect. The ipsilateral primary motor cortex activation observed in the patients treated with levodopa could be related to levodopa-induced abnormal involuntary movements.</p></abstract></article-meta></front></pmc><affiliations><list></list><tree><noCountry><name sortKey="Celsis, P" sort="Celsis, P" uniqKey="Celsis P" first="P" last="Celsis">P. Celsis</name><name sortKey="Chollet, F" sort="Chollet, F" uniqKey="Chollet F" first="F" last="Chollet">F. Chollet</name><name sortKey="Fabre, N" sort="Fabre, N" uniqKey="Fabre N" first="N" last="Fabre">N. Fabre</name><name sortKey="Marc Vergnes, J P" sort="Marc Vergnes, J P" uniqKey="Marc Vergnes J" first="J P" last="Marc-Vergnes">J P Marc-Vergnes</name><name sortKey="Montastruc, J L" sort="Montastruc, J L" uniqKey="Montastruc J" first="J L" last="Montastruc">J L Montastruc</name><name sortKey="Rascol, A" sort="Rascol, A" uniqKey="Rascol A" first="A" last="Rascol">A. Rascol</name><name sortKey="Rascol, O" sort="Rascol, O" uniqKey="Rascol O" first="O" last="Rascol">O. Rascol</name><name sortKey="Sabatini, U" sort="Sabatini, U" uniqKey="Sabatini U" first="U" last="Sabatini">U. Sabatini</name><name sortKey="Senard, J M" sort="Senard, J M" uniqKey="Senard J" first="J M" last="Senard">J M Senard</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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