Spatial Localization of Sources in the Rat Subthalamic Motor Region Using an Inverse Current Source Density Method
Identifieur interne : 000027 ( Pmc/Checkpoint ); précédent : 000026; suivant : 000028Spatial Localization of Sources in the Rat Subthalamic Motor Region Using an Inverse Current Source Density Method
Auteurs : Kees J. Van Dijk [Pays-Bas] ; Marcus L. F. Janssen [Pays-Bas, France] ; Daphne G. M. Zwartjes [Pays-Bas] ; Yasin Temel [Pays-Bas] ; Veerle Visser-Vandewalle [Allemagne] ; Peter H. Veltink [Pays-Bas] ; Abdelhamid Benazzouz [France] ; Tjitske Heida [Pays-Bas]Source :
- Frontiers in Neural Circuits [ 1662-5110 ] ; 2016.
Abstract
Url:
DOI: 10.3389/fncir.2016.00087
PubMed: 27857684
PubMed Central: 5093117
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Spatial Localization of Sources in the Rat Subthalamic Motor Region Using an Inverse Current Source Density Method</title><author><name sortKey="Van Dijk, Kees J" sort="Van Dijk, Kees J" uniqKey="Van Dijk K" first="Kees J." last="Van Dijk">Kees J. Van Dijk</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Biomedical Signals and Systems Group, MIRA institute for Biomedical Engineering and Technical Medicine, University of Twente</institution><country>Enschede, Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Janssen, Marcus L F" sort="Janssen, Marcus L F" uniqKey="Janssen M" first="Marcus L. F." last="Janssen">Marcus L. F. Janssen</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Department of Neuroscience, School for Mental Health and Neuroscience, Maastricht University</institution><country>Maastricht, Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea></wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Department of Neurology, Maastricht University Medical Center</institution><country>Maastricht, Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea></wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff4"><institution>University de Bordeaux, Institut des Maladies Neurodégénératives, Centre National de la Recherche Scientifique UMR 5293</institution><country>Bordeaux, France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Zwartjes, Daphne G M" sort="Zwartjes, Daphne G M" uniqKey="Zwartjes D" first="Daphne G. M." last="Zwartjes">Daphne G. M. Zwartjes</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Biomedical Signals and Systems Group, MIRA institute for Biomedical Engineering and Technical Medicine, University of Twente</institution><country>Enschede, Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Temel, Yasin" sort="Temel, Yasin" uniqKey="Temel Y" first="Yasin" last="Temel">Yasin Temel</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Department of Neuroscience, School for Mental Health and Neuroscience, Maastricht University</institution><country>Maastricht, Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea></wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff5"><institution>Department of Neurosurgery, Maastricht University Medical Center</institution><country>Maastricht, Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Visser Vandewalle, Veerle" sort="Visser Vandewalle, Veerle" uniqKey="Visser Vandewalle V" first="Veerle" last="Visser-Vandewalle">Veerle Visser-Vandewalle</name><affiliation wicri:level="1"><nlm:aff id="aff6"><institution>Department of Stereotactic and Functional Neurosurgery, University of Cologne</institution><country>Cologne, Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Veltink, Peter H" sort="Veltink, Peter H" uniqKey="Veltink P" first="Peter H." last="Veltink">Peter H. Veltink</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Biomedical Signals and Systems Group, MIRA institute for Biomedical Engineering and Technical Medicine, University of Twente</institution><country>Enschede, Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Benazzouz, Abdelhamid" sort="Benazzouz, Abdelhamid" uniqKey="Benazzouz A" first="Abdelhamid" last="Benazzouz">Abdelhamid Benazzouz</name><affiliation wicri:level="1"><nlm:aff id="aff4"><institution>University de Bordeaux, Institut des Maladies Neurodégénératives, Centre National de la Recherche Scientifique UMR 5293</institution><country>Bordeaux, France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Heida, Tjitske" sort="Heida, Tjitske" uniqKey="Heida T" first="Tjitske" last="Heida">Tjitske Heida</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Biomedical Signals and Systems Group, MIRA institute for Biomedical Engineering and Technical Medicine, University of Twente</institution><country>Enschede, Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea></wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27857684</idno><idno type="pmc">5093117</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5093117</idno><idno type="RBID">PMC:5093117</idno><idno type="doi">10.3389/fncir.2016.00087</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">000745</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000745</idno><idno type="wicri:Area/Pmc/Curation">000742</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000742</idno><idno