Pharmacokinetics of apomorphine in parkinsonian patients
Identifieur interne : 001A37 ( PascalFrancis/Corpus ); précédent : 001A36; suivant : 001A38Pharmacokinetics of apomorphine in parkinsonian patients
Auteurs : E. Nicolle ; P. Pollak ; F. Serre-Debeauvais ; P. Richard ; C. L. Gervason ; E. Broussolle ; M. GavendSource :
- Fundamental and clinical pharmacology [ 0767-3981 ] ; 1993.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
Apomorphine, a dopamine agonist, has been used efficiently in parkinsonian patients to treat severe levodopa-induced on-off phenomenon. Motor improvement has been obtained both with continuous subcutaneous (SC) infusions, and multiple SC injections. So as to assist in the understanding of the clinical results, we studied the peripheral pharmacokinetics of apomorphine in 20 patients after intravenous (IV) or SC injections in the anterior abdominal wall and in the thigh at vinous doses, or SC infusion. Plasma apomorphine levels were measured by high-performance liquid chromatography with electrochemical detection. After an SC injection in the abdominal wall, the Tmax, was brief (16±11 min) the drug was rapidly cleared from the plasma and had a short plasma half-life (69.7±25.8 min)
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Pour connaître la documentation sur le format Inist Standard.
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Format Inist (serveur)
NO : | PASCAL 93-0470461 INIST |
---|---|
ET : | Pharmacokinetics of apomorphine in parkinsonian patients |
AU : | NICOLLE (E.); POLLAK (P.); SERRE-DEBEAUVAIS (F.); RICHARD (P.); GERVASON (C. L.); BROUSSOLLE (E.); GAVEND (M.) |
AF : | Cent. hosp. univ. Grenoble, clin. neurologique, lab. pharmacologie/38043 Grenoble/France (1 aut., 3 aut., 7 aut.); Cent. hosp. univ., clin. neurologique, dép. neurosci. clin. biologiques/38043 Grenoble/France (2 aut., 4 aut., 5 aut.); Hôp. Antiquaille, serv. neurologie/69321 Lyon/France (6 aut.) |
DT : | Publication en série; Niveau analytique |
SO : | Fundamental and clinical pharmacology; ISSN 0767-3981; Coden FCPHEZ; France; Da. 1993; Vol. 7; No. 5; Pp. 245-252; Bibl. 19 ref. |
LA : | Anglais |
EA : | Apomorphine, a dopamine agonist, has been used efficiently in parkinsonian patients to treat severe levodopa-induced on-off phenomenon. Motor improvement has been obtained both with continuous subcutaneous (SC) infusions, and multiple SC injections. So as to assist in the understanding of the clinical results, we studied the peripheral pharmacokinetics of apomorphine in 20 patients after intravenous (IV) or SC injections in the anterior abdominal wall and in the thigh at vinous doses, or SC infusion. Plasma apomorphine levels were measured by high-performance liquid chromatography with electrochemical detection. After an SC injection in the abdominal wall, the Tmax, was brief (16±11 min) the drug was rapidly cleared from the plasma and had a short plasma half-life (69.7±25.8 min) |
CC : | 002B02B06 |
FD : | Apomorphine; Stimulant dopaminergique; Parkinson maladie; Voie souscutanée; Pharmacocinétique; Homme; Voie intraveineuse |
FG : | Encéphale pathologie; Extrapyramidal syndrome; Maladie dégénérative; Système nerveux pathologie; Système nerveux central pathologie |
ED : | Dopamine agonist; Parkinson disease; Subcutaneous administration; Pharmacokinetics; Human; Intravenous administration |
EG : | Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Nervous system diseases |
SD : | Estimulante dopaminérgico; Parkinson enfermedad; Vía subcutánea; Farmacocinética; Hombre; Vía intravenosa |
LO : | INIST-14711.354000033771820060 |
ID : | 93-0470461 |
Links to Exploration step
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<front><div type="abstract" xml:lang="en">Apomorphine, a dopamine agonist, has been used efficiently in parkinsonian patients to treat severe levodopa-induced on-off phenomenon. Motor improvement has been obtained both with continuous subcutaneous (SC) infusions, and multiple SC injections. So as to assist in the understanding of the clinical results, we studied the peripheral pharmacokinetics of apomorphine in 20 patients after intravenous (IV) or SC injections in the anterior abdominal wall and in the thigh at vinous doses, or SC infusion. Plasma apomorphine levels were measured by high-performance liquid chromatography with electrochemical detection. After an SC injection in the abdominal wall, the T<sub>max</sub>
, was brief (16±11 min) the drug was rapidly cleared from the plasma and had a short plasma half-life (69.7±25.8 min)</div>
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<ET>Pharmacokinetics of apomorphine in parkinsonian patients</ET>
<AU>NICOLLE (E.); POLLAK (P.); SERRE-DEBEAUVAIS (F.); RICHARD (P.); GERVASON (C. L.); BROUSSOLLE (E.); GAVEND (M.)</AU>
<AF>Cent. hosp. univ. Grenoble, clin. neurologique, lab. pharmacologie/38043 Grenoble/France (1 aut., 3 aut., 7 aut.); Cent. hosp. univ., clin. neurologique, dép. neurosci. clin. biologiques/38043 Grenoble/France (2 aut., 4 aut., 5 aut.); Hôp. Antiquaille, serv. neurologie/69321 Lyon/France (6 aut.)</AF>
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<EA>Apomorphine, a dopamine agonist, has been used efficiently in parkinsonian patients to treat severe levodopa-induced on-off phenomenon. Motor improvement has been obtained both with continuous subcutaneous (SC) infusions, and multiple SC injections. So as to assist in the understanding of the clinical results, we studied the peripheral pharmacokinetics of apomorphine in 20 patients after intravenous (IV) or SC injections in the anterior abdominal wall and in the thigh at vinous doses, or SC infusion. Plasma apomorphine levels were measured by high-performance liquid chromatography with electrochemical detection. After an SC injection in the abdominal wall, the T<sub>max</sub>
, was brief (16±11 min) the drug was rapidly cleared from the plasma and had a short plasma half-life (69.7±25.8 min)</EA>
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