Divalent metal transporter 1 (DMT1) contributes to neurodegeneration in animal models of Parkinson's disease
Identifieur interne : 000859 ( Pmc/Checkpoint ); précédent : 000858; suivant : 000860Divalent metal transporter 1 (DMT1) contributes to neurodegeneration in animal models of Parkinson's disease
Auteurs : Julio Salazar [France, Chili] ; Natalia Mena [Chili] ; Stephane Hunot [France] ; Annick Prigent [France] ; Daniel Alvarez-Fischer [France] ; Miguel Arredondo [Chili] ; Charles Duyckaerts [France] ; Veronique Sazdovitch [France] ; Lin Zhao [États-Unis] ; Laura M. Garrick [États-Unis] ; Marco T. Nu Ez [Chili] ; Michael D. Garrick [États-Unis] ; Rita Raisman-Vozari [France] ; Etienne C. Hirsch [France]Source :
- Proceedings of the National Academy of Sciences of the United States of America [ 0027-8424 ] ; 2008.
Abstract
Dopaminergic cell death in the substantia nigra (SN) is central to Parkinson's disease (PD), but the neurodegenerative mechanisms have not been completely elucidated. Iron accumulation in dopaminergic and glial cells in the SN of PD patients may contribute to the generation of oxidative stress, protein aggregation, and neuronal death. The mechanisms involved in iron accumulation also remain unclear. Here, we describe an increase in the expression of an isoform of the divalent metal transporter 1 (DMT1/Nramp2/Slc11a2) in the SN of PD patients. Using the PD animal model of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) intoxication in mice, we showed that DMT1 expression increases in the ventral mesencephalon of intoxicated animals, concomitant with iron accumulation, oxidative stress, and dopaminergic cell loss. In addition, we report that a mutation in DMT1 that impairs iron transport protects rodents against parkinsonism-inducing neurotoxins MPTP and 6-hydroxydopamine. This study supports a critical role for DMT1 in iron-mediated neurodegeneration in PD.
Url:
DOI: 10.1073/pnas.0804373105
PubMed: 19011085
PubMed Central: 2587621
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
PMC:2587621Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Divalent metal transporter 1 (DMT1) contributes to neurodegeneration in animal models of Parkinson's disease</title><author><name sortKey="Salazar, Julio" sort="Salazar, Julio" uniqKey="Salazar J" first="Julio" last="Salazar">Julio Salazar</name><affiliation wicri:level="3"><nlm:aff id="aff1">Institut National de la Santé et de la Recherche Médicale, Neurologie et Thérapeutique Expérimentale, Unité Mixte de Recherche S679, 47 Boulevard de l'Hôpital, 75013 Paris, France;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut National de la Santé et de la Recherche Médicale, Neurologie et Thérapeutique Expérimentale, Unité Mixte de Recherche S679, 47 Boulevard de l'Hôpital, 75013 Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff2">Unité Mixte de Recherche S679, Université Pierre et Marie Curie, Boulevard de l'Hôpital, 75013 Paris, France;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Unité Mixte de Recherche S679, Université Pierre et Marie Curie, Boulevard de l'Hôpital, 75013 Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName><orgName type="university">Université Pierre-et-Marie-Curie</orgName></affiliation><affiliation wicri:level="1"><nlm:aff wicri:cut="; and" id="aff3">Millennium Institute for Cell Dynamics and Biotechnology and Department of Biology, Faculty of Sciences, Universidad de Chile, Las Encinas 3370, Santiago, Chile</nlm:aff><country xml:lang="fr">Chili</country><wicri:regionArea>Millennium Institute for Cell Dynamics and Biotechnology and Department of Biology, Faculty of Sciences, Universidad de Chile, Las Encinas 3370, Santiago</wicri:regionArea><wicri:noRegion>Santiago</wicri:noRegion></affiliation></author><author><name sortKey="Mena, Natalia" sort="Mena, Natalia" uniqKey="Mena N" first="Natalia" last="Mena">Natalia Mena</name><affiliation wicri:level="1"><nlm:aff wicri:cut="; and" id="aff3">Millennium Institute for Cell Dynamics and Biotechnology and Department of Biology, Faculty of Sciences, Universidad de Chile, Las Encinas 3370, Santiago, Chile</nlm:aff><country xml:lang="fr">Chili</country><wicri:regionArea>Millennium Institute for Cell Dynamics and Biotechnology and Department of Biology, Faculty of Sciences, Universidad de Chile, Las Encinas 3370, Santiago</wicri:regionArea><wicri:noRegion>Santiago</wicri:noRegion></affiliation></author><author><name sortKey="Hunot, Stephane" sort="Hunot, Stephane" uniqKey="Hunot S" first="Stephane" last="Hunot">Stephane Hunot</name><affiliation wicri:level="3"><nlm:aff id="aff1">Institut National de la Santé et de la Recherche Médicale, Neurologie et Thérapeutique Expérimentale, Unité Mixte de Recherche S679, 47 Boulevard de l'Hôpital, 75013 Paris, France;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut National de la Santé et de la Recherche Médicale, Neurologie et Thérapeutique Expérimentale, Unité Mixte de Recherche S679, 47 Boulevard de l'Hôpital, 75013 Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff2">Unité Mixte de Recherche