ParkinsonFranceV1, PascalFrancis, Curation, bibRecord, 001000

Imaging correlates of apathy and depression in Parkinson's disease

Identifieur interne : 001000 ( PascalFrancis/Curation ); précédent : 000F99; suivant : 001001

Imaging correlates of apathy and depression in Parkinson's disease

Auteurs : Michel Benoit [France] ; Philippe H. Robert [France]

Source :

Journal of the neurological sciences [ 0022-510X ] ; 2011.

RBID : Pascal:11-0499900

Descripteurs français

Pascal (Inist)
- Etat dépressif, Maladie de Parkinson, Trouble du comportement, Pathologie du système nerveux, Encéphale, Métabolisme, Apathie.

English descriptors

KwdEn :
- Apathy, Behavioral disorder, Depression, Encephalon, Metabolism, Nervous system diseases, Parkinson disease.

Abstract

Though the core symptoms of Parkinson's disease (PD) are motor-related, a majority of patients also have neuropsychiatric symptoms concerning mood, behavior and cognition. Apathy and depression are considered among the most frequent ones, and have a negative impact on global functioning and quality of life. Recent neuroimaging studies have provided specific findings related with these symptoms. Depression in PD has been specifically associated with morphological and functional changes in prefrontal cortex, cingulate and thalamus, as with 5-HT transmission reduction in posterior cingulated and amygdala-hippocampus complex. Apathy has received less attention, but has been related with gray matter volume reductions or functional deficits in many regions, as anterior and posterior cingulate and dorsolateral or inferior frontal gyrus. Some of these deficits may be also related with a more pronounced reduction in striatal dopamine transmission. As neuroimaging studies give more arguments to the mechanisms of these symptoms, they also stimulate research for a better individualization of specific affective dimensions in Parkinson's disease.

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A02	`01`			`@0 JNSCAG`
A03		`1`		`@0 J. neurol. sci.`
A05				`@2 310`
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A08	`01`	`1`	`ENG`	`@1 Imaging correlates of apathy and depression in Parkinson's disease`
A09	`01`	`1`	`ENG`	`@1 Proceeding of the 7th International Congress on Mental Dysfunction and other Non-Motor Features in Parkinson's Disease Related Disorders, Barcelona, Spain, 9-12 December, 2010`
A11	`01`	`1`		`@1 BENOIT (Michel)`
A11	`02`	`1`		`@1 ROBERT (Philippe H.)`
A12	`01`	`1`		`@1 KORCZYN (A. D.) @9 ed.`
A12	`02`	`1`		`@1 REICHMANN (H.) @9 ed.`
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A14	`01`			`@1 Service de Psychiatrie, Pole des Neurosciences Cliniques, CHU de Nice @3 FRA @Z 1 aut.`
A14	`02`			`@1 Centre Mémoire de Ressources et de Recherche, Pole de Gérontologie, CHU de Nice @3 FRA @Z 2 aut.`
A15	`01`			`@1 Department of Neurology, Tel-Aviv University Medical School @2 Ramat Aviv 69978 @3 ISR @Z 1 aut. @Z 2 aut. @Z 3 aut.`
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C03	`01`	`X`	`FRE`	`@0 Etat dépressif @5 01`
C03	`01`	`X`	`ENG`	`@0 Depression @5 01`
C03	`01`	`X`	`SPA`	`@0 Estado depresivo @5 01`
C03	`02`	`X`	`FRE`	`@0 Maladie de Parkinson @2 NM @5 02`
C03	`02`	`X`	`ENG`	`@0 Parkinson disease @2 NM @5 02`
C03	`02`	`X`	`SPA`	`@0 Parkinson enfermedad @2 NM @5 02`
C03	`03`	`X`	`FRE`	`@0 Trouble du comportement @5 03`
C03	`03`	`X`	`ENG`	`@0 Behavioral disorder @5 03`
C03	`03`	`X`	`SPA`	`@0 Trastorno conducta @5 03`
C03	`04`	`X`	`FRE`	`@0 Pathologie du système nerveux @5 04`
C03	`04`	`X`	`ENG`	`@0 Nervous system diseases @5 04`
C03	`04`	`X`	`SPA`	`@0 Sistema nervioso patología @5 04`
C03	`05`	`X`	`FRE`	`@0 Encéphale @5 09`
C03	`05`	`X`	`ENG`	`@0 Encephalon @5 09`
C03	`05`	`X`	`SPA`	`@0 Encéfalo @5 09`
C03	`06`	`X`	`FRE`	`@0 Métabolisme @5 10`
C03	`06`	`X`	`ENG`	`@0 Metabolism @5 10`
C03	`06`	`X`	`SPA`	`@0 Metabolismo @5 10`
C03	`07`	`X`	`FRE`	`@0 Apathie @4 CD @5 96`
C03	`07`	`X`	`ENG`	`@0 Apathy @4 CD @5 96`
C03	`07`	`X`	`SPA`	`@0 Apatía @4 CD @5 96`
C07	`01`	`X`	`FRE`	`@0 Trouble de l'humeur @5 37`
C07	`01`	`X`	`ENG`	`@0 Mood disorder @5 37`
C07	`01`	`X`	`SPA`	`@0 Trastorno humor @5 37`
C07	`02`	`X`	`FRE`	`@0 Pathologie de l'encéphale @5 38`
C07	`02`	`X`	`ENG`	`@0 Cerebral disorder @5 38`
C07	`02`	`X`	`SPA`	`@0 Encéfalo patología @5 38`
C07	`03`	`X`	`FRE`	`@0 Syndrome extrapyramidal @5 39`
C07	`03`	`X`	`ENG`	`@0 Extrapyramidal syndrome @5 39`
C07	`03`	`X`	`SPA`	`@0 Extrapiramidal síndrome @5 39`
C07	`04`	`X`	`FRE`	`@0 Maladie dégénérative @5 40`
C07	`04`	`X`	`ENG`	`@0 Degenerative disease @5 40`
C07	`04`	`X`	`SPA`	`@0 Enfermedad degenerativa @5 40`
C07	`05`	`X`	`FRE`	`@0 Pathologie du système nerveux central @5 41`
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C07	`06`	`X`	`SPA`	`@0 Sistema nervioso central @5 43`
N21				`@1 346`
N44	`01`			`@1 OTO`
N82				`@1 OTO`

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Le document en format XML

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<front><div type="abstract" xml:lang="en">Though the core symptoms of Parkinson's disease (PD) are motor-related, a majority of patients also have neuropsychiatric symptoms concerning mood, behavior and cognition. Apathy and depression are considered among the most frequent ones, and have a negative impact on global functioning and quality of life. Recent neuroimaging studies have provided specific findings related with these symptoms. Depression in PD has been specifically associated with morphological and functional changes in prefrontal cortex, cingulate and thalamus, as with 5-HT transmission reduction in posterior cingulated and amygdala-hippocampus complex. Apathy has received less attention, but has been related with gray matter volume reductions or functional deficits in many regions, as anterior and posterior cingulate and dorsolateral or inferior frontal gyrus. Some of these deficits may be also related with a more pronounced reduction in striatal dopamine transmission. As neuroimaging studies give more arguments to the mechanisms of these symptoms, they also stimulate research for a better individualization of specific affective dimensions in Parkinson's disease.</div>
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	La maladie de Parkinson en France (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

La maladie de Parkinson en France (serveur d'exploration)

Imaging correlates of apathy and depression in Parkinson's disease

Imaging correlates of apathy and depression in Parkinson's disease

Source :

Descripteurs français

English descriptors

Abstract

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