Decreased tyrosine hydroxylase content in the dopaminergic neurons of MPTP-intoxicated monkeys : effect of levodopa and GM1 ganglioside therpay
Identifieur interne : 001952 ( PascalFrancis/Corpus ); précédent : 001951; suivant : 001953Decreased tyrosine hydroxylase content in the dopaminergic neurons of MPTP-intoxicated monkeys : effect of levodopa and GM1 ganglioside therpay
Auteurs : A. Kastner ; M. T. Herrero ; E. C. Hirsch ; J. Guillen ; M. R. Luquin ; F. Javoy-Agid ; J. A. Obeso ; Y. AgidSource :
- Annals of neurology [ 0364-5134 ] ; 1994.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
Parkinson's disease is characterized by the degeneration of melanized dopaminergic neurons of the substantia nigra. The functional capacity of the surviving dopaminergic neurons is affected, as suggested by the subnormal levels of tyrosine hydroxylase messenger RNA and protein found in the remaining cells. The reduced expression of tyrosine hydroxylase may be due to either the evolving neurodegenerative process or its downregulation, possibly secondary to chronic levodopa treatment. The cellular content of tyrosine hydroxylase was determined in the mesencephalon from 16 Macaca fascicularis monkeys, wing a semiquantitative immunocytochemical method
Notice en format standard (ISO 2709)
Pour connaître la documentation sur le format Inist Standard.
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Format Inist (serveur)
NO : | PASCAL 94-0581048 INIST |
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ET : | Decreased tyrosine hydroxylase content in the dopaminergic neurons of MPTP-intoxicated monkeys : effect of levodopa and GM1 ganglioside therpay |
AU : | KASTNER (A.); HERRERO (M. T); HIRSCH (E. C.); GUILLEN (J.); LUQUIN (M. R.); JAVOY-AGID (F.); OBESO (J. A.); AGID (Y.) |
AF : | INSERM, U289/75013 Paris/France (1 aut., 2 aut., 3 aut., 6 aut., 8 aut.) |
DT : | Publication en série; Niveau analytique |
SO : | Annals of neurology; ISSN 0364-5134; Coden ANNED3; Etats-Unis; Da. 1994; Vol. 36; No. 2; Pp. 206-214; Bibl. 46 ref. |
LA : | Anglais |
EA : | Parkinson's disease is characterized by the degeneration of melanized dopaminergic neurons of the substantia nigra. The functional capacity of the surviving dopaminergic neurons is affected, as suggested by the subnormal levels of tyrosine hydroxylase messenger RNA and protein found in the remaining cells. The reduced expression of tyrosine hydroxylase may be due to either the evolving neurodegenerative process or its downregulation, possibly secondary to chronic levodopa treatment. The cellular content of tyrosine hydroxylase was determined in the mesencephalon from 16 Macaca fascicularis monkeys, wing a semiquantitative immunocytochemical method |
CC : | 002B02B06 |
FD : | Parkinson maladie; Pyridine(1-méthyl-4-phényl-1,2,3,6-tétrahydro); Tyrosine 3-monooxygenase; Neurone dopaminergique; Lévodopa; Antiparkinsonien; Locus niger; Chimiothérapie; Traitement; Effet biologique; Singe; Animal; Ganglioside GM1 |
FG : | Oxidoreductases; Enzyme; Primates; Mammalia; Vertebrata; Système nerveux pathologie; Système nerveux central pathologie; Encéphale pathologie; Extrapyramidal syndrome; Maladie dégénérative |
ED : | Parkinson disease; Tyrosine 3-monooxygenase; Dopaminergic neuron; Levodopa; Antiparkinson agent; Locus niger; Chemotherapy; Treatment; Biological effect; Monkey; Animal |
EG : | Oxidoreductases; Enzyme; Primates; Mammalia; Vertebrata; Nervous system diseases; Central nervous system disease; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease |
GD : | Aufbereiten |
SD : | Parkinson enfermedad; Tyrosine 3-monooxygenase; Neurona dopaminérgica; Levodopa; Antiparkinsoniano; Locus níger; Quimioterapia; Tratamiento; Efecto biológico; Mono; Animal |
LO : | INIST-16555.354000040919720120 |
ID : | 94-0581048 |
Links to Exploration step
Pascal:94-0581048Le document en format XML
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<term>Locus niger</term>
