Parkinsonism-associated Protein DJ-1/Park7 Is a Major Protein Deglycase That Repairs Methylglyoxal- and Glyoxal-glycated Cysteine, Arginine, and Lysine Residues
Identifieur interne : 000318 ( Pmc/Checkpoint ); précédent : 000317; suivant : 000319Parkinsonism-associated Protein DJ-1/Park7 Is a Major Protein Deglycase That Repairs Methylglyoxal- and Glyoxal-glycated Cysteine, Arginine, and Lysine Residues
Auteurs : Gilbert Richarme ; Mouadh Mihoub ; Julien Dairou ; Linh Chi Bui ; Thibaut Leger ; Aazdine LamouriSource :
- The Journal of Biological Chemistry [ 0021-9258 ] ; 2014.
Abstract
Url:
DOI: 10.1074/jbc.M114.597815
PubMed: 25416785
PubMed Central: 4340429
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Parkinsonism-associated Protein DJ-1/Park7 Is a Major Protein Deglycase That Repairs Methylglyoxal- and Glyoxal-glycated Cysteine, Arginine, and Lysine Residues</title>
<author><name sortKey="Richarme, Gilbert" sort="Richarme, Gilbert" uniqKey="Richarme G" first="Gilbert" last="Richarme">Gilbert Richarme</name>
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<author><name sortKey="Mihoub, Mouadh" sort="Mihoub, Mouadh" uniqKey="Mihoub M" first="Mouadh" last="Mihoub">Mouadh Mihoub</name>
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<author><name sortKey="Dairou, Julien" sort="Dairou, Julien" uniqKey="Dairou J" first="Julien" last="Dairou">Julien Dairou</name>
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<author><name sortKey="Bui, Linh Chi" sort="Bui, Linh Chi" uniqKey="Bui L" first="Linh Chi" last="Bui">Linh Chi Bui</name>
<affiliation><nlm:aff id="aff2"></nlm:aff>
</affiliation>
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<author><name sortKey="Leger, Thibaut" sort="Leger, Thibaut" uniqKey="Leger T" first="Thibaut" last="Leger">Thibaut Leger</name>
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</affiliation>
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<author><name sortKey="Lamouri, Aazdine" sort="Lamouri, Aazdine" uniqKey="Lamouri A" first="Aazdine" last="Lamouri">Aazdine Lamouri</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Parkinsonism-associated Protein DJ-1/Park7 Is a Major Protein Deglycase That Repairs Methylglyoxal- and Glyoxal-glycated Cysteine, Arginine, and Lysine Residues</title>
<author><name sortKey="Richarme, Gilbert" sort="Richarme, Gilbert" uniqKey="Richarme G" first="Gilbert" last="Richarme">Gilbert Richarme</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Mihoub, Mouadh" sort="Mihoub, Mouadh" uniqKey="Mihoub M" first="Mouadh" last="Mihoub">Mouadh Mihoub</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
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<author><name sortKey="Dairou, Julien" sort="Dairou, Julien" uniqKey="Dairou J" first="Julien" last="Dairou">Julien Dairou</name>
<affiliation><nlm:aff id="aff2"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Bui, Linh Chi" sort="Bui, Linh Chi" uniqKey="Bui L" first="Linh Chi" last="Bui">Linh Chi Bui</name>
<affiliation><nlm:aff id="aff2"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Leger, Thibaut" sort="Leger, Thibaut" uniqKey="Leger T" first="Thibaut" last="Leger">Thibaut Leger</name>
<affiliation><nlm:aff id="aff3"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Lamouri, Aazdine" sort="Lamouri, Aazdine" uniqKey="Lamouri A" first="Aazdine" last="Lamouri">Aazdine Lamouri</name>
<affiliation><nlm:aff id="aff4"></nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">The Journal of Biological Chemistry</title>
<idno type="ISSN">0021-9258</idno>
<idno type="eISSN">1083-351X</idno>
<imprint><date when="2014">2014</date>
</imprint>
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<front><div type="abstract" xml:lang="en"><p><bold>Background:</bold>