type="wicri:Area/Pmc/Checkpoint">000027</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000027</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Spatial Localization of Sources in the Rat Subthalamic Motor Region Using an Inverse Current Source Density Method</title><author><name sortKey="Van Dijk, Kees J" sort="Van Dijk, Kees J" uniqKey="Van Dijk K" first="Kees J." last="Van Dijk">Kees J. Van Dijk</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Biomedical Signals and Systems Group, MIRA institute for Biomedical Engineering and Technical Medicine, University of Twente</institution><country>Enschede, Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Janssen, Marcus L F" sort="Janssen, Marcus L F" uniqKey="Janssen M" first="Marcus L. F." last="Janssen">Marcus L. F. Janssen</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Department of Neuroscience, School for Mental Health and Neuroscience, Maastricht University</institution><country>Maastricht, Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea></wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Department of Neurology, Maastricht University Medical Center</institution><country>Maastricht, Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea></wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff4"><institution>University de Bordeaux, Institut des Maladies Neurodégénératives, Centre National de la Recherche Scientifique UMR 5293</institution><country>Bordeaux, France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Zwartjes, Daphne G M" sort="Zwartjes, Daphne G M" uniqKey="Zwartjes D" first="Daphne G. M." last="Zwartjes">Daphne G. M. Zwartjes</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Biomedical Signals and Systems Group, MIRA institute for Biomedical Engineering and Technical Medicine, University of Twente</institution><country>Enschede, Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Temel, Yasin" sort="Temel, Yasin" uniqKey="Temel Y" first="Yasin" last="Temel">Yasin Temel</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Department of Neuroscience, School for Mental Health and Neuroscience, Maastricht University</institution><country>Maastricht, Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea></wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff5"><institution>Department of Neurosurgery, Maastricht University Medical Center</institution><country>Maastricht, Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Visser Vandewalle, Veerle" sort="Visser Vandewalle, Veerle" uniqKey="Visser Vandewalle V" first="Veerle" last="Visser-Vandewalle">Veerle Visser-Vandewalle</name><affiliation wicri:level="1"><nlm:aff id="aff6"><institution>Department of Stereotactic and Functional Neurosurgery, University of Cologne</institution><country>Cologne, Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Veltink, Peter H" sort="Veltink, Peter H" uniqKey="Veltink P" first="Peter H." last="Veltink">Peter H. Veltink</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Biomedical Signals and Systems Group, MIRA institute for Biomedical Engineering and Technical Medicine, University of Twente</institution><country>Enschede, Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Benazzouz, Abdelhamid" sort="Benazzouz, Abdelhamid" uniqKey="Benazzouz A" first="Abdelhamid" last="Benazzouz">Abdelhamid Benazzouz</name><affiliation wicri:level="1"><nlm:aff id="aff4"><institution>University de Bordeaux, Institut des Maladies Neurodégénératives, Centre National de la Recherche Scientifique UMR 5293</institution><country>Bordeaux, France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Heida, Tjitske" sort="Heida, Tjitske" uniqKey="Heida T" first="Tjitske" last="Heida">Tjitske Heida</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Biomedical Signals and Systems Group, MIRA institute for Biomedical Engineering and Technical Medicine, University of Twente</institution><country>Enschede, Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea></wicri:regionArea></affiliation></author></analytic><series><title level="j">Frontiers in Neural Circuits</title><idno type="eISSN">1662-5110</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><bold>Objective:</bold> In this study we introduce the use of the current source density (CSD) method as a way to visualize the spatial organization of evoked responses in the rat subthalamic nucleus (STN) at fixed time stamps resulting from motor cortex stimulation. This method offers opportunities to visualize neuronal input and study the relation between the synaptic input and the neural output of neural populations.</p><p><bold>Approach:</bold> Motor cortex evoked local field potentials and unit activity were measured in the subthalamic region, with a 3D measurement grid consisting of 320 measurement points and high spatial resolution. This allowed us to visualize the evoked synaptic input by estimating the current source density (CSD) from the measured local field potentials, using the inverse CSD method. At the same time, the neuronal output of the cells within the grid is assessed by calculating post stimulus time histograms.