Parkinsonism-associated Protein DJ-1/Park7 Is a Major Protein Deglycase That Repairs Methylglyoxal- and Glyoxal-glycated Cysteine, Arginine, and Lysine Residues
Identifieur interne : 000318 ( Pmc/Checkpoint ); précédent : 000317; suivant : 000319Parkinsonism-associated Protein DJ-1/Park7 Is a Major Protein Deglycase That Repairs Methylglyoxal- and Glyoxal-glycated Cysteine, Arginine, and Lysine Residues
Auteurs : Gilbert Richarme ; Mouadh Mihoub ; Julien Dairou ; Linh Chi Bui ; Thibaut Leger ; Aazdine LamouriSource :
- The Journal of Biological Chemistry [ 0021-9258 ] ; 2014.
Abstract
Url:
DOI: 10.1074/jbc.M114.597815
PubMed: 25416785
PubMed Central: 4340429
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Parkinsonism-associated Protein DJ-1/Park7 Is a Major Protein Deglycase That Repairs Methylglyoxal- and Glyoxal-glycated Cysteine, Arginine, and Lysine Residues</title><author><name sortKey="Richarme, Gilbert" sort="Richarme, Gilbert" uniqKey="Richarme G" first="Gilbert" last="Richarme">Gilbert Richarme</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Mihoub, Mouadh" sort="Mihoub, Mouadh" uniqKey="Mihoub M" first="Mouadh" last="Mihoub">Mouadh Mihoub</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Dairou, Julien" sort="Dairou, Julien" uniqKey="Dairou J" first="Julien" last="Dairou">Julien Dairou</name><affiliation><nlm:aff id="aff2"></nlm:aff></affiliation></author><author><name sortKey="Bui, Linh Chi" sort="Bui, Linh Chi" uniqKey="Bui L" first="Linh Chi" last="Bui">Linh Chi Bui</name><affiliation><nlm:aff id="aff2"></nlm:aff></affiliation></author><author><name sortKey="Leger, Thibaut" sort="Leger, Thibaut" uniqKey="Leger T" first="Thibaut" last="Leger">Thibaut Leger</name><affiliation><nlm:aff id="aff3"></nlm:aff></affiliation></author><author><name sortKey="Lamouri, Aazdine" sort="Lamouri, Aazdine" uniqKey="Lamouri A" first="Aazdine" last="Lamouri">Aazdine Lamouri</name><affiliation><nlm:aff id="aff4"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25416785</idno><idno type="pmc">4340429</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340429</idno><idno type="RBID">PMC:4340429</idno><idno type="doi">10.1074/jbc.M114.597815</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">000480</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000480</idno><idno type="wicri:Area/Pmc/Curation">000477</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000477</idno><idno type="wicri:Area/Pmc/Checkpoint">000318</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000318</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Parkinsonism-associated Protein DJ-1/Park7 Is a Major Protein Deglycase That Repairs Methylglyoxal- and Glyoxal-glycated Cysteine, Arginine, and Lysine Residues</title><author><name sortKey="Richarme, Gilbert" sort="Richarme, Gilbert" uniqKey="Richarme G" first="Gilbert" last="Richarme">Gilbert Richarme</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Mihoub, Mouadh" sort="Mihoub, Mouadh" uniqKey="Mihoub M" first="Mouadh" last="Mihoub">Mouadh Mihoub</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Dairou, Julien" sort="Dairou, Julien" uniqKey="Dairou J" first="Julien" last="Dairou">Julien Dairou</name><affiliation><nlm:aff id="aff2"></nlm:aff></affiliation></author><author><name sortKey="Bui, Linh Chi" sort="Bui, Linh Chi" uniqKey="Bui L" first="Linh Chi" last="Bui">Linh Chi Bui</name><affiliation><nlm:aff id="aff2"></nlm:aff></affiliation></author><author><name sortKey="Leger, Thibaut" sort="Leger, Thibaut" uniqKey="Leger T" first="Thibaut" last="Leger">Thibaut Leger</name><affiliation><nlm:aff id="aff3"></nlm:aff></affiliation></author><author><name sortKey="Lamouri, Aazdine" sort="Lamouri, Aazdine" uniqKey="Lamouri A" first="Aazdine" last="Lamouri">Aazdine Lamouri</name><affiliation><nlm:aff id="aff4"></nlm:aff></affiliation></author></analytic><series><title level="j">The Journal of Biological Chemistry</title><idno type="ISSN">0021-9258</idno><idno type="eISSN">1083-351X</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><bold>Background:</bold> Protein glycation is a nonenzymatic covalent reaction between proteins and carbonyl groups resulting in protein denaturation.