Is the cardiac monitoring function related to the self in both the default network and right anterior insula?
Identifieur interne : 000067 ( Pmc/Checkpoint ); précédent : 000066; suivant : 000068Is the cardiac monitoring function related to the self in both the default network and right anterior insula?
Auteurs : Mariana Babo-Rebelo [France] ; Nicolai Wolpert [France] ; Claude Adam [France] ; Dominique Hasboun [France] ; Catherine Tallon-Baudry [France]Source :
- Philosophical Transactions of the Royal Society B: Biological Sciences [ 0962-8436 ] ; 2016.
Abstract
The self has been proposed to be rooted in the neural monitoring of internal bodily signals and might thus involve interoceptive areas, notably the right anterior insula (rAI). However, studies on the self consistently showed the involvement of midline default network (DN) nodes, without referring to visceral monitoring. Here, we investigate this apparent discrepancy. We previously showed that neural responses to heartbeats in the DN encode two different self-dimensions, the agentive ‘I’ and the introspective ‘Me’, in a whole-brain analysis of magnetoencephalography (MEG) data. Here, we confirm and anatomically refine this result with intracranial recordings (intracranial electroencephalography, iEEG). In two patients, we show a parametric modulation of neural responses to heartbeats by the self-relatedness of thoughts, at the single trial level. A region-of-interest analysis of the insula reveals that MEG responses to heartbeats in the rAI encode the ‘I’ self-dimension. The effect in rAI was weaker than in the DN and was replicated in iEEG data in one patient out of two. We propose that a common mechanism, the neural monitoring of cardiac signals, underlies the self in both the DN and rAI. This might reconcile studies on the self highlighting the DN, with studies on interoception focusing on the insula.
This article is part of the themed issue ‘Interoception beyond homeostasis: affect, cognition and mental health’.
Url:
DOI: 10.1098/rstb.2016.0004
PubMed: 28080963
PubMed Central: 5062094
Affiliations:
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Rebelo M" first="Mariana" last="Babo-Rebelo">Mariana Babo-Rebelo</name><affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>Laboratoire de Neurosciences Cognitives (ENS – INSERM U960), Département d'Etudes Cognitives</addr-line>,<institution>Ecole Normale Supérieure – PSL Research University</institution>,<addr-line>75005 Paris</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wolpert, Nicolai" sort="Wolpert, Nicolai" uniqKey="Wolpert N" first="Nicolai" last="Wolpert">Nicolai Wolpert</name><affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>Laboratoire de Neurosciences Cognitives (ENS – INSERM U960), Département d'Etudes Cognitives</addr-line>,<institution>Ecole Normale Supérieure – PSL Research University</institution>,<addr-line>75005 Paris</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Adam, Claude" sort="Adam, Claude" uniqKey="Adam C" first="Claude" last="Adam">Claude Adam</name><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>AP-HP</addr-line>,<institution>Groupe Hospitalier Pitié-Salpêtrière</institution>,<addr-line>Paris 75013</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hasboun, Dominique" sort="Hasboun, Dominique" uniqKey="Hasboun D" first="Dominique" last="Hasboun">Dominique Hasboun</name><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>AP-HP</addr-line>,<institution>Groupe Hospitalier Pitié-Salpêtrière</institution>,<addr-line>Paris 75013</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tallon Baudry, Catherine" sort="Tallon Baudry, Catherine" uniqKey="Tallon Baudry C" first="Catherine" last="Tallon-Baudry">Catherine Tallon-Baudry</name><affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>Laboratoire de Neurosciences Cognitives (ENS – INSERM U960), Département d'Etudes Cognitives</addr-line>,<institution>Ecole Normale Supérieure – PSL Research University</institution>,<addr-line>75005 Paris</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Philosophical Transactions of the Royal Society B: Biological Sciences</title><idno type="ISSN">0962-8436</idno><idno type="eISSN">1471-2970</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The self has been proposed to be rooted in the neural monitoring of internal bodily signals and might thus involve interoceptive areas, notably the right anterior insula (rAI). However, studies on the self consistently showed the involvement of midline default network (DN) nodes, without referring to visceral monitoring. Here, we