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<front><div type="abstract" xml:lang="en">Parkinson's disease is characterized by the degeneration of melanized dopaminergic neurons of the substantia nigra. The functional capacity of the surviving dopaminergic neurons is affected, as suggested by the subnormal levels of tyrosine hydroxylase messenger RNA and protein found in the remaining cells. The reduced expression of tyrosine hydroxylase may be due to either the evolving neurodegenerative process or its downregulation, possibly secondary to chronic levodopa treatment. The cellular content of tyrosine hydroxylase was determined in the mesencephalon from 16 Macaca fascicularis monkeys, wing a semiquantitative immunocytochemical method</div>
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<s2>NS</s2>
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<fC07 i1="05" i2="X" l="SPA"><s0>Vertebrata</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Système nerveux pathologie</s0>
<s5>37</s5>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Nervous system diseases</s0>
<s5>37</s5>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Sistema nervioso patología</s0>
<s5>37</s5>
</fC07>
<fC07 i1="07" i2="X" l="FRE"><s0>Système nerveux central pathologie</s0>
<s5>38</s5>
</fC07>
<fC07 i1="07" i2="X" l="ENG"><s0>Central nervous system disease</s0>
<s5>38</s5>
</fC07>
<fC07 i1="07" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0>
<s5>38</s5>
</fC07>
<fC07 i1="08" i2="X" l="FRE"><s0>Encéphale pathologie</s0>
<s5>39</s5>
</fC07>
<fC07 i1="08" i2="X" l="ENG"><s0>Cerebral disorder</s0>
<s5>39</s5>
</fC07>
<fC07 i1="08" i2="X" l="SPA"><s0>Encéfalo patología</s0>
<s5>39</s5>
</fC07>
<fC07 i1="09" i2="X" l="FRE"><s0>Extrapyramidal syndrome</s0>
<s5>40</s5>
</fC07>
<fC07 i1="09" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0>
<s5>40</s5>
</fC07>
<fC07 i1="09" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0>
<s5>40</s5>
</fC07>
<fC07 i1="10" i2="X" l="FRE"><s0>Maladie dégénérative</s0>
<s5>41</s5>
</fC07>
<fC07 i1="10" i2="X" l="ENG"><s0>Degenerative disease</s0>
<s5>41</s5>
</fC07>
<fC07 i1="10" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0>
<s5>41</s5>
</fC07>
<fN21><s1>283</s1>
</fN21>
</pA>
</standard>
<server><NO>PASCAL 94-0581048 INIST</NO>
<ET>Decreased tyrosine hydroxylase content in the dopaminergic neurons of MPTP-intoxicated monkeys : effect of levodopa and GM1 ganglioside therpay</ET>
<AU>KASTNER (A.); HERRERO (M. T); HIRSCH (E. C.); GUILLEN (J.); LUQUIN (M. R.); JAVOY-AGID (F.); OBESO (J. A.); AGID (Y.)</AU>
<AF>INSERM, U289/75013 Paris/France (1 aut., 2 aut., 3 aut., 6 aut., 8 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Annals of neurology; ISSN 0364-5134; Coden ANNED3; Etats-Unis; Da. 1994; Vol. 36; No. 2; Pp. 206-214; Bibl. 46 ref.</SO>
<LA>Anglais</LA>
<EA>Parkinson's disease is characterized by the degeneration of melanized dopaminergic neurons of the substantia nigra. The functional capacity of the surviving dopaminergic neurons is affected, as suggested by the subnormal levels of tyrosine hydroxylase messenger RNA and protein found in the remaining cells. The reduced expression of tyrosine hydroxylase may be due to either the evolving neurodegenerative process or its downregulation, possibly secondary to chronic levodopa treatment. The cellular content of tyrosine hydroxylase was determined in the mesencephalon from 16 Macaca fascicularis monkeys, wing a semiquantitative immunocytochemical method</EA>
<CC>002B02B06</CC>
<FD>Parkinson maladie; Pyridine(1-méthyl-4-phényl-1,2,3,6-tétrahydro); Tyrosine 3-monooxygenase; Neurone dopaminergique; Lévodopa; Antiparkinsonien; Locus niger; Chimiothérapie; Traitement; Effet biologique; Singe; Animal; Ganglioside GM1</FD>
<FG>Oxidoreductases; Enzyme; Primates; Mammalia; Vertebrata; Système nerveux pathologie; Système nerveux central pathologie; Encéphale pathologie; Extrapyramidal syndrome; Maladie dégénérative</FG>
<ED>Parkinson disease; Tyrosine 3-monooxygenase; Dopaminergic neuron; Levodopa; Antiparkinson agent; Locus niger; Chemotherapy; Treatment; Biological effect; Monkey; Animal</ED>
<EG>Oxidoreductases; Enzyme; Primates; Mammalia; Vertebrata; Nervous system diseases; Central nervous system disease; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease</EG>
<GD>Aufbereiten</GD>
<SD>Parkinson enfermedad; Tyrosine 3-monooxygenase; Neurona dopaminérgica; Levodopa; Antiparkinsoniano; Locus níger; Quimioterapia; Tratamiento; Efecto biológico; Mono; Animal</SD>
<LO>INIST-16555.354000040919720120</LO>
<ID>94-0581048</ID>
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