S679, Université Pierre et Marie Curie, Boulevard de l'Hôpital, 75013 Paris, France;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Unité Mixte de Recherche S679, Université Pierre et Marie Curie, Boulevard de l'Hôpital, 75013 Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName><orgName type="university">Université Pierre-et-Marie-Curie</orgName></affiliation></author><author><name sortKey="Prigent, Annick" sort="Prigent, Annick" uniqKey="Prigent A" first="Annick" last="Prigent">Annick Prigent</name><affiliation wicri:level="3"><nlm:aff id="aff1">Institut National de la Santé et de la Recherche Médicale, Neurologie et Thérapeutique Expérimentale, Unité Mixte de Recherche S679, 47 Boulevard de l'Hôpital, 75013 Paris, France;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut National de la Santé et de la Recherche Médicale, Neurologie et Thérapeutique Expérimentale, Unité Mixte de Recherche S679, 47 Boulevard de l'Hôpital, 75013 Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff2">Unité Mixte de Recherche S679, Université Pierre et Marie Curie, Boulevard de l'Hôpital, 75013 Paris, France;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Unité Mixte de Recherche S679, Université Pierre et Marie Curie, Boulevard de l'Hôpital, 75013 Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName><orgName type="university">Université Pierre-et-Marie-Curie</orgName></affiliation></author><author><name sortKey="Alvarez Fischer, Daniel" sort="Alvarez Fischer, Daniel" uniqKey="Alvarez Fischer D" first="Daniel" last="Alvarez-Fischer">Daniel Alvarez-Fischer</name><affiliation wicri:level="3"><nlm:aff id="aff1">Institut National de la Santé et de la Recherche Médicale, Neurologie et Thérapeutique Expérimentale, Unité Mixte de Recherche S679, 47 Boulevard de l'Hôpital, 75013 Paris, France;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut National de la Santé et de la Recherche Médicale, Neurologie et Thérapeutique Expérimentale, Unité Mixte de Recherche S679, 47 Boulevard de l'Hôpital, 75013 Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff2">Unité Mixte de Recherche S679, Université Pierre et Marie Curie, Boulevard de l'Hôpital, 75013 Paris, France;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Unité Mixte de Recherche S679, Université Pierre et Marie Curie, Boulevard de l'Hôpital, 75013 Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName><orgName type="university">Université Pierre-et-Marie-Curie</orgName></affiliation></author><author><name sortKey="Arredondo, Miguel" sort="Arredondo, Miguel" uniqKey="Arredondo M" first="Miguel" last="Arredondo">Miguel Arredondo</name><affiliation wicri:level="1"><nlm:aff wicri:cut="; and" id="aff3">Millennium Institute for Cell Dynamics and Biotechnology and Department of Biology, Faculty of Sciences, Universidad de Chile, Las Encinas 3370, Santiago, Chile</nlm:aff><country xml:lang="fr">Chili</country><wicri:regionArea>Millennium Institute for Cell Dynamics and Biotechnology and Department of Biology, Faculty of Sciences, Universidad de Chile, Las Encinas 3370, Santiago</wicri:regionArea><wicri:noRegion>Santiago</wicri:noRegion></affiliation></author><author><name sortKey="Duyckaerts, Charles" sort="Duyckaerts, Charles" uniqKey="Duyckaerts C" first="Charles" last="Duyckaerts">Charles Duyckaerts</name><affiliation wicri:level="3"><nlm:aff id="aff1">Institut National de la Santé et de la Recherche Médicale, Neurologie et Thérapeutique Expérimentale, Unité Mixte de Recherche S679, 47 Boulevard de l'Hôpital, 75013 Paris, France;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut National de la Santé et de la Recherche Médicale, Neurologie et Thérapeutique Expérimentale, Unité Mixte de Recherche S679, 47 Boulevard de l'Hôpital, 75013 Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff2">Unité Mixte de Recherche S679, Université Pierre et Marie Curie, Boulevard de l'Hôpital, 75013 Paris, France;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Unité Mixte de Recherche S679, Université Pierre et Marie Curie, Boulevard de l'Hôpital, 75013 Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName><orgName type="university">Université Pierre-et-Marie-Curie</orgName></affiliation></author><author><name sortKey="Sazdovitch, Veronique" sort="Sazdovitch, Veronique" uniqKey="Sazdovitch V" first="Veronique" last="Sazdovitch">Veronique Sazdovitch</name><affiliation wicri:level="3"><nlm:aff id="aff1">Institut National de la Santé et de la Recherche Médicale, Neurologie et Thérapeutique Expérimentale, Unité Mixte de Recherche S679, 47 Boulevard de l'Hôpital, 75013 Paris, France;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut National de la Santé et de la Recherche Médicale, Neurologie et Thérapeutique Expérimentale, Unité Mixte de Recherche S679, 47 Boulevard de l'Hôpital, 75013 Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff2">Unité Mixte de Recherche S679, Université Pierre et Marie Curie, Boulevard de l'Hôpital, 75013 Paris, France;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Unité Mixte de Recherche S679, Université