investigate this apparent discrepancy. We previously showed that neural responses to heartbeats in the DN encode two different self-dimensions, the agentive ‘I’ and the introspective ‘Me’, in a whole-brain analysis of magnetoencephalography (MEG) data. Here, we confirm and anatomically refine this result with intracranial recordings (intracranial electroencephalography, iEEG). In two patients, we show a parametric modulation of neural responses to heartbeats by the self-relatedness of thoughts, at the single trial level. A region-of-interest analysis of the insula reveals that MEG responses to heartbeats in the rAI encode the ‘I’ self-dimension. The effect in rAI was weaker than in the DN and was replicated in iEEG data in one patient out of two. We propose that a common mechanism, the neural monitoring of cardiac signals, underlies the self in both the DN and rAI. This might reconcile studies on the self highlighting the DN, with studies on interoception focusing on the insula.</p><p>This article is part of the themed issue ‘Interoception beyond homeostasis: affect, cognition and mental health’.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Damasio, Ar" uniqKey="Damasio A">AR Damasio</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Park, H D" uniqKey="Park H">H-D Park</name></author><author><name sortKey="Tallon Baudry, C" uniqKey="Tallon Baudry C">C Tallon-Baudry</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Craig, Ad" uniqKey="Craig A">AD Craig</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Critchley, Hd" uniqKey="Critchley H">HD Critchley</name></author><author><name sortKey="Wiens, S" uniqKey="Wiens S">S Wiens</name></author><author><name sortKey="Rotshtein, P" 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Philos Trans R Soc Lond B Biol Sci</journal-id><journal-id journal-id-type="iso-abbrev">Philos. Trans. R. Soc. Lond., B, Biol. Sci</journal-id><journal-id journal-id-type="publisher-id">RSTB</journal-id><journal-id journal-id-type="hwp">royptb</journal-id><journal-title-group><journal-title>Philosophical Transactions of the Royal Society B: Biological Sciences</journal-title></journal-title-group><issn pub-type="ppub">0962-8436</issn><issn pub-type="epub">1471-2970</issn><publisher><publisher-name>The Royal Society</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">28080963</article-id><article-id pub-id-type="pmc">5062094</article-id><article-id pub-id-type="doi">10.1098/rstb.2016.0004</article-id><article-id pub-id-type="publisher-id">rstb20160004</article-id><article-categories><subj-group subj-group-type="hwp-journal-coll"><subject>1001</subject><subject>42</subject><subject>133</subject></subj-group><subj-group subj-group-type="heading"><subject>Articles</subject></subj-group><subj-group subj-group-type="leader"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title>Is the cardiac monitoring function related to the self in both the default network and right anterior insula?</article-title><alt-title alt-title-type="short">Cardiac monitoring and the self</alt-title></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="false">http://orcid.org/0000-0001-8664-7427</contrib-id><name><surname>Babo-Rebelo</surname><given-names>Mariana</given-names></name><xref ref-type="aff" rid="af1">1</xref><xref ref-type="corresp" rid="cor1"></xref></contrib><contrib contrib-type="author"><name><surname>Wolpert</surname><given-names>Nicolai</given-names></name><xref ref-type="aff" rid="af1">1</xref></contrib><contrib contrib-type="author"><name><surname>Adam</surname><given-names>Claude</given-names></name><xref ref-type="aff" rid="af2">2</xref></contrib><contrib contrib-type="author"><name><surname>Hasboun</surname><given-names>Dominique</given-names></name><xref ref-type="aff" rid="af2">2</xref></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="false">http://orcid.org/0000-0001-8480-5831</contrib-id><name><surname>Tallon-Baudry</surname><given-names>Catherine</given-names></name><xref ref-type="aff" rid="af1">1</xref></contrib></contrib-group><aff id="af1"><label>1</label><addr-line>Laboratoire de Neurosciences Cognitives (ENS – INSERM U960), Département d'Etudes Cognitives</addr-line>,<institution>Ecole Normale Supérieure – PSL Research University</institution>,<addr-line>75005 Paris</addr-line>,<country>France</country></aff><aff id="af2"><label>2</label><addr-line>AP-HP</addr-line>,<institution>Groupe Hospitalier Pitié-Salpêtrière</institution>,<addr-line>Paris 75013</addr-line>,<country>France</country></aff><author-notes><corresp id="cor1">e-mail: <email>mariana.babo-rebelo@ens.fr</email></corresp><fn><p>One contribution of 16 to a theme issue ‘<ext-link ext-link-type="uri" xlink:href="http://dx.doi.org/10.1098/rstb/371/1708">Interoception beyond homeostasis: affect, cognition and mental health</ext-link>’.</p></fn><fn><p>Electronic supplementary material is available online at <uri xlink:href="https://dx.doi.org/10.6084/m9.figshare.c.3464844">https://dx.doi.org/10.6084/m9.figshare.c.3464844</uri>.</p></fn></author-notes><pub-date pub-type="ppub"><day>19</day><month>11</month><year>2016</year></pub-date><pub-date pub-type="pmc-release"><day>19</day><month>11</month><year>2016</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on the