Protein glycation is a nonenzymatic covalent reaction between proteins and carbonyl groups resulting in protein denaturation.</p>
<p><bold>Results:</bold>
DJ-1 is the first protein deglycase that repairs proteins from glycation by glyoxals, which constitutes most glycation damage.</p>
<p><bold>Conclusion:</bold>
DJ-1 is a novel protein repair enzyme that protects proteins against glycation.</p>
<p><bold>Significance:</bold>
DJ-1 deglycase activity changes our view on glycation/deglycation and DJ-1-associated Parkinsonism.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Biol Chem</journal-id>
<journal-id journal-id-type="iso-abbrev">J. Biol. Chem</journal-id>
<journal-id journal-id-type="hwp">jbc</journal-id>
<journal-id journal-id-type="pmc">jbc</journal-id>
<journal-id journal-id-type="publisher-id">JBC</journal-id>
<journal-title-group><journal-title>The Journal of Biological Chemistry</journal-title>
</journal-title-group>
<issn pub-type="ppub">0021-9258</issn>
<issn pub-type="epub">1083-351X</issn>
<publisher><publisher-name>American Society for Biochemistry and Molecular Biology</publisher-name>
<publisher-loc>9650 Rockville Pike, Bethesda, MD 20814, U.S.A.</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">25416785</article-id>
<article-id pub-id-type="pmc">4340429</article-id>
<article-id pub-id-type="publisher-id">M114.597815</article-id>
<article-id pub-id-type="doi">10.1074/jbc.M114.597815</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Protein Structure and Folding</subject>
</subj-group>
</article-categories>
<title-group><article-title>Parkinsonism-associated Protein DJ-1/Park7 Is a Major Protein Deglycase That Repairs Methylglyoxal- and Glyoxal-glycated Cysteine, Arginine, and Lysine Residues</article-title>
<alt-title alt-title-type="short">Protein Deglycase DJ-1/Park7</alt-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Richarme</surname>
<given-names>Gilbert</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>‡</sup>
</xref>
<xref ref-type="corresp" rid="cor1"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Mihoub</surname>
<given-names>Mouadh</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>‡</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Dairou</surname>
<given-names>Julien</given-names>
</name>
<xref ref-type="aff" rid="aff2"><sup>§</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Bui</surname>
<given-names>Linh Chi</given-names>
</name>
<xref ref-type="aff" rid="aff2"><sup>§</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Leger</surname>
<given-names>Thibaut</given-names>
</name>
<xref ref-type="aff" rid="aff3"><sup>¶</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lamouri</surname>
<given-names>Aazdine</given-names>
</name>
<xref ref-type="aff" rid="aff4"><sup>‖</sup>
</xref>
</contrib>
<aff id="aff1">From the<label>‡</label>
Stress Molecules, Institut Jacques Monod, Université Paris 7, CNRS UMR 7592, 75013 Paris, France,</aff>
<aff id="aff2">the<label>§</label>
Université Paris Diderot, Sorbonne Paris Cité, Unité de Biologie Fonctionnelle et Adaptative UMR 8251 CNRS, Bioprofiler Facility, F-75205, Paris, France,</aff>
<aff id="aff3">the<label>¶</label>
Proteomics Facility, Institut Jacques Monod, Université Paris 7, CNRS, UMR 7592, 75013 Paris, France, and</aff>
<aff id="aff4">the<label>‖</label>
Université Paris Diderot, Sorbonne Paris Cite, ITODYS, UMR 7086 CNRS, 75013 Paris, France</aff>
</contrib-group>
<author-notes><corresp id="cor1"><label>1</label>
To whom correspondence should be addressed: <addr-line>Stress Molecules, Inst. Jacques Monod, Université Paris 7, CNRS UMR 7592, 15 Rue Hélène Brion, 75013 Paris, France.</addr-line>
Tel.: <phone>33-1-57-27-80-57</phone>