Pierre et Marie Curie, Boulevard de l'Hôpital, 75013 Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName><orgName type="university">Université Pierre-et-Marie-Curie</orgName></affiliation></author><author><name sortKey="Zhao, Lin" sort="Zhao, Lin" uniqKey="Zhao L" first="Lin" last="Zhao">Lin Zhao</name><affiliation wicri:level="2"><nlm:aff id="aff4">Department of Biochemistry, University at Buffalo, State University of New York, 140 Farber Hall, 3435 Main Street, Buffalo, NY 14214</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Department of Biochemistry, University at Buffalo, State University of New York, 140 Farber Hall, 3435 Main Street, Buffalo</wicri:cityArea></affiliation></author><author><name sortKey="Garrick, Laura M" sort="Garrick, Laura M" uniqKey="Garrick L" first="Laura M." last="Garrick">Laura M. Garrick</name><affiliation wicri:level="2"><nlm:aff id="aff4">Department of Biochemistry, University at Buffalo, State University of New York, 140 Farber Hall, 3435 Main Street, Buffalo, NY 14214</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Department of Biochemistry, University at Buffalo, State University of New York, 140 Farber Hall, 3435 Main Street, Buffalo</wicri:cityArea></affiliation></author><author><name sortKey="Nu Ez, Marco T" sort="Nu Ez, Marco T" uniqKey="Nu Ez M" first="Marco T." last="Nu Ez">Marco T. Nu Ez</name><affiliation wicri:level="1"><nlm:aff wicri:cut="; and" id="aff3">Millennium Institute for Cell Dynamics and Biotechnology and Department of Biology, Faculty of Sciences, Universidad de Chile, Las Encinas 3370, Santiago, Chile</nlm:aff><country xml:lang="fr">Chili</country><wicri:regionArea>Millennium Institute for Cell Dynamics and Biotechnology and Department of Biology, Faculty of Sciences, Universidad de Chile, Las Encinas 3370, Santiago</wicri:regionArea><wicri:noRegion>Santiago</wicri:noRegion></affiliation></author><author><name sortKey="Garrick, Michael D" sort="Garrick, Michael D" uniqKey="Garrick M" first="Michael D." last="Garrick">Michael D. Garrick</name><affiliation wicri:level="2"><nlm:aff id="aff4">Department of Biochemistry, University at Buffalo, State University of New York, 140 Farber Hall, 3435 Main Street, Buffalo, NY 14214</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Department of Biochemistry, University at Buffalo, State University of New York, 140 Farber Hall, 3435 Main Street, Buffalo</wicri:cityArea></affiliation></author><author><name sortKey="Raisman Vozari, Rita" sort="Raisman Vozari, Rita" uniqKey="Raisman Vozari R" first="Rita" last="Raisman-Vozari">Rita Raisman-Vozari</name><affiliation wicri:level="3"><nlm:aff id="aff1">Institut National de la Santé et de la Recherche Médicale, Neurologie et Thérapeutique Expérimentale, Unité Mixte de Recherche S679, 47 Boulevard de l'Hôpital, 75013 Paris, France;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut National de la Santé et de la Recherche Médicale, Neurologie et Thérapeutique Expérimentale, Unité Mixte de Recherche S679, 47 Boulevard de l'Hôpital, 75013 Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff2">Unité Mixte de Recherche S679, Université Pierre et Marie Curie, Boulevard de l'Hôpital, 75013 Paris, France;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Unité Mixte de Recherche S679, Université Pierre et Marie Curie, Boulevard de l'Hôpital, 75013 Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName><orgName type="university">Université Pierre-et-Marie-Curie</orgName></affiliation></author><author><name sortKey="Hirsch, Etienne C" sort="Hirsch, Etienne C" uniqKey="Hirsch E" first="Etienne C." last="Hirsch">Etienne C. Hirsch</name><affiliation wicri:level="3"><nlm:aff id="aff1">Institut National de la Santé et de la Recherche Médicale, Neurologie et Thérapeutique Expérimentale, Unité Mixte de Recherche S679, 47 Boulevard de l'Hôpital, 75013 Paris, France;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut National de la Santé et de la Recherche Médicale, Neurologie et Thérapeutique Expérimentale, Unité Mixte de Recherche S679, 47 Boulevard de l'Hôpital, 75013 Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff2">Unité Mixte de Recherche S679, Université Pierre et Marie Curie, Boulevard de l'Hôpital, 75013 Paris, France;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Unité Mixte de Recherche S679, Université Pierre et Marie Curie, Boulevard de l'Hôpital, 75013 Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName><orgName type="university">Université Pierre-et-Marie-Curie</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">19011085</idno><idno type="pmc">2587621</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2587621</idno><idno type="RBID">PMC:2587621</idno><idno type="doi">10.1073/pnas.0804373105</idno><date when="2008">2008</date><idno type="wicri:Area/Pmc/Corpus">000532</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000532</idno><idno type="wicri:Area/Pmc/Curation">000529</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000529</idno><idno