ParkinsonFranceV1, PascalFrancis, Curation, bibRecord, 000687

Uncovering the mechanism(s) of action of deep brain stimulation: activation, inhibition, or both

Identifieur interne : 000687 ( PascalFrancis/Curation ); précédent : 000686; suivant : 000688

Uncovering the mechanism(s) of action of deep brain stimulation: activation, inhibition, or both

Auteurs : Cameron C. Mcintyre [États-Unis] ; Marc Savasta [France] ; Lydia Kerkerian-Le Goff [France] ; Jerrold L. Vitek [États-Unis]

Source :

Clinical neurophysiology [ 1388-2457 ] ; 2004.

RBID : Pascal:04-0604031

Descripteurs français

Pascal (Inist)
- Mécanisme action, Inhibition synaptique, Haute fréquence, Thalamus, Noyau gris central, Technique, Parkinson maladie, Tremblement, Dépolarisation, Dépression synaptique, Traitement instrumental, Dystonie, Contrôle moteur, Stimulation cérébrale profonde.

English descriptors

KwdEn :
- Basal ganglion, Deep brain stimulation, Depolarization, Dystonia, High frequency, Instrumentation therapy, Mechanism of action, Motor control, Parkinson disease, Synaptic depression, Synaptic inhibition, Technique, Thalamus, Tremor.

Abstract

High-frequency deep brain stimulation (DBS) of the thalamus or basal ganglia represents an effective clinical technique for the treatment of several medically refractory movement disorders. However, understanding of the mechanisms responsible for the therapeutic action of DBS remains elusive. The goal of this review is to address our present knowledge of the effects of high-frequency stimulation within the central nervous system and comment on the functional implications of this knowledge for uncovering the mechanism(s) of DBS. Four general hypotheses have been developed to explain the mechanism(s) of DBS: depolarization blockade, synaptic inhibition, synaptic depression, and stimulation-induced modulation of pathological network activity. Using the results from functional imaging, neurochemistry, neural recording, and neural modeling experiments we address the general hypotheses and attempt to reconcile what have been considered conflicting results from these different research modalities. Our analysis suggests stimulation-induced modulation of pathological network activity represents the most likely mechanism of DBS; however, several open questions remain to explicitly link the effects of DBS with therapeutic outcomes.