</p><p><bold>Results:</bold> DJ-1 is the first protein deglycase that repairs proteins from glycation by glyoxals, which constitutes most glycation damage.</p><p><bold>Conclusion:</bold> DJ-1 is a novel protein repair enzyme that protects proteins against glycation.</p><p><bold>Significance:</bold> DJ-1 deglycase activity changes our view on glycation/deglycation and DJ-1-associated Parkinsonism.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Biol Chem</journal-id><journal-id journal-id-type="iso-abbrev">J. Biol. Chem</journal-id><journal-id journal-id-type="hwp">jbc</journal-id><journal-id journal-id-type="pmc">jbc</journal-id><journal-id journal-id-type="publisher-id">JBC</journal-id><journal-title-group><journal-title>The Journal of Biological Chemistry</journal-title></journal-title-group><issn pub-type="ppub">0021-9258</issn><issn pub-type="epub">1083-351X</issn><publisher><publisher-name>American Society for Biochemistry and Molecular Biology</publisher-name><publisher-loc>9650 Rockville Pike, Bethesda, MD 20814, U.S.A.</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">25416785</article-id><article-id pub-id-type="pmc">4340429</article-id><article-id pub-id-type="publisher-id">M114.597815</article-id><article-id pub-id-type="doi">10.1074/jbc.M114.597815</article-id><article-categories><subj-group subj-group-type="heading"><subject>Protein Structure and Folding</subject></subj-group></article-categories><title-group><article-title>Parkinsonism-associated Protein DJ-1/Park7 Is a Major Protein Deglycase That Repairs Methylglyoxal- and Glyoxal-glycated Cysteine, Arginine, and Lysine Residues</article-title><alt-title alt-title-type="short">Protein Deglycase DJ-1/Park7</alt-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Richarme</surname><given-names>Gilbert</given-names></name><xref ref-type="aff" rid="aff1"><sup>‡</sup></xref><xref ref-type="corresp" rid="cor1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Mihoub</surname><given-names>Mouadh</given-names></name><xref ref-type="aff" rid="aff1"><sup>‡</sup></xref></contrib><contrib contrib-type="author"><name><surname>Dairou</surname><given-names>Julien</given-names></name><xref ref-type="aff" rid="aff2"><sup>§</sup></xref></contrib><contrib contrib-type="author"><name><surname>Bui</surname><given-names>Linh Chi</given-names></name><xref ref-type="aff" rid="aff2"><sup>§</sup></xref></contrib><contrib contrib-type="author"><name><surname>Leger</surname><given-names>Thibaut</given-names></name><xref ref-type="aff" rid="aff3"><sup>¶</sup></xref></contrib><contrib contrib-type="author"><name><surname>Lamouri</surname><given-names>Aazdine</given-names></name><xref ref-type="aff" rid="aff4"><sup>‖</sup></xref></contrib><aff id="aff1">From the<label>‡</label>Stress Molecules, Institut Jacques Monod, Université Paris 7, CNRS UMR 7592, 75013 Paris, France,</aff><aff id="aff2">the<label>§</label>Université Paris Diderot, Sorbonne Paris Cité, Unité de Biologie Fonctionnelle et Adaptative UMR 8251 CNRS, Bioprofiler Facility, F-75205, Paris, France,</aff><aff id="aff3">the<label>¶</label>Proteomics Facility, Institut Jacques Monod, Université Paris 7, CNRS, UMR 7592, 75013 Paris, France, and</aff><aff id="aff4">the<label>‖</label>Université Paris Diderot, Sorbonne Paris Cite, ITODYS, UMR 7086 CNRS, 75013 Paris, France</aff></contrib-group><author-notes><corresp id="cor1"><label>1</label> To whom correspondence should be addressed: <addr-line>Stress Molecules, Inst. Jacques Monod, Université Paris 7, CNRS UMR 7592, 15 Rue Hélène Brion, 75013 Paris, France.