type="wicri:Area/Pmc/Checkpoint">000859</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000859</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Divalent metal transporter 1 (DMT1) contributes to neurodegeneration in animal models of Parkinson's disease</title><author><name sortKey="Salazar, Julio" sort="Salazar, Julio" uniqKey="Salazar J" first="Julio" last="Salazar">Julio Salazar</name><affiliation wicri:level="3"><nlm:aff id="aff1">Institut National de la Santé et de la Recherche Médicale, Neurologie et Thérapeutique Expérimentale, Unité Mixte de Recherche S679, 47 Boulevard de l'Hôpital, 75013 Paris, France;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut National de la Santé et de la Recherche Médicale, Neurologie et Thérapeutique Expérimentale, Unité Mixte de Recherche S679, 47 Boulevard de l'Hôpital, 75013 Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff2">Unité Mixte de Recherche S679, Université Pierre et Marie Curie, Boulevard de l'Hôpital, 75013 Paris, France;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Unité Mixte de Recherche S679, Université Pierre et Marie Curie, Boulevard de l'Hôpital, 75013 Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName><orgName type="university">Université Pierre-et-Marie-Curie</orgName></affiliation><affiliation wicri:level="1"><nlm:aff wicri:cut="; and" id="aff3">Millennium Institute for Cell Dynamics and Biotechnology and Department of Biology, Faculty of Sciences, Universidad de Chile, Las Encinas 3370, Santiago, Chile</nlm:aff><country xml:lang="fr">Chili</country><wicri:regionArea>Millennium Institute for Cell Dynamics and Biotechnology and Department of Biology, Faculty of Sciences, Universidad de Chile, Las Encinas 3370, Santiago</wicri:regionArea><wicri:noRegion>Santiago</wicri:noRegion></affiliation></author><author><name sortKey="Mena, Natalia" sort="Mena, Natalia" uniqKey="Mena N" first="Natalia" last="Mena">Natalia Mena</name><affiliation wicri:level="1"><nlm:aff wicri:cut="; and" id="aff3">Millennium Institute for Cell Dynamics and Biotechnology and Department of Biology, Faculty of Sciences, Universidad de Chile, Las Encinas 3370, Santiago, Chile</nlm:aff><country xml:lang="fr">Chili</country><wicri:regionArea>Millennium Institute for Cell Dynamics and Biotechnology and Department of Biology, Faculty of Sciences, Universidad de Chile, Las Encinas 3370, Santiago</wicri:regionArea><wicri:noRegion>Santiago</wicri:noRegion></affiliation></author><author><name sortKey="Hunot, Stephane" sort="Hunot, Stephane" uniqKey="Hunot S" first="Stephane" last="Hunot">Stephane Hunot</name><affiliation wicri:level="3"><nlm:aff id="aff1">Institut National de la Santé et de la Recherche Médicale, Neurologie et Thérapeutique Expérimentale, Unité Mixte de Recherche S679, 47 Boulevard de l'Hôpital, 75013 Paris, France;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut National de la Santé et de la Recherche Médicale, Neurologie et Thérapeutique Expérimentale, Unité Mixte de Recherche S679, 47 Boulevard de l'Hôpital, 75013 Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff2">Unité Mixte de Recherche S679, Université Pierre et Marie Curie, Boulevard de l'Hôpital, 75013 Paris, France;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Unité Mixte de Recherche S679, Université Pierre et Marie Curie, Boulevard de l'Hôpital, 75013 Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName><orgName type="university">Université Pierre-et-Marie-Curie</orgName></affiliation></author><author><name sortKey="Prigent, Annick" sort="Prigent, Annick" uniqKey="Prigent A" first="Annick" last="Prigent">Annick Prigent</name><affiliation wicri:level="3"><nlm:aff id="aff1">Institut National de la Santé et de la Recherche Médicale, Neurologie et Thérapeutique Expérimentale, Unité Mixte de Recherche S679, 47 Boulevard de l'Hôpital, 75013 Paris, France;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut National de la Santé et de la Recherche Médicale, Neurologie et Thérapeutique Expérimentale, Unité Mixte de Recherche S679, 47 Boulevard de l'Hôpital, 75013 Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff2">Unité Mixte de Recherche S679, Université Pierre et Marie Curie, Boulevard de l'Hôpital, 75013 Paris, France;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Unité Mixte de Recherche S679, Université Pierre et Marie Curie, Boulevard de l'Hôpital, 75013 Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName><orgName type="university">Université Pierre-et-Marie-Curie</orgName></affiliation></author><author><name sortKey="Alvarez Fischer, Daniel" sort="Alvarez Fischer, Daniel" uniqKey="Alvarez Fischer D" first="Daniel" last="Alvarez-Fischer">Daniel Alvarez-Fischer</name><affiliation wicri:level="3"><nlm:aff id="aff1">Institut National de la Santé et de la Recherche Médicale, Neurologie et Thérapeutique Expérimentale, Unité Mixte de Recherche S679, 47 Boulevard de l'Hôpital, 75013 Paris, France;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut National de la Santé et de la Recherche Médicale, Neurologie et Thérapeutique Expérimentale, Unité Mixte de Recherche S679, 47 Boulevard