</p><p><bold>Main results:</bold> The CSD method resulted in clear and distinguishable sources and sinks of the neuronal input activity in the STN after motor cortex stimulation. We showed that the center of the synaptic input of the STN from the motor cortex is located dorsal to the input from globus pallidus.</p><p><bold>Significance:</bold> For the first time we have performed CSD analysis on motor cortex stimulation evoked LFP responses in the rat STN as a proof of principle. Our results suggest that the CSD method can be used to gain new insights into the spatial extent of synaptic pathways in brain structures.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Afsharpour, S" uniqKey="Afsharpour S">S. Afsharpour</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Andreuccetti, D" uniqKey="Andreuccetti D">D. Andreuccetti</name></author><author><name sortKey="Fossi, R" uniqKey="Fossi R">R. Fossi</name></author><author><name sortKey="Petrucci, C" uniqKey="Petrucci C">C. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Front Neural Circuits</journal-id><journal-id journal-id-type="iso-abbrev">Front Neural Circuits</journal-id><journal-id journal-id-type="publisher-id">Front. Neural Circuits</journal-id><journal-title-group><journal-title>Frontiers in Neural Circuits</journal-title></journal-title-group><issn pub-type="epub">1662-5110</issn><publisher><publisher-name>Frontiers Media S.A.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">27857684</article-id><article-id pub-id-type="pmc">5093117</article-id><article-id pub-id-type="doi">10.3389/fncir.2016.00087</article-id><article-categories><subj-group subj-group-type="heading"><subject>Neuroscience</subject><subj-group><subject>Original Research</subject></subj-group></subj-group></article-categories><title-group><article-title>Spatial Localization of Sources in the Rat Subthalamic Motor Region Using an Inverse Current Source Density Method</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>van Dijk</surname><given-names>Kees J.</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="author-notes" rid="fn001"><sup>*</sup></xref><uri xlink:type="simple" xlink:href="http://loop.frontiersin.org/people/354483/overview"></uri></contrib><contrib contrib-type="author"><name><surname>Janssen</surname><given-names>Marcus L. F.</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref><xref ref-type="aff" rid="aff3"><sup>3</sup></xref><xref ref-type="aff" rid="aff4"><sup>4</sup></xref></contrib><contrib contrib-type="author"><name><surname>Zwartjes</surname><given-names>Daphne G. M.</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Temel</surname><given-names>Yasin</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref><xref ref-type="aff" rid="aff5"><sup>5</sup></xref><uri xlink:type="simple" xlink:href="http://loop.frontiersin.org/people/58959/overview"></uri></contrib><contrib contrib-type="author"><name><surname>Visser-Vandewalle</surname><given-names>Veerle</given-names></name><xref ref-type="aff" rid="aff6"><sup>6</sup></xref><uri xlink:type="simple" xlink:href="http://loop.frontiersin.org/people/262285/overview"></uri></contrib><contrib contrib-type="author"><name><surname>Veltink</surname><given-names>Peter H.</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><uri xlink:type="simple" xlink:href="http://loop.frontiersin.org/people/320377/overview"></uri></contrib><contrib contrib-type="author"><name><surname>Benazzouz</surname><given-names>Abdelhamid</given-names></name><xref ref-type="aff" rid="aff4"><sup>4</sup></xref></contrib><contrib contrib-type="author"><name><surname>Heida</surname><given-names>Tjitske</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib></contrib-group><aff id="aff1"><sup>1</sup><institution>Biomedical Signals and Systems Group, MIRA institute for Biomedical Engineering and Technical Medicine, University of Twente</institution><country>Enschede, Netherlands</country></aff><aff id="aff2"><sup>2</sup><institution>Department of Neuroscience, School for Mental Health and Neuroscience, Maastricht University</institution><country>Maastricht, Netherlands</country></aff><aff id="aff3"><sup>3</sup><institution>Department of Neurology, Maastricht University Medical Center</institution><country>Maastricht, Netherlands</country></aff><aff id="aff4"><sup>4</sup><institution>University de Bordeaux, Institut des Maladies Neurodégénératives, Centre National de la Recherche Scientifique UMR 5293</institution><country>Bordeaux, France</country></aff><aff id="aff5"><sup>5</sup><institution>Department of Neurosurgery, Maastricht University Medical Center</institution><country>Maastricht, Netherlands</country></aff><aff id="aff6"><sup>6</sup><institution>Department of Stereotactic and Functional Neurosurgery, University of Cologne</institution><country>Cologne, Germany</country></aff><author-notes><fn fn-type="edited-by"><p>Edited by: Michael M. Halassa, New York University, USA</p></fn><fn