</addr-line> Tel.: <phone>33-1-57-27-80-57</phone>; Fax: <fax>33-1-57-27-81-01</fax>; E-mail: <email>richarme@paris7.jussieu.fr</email>.</corresp></author-notes><pub-date pub-type="ppub"><day>16</day><month>1</month><year>2015</year></pub-date><pub-date pub-type="epub"><day>21</day><month>11</month><year>2014</year></pub-date><volume>290</volume><issue>3</issue><fpage>1885</fpage><lpage>1897</lpage><history><date date-type="received"><day>17</day><month>7</month><year>2014</year></date><date date-type="rev-recd"><day>20</day><month>11</month><year>2014</year></date></history><permissions><copyright-statement>© 2015 by The American Society for Biochemistry and Molecular Biology, Inc.</copyright-statement><copyright-year>2015</copyright-year></permissions><self-uri xlink:title="pdf" xlink:type="simple" xlink:href="zbc00315001885.pdf"></self-uri><abstract abstract-type="teaser"><p><bold>Background:</bold> Protein glycation is a nonenzymatic covalent reaction between proteins and carbonyl groups resulting in protein denaturation.</p><p><bold>Results:</bold> DJ-1 is the first protein deglycase that repairs proteins from glycation by glyoxals, which constitutes most glycation damage.</p><p><bold>Conclusion:</bold> DJ-1 is a novel protein repair enzyme that protects proteins against glycation.</p><p><bold>Significance:</bold> DJ-1 deglycase activity changes our view on glycation/deglycation and DJ-1-associated Parkinsonism.</p></abstract><abstract><p>Glycation is an inevitable nonenzymatic covalent reaction between proteins and endogenous reducing sugars or dicarbonyls (methylglyoxal, glyoxal) that results in protein inactivation. DJ-1 was reported to be a multifunctional oxidative stress response protein with poorly defined function. Here, we show that human DJ-1 is a protein deglycase that repairs methylglyoxal- and glyoxal-glycated amino acids and proteins by acting on early glycation intermediates and releases repaired proteins and lactate or glycolate, respectively. DJ-1 deglycates cysteines, arginines, and lysines (the three major glycated amino acids) of serum albumin, glyceraldehyde-3-phosphate dehydrogenase, aldolase, and aspartate aminotransferase and thus reactivates these proteins. DJ-1 prevented protein glycation in an <italic>Escherichia coli</italic> mutant deficient in the DJ-1 homolog YajL and restored cell viability in glucose-containing media. These results suggest that DJ-1-associated Parkinsonism results from excessive protein glycation and establishes DJ-1 as a major anti-glycation and anti-aging protein.</p></abstract><kwd-group><kwd>Glycation</kwd><kwd>Protein Aggregation</kwd><kwd>Protein Chemical Modification</kwd><kwd>Protein Conformation</kwd><kwd>Protein Denaturation</kwd><kwd>Carbonyl Stress</kwd><kwd>Dicarbonyl Compounds</kwd><kwd>Electrophile Stress</kwd></kwd-group></article-meta></front></pmc><affiliations><list></list><tree><noCountry><name sortKey="Bui, Linh Chi" sort="Bui, Linh Chi" uniqKey="Bui L" first="Linh Chi" last="Bui">Linh Chi Bui</name><name sortKey="Dairou, Julien" sort="Dairou, Julien" uniqKey="Dairou J" first="Julien" last="Dairou">Julien Dairou</name><name sortKey="Lamouri, Aazdine" sort="Lamouri, Aazdine" uniqKey="Lamouri A" first="Aazdine" last="Lamouri">Aazdine Lamouri</name><name sortKey="Leger, Thibaut" sort="Leger, Thibaut" uniqKey="Leger T" first="Thibaut" last="Leger">Thibaut Leger</name><name sortKey="Mihoub, Mouadh" sort="Mihoub, Mouadh" uniqKey="Mihoub M" first="Mouadh" last="Mihoub">Mouadh Mihoub</name><name sortKey="Richarme, Gilbert" sort="Richarme, Gilbert" uniqKey="Richarme G" first="Gilbert" last="Richarme">Gilbert Richarme</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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