de l'Hôpital, 75013 Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff2">Unité Mixte de Recherche S679, Université Pierre et Marie Curie, Boulevard de l'Hôpital, 75013 Paris, France;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Unité Mixte de Recherche S679, Université Pierre et Marie Curie, Boulevard de l'Hôpital, 75013 Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName><orgName type="university">Université Pierre-et-Marie-Curie</orgName></affiliation></author><author><name sortKey="Arredondo, Miguel" sort="Arredondo, Miguel" uniqKey="Arredondo M" first="Miguel" last="Arredondo">Miguel Arredondo</name><affiliation wicri:level="1"><nlm:aff wicri:cut="; and" id="aff3">Millennium Institute for Cell Dynamics and Biotechnology and Department of Biology, Faculty of Sciences, Universidad de Chile, Las Encinas 3370, Santiago, Chile</nlm:aff><country xml:lang="fr">Chili</country><wicri:regionArea>Millennium Institute for Cell Dynamics and Biotechnology and Department of Biology, Faculty of Sciences, Universidad de Chile, Las Encinas 3370, Santiago</wicri:regionArea><wicri:noRegion>Santiago</wicri:noRegion></affiliation></author><author><name sortKey="Duyckaerts, Charles" sort="Duyckaerts, Charles" uniqKey="Duyckaerts C" first="Charles" last="Duyckaerts">Charles Duyckaerts</name><affiliation wicri:level="3"><nlm:aff id="aff1">Institut National de la Santé et de la Recherche Médicale, Neurologie et Thérapeutique Expérimentale, Unité Mixte de Recherche S679, 47 Boulevard de l'Hôpital, 75013 Paris, France;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut National de la Santé et de la Recherche Médicale, Neurologie et Thérapeutique Expérimentale, Unité Mixte de Recherche S679, 47 Boulevard de l'Hôpital, 75013 Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff2">Unité Mixte de Recherche S679, Université Pierre et Marie Curie, Boulevard de l'Hôpital, 75013 Paris, France;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Unité Mixte de Recherche S679, Université Pierre et Marie Curie, Boulevard de l'Hôpital, 75013 Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName><orgName type="university">Université Pierre-et-Marie-Curie</orgName></affiliation></author><author><name sortKey="Sazdovitch, Veronique" sort="Sazdovitch, Veronique" uniqKey="Sazdovitch V" first="Veronique" last="Sazdovitch">Veronique Sazdovitch</name><affiliation wicri:level="3"><nlm:aff id="aff1">Institut National de la Santé et de la Recherche Médicale, Neurologie et Thérapeutique Expérimentale, Unité Mixte de Recherche S679, 47 Boulevard de l'Hôpital, 75013 Paris, France;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut National de la Santé et de la Recherche Médicale, Neurologie et Thérapeutique Expérimentale, Unité Mixte de Recherche S679, 47 Boulevard de l'Hôpital, 75013 Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff2">Unité Mixte de Recherche S679, Université Pierre et Marie Curie, Boulevard de l'Hôpital, 75013 Paris, France;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Unité Mixte de Recherche S679, Université Pierre et Marie Curie, Boulevard de l'Hôpital, 75013 Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName><orgName type="university">Université Pierre-et-Marie-Curie</orgName></affiliation></author><author><name sortKey="Zhao, Lin" sort="Zhao, Lin" uniqKey="Zhao L" first="Lin" last="Zhao">Lin Zhao</name><affiliation wicri:level="2"><nlm:aff id="aff4">Department of Biochemistry, University at Buffalo, State University of New York, 140 Farber Hall, 3435 Main Street, Buffalo, NY 14214</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Department of Biochemistry, University at Buffalo, State University of New York, 140 Farber Hall, 3435 Main Street, Buffalo</wicri:cityArea></affiliation></author><author><name sortKey="Garrick, Laura M" sort="Garrick, Laura M" uniqKey="Garrick L" first="Laura M." last="Garrick">Laura M. Garrick</name><affiliation wicri:level="2"><nlm:aff id="aff4">Department of Biochemistry, University at Buffalo, State University of New York, 140 Farber Hall, 3435 Main Street, Buffalo, NY 14214</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Department of Biochemistry, University at Buffalo, State University of New York, 140 Farber Hall, 3435 Main Street, Buffalo</wicri:cityArea></affiliation></author><author><name sortKey="Nu Ez, Marco T" sort="Nu Ez, Marco T" uniqKey="Nu Ez M" first="Marco T." last="Nu Ez">Marco T. Nu Ez</name><affiliation wicri:level="1"><nlm:aff wicri:cut="; and" id="aff3">Millennium Institute for Cell Dynamics and Biotechnology and Department of Biology, Faculty of Sciences, Universidad de Chile, Las Encinas 3370, Santiago, Chile</nlm:aff><country xml:lang="fr">Chili</country><wicri:regionArea>Millennium Institute for Cell Dynamics and Biotechnology and Department of Biology, Faculty of Sciences, Universidad de Chile, Las Encinas 3370, Santiago</wicri:regionArea><wicri:noRegion>Santiago</wicri:noRegion></affiliation></author><author><name sortKey="Garrick, Michael D" sort="Garrick, Michael D" uniqKey="Garrick M" first="Michael