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A03		`1`		`@0 Clin. neurophysiol.`
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A08	`01`	`1`	`ENG`	`@1 Uncovering the mechanism(s) of action of deep brain stimulation: activation, inhibition, or both`
A11	`01`	`1`		`@1 MCINTYRE (Cameron C.)`
A11	`02`	`1`		`@1 SAVASTA (Marc)`
A11	`03`	`1`		`@1 KERKERIAN-LE GOFF (Lydia)`
A11	`04`	`1`		`@1 VITEK (Jerrold L.)`
A14	`01`			`@1 Department of Neurology, Emory University School of Medicine, Woodruff Memorial Research Building, Suite 6000, 1639 Pierce Drive @2 Atlanta, GA 30322 @3 USA @Z 1 aut. @Z 4 aut.`
A14	`02`			`@1 Neurochimie et Neuroplastisté Fonctionnelles, INSERM U318, Université Joseph Fourier, CHU de Grenoble, Departement de Neurologie, BP 217 @2 38043 Grenoble @3 FRA @Z 2 aut.`
A14	`03`			`@1 Laboratoire de Neurobiologie Cellulaire et Fonctionnelle, CNRS, 31 Chemin Joseph Aiguier @2 13402 Marseille @3 FRA @Z 3 aut.`
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C01	`01`		`ENG`	@0 High-frequency deep brain stimulation (DBS) of the thalamus or basal ganglia represents an effective clinical technique for the treatment of several medically refractory movement disorders. However, understanding of the mechanisms responsible for the therapeutic action of DBS remains elusive. The goal of this review is to address our present knowledge of the effects of high-frequency stimulation within the central nervous system and comment on the functional implications of this knowledge for uncovering the mechanism(s) of DBS. Four general hypotheses have been developed to explain the mechanism(s) of DBS: depolarization blockade, synaptic inhibition, synaptic depression, and stimulation-induced modulation of pathological network activity. Using the results from functional imaging, neurochemistry, neural recording, and neural modeling experiments we address the general hypotheses and attempt to reconcile what have been considered conflicting results from these different research modalities. Our analysis suggests stimulation-induced modulation of pathological network activity represents the most likely mechanism of DBS; however, several open questions remain to explicitly link the effects of DBS with therapeutic outcomes.
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C03	`04`	`X`	`FRE`	`@0 Thalamus @5 04`
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C03	`04`	`X`	`SPA`	`@0 Tálamo @5 04`
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C03	`06`	`X`	`SPA`	`@0 Técnica @5 06`
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C03	`08`	`X`	`FRE`	`@0 Tremblement @5 12`
C03	`08`	`X`	`ENG`	`@0 Tremor @5 12`
C03	`08`	`X`	`SPA`	`@0 Temblor @5 12`
C03	`09`	`X`	`FRE`	`@0 Dépolarisation @5 13`
C03	`09`	`X`	`ENG`	`@0 Depolarization @5 13`
C03	`09`	`X`	`SPA`	`@0 Despolarización @5 13`
C03	`10`	`X`	`FRE`	`@0 Dépression synaptique @5 14`
C03	`10`	`X`	`ENG`	`@0 Synaptic depression @5 14`
C03	`10`	`X`	`SPA`	`@0 Depresión sináptica @5 14`
C03	`11`	`X`	`FRE`	`@0 Traitement instrumental @5 57`
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C03	`12`	`X`	`FRE`	`@0 Dystonie @5 58`
C03	`12`	`X`	`ENG`	`@0 Dystonia @5 58`
C03	`12`	`X`	`SPA`	`@0 Distonía @5 58`
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C03	`13`	`X`	`ENG`	`@0 Motor control @5 69`
C03	`13`	`X`	`SPA`	`@0 Control motor @5 69`
C03	`14`	`X`	`FRE`	`@0 Stimulation cérébrale profonde @4 CD @5 96`
C03	`14`	`X`	`ENG`	`@0 Deep brain stimulation @4 CD @5 96`
C07	`01`	`X`	`FRE`	`@0 Encéphale pathologie @5 20`
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C07	`01`	`X`	`SPA`	`@0 Encéfalo patología @5 20`
C07	`02`	`X`	`FRE`	`@0 Transmission synaptique @5 21`
C07	`02`	`X`	`ENG`	`@0 Synaptic transmission @5 21`
C07	`02`	`X`	`SPA`	`@0 Transmisión sináptica @5 21`
C07	`03`	`X`	`FRE`	`@0 Système nerveux pathologie @5 22`
C07	`03`	`X`	`ENG`	`@0 Nervous system diseases @5 22`
C07	`03`	`X`	`SPA`	`@0 Sistema nervioso patología @5 22`
C07	`04`	`X`	`FRE`	`@0 Extrapyramidal syndrome @5 23`
C07	`04`	`X`	`ENG`	`@0 Extrapyramidal syndrome @5 23`
C07	`04`	`X`	`SPA`	`@0 Extrapiramidal síndrome @5 23`
C07	`05`	`X`	`FRE`	`@0 Maladie dégénérative @5 24`
C07	`05`	`X`	`ENG`	`@0 Degenerative disease @5 24`
C07	`05`	`X`	`SPA`	`@0 Enfermedad degenerativa @5 24`
C07	`06`	`X`	`FRE`	`@0 Système nerveux central pathologie @5 25`
C07	`06`	`X`	`ENG`	`@0 Central nervous system disease @5 25`
C07	`06`	`X`	`SPA`	`@0 Sistema nervosio central patología @5 25`
C07	`07`	`X`	`FRE`	`@0 Mouvement involontaire @5 26`
C07	`07`	`X`	`ENG`	`@0 Involuntary movement @5 26`
C07	`07`	`X`	`SPA`	`@0 Movimiento involuntario @5 26`
C07	`08`	`X`	`FRE`	`@0 Trouble neurologique @5 27`
C07	`08`	`X`	`ENG`	`@0 Neurological disorder @5 27`
C07	`08`	`X`	`SPA`	`@0 Trastorno neurológico @5 27`
C07	`09`	`X`	`FRE`	`@0 Muscle strié pathologie @5 28`
C07	`09`	`X`	`ENG`	`@0 Striated muscle disease @5 28`
C07	`09`	`X`	`SPA`	`@0 Músculo estriado patología @5 28`
N21				`@1 348`

