Synchronisation in the beta frequency-band — The bad boy of parkinsonism or an innocent bystander?
Identifieur interne : 000792 ( Pmc/Checkpoint ); précédent : 000791; suivant : 000793Synchronisation in the beta frequency-band — The bad boy of parkinsonism or an innocent bystander?
Auteurs : Alexandre Eusebio [France, Royaume-Uni] ; Peter Brown [Royaume-Uni]Source :
- Experimental Neurology [ 0014-4886 ] ; 2009.
Abstract
Excessive synchronisation of basal ganglia neuronal activity in the beta frequency band has been implicated in Parkinson's disease. In a recent issue of Experimental Neurology, Bronte-Stewart, H., Barberini, C., Koop, M.M., Hill, B.C., Henderson, J.M., Wingeier, B., 2009. The STN beta-band profile in Parkinson's disease is stationary and shows prolonged attenuation after deep brain stimulation. Exp. Neurol. 215, 20–28. demonstrate that such activity is consistent over time and provide further evidence that deep brain stimulation is associated with its suppression. However, the extent to which beta synchrony has a mechanistic (rather than epiphenomenal) role in parkinsonism remains unclear, and the suppression of this activity by deep brain stimulation is contentious. This commentary discusses the evidence for and against a role for excessive beta synchrony in mediating the parkinsonian phenotype and in providing a possible mechanism to explain the therapeutic effects of deep brain stimulation in Parkinson's disease.
Url:
DOI: 10.1016/j.expneurol.2009.02.003
PubMed: 19233172
PubMed Central: 2697315
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Synchronisation in the beta frequency-band — The bad boy of parkinsonism or an innocent bystander?</title><author><name sortKey="Eusebio, Alexandre" sort="Eusebio, Alexandre" uniqKey="Eusebio A" first="Alexandre" last="Eusebio">Alexandre Eusebio</name><affiliation wicri:level="3"><nlm:aff id="aff1">Department of Neurology and Movement Disorders, CHU Timone, Marseille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Neurology and Movement Disorders, CHU Timone, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2">Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, 33 Queen Square, London, WCIN 3BG, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, 33 Queen Square, London, WCIN 3BG</wicri:regionArea><wicri:noRegion>WCIN 3BG</wicri:noRegion></affiliation></author><author><name sortKey="Brown, Peter" sort="Brown, Peter" uniqKey="Brown P" first="Peter" last="Brown">Peter Brown</name><affiliation wicri:level="1"><nlm:aff id="aff2">Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, 33 Queen Square, London, WCIN 3BG, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, 33 Queen Square, London, WCIN 3BG</wicri:regionArea><wicri:noRegion>WCIN 3BG</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">19233172</idno><idno type="pmc">2697315</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2697315</idno><idno type="RBID">PMC:2697315</idno><idno type="doi">10.1016/j.expneurol.2009.02.003</idno><date when="2009">2009</date><idno type="wicri:Area/Pmc/Corpus">000341</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000341</idno><idno type="wicri:Area/Pmc/Curation">000339</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000339</idno><idno type="wicri:Area/Pmc/Checkpoint">000792</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000792</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Synchronisation in the beta frequency-band — The bad boy of parkinsonism or an innocent bystander?</title><author><name sortKey="Eusebio, Alexandre" sort="Eusebio, Alexandre" uniqKey="Eusebio A" first="Alexandre" last="Eusebio">Alexandre Eusebio</name><affiliation wicri:level="3"><nlm:aff id="aff1">Department of Neurology and Movement Disorders, CHU Timone, Marseille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Neurology and Movement Disorders, CHU Timone, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2">Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, 33 Queen Square, London, WCIN 3BG, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, 33 Queen Square, London, WCIN 3BG</wicri:regionArea><wicri:noRegion>WCIN 3BG</wicri:noRegion></affiliation></author><author><name sortKey="Brown, Peter" sort="Brown, Peter" uniqKey="Brown P" first="Peter" last="Brown">Peter Brown</name><affiliation wicri:level="1"><nlm:aff id="aff2">Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, 33 Queen Square, London, WCIN 3BG, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, 33 Queen Square, London, WCIN 3BG</wicri:regionArea><wicri:noRegion>WCIN 3BG</wicri:noRegion></affiliation></author></analytic><series><title level="j">Experimental Neurology</title><idno type="ISSN">0014-4886</idno><idno type="eISSN">1090-2430</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Excessive synchronisation of basal ganglia neuronal activity in the beta frequency band has been implicated in Parkinson's disease. In a recent issue of Experimental Neurology, Bronte-Stewart, H., Barberini, C., Koop, M.M., Hill, B.C., Henderson, J.M., Wingeier, B., 2009. The STN beta-band profile in Parkinson's disease is stationary and shows prolonged attenuation after deep brain stimulation. Exp. Neurol. 215, 20–28. demonstrate that such activity is consistent over time and provide further evidence that deep brain stimulation is associated with its suppression. However, the extent to which beta synchrony has a mechanistic (rather than epiphenomenal) role in parkinsonism remains unclear, and the suppression of this activity by deep brain stimulation is contentious. 