D." last="Garrick">Michael D. Garrick</name><affiliation wicri:level="2"><nlm:aff id="aff4">Department of Biochemistry, University at Buffalo, State University of New York, 140 Farber Hall, 3435 Main Street, Buffalo, NY 14214</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Department of Biochemistry, University at Buffalo, State University of New York, 140 Farber Hall, 3435 Main Street, Buffalo</wicri:cityArea></affiliation></author><author><name sortKey="Raisman Vozari, Rita" sort="Raisman Vozari, Rita" uniqKey="Raisman Vozari R" first="Rita" last="Raisman-Vozari">Rita Raisman-Vozari</name><affiliation wicri:level="3"><nlm:aff id="aff1">Institut National de la Santé et de la Recherche Médicale, Neurologie et Thérapeutique Expérimentale, Unité Mixte de Recherche S679, 47 Boulevard de l'Hôpital, 75013 Paris, France;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut National de la Santé et de la Recherche Médicale, Neurologie et Thérapeutique Expérimentale, Unité Mixte de Recherche S679, 47 Boulevard de l'Hôpital, 75013 Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff2">Unité Mixte de Recherche S679, Université Pierre et Marie Curie, Boulevard de l'Hôpital, 75013 Paris, France;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Unité Mixte de Recherche S679, Université Pierre et Marie Curie, Boulevard de l'Hôpital, 75013 Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName><orgName type="university">Université Pierre-et-Marie-Curie</orgName></affiliation></author><author><name sortKey="Hirsch, Etienne C" sort="Hirsch, Etienne C" uniqKey="Hirsch E" first="Etienne C." last="Hirsch">Etienne C. Hirsch</name><affiliation wicri:level="3"><nlm:aff id="aff1">Institut National de la Santé et de la Recherche Médicale, Neurologie et Thérapeutique Expérimentale, Unité Mixte de Recherche S679, 47 Boulevard de l'Hôpital, 75013 Paris, France;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut National de la Santé et de la Recherche Médicale, Neurologie et Thérapeutique Expérimentale, Unité Mixte de Recherche S679, 47 Boulevard de l'Hôpital, 75013 Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff2">Unité Mixte de Recherche S679, Université Pierre et Marie Curie, Boulevard de l'Hôpital, 75013 Paris, France;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Unité Mixte de Recherche S679, Université Pierre et Marie Curie, Boulevard de l'Hôpital, 75013 Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName><orgName type="university">Université Pierre-et-Marie-Curie</orgName></affiliation></author></analytic><series><title level="j">Proceedings of the National Academy of Sciences of the United States of America</title><idno type="ISSN">0027-8424</idno><idno type="eISSN">1091-6490</idno><imprint><date when="2008">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Dopaminergic cell death in the substantia nigra (SN) is central to Parkinson's disease (PD), but the neurodegenerative mechanisms have not been completely elucidated. Iron accumulation in dopaminergic and glial cells in the SN of PD patients may contribute to the generation of oxidative stress, protein aggregation, and neuronal death. The mechanisms involved in iron accumulation also remain unclear. Here, we describe an increase in the expression of an isoform of the divalent metal transporter 1 (DMT1/Nramp2/Slc11a2) in the SN of PD patients. Using the PD animal model of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) intoxication in mice, we showed that DMT1 expression increases in the ventral mesencephalon of intoxicated animals, concomitant with iron accumulation, oxidative stress, and dopaminergic cell loss. In addition, we report that a mutation in DMT1 that impairs iron transport protects rodents against parkinsonism-inducing neurotoxins MPTP and 6-hydroxydopamine. This study supports a critical role for DMT1 in iron-mediated neurodegeneration in PD.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Proc Natl Acad Sci U S A</journal-id><journal-id journal-id-type="hwp">pnas</journal-id><journal-id journal-id-type="pmc">pnas</journal-id><journal-id journal-id-type="publisher-id">PNAS</journal-id><journal-title-group><journal-title>Proceedings of the National Academy of Sciences of the United States of America</journal-title></journal-title-group><issn pub-type="ppub">0027-8424</issn><issn pub-type="epub">1091-6490</issn><publisher><publisher-name>National Academy of Sciences</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">19011085</article-id><article-id pub-id-type="pmc">2587621</article-id><article-id pub-id-type="publisher-id">5505</article-id><article-id pub-id-type="doi">10.1073/pnas.0804373105</article-id><article-categories><subj-group subj-group-type="heading"><subject>Biological Sciences</subject><subj-group><subject>Neuroscience</subject></subj-group></subj-group></article-categories><title-group><article-title>Divalent metal transporter 1 (DMT1) contributes to neurodegeneration in animal models of Parkinson's disease</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Salazar</surname><given-names>Julio</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref><xref