fn-type="edited-by"><p>Reviewed by: Masahiko Takada, Kyoto University, Japan; Charles J. Wilson, University of Texas at San Antonio, USA</p></fn><corresp id="fn001">*Correspondence: Kees J. van Dijk <email xlink:type="simple">k.j.vandijk@utwente.nl</email></corresp></author-notes><pub-date pub-type="epub"><day>03</day><month>11</month><year>2016</year></pub-date><pub-date pub-type="collection"><year>2016</year></pub-date><volume>10</volume><elocation-id>87</elocation-id><history><date date-type="received"><day>04</day><month>7</month><year>2016</year></date><date date-type="accepted"><day>14</day><month>10</month><year>2016</year></date></history><permissions><copyright-statement>Copyright © 2016 van Dijk, Janssen, Zwartjes, Temel, Visser-Vandewalle, Veltink, Benazzouz and Heida.</copyright-statement><copyright-year>2016</copyright-year><copyright-holder>van Dijk, Janssen, Zwartjes, Temel, Visser-Vandewalle, Veltink, Benazzouz and Heida</copyright-holder><license xlink:href="http://creativecommons.org/licenses/by/4.0/"><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.</license-p></license></permissions><abstract><p><bold>Objective:</bold> In this study we introduce the use of the current source density (CSD) method as a way to visualize the spatial organization of evoked responses in the rat subthalamic nucleus (STN) at fixed time stamps resulting from motor cortex stimulation. This method offers opportunities to visualize neuronal input and study the relation between the synaptic input and the neural output of neural populations.</p><p><bold>Approach:</bold> Motor cortex evoked local field potentials and unit activity were measured in the subthalamic region, with a 3D measurement grid consisting of 320 measurement points and high spatial resolution. This allowed us to visualize the evoked synaptic input by estimating the current source density (CSD) from the measured local field potentials, using the inverse CSD method. At the same time, the neuronal output of the cells within the grid is assessed by calculating post stimulus time histograms.</p><p><bold>Main results:</bold> The CSD method resulted in clear and distinguishable sources and sinks of the neuronal input activity in the STN after motor cortex stimulation. We showed that the center of the synaptic input of the STN from the motor cortex is located dorsal to the input from globus pallidus.</p><p><bold>Significance:</bold> For the first time we have performed CSD analysis on motor cortex stimulation evoked LFP responses in the rat STN as a proof of principle. Our results suggest that the CSD method can be used to gain new insights into the spatial extent of synaptic pathways in brain structures.</p></abstract><kwd-group><kwd>inverse current source density analysis</kwd><kwd>local field potentials</kwd><kwd>action potentials</kwd><kwd>cortical stimulation</kwd><kwd>subthalamic nucleus</kwd><kwd>rodents</kwd></kwd-group><counts><fig-count count="5"></fig-count><table-count count="0"></table-count><equation-count count="3"></equation-count><ref-count count="47"></ref-count><page-count count="11"></page-count><word-count count="7730"></word-count></counts></article-meta></front></pmc><affiliations><list><country><li>Allemagne</li><li>France</li><li>Pays-Bas</li></country></list><tree><country name="Pays-Bas"><noRegion><name sortKey="Van Dijk, Kees J" sort="Van Dijk, Kees J" uniqKey="Van Dijk K" first="Kees J." last="Van Dijk">Kees J. Van Dijk</name></noRegion><name sortKey="Heida, Tjitske" sort="Heida, Tjitske" uniqKey="Heida T" first="Tjitske" last="Heida">Tjitske Heida</name><name sortKey="Janssen, Marcus L F" sort="Janssen, Marcus L F" uniqKey="Janssen M" first="Marcus L. F." last="Janssen">Marcus L. F. Janssen</name><name sortKey="Janssen, Marcus L F" sort="Janssen, Marcus L F" uniqKey="Janssen M" first="Marcus L. F." last="Janssen">Marcus L. F. Janssen</name><name sortKey="Temel, Yasin" sort="Temel, Yasin" uniqKey="Temel Y" first="Yasin" last="Temel">Yasin Temel</name><name sortKey="Temel, Yasin" sort="Temel, Yasin" uniqKey="Temel Y" first="Yasin" last="Temel">Yasin Temel</name><name sortKey="Veltink, Peter H" sort="Veltink, Peter H" uniqKey="Veltink P" first="Peter H." last="Veltink">Peter H. Veltink</name><name sortKey="Zwartjes, Daphne G M" sort="Zwartjes, Daphne G M" uniqKey="Zwartjes D" first="Daphne G. M." last="Zwartjes">Daphne G. M. Zwartjes</name></country><country name="France"><noRegion><name sortKey="Janssen, Marcus L F" sort="Janssen, Marcus L F" uniqKey="Janssen M" first="Marcus L. F." last="Janssen">Marcus L. F. Janssen</name></noRegion><name sortKey="Benazzouz, Abdelhamid" sort="Benazzouz, Abdelhamid" uniqKey="Benazzouz A" first="Abdelhamid" last="Benazzouz">Abdelhamid Benazzouz</name></country><country name="Allemagne"><noRegion><name sortKey="Visser Vandewalle, Veerle" sort="Visser Vandewalle, Veerle" uniqKey="Visser Vandewalle V" first="Veerle" last="Visser-Vandewalle">Veerle Visser-Vandewalle</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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