Sulfonylurea binding sites in normal human brain and in Parkinson's disease, progressive supranuclear palsy and Huntington's disease
Identifieur interne : 001675 ( PascalFrancis/Curation ); précédent : 001674; suivant : 001676Sulfonylurea binding sites in normal human brain and in Parkinson's disease, progressive supranuclear palsy and Huntington's disease
Auteurs : S. Holemans [Belgique] ; F. Javoy-Agid [France] ; Y. Agid [France] ; F. De Paermentier ; E. C. Laterre [Belgique] ; J.-M. Maloteaux [Belgique]Source :
- Brain research [ 0006-8993 ] ; 1994.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
Abstract
In human brain, [3H]glibenclamide binds with high affinity (KD about 3.5 nM) to sulfonylurea binding sites which are associated with ATP-sensitive potassium (KATP) channels. Regarding to the important neuromodulatory action of KATP channels in some neuronal populations, sulfonylurea binding sites were measured in several cortical areas (frontal and temporal cortex, hippocampus) and striatum (caudate nucleus and putamen) in controls and patients with Parkinson's disease or progressive supranuclear palsy. There was no modification of [3H]glibenclamide specific binding in the cerebral regions studied in both pathologies
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<front><div type="abstract" xml:lang="en">In human brain, [<sup>3</sup>
H]glibenclamide binds with high affinity (K<sub>D</sub>
about 3.5 nM) to sulfonylurea binding sites which are associated with ATP-sensitive potassium (K<sub>ATP</sub>
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channels in some neuronal populations, sulfonylurea binding sites were measured in several cortical areas (frontal and temporal cortex, hippocampus) and striatum (caudate nucleus and putamen) in controls and patients with Parkinson's disease or progressive supranuclear palsy. There was no modification of [<sup>3</sup>
H]glibenclamide specific binding in the cerebral regions studied in both pathologies</div>
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