ref-type="aff" rid="aff2"><sup>b</sup></xref><xref ref-type="aff" rid="aff3"><sup>c</sup></xref></contrib><contrib contrib-type="author"><name><surname>Mena</surname><given-names>Natalia</given-names></name><xref ref-type="aff" rid="aff3"><sup>c</sup></xref></contrib><contrib contrib-type="author"><name><surname>Hunot</surname><given-names>Stephane</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref><xref ref-type="aff" rid="aff2"><sup>b</sup></xref></contrib><contrib contrib-type="author"><name><surname>Prigent</surname><given-names>Annick</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref><xref ref-type="aff" rid="aff2"><sup>b</sup></xref></contrib><contrib contrib-type="author"><name><surname>Alvarez-Fischer</surname><given-names>Daniel</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref><xref ref-type="aff" rid="aff2"><sup>b</sup></xref></contrib><contrib contrib-type="author"><name><surname>Arredondo</surname><given-names>Miguel</given-names></name><xref ref-type="aff" rid="aff3"><sup>c</sup></xref></contrib><contrib contrib-type="author"><name><surname>Duyckaerts</surname><given-names>Charles</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref><xref ref-type="aff" rid="aff2"><sup>b</sup></xref></contrib><contrib contrib-type="author"><name><surname>Sazdovitch</surname><given-names>Veronique</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref><xref ref-type="aff" rid="aff2"><sup>b</sup></xref></contrib><contrib contrib-type="author"><name><surname>Zhao</surname><given-names>Lin</given-names></name><xref ref-type="aff" rid="aff4"><sup>d</sup></xref></contrib><contrib contrib-type="author"><name><surname>Garrick</surname><given-names>Laura M.</given-names></name><xref ref-type="aff" rid="aff4"><sup>d</sup></xref></contrib><contrib contrib-type="author"><name><surname>Nuñez</surname><given-names>Marco T.</given-names></name><xref ref-type="aff" rid="aff3"><sup>c</sup></xref></contrib><contrib contrib-type="author"><name><surname>Garrick</surname><given-names>Michael D.</given-names></name><xref ref-type="aff" rid="aff4"><sup>d</sup></xref></contrib><contrib contrib-type="author"><name><surname>Raisman-Vozari</surname><given-names>Rita</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref><xref ref-type="aff" rid="aff2"><sup>b</sup></xref></contrib><contrib contrib-type="author"><name><surname>Hirsch</surname><given-names>Etienne C.</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref><xref ref-type="aff" rid="aff2"><sup>b</sup></xref><xref ref-type="corresp" rid="cor1"><sup>1</sup></xref></contrib><aff id="aff1"><sup>a</sup>Institut National de la Santé et de la Recherche Médicale, Neurologie et Thérapeutique Expérimentale, Unité Mixte de Recherche S679, 47 Boulevard de l'Hôpital, 75013 Paris, France;</aff><aff id="aff2"><sup>b</sup>Unité Mixte de Recherche S679, Université Pierre et Marie Curie, Boulevard de l'Hôpital, 75013 Paris, France;</aff><aff id="aff3"><sup>c</sup>Millennium Institute for Cell Dynamics and Biotechnology and Department of Biology, Faculty of Sciences, Universidad de Chile, Las Encinas 3370, Santiago, Chile; and</aff><aff id="aff4"><sup>d</sup>Department of Biochemistry, University at Buffalo, State University of New York, 140 Farber Hall, 3435 Main Street, Buffalo, NY 14214</aff></contrib-group><author-notes><corresp id="cor1"><sup>1</sup>To whom correspondence should be addressed. E-mail: <email>etienne.hirsch@upmc.fr</email></corresp><fn fn-type="edited-by"><p>Edited by Richard D. Palmiter, University of Washington School of Medicine, Seattle, WA, and approved September 18, 2008</p></fn><fn fn-type="con"><p>Author contributions: J.S., S.H., L.M.G., M.D.G., and E.C.H. designed research; J.S., N.M., A.P., D.A.-F., M.A., L.Z., and L.M.G. performed research; M.A., C.D., and V.S. contributed new reagents/analytic tools; J.S., S.H., D.A.-F., M.T.N., M.D.G., R.R.-V., and E.C.H. analyzed data; and J.S., L.M.G., M.D.G., and E.C.H. wrote the paper.</p></fn></author-notes><pub-date pub-type="ppub"><day>25</day><month>11</month><year>2008</year></pub-date><pub-date pub-type="epub"><day>14</day><month>11</month><year>2008</year></pub-date><volume>105</volume><issue>47</issue><fpage>18578</fpage><lpage>18583</lpage><history><date date-type="received"><day>6</day><month>5</month><year>2008</year></date></history><permissions><copyright-statement>© 2008 by The National Academy of Sciences of the USA</copyright-statement></permissions><self-uri xlink:title="pdf" xlink:type="simple" xlink:href="zpq04708018578.pdf"></self-uri><abstract><p>Dopaminergic cell death in the substantia nigra (SN) is central to Parkinson's disease (PD), but the neurodegenerative mechanisms have not been completely elucidated. Iron accumulation in dopaminergic and glial cells in the SN of PD patients may contribute to the generation of oxidative stress, protein aggregation, and neuronal death. The mechanisms involved in iron accumulation also remain unclear. Here, we describe an increase in the expression of an isoform of the divalent metal transporter 1 (DMT1/Nramp2/Slc11a2) in the SN of PD patients. Using the PD animal model of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) intoxication in mice, we showed that DMT1 expression increases in the ventral mesencephalon of intoxicated animals, concomitant with iron accumulation, oxidative stress, and dopaminergic cell loss. In addition, we report that a mutation in DMT1 that impairs iron transport protects rodents against parkinsonism-inducing neurotoxins MPTP and 6-hydroxydopamine. This study supports a critical role for DMT1 in iron-mediated neurodegeneration in PD.