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<fC03 i1="05" i2="X" l="FRE"><s0>Noyau gris central</s0>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Basal ganglion</s0>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Núcleo basal</s0>
<s5>05</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Technique</s0>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Technique</s0>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Técnica</s0>
<s5>06</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Parkinson maladie</s0>
<s5>09</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Parkinson disease</s0>
<s5>09</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Parkinson enfermedad</s0>
<s5>09</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE"><s0>Tremblement</s0>
<s5>12</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG"><s0>Tremor</s0>
<s5>12</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA"><s0>Temblor</s0>
<s5>12</s5>
</fC03>
<fC03 i1="09" i2="X" l="FRE"><s0>Dépolarisation</s0>
<s5>13</s5>
</fC03>
<fC03 i1="09" i2="X" l="ENG"><s0>Depolarization</s0>
<s5>13</s5>
</fC03>
<fC03 i1="09" i2="X" l="SPA"><s0>Despolarización</s0>
<s5>13</s5>
</fC03>
<fC03 i1="10" i2="X" l="FRE"><s0>Dépression synaptique</s0>
<s5>14</s5>
</fC03>
<fC03 i1="10" i2="X" l="ENG"><s0>Synaptic depression</s0>
<s5>14</s5>
</fC03>
<fC03 i1="10" i2="X" l="SPA"><s0>Depresión sináptica</s0>
<s5>14</s5>
</fC03>
<fC03 i1="11" i2="X" l="FRE"><s0>Traitement instrumental</s0>
<s5>57</s5>
</fC03>
<fC03 i1="11" i2="X" l="ENG"><s0>Instrumentation therapy</s0>
<s5>57</s5>
</fC03>
<fC03 i1="11" i2="X" l="SPA"><s0>Tratamiento instrumental</s0>
<s5>57</s5>
</fC03>
<fC03 i1="12" i2="X" l="FRE"><s0>Dystonie</s0>
<s5>58</s5>
</fC03>
<fC03 i1="12" i2="X" l="ENG"><s0>Dystonia</s0>
<s5>58</s5>
</fC03>
<fC03 i1="12" i2="X" l="SPA"><s0>Distonía</s0>
<s5>58</s5>
</fC03>
<fC03 i1="13" i2="X" l="FRE"><s0>Contrôle moteur</s0>
<s5>69</s5>
</fC03>
<fC03 i1="13" i2="X" l="ENG"><s0>Motor control</s0>
<s5>69</s5>
</fC03>
<fC03 i1="13" i2="X" l="SPA"><s0>Control motor</s0>
<s5>69</s5>
</fC03>
<fC03 i1="14" i2="X" l="FRE"><s0>Stimulation cérébrale profonde</s0>
<s4>CD</s4>
<s5>96</s5>
</fC03>
<fC03 i1="14" i2="X" l="ENG"><s0>Deep brain stimulation</s0>
<s4>CD</s4>
<s5>96</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Encéphale pathologie</s0>
<s5>20</s5>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Cerebral disorder</s0>
<s5>20</s5>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Encéfalo patología</s0>
<s5>20</s5>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Transmission synaptique</s0>
<s5>21</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Synaptic transmission</s0>
<s5>21</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Transmisión sináptica</s0>
<s5>21</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Système nerveux pathologie</s0>
<s5>22</s5>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Nervous system diseases</s0>
<s5>22</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Sistema nervioso patología</s0>
<s5>22</s5>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Extrapyramidal syndrome</s0>
<s5>23</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0>
<s5>23</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0>
<s5>23</s5>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Maladie dégénérative</s0>
<s5>24</s5>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Degenerative disease</s0>
<s5>24</s5>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0>
<s5>24</s5>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Système nerveux central pathologie</s0>
<s5>25</s5>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Central nervous system disease</s0>
<s5>25</s5>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0>
<s5>25</s5>
</fC07>
<fC07 i1="07" i2="X" l="FRE"><s0>Mouvement involontaire</s0>
<s5>26</s5>
</fC07>
<fC07 i1="07" i2="X" l="ENG"><s0>Involuntary movement</s0>
<s5>26</s5>
</fC07>
<fC07 i1="07" i2="X" l="SPA"><s0>Movimiento involuntario</s0>
<s5>26</s5>
</fC07>
<fC07 i1="08" i2="X" l="FRE"><s0>Trouble neurologique</s0>
<s5>27</s5>
</fC07>
<fC07 i1="08" i2="X" l="ENG"><s0>Neurological disorder</s0>
<s5>27</s5>
</fC07>
<fC07 i1="08" i2="X" l="SPA"><s0>Trastorno neurológico</s0>
<s5>27</s5>
</fC07>
<fC07 i1="09" i2="X" l="FRE"><s0>Muscle strié pathologie</s0>
<s5>28</s5>
</fC07>
<fC07 i1="09" i2="X" l="ENG"><s0>Striated muscle disease</s0>
<s5>28</s5>
</fC07>
<fC07 i1="09" i2="X" l="SPA"><s0>Músculo estriado patología</s0>
<s5>28</s5>
</fC07>
<fN21><s1>348</s1>
</fN21>
</pA>
</standard>
</inist>
</record>

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	La maladie de Parkinson en France (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

La maladie de Parkinson en France (serveur d'exploration)

Uncovering the mechanism(s) of action of deep brain stimulation: activation, inhibition, or both

Uncovering the mechanism(s) of action of deep brain stimulation: activation, inhibition, or both

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