; Fax: <fax>33-1-57-27-81-01</fax>
; E-mail: <email>richarme@paris7.jussieu.fr</email>
.</corresp>
</author-notes>
<pub-date pub-type="ppub"><day>16</day>
<month>1</month>
<year>2015</year>
</pub-date>
<pub-date pub-type="epub"><day>21</day>
<month>11</month>
<year>2014</year>
</pub-date>
<volume>290</volume>
<issue>3</issue>
<fpage>1885</fpage>
<lpage>1897</lpage>
<history><date date-type="received"><day>17</day>
<month>7</month>
<year>2014</year>
</date>
<date date-type="rev-recd"><day>20</day>
<month>11</month>
<year>2014</year>
</date>
</history>
<permissions><copyright-statement>© 2015 by The American Society for Biochemistry and Molecular Biology, Inc.</copyright-statement>
<copyright-year>2015</copyright-year>
</permissions>
<self-uri xlink:title="pdf" xlink:type="simple" xlink:href="zbc00315001885.pdf"></self-uri>
<abstract abstract-type="teaser"><p><bold>Background:</bold>
Protein glycation is a nonenzymatic covalent reaction between proteins and carbonyl groups resulting in protein denaturation.</p>
<p><bold>Results:</bold>
DJ-1 is the first protein deglycase that repairs proteins from glycation by glyoxals, which constitutes most glycation damage.</p>
<p><bold>Conclusion:</bold>
DJ-1 is a novel protein repair enzyme that protects proteins against glycation.</p>
<p><bold>Significance:</bold>
DJ-1 deglycase activity changes our view on glycation/deglycation and DJ-1-associated Parkinsonism.</p>
</abstract>
<abstract><p>Glycation is an inevitable nonenzymatic covalent reaction between proteins and endogenous reducing sugars or dicarbonyls (methylglyoxal, glyoxal) that results in protein inactivation. DJ-1 was reported to be a multifunctional oxidative stress response protein with poorly defined function. Here, we show that human DJ-1 is a protein deglycase that repairs methylglyoxal- and glyoxal-glycated amino acids and proteins by acting on early glycation intermediates and releases repaired proteins and lactate or glycolate, respectively. DJ-1 deglycates cysteines, arginines, and lysines (the three major glycated amino acids) of serum albumin, glyceraldehyde-3-phosphate dehydrogenase, aldolase, and aspartate aminotransferase and thus reactivates these proteins. DJ-1 prevented protein glycation in an <italic>Escherichia coli</italic>
mutant deficient in the DJ-1 homolog YajL and restored cell viability in glucose-containing media. These results suggest that DJ-1-associated Parkinsonism results from excessive protein glycation and establishes DJ-1 as a major anti-glycation and anti-aging protein.</p>
</abstract>
<kwd-group><kwd>Glycation</kwd>
<kwd>Protein Aggregation</kwd>
<kwd>Protein Chemical Modification</kwd>
<kwd>Protein Conformation</kwd>
<kwd>Protein Denaturation</kwd>
<kwd>Carbonyl Stress</kwd>
<kwd>Dicarbonyl Compounds</kwd>
<kwd>Electrophile Stress</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
<affiliations><list></list>
<tree><noCountry><name sortKey="Bui, Linh Chi" sort="Bui, Linh Chi" uniqKey="Bui L" first="Linh Chi" last="Bui">Linh Chi Bui</name>
<name sortKey="Dairou, Julien" sort="Dairou, Julien" uniqKey="Dairou J" first="Julien" last="Dairou">Julien Dairou</name>
<name sortKey="Lamouri, Aazdine" sort="Lamouri, Aazdine" uniqKey="Lamouri A" first="Aazdine" last="Lamouri">Aazdine Lamouri</name>
<name sortKey="Leger, Thibaut" sort="Leger, Thibaut" uniqKey="Leger T" first="Thibaut" last="Leger">Thibaut Leger</name>
<name sortKey="Mihoub, Mouadh" sort="Mihoub, Mouadh" uniqKey="Mihoub M" first="Mouadh" last="Mihoub">Mouadh Mihoub</name>
<name sortKey="Richarme, Gilbert" sort="Richarme, Gilbert" uniqKey="Richarme G" first="Gilbert" last="Richarme">Gilbert Richarme</name>
</noCountry>
</tree>
</affiliations>
</record>
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