</p></abstract><kwd-group><kwd>iron</kwd><kwd>oxidative stress</kwd><kwd>substantia nigra</kwd><kwd>MPTP</kwd><kwd>6-hydroxydopamine</kwd></kwd-group></article-meta></front></pmc><affiliations><list><country><li>Chili</li><li>France</li><li>États-Unis</li></country><region><li>État de New York</li><li>Île-de-France</li></region><settlement><li>Paris</li></settlement><orgName><li>Université Pierre-et-Marie-Curie</li></orgName></list><tree><country name="France"><region name="Île-de-France"><name sortKey="Salazar, Julio" sort="Salazar, Julio" uniqKey="Salazar J" first="Julio" last="Salazar">Julio Salazar</name></region><name sortKey="Alvarez Fischer, Daniel" sort="Alvarez Fischer, Daniel" uniqKey="Alvarez Fischer D" first="Daniel" last="Alvarez-Fischer">Daniel Alvarez-Fischer</name><name sortKey="Alvarez Fischer, Daniel" sort="Alvarez Fischer, Daniel" uniqKey="Alvarez Fischer D" first="Daniel" last="Alvarez-Fischer">Daniel Alvarez-Fischer</name><name sortKey="Duyckaerts, Charles" sort="Duyckaerts, Charles" uniqKey="Duyckaerts C" first="Charles" last="Duyckaerts">Charles Duyckaerts</name><name sortKey="Duyckaerts, Charles" sort="Duyckaerts, Charles" uniqKey="Duyckaerts C" first="Charles" last="Duyckaerts">Charles Duyckaerts</name><name sortKey="Hirsch, Etienne C" sort="Hirsch, Etienne C" uniqKey="Hirsch E" first="Etienne C." last="Hirsch">Etienne C. Hirsch</name><name sortKey="Hirsch, Etienne C" sort="Hirsch, Etienne C" uniqKey="Hirsch E" first="Etienne C." last="Hirsch">Etienne C. Hirsch</name><name sortKey="Hunot, Stephane" sort="Hunot, Stephane" uniqKey="Hunot S" first="Stephane" last="Hunot">Stephane Hunot</name><name sortKey="Hunot, Stephane" sort="Hunot, Stephane" uniqKey="Hunot S" first="Stephane" last="Hunot">Stephane Hunot</name><name sortKey="Prigent, Annick" sort="Prigent, Annick" uniqKey="Prigent A" first="Annick" last="Prigent">Annick Prigent</name><name sortKey="Prigent, Annick" sort="Prigent, Annick" uniqKey="Prigent A" first="Annick" last="Prigent">Annick Prigent</name><name sortKey="Raisman Vozari, Rita" sort="Raisman Vozari, Rita" uniqKey="Raisman Vozari R" first="Rita" last="Raisman-Vozari">Rita Raisman-Vozari</name><name sortKey="Raisman Vozari, Rita" sort="Raisman Vozari, Rita" uniqKey="Raisman Vozari R" first="Rita" last="Raisman-Vozari">Rita Raisman-Vozari</name><name sortKey="Salazar, Julio" sort="Salazar, Julio" uniqKey="Salazar J" first="Julio" last="Salazar">Julio Salazar</name><name sortKey="Sazdovitch, Veronique" sort="Sazdovitch, Veronique" uniqKey="Sazdovitch V" first="Veronique" last="Sazdovitch">Veronique Sazdovitch</name><name sortKey="Sazdovitch, Veronique" sort="Sazdovitch, Veronique" uniqKey="Sazdovitch V" first="Veronique" last="Sazdovitch">Veronique Sazdovitch</name></country><country name="Chili"><noRegion><name sortKey="Salazar, Julio" sort="Salazar, Julio" uniqKey="Salazar J" first="Julio" last="Salazar">Julio Salazar</name></noRegion><name sortKey="Arredondo, Miguel" sort="Arredondo, Miguel" uniqKey="Arredondo M" first="Miguel" last="Arredondo">Miguel Arredondo</name><name sortKey="Mena, Natalia" sort="Mena, Natalia" uniqKey="Mena N" first="Natalia" last="Mena">Natalia Mena</name><name sortKey="Nu Ez, Marco T" sort="Nu Ez, Marco T" uniqKey="Nu Ez M" first="Marco T." last="Nu Ez">Marco T. Nu Ez</name></country><country name="États-Unis"><region name="État de New York"><name sortKey="Zhao, Lin" sort="Zhao, Lin" uniqKey="Zhao L" first="Lin" last="Zhao">Lin Zhao</name></region><name sortKey="Garrick, Laura M" sort="Garrick, Laura M" uniqKey="Garrick L" first="Laura M." last="Garrick">Laura M. Garrick</name><name sortKey="Garrick, Michael D" sort="Garrick, Michael D" uniqKey="Garrick M" first="Michael D." last="Garrick">Michael D. Garrick</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/Pmc/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000859 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Checkpoint/biblio.hfd -nk 000859 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonFranceV1
|flux= Pmc
|étape= Checkpoint
|type= RBID
|clé= PMC:2587621
|texte= Divalent metal transporter 1 (DMT1) contributes to neurodegeneration in animal models of Parkinson's disease
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Checkpoint/RBID.i -Sk "pubmed:19011085" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Checkpoint/biblio.hfd \
| NlmPubMed2Wicri -a ParkinsonFranceV1
| This area was generated with Dilib version V0.6.29. |  |