<volume>371</volume><issue>1708</issue><issue-title>Theme issue ‘Interoception beyond homeostasis: affect, cognition and mental health’ compiled and edited by Manos Tsakiris and Hugo D. Critchley</issue-title><elocation-id>20160004</elocation-id><history><date date-type="accepted"><day>5</day><month>8</month><year>2016</year></date></history><permissions><copyright-statement>© 2016 The Authors.</copyright-statement><copyright-year>2016</copyright-year><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/4.0/"><license-p>Published by the Royal Society under the terms of the Creative Commons Attribution License <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</ext-link>, which permits unrestricted use, provided the original author and source are credited.</license-p></license></permissions><self-uri content-type="pdf" xlink:href="rstb20160004.pdf"></self-uri><abstract><p>The self has been proposed to be rooted in the neural monitoring of internal bodily signals and might thus involve interoceptive areas, notably the right anterior insula (rAI). However, studies on the self consistently showed the involvement of midline default network (DN) nodes, without referring to visceral monitoring. Here, we investigate this apparent discrepancy. We previously showed that neural responses to heartbeats in the DN encode two different self-dimensions, the agentive ‘I’ and the introspective ‘Me’, in a whole-brain analysis of magnetoencephalography (MEG) data. Here, we confirm and anatomically refine this result with intracranial recordings (intracranial electroencephalography, iEEG). In two patients, we show a parametric modulation of neural responses to heartbeats by the self-relatedness of thoughts, at the single trial level. A region-of-interest analysis of the insula reveals that MEG responses to heartbeats in the rAI encode the ‘I’ self-dimension. The effect in rAI was weaker than in the DN and was replicated in iEEG data in one patient out of two. We propose that a common mechanism, the neural monitoring of cardiac signals, underlies the self in both the DN and rAI. This might reconcile studies on the self highlighting the DN, with studies on interoception focusing on the insula.</p><p>This article is part of the themed issue ‘Interoception beyond homeostasis: affect, cognition and mental health’.</p></abstract><kwd-group><kwd>intracranial electroencephalography</kwd><kwd>magnetoencephalography</kwd><kwd>neural responses to heartbeats</kwd><kwd>heartbeat-evoked responses</kwd><kwd>interoception</kwd><kwd>spontaneous cognition</kwd></kwd-group><funding-group specific-use="FundRef"><award-group><funding-source><institution-wrap><institution>European Research Council</institution><institution-id>http://dx.doi.org/10.13039/501100000781</institution-id></institution-wrap></funding-source><award-id>670325</award-id></award-group></funding-group><custom-meta-group><custom-meta><meta-name>cover-date</meta-name><meta-value>November 19, 2016</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc><affiliations><list><country><li>France</li></country></list><tree><country name="France"><noRegion><name sortKey="Babo Rebelo, Mariana" sort="Babo Rebelo, Mariana" uniqKey="Babo Rebelo M" first="Mariana" last="Babo-Rebelo">Mariana Babo-Rebelo</name></noRegion><name sortKey="Adam, Claude" sort="Adam, Claude" uniqKey="Adam C" first="Claude" last="Adam">Claude Adam</name><name sortKey="Hasboun, Dominique" sort="Hasboun, Dominique" uniqKey="Hasboun D" first="Dominique" last="Hasboun">Dominique Hasboun</name><name sortKey="Tallon Baudry, Catherine" sort="Tallon Baudry, Catherine" uniqKey="Tallon Baudry C" first="Catherine" last="Tallon-Baudry">Catherine Tallon-Baudry</name><name sortKey="Wolpert, Nicolai" sort="Wolpert, Nicolai" uniqKey="Wolpert N" first="Nicolai" last="Wolpert">Nicolai Wolpert</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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