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Vingerhoets</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Weinberger, M" uniqKey="Weinberger M">M. Weinberger</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Wingeier, B" uniqKey="Wingeier B">B. Wingeier</name></author><author><name sortKey="Tcheng, T" uniqKey="Tcheng T">T. Tcheng</name></author><author><name sortKey="Koop, M M" uniqKey="Koop M">M.M. Koop</name></author><author><name sortKey="Hill, B C" uniqKey="Hill B">B.C. Hill</name></author><author><name sortKey="Heit, G" uniqKey="Heit G">G. Heit</name></author><author><name sortKey="Bronte Stewart, H M" uniqKey="Bronte Stewart H">H.M. Bronte-Stewart</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="discussion"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Exp Neurol</journal-id><journal-id journal-id-type="iso-abbrev">Exp. Neurol</journal-id><journal-title-group><journal-title>Experimental Neurology</journal-title></journal-title-group><issn pub-type="ppub">0014-4886</issn><issn pub-type="epub">1090-2430</issn><publisher><publisher-name>Academic Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">19233172</article-id><article-id pub-id-type="pmc">2697315</article-id><article-id pub-id-type="publisher-id">S0014-4886(09)00055-7</article-id><article-id pub-id-type="doi">10.1016/j.expneurol.2009.02.003</article-id><article-categories><subj-group subj-group-type="heading"><subject>Commentary</subject></subj-group></article-categories><title-group><article-title>Synchronisation in the beta frequency-band — The bad boy of parkinsonism or an innocent bystander?</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Eusebio</surname><given-names>Alexandre</given-names></name><xref rid="aff1" ref-type="aff">a</xref><xref rid="aff2" ref-type="aff">b</xref></contrib><contrib contrib-type="author"><name><surname>Brown</surname><given-names>Peter</given-names></name><email>p.brown@ion.ucl.ac.uk</email><xref rid="aff2" ref-type="aff">b</xref><xref rid="cor1" ref-type="corresp">⁎</xref></contrib></contrib-group><aff id="aff1"><label>a</label>Department of Neurology and Movement Disorders, CHU Timone, Marseille, France</aff><aff id="aff2"><label>b</label>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, 33 Queen Square, London, WCIN 3BG, UK.</aff><author-notes><corresp id="cor1"><label>⁎</label>Corresponding author. Fax: +44 (0)20 7278 9836. <email>p.brown@ion.ucl.ac.uk</email></corresp></author-notes><pub-date pub-type="pmc-release"><day>1</day><month>5</month><year>2009</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="ppub"><month>5</month><year>2009</year></pub-date><volume>217</volume><issue>1</issue><fpage>1</fpage><lpage>3</lpage><history><date date-type="received"><day>25</day><month>11</month><year>2008</year></date><date date-type="rev-recd"><day>28</day><month>1</month><year>2009</year></date><date date-type="accepted"><day>11</day><month>2</month><year>2009</year></date></history><permissions><copyright-statement>© 2009 Elsevier Inc.</copyright-statement><copyright-year>2009</copyright-year><copyright-holder>Elsevier Inc.</copyright-holder><license xlink:href="https://creativecommons.org/licenses/by/3.0/"><license-p>Open Access under <ext-link ext-link-type="uri" xlink:href="https://creativecommons.org/licenses/by/3.0/">CC BY 3.0</ext-link> license</license-p></license></permissions><abstract><p>Excessive synchronisation of basal ganglia neuronal activity in the beta frequency band has been implicated in Parkinson's disease. In a recent issue of Experimental Neurology, Bronte-Stewart, H., Barberini, C., Koop, M.M., Hill, B.C., Henderson, J.M., Wingeier, B., 2009. The STN beta-band profile in Parkinson's disease is stationary and shows prolonged attenuation after deep brain stimulation. Exp. Neurol. 215, 20–28. demonstrate that such activity is consistent over time and provide further evidence that deep brain stimulation is associated with its suppression. However, the extent to which beta synchrony has a mechanistic (rather than epiphenomenal) role in parkinsonism remains unclear, and the suppression of this activity by deep brain stimulation is contentious. This commentary discusses the evidence for and against a role for excessive beta synchrony in mediating the parkinsonian phenotype and in providing a possible mechanism to explain the therapeutic effects of deep brain stimulation in Parkinson's disease.</p></abstract></article-meta></front></pmc><affiliations><list><country><li>France</li><li>Royaume-Uni</li></country><region><li>Provence-Alpes-Côte d'Azur</li></region><settlement><li>Marseille</li></settlement></list><tree><country name="France"><region name="Provence-Alpes-Côte d'Azur"><name sortKey="Eusebio, Alexandre" sort="Eusebio, Alexandre" uniqKey="Eusebio A" first="Alexandre" last="Eusebio">Alexandre Eusebio</name></region></country><country name="Royaume-Uni"><noRegion><name sortKey="Eusebio, Alexandre" sort="Eusebio, Alexandre" uniqKey="Eusebio A" first="Alexandre" last="Eusebio">Alexandre Eusebio</name></noRegion><name sortKey="Brown, Peter" sort="Brown, Peter" uniqKey="Brown P" first="Peter" last="Brown">Peter Brown</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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