Chronic MPTP treatment reproduces in baboons the differential vulnerability of mesencephalic dopaminergic neurons observed in Parkinson's disease
Identifieur interne : 001933 ( PascalFrancis/Corpus ); précédent : 001932; suivant : 001934Chronic MPTP treatment reproduces in baboons the differential vulnerability of mesencephalic dopaminergic neurons observed in Parkinson's disease
Auteurs : M. Varastet ; D. Riche ; M. Maziere ; P. HantrayeSource :
- Neuroscience [ 0306-4522 ] ; 1994.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
Chronic administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to baboons was shown previously to result in a motor syndrome and a pattern of striatal dopaminergic fibre loss similar to those observed in idiopathic Parkinson's disease. In the present study, tyrosine hydroxylase-immunoreactive neurons were qwantified in the mesencephalon of control (n=4) and chronically MPTP-treated (n=3) baboons. MPTP induced a significant reduction in neuronal cell density in the substantia nigra (63.8% reduction) and the ventral tegmental area (53.1%). Within the substantia nigra, obvious mediolateral and dorsoventral gradients of neuronal cell loss were observed
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Pour connaître la documentation sur le format Inist Standard.
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Format Inist (serveur)
NO : | PASCAL 94-0715673 INIST |
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ET : | Chronic MPTP treatment reproduces in baboons the differential vulnerability of mesencephalic dopaminergic neurons observed in Parkinson's disease |
AU : | VARASTET (M.); RICHE (D.); MAZIERE (M.); HANTRAYE (P.) |
AF : | CEA CNRS, DRIPP, serv. hosp. Frédéric Joliot/91401 Orsay/France (1 aut., 3 aut., 4 aut.); CNRS Inst. Alfred Fessard/91198 Gif-sur-Yvette/France (2 aut.) |
DT : | Publication en série; Niveau analytique |
SO : | Neuroscience; ISSN 0306-4522; Coden NRSCDN; Royaume-Uni; Da. 1994; Vol. 63; No. 1; Pp. 47-56; Bibl. 61 ref. |
LA : | Anglais |
EA : | Chronic administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to baboons was shown previously to result in a motor syndrome and a pattern of striatal dopaminergic fibre loss similar to those observed in idiopathic Parkinson's disease. In the present study, tyrosine hydroxylase-immunoreactive neurons were qwantified in the mesencephalon of control (n=4) and chronically MPTP-treated (n=3) baboons. MPTP induced a significant reduction in neuronal cell density in the substantia nigra (63.8% reduction) and the ventral tegmental area (53.1%). Within the substantia nigra, obvious mediolateral and dorsoventral gradients of neuronal cell loss were observed |
CC : | 002B17G |
FD : | Tyrosine 3-monooxygenase; Mésencéphale; Neurone dopaminergique; Parkinson maladie; Neurotoxine; Pathologie expérimentale; Animal; Singe; MPTP |
FG : | Oxidoreductases; Enzyme; Système nerveux central; Maladie dégénérative; Système nerveux pathologie; Primates; Mammalia; Vertebrata |
ED : | Tyrosine 3-monooxygenase; Midbrain; Dopaminergic neuron; Parkinson disease; Neurotoxin; Experimental disease; Animal; Monkey |
EG : | Oxidoreductases; Enzyme; Central nervous system; Degenerative disease; Nervous system diseases; Primates; Mammalia; Vertebrata |
SD : | Tyrosine 3-monooxygenase; Mesencéfalo; Neurona dopaminérgica; Parkinson enfermedad; Neurotoxina; Patología experimental; Animal; Mono |
LO : | INIST-17194.354000042107130050 |
ID : | 94-0715673 |
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Pascal:94-0715673Le document en format XML
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<front><div type="abstract" xml:lang="en">Chronic administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to baboons was shown previously to result in a motor syndrome and a pattern of striatal dopaminergic fibre loss similar to those observed in idiopathic Parkinson's disease. In the present study, tyrosine hydroxylase-immunoreactive neurons were qwantified in the mesencephalon of control (n=4) and chronically MPTP-treated (n=3) baboons. MPTP induced a significant reduction in neuronal cell density in the substantia nigra (63.8% reduction) and the ventral tegmental area (53.1%). Within the substantia nigra, obvious mediolateral and dorsoventral gradients of neuronal cell loss were observed</div>
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<ET>Chronic MPTP treatment reproduces in baboons the differential vulnerability of mesencephalic dopaminergic neurons observed in Parkinson's disease</ET>
<AU>VARASTET (M.); RICHE (D.); MAZIERE (M.); HANTRAYE (P.)</AU>
<AF>CEA CNRS, DRIPP, serv. hosp. Frédéric Joliot/91401 Orsay/France (1 aut., 3 aut., 4 aut.); CNRS Inst. Alfred Fessard/91198 Gif-sur-Yvette/France (2 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Neuroscience; ISSN 0306-4522; Coden NRSCDN; Royaume-Uni; Da. 1994; Vol. 63; No. 1; Pp. 47-56; Bibl. 61 ref.</SO>
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<EA>Chronic administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to baboons was shown previously to result in a motor syndrome and a pattern of striatal dopaminergic fibre loss similar to those observed in idiopathic Parkinson's disease. In the present study, tyrosine hydroxylase-immunoreactive neurons were qwantified in the mesencephalon of control (n=4) and chronically MPTP-treated (n=3) baboons. MPTP induced a significant reduction in neuronal cell density in the substantia nigra (63.8% reduction) and the ventral tegmental area (53.1%). Within the substantia nigra, obvious mediolateral and dorsoventral gradients of neuronal cell loss were observed</EA>
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