Modeling Retinal Dystrophies Using Patient-Derived Induced Pluripotent Stem Cells
Identifieur interne : 000332 ( Pmc/Checkpoint ); précédent : 000331; suivant : 000333Modeling Retinal Dystrophies Using Patient-Derived Induced Pluripotent Stem Cells
Auteurs : Karl J. Wahlin ; Julien Maruotti ; Donald J. ZackSource :
- Advances in experimental medicine and biology [ 0065-2598 ] ; 2014.
Abstract
Url:
DOI: 10.1007/978-1-4614-3209-8_20
PubMed: 24664693
PubMed Central: 4117190
Affiliations:
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PMC:4117190Le document en format XML
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<author><name sortKey="Maruotti, Julien" sort="Maruotti, Julien" uniqKey="Maruotti J" first="Julien" last="Maruotti">Julien Maruotti</name>
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<author><name sortKey="Zack, Donald J" sort="Zack, Donald J" uniqKey="Zack D" first="Donald J." last="Zack">Donald J. Zack</name>
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<author><name sortKey="Wahlin, Karl J" sort="Wahlin, Karl J" uniqKey="Wahlin K" first="Karl J." last="Wahlin">Karl J. Wahlin</name>
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<author><name sortKey="Maruotti, Julien" sort="Maruotti, Julien" uniqKey="Maruotti J" first="Julien" last="Maruotti">Julien Maruotti</name>
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<author><name sortKey="Zack, Donald J" sort="Zack, Donald J" uniqKey="Zack D" first="Donald J." last="Zack">Donald J. Zack</name>
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<front><div type="abstract" xml:lang="en"><p id="P1"><italic>Retinal</italic>
degenerative disease involving photoreceptor (PR) cell loss results in permanent vision loss and often blindness. Generation of induced pluripotent stem cell (iPSC)-derived retinal cells and tissues from individuals with retinal dystrophies is a relatively new and promising method for studying retinal degeneration mechanisms in vitro. Recent advancements in strategies to differentiate human iPSCs (hiPSCs) into 3D retinal eyecups with a strong resemblance to the mature retina raise the possibility that this system could offer a reliable model for translational drug studies. However, despite the potential benefits, there are challenges that remain to be overcome before stem-cell-derived retinal eyecups can be routinely used to model human retinal diseases. This chapter will discuss both the potential of these 3D eyecup approaches and the nature of some of the challenges that remain.</p>
</div>
</front>
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<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
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<front><journal-meta><journal-id journal-id-type="nlm-journal-id">0121103</journal-id>
<journal-id journal-id-type="pubmed-jr-id">280</journal-id>
<journal-id journal-id-type="nlm-ta">Adv Exp Med Biol</journal-id>
<journal-id journal-id-type="iso-abbrev">Adv. Exp. Med. Biol.</journal-id>
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<title-group><article-title>Modeling Retinal Dystrophies Using Patient-Derived Induced Pluripotent Stem Cells</article-title>
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<contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Wahlin</surname>
<given-names>Karl J.</given-names>
</name>
<aff id="A1">Department of Ophthalmology, The Johns Hopkins University School of Medicine, Smith Building Rm 3029, 400 N Broadway, Baltimore, MD, USA</aff>
<email>kwahlin1@jhmi.edu</email>
</contrib>
<contrib contrib-type="author"><name><surname>Maruotti</surname>
<given-names>Julien</given-names>
</name>
<aff id="A2">Department of Ophthalmology, The Johns Hopkins University School of Medicine, Smith Building Rm 3029, 400 N Broadway, Baltimore, MD, USA</aff>
</contrib>
<contrib contrib-type="author"><name><surname>Zack</surname>
<given-names>Donald J.</given-names>
</name>
<aff id="A3">Department of Ophthalmology, The Johns Hopkins University School of Medicine, Smith Building Rm 3029, 400 N Broadway, Baltimore, MD, USA. Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, MD, USA. Department of Molecular Biology and Genetics, The Johns Hopkins University School of Medicine, Baltimore, MD, USA. Institute of Genetic Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA. Institut de la Vision, Paris 75012, Paris, France</aff>
<email>dzack@jhmi.edu</email>
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<pub-date pub-type="nihms-submitted"><day>4</day>
<month>6</month>
<year>2014</year>
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<pub-date pub-type="ppub"><year>2014</year>
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<pub-date pub-type="pmc-release"><day>31</day>
<month>7</month>
<year>2014</year>
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<volume>801</volume>
<fpage>157</fpage>
<lpage>164</lpage>
<pmc-comment>elocation-id from pubmed: 10.1007/978-1-4614-3209-8_20</pmc-comment>
<permissions><copyright-statement>© Springer Science+Business Media, LLC 2014</copyright-statement>
<copyright-year>2014</copyright-year>
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<abstract><p id="P1"><italic>Retinal</italic>
degenerative disease involving photoreceptor (PR) cell loss results in permanent vision loss and often blindness. Generation of induced pluripotent stem cell (iPSC)-derived retinal cells and tissues from individuals with retinal dystrophies is a relatively new and promising method for studying retinal degeneration mechanisms in vitro. Recent advancements in strategies to differentiate human iPSCs (hiPSCs) into 3D retinal eyecups with a strong resemblance to the mature retina raise the possibility that this system could offer a reliable model for translational drug studies. However, despite the potential benefits, there are challenges that remain to be overcome before stem-cell-derived retinal eyecups can be routinely used to model human retinal diseases. This chapter will discuss both the potential of these 3D eyecup approaches and the nature of some of the challenges that remain.</p>
</abstract>
<kwd-group><kwd>Retinal degeneration</kwd>
<kwd>Patient</kwd>
<kwd>Dystrophy</kwd>
<kwd>Stem cell</kwd>
<kwd>hiPSC</kwd>
<kwd>Pluripotent</kwd>
<kwd>Eyecup</kwd>
</kwd-group>
</article-meta>
</front>
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<affiliations><list></list>
<tree><noCountry><name sortKey="Maruotti, Julien" sort="Maruotti, Julien" uniqKey="Maruotti J" first="Julien" last="Maruotti">Julien Maruotti</name>
<name sortKey="Wahlin, Karl J" sort="Wahlin, Karl J" uniqKey="Wahlin K" first="Karl J." last="Wahlin">Karl J. Wahlin</name>
<name sortKey="Zack, Donald J" sort="Zack, Donald J" uniqKey="Zack D" first="Donald J." last="Zack">Donald J. Zack</name>
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