ParkinsonFranceV1, PascalFrancis, Corpus, bibRecord, 001737

Intrastriatal grafts of embryonic mesencephalic rat neurons genetically modified using an adenovirus encoding human Cu/Zn superoxide dismutase

Identifieur interne : 001737 ( PascalFrancis/Corpus ); précédent : 001736; suivant : 001738

Intrastriatal grafts of embryonic mesencephalic rat neurons genetically modified using an adenovirus encoding human Cu/Zn superoxide dismutase

Auteurs : M. Barkats ; N. Nakao ; E. M. Grasbon-Frodl ; A. Bilang-Bleuel ; F. Revah ; J. Mallet ; P. Brundin

Source :

Neuroscience [ 0306-4522 ] ; 1997.

RBID : Pascal:97-0287749

Descripteurs français

Pascal (Inist)
- Greffe, Corps strié, Mésencéphale, Homme, Superoxide dismutase, Parkinson maladie, Rat.

English descriptors

KwdEn :
- Corpus striatum, Graft, Human, Midbrain, Parkinson disease, Rat, Superoxide dismutase.

Abstract

Intrastriatal grafting of embryonic dopamine-containing neurons is a promising approach for treating clinical and experimental Parkinson's disease. However, neuropathological analyses of grafted patients and transplanted rats have demonstrated that the survival of grafted dopamine neurons is relatively poor. In the present study, we pursued a strategy of transferring a potentially neuroprotective gene into rat embryonic mesencephalic rat cells in vitro, before grafting them into the denervated striatum of 6-hydroxydopamine-lesioned rats. We performed intrastriatal grafts of embryonic day 14 mesencephalic cells infected with replication-defective adenoviruses bearing either the human copper-zinc superoxide dismutase gene or, as a control, the E. coli lac Z marker gene. The transgenes were expressed in the grafts four days after transplantation and the expression persisted for at least five weeks thereafter. After five weeks postgrafting, there was more extensive functional recovery in the superoxide dismutase group as compared to the control (uninfected cells) and β-galactosidase groups. The functional recovery was significantly correlated with the number of tyrosine hydroxylase-positive cells in the grafts, although the clear trend to increased survival of the dopamine neurons in the superoxide dismutase grafts did not reach statistical significance. Only a moderate inflammatory reaction was revealed by OX-42 immunostaining in all groups. suggesting that ex vivo gene transfer using adenoviral vectors is a promising method for delivering functional proteins into brain grafts.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A08	`01`	`1`	`ENG`	`@1 Intrastriatal grafts of embryonic mesencephalic rat neurons genetically modified using an adenovirus encoding human Cu/Zn superoxide dismutase`
A11	`01`	`1`		`@1 BARKATS (M.)`
A11	`02`	`1`		`@1 NAKAO (N.)`
A11	`03`	`1`		`@1 GRASBON-FRODL (E. M.)`
A11	`04`	`1`		`@1 BILANG-BLEUEL (A.)`
A11	`05`	`1`		`@1 REVAH (F.)`
A11	`06`	`1`		`@1 MALLET (J.)`
A11	`07`	`1`		`@1 BRUNDIN (P.)`
A14	`01`			`@1 Laboratoire de Génétique Moléculaire de la Neurotransmission et des Processus Neurodégénératifs, UMR CNRS C9923, Hôpital de la Pitié Salpêtrière @2 Paris @3 FRA @Z 1 aut. @Z 4 aut. @Z 6 aut.`
A14	`02`			`@1 Section for Neuronal Survival, Department of Physiology and Neuroscience, University of Lund @2 Lund @3 SWE @Z 2 aut. @Z 3 aut. @Z 7 aut.`
A14	`03`			`@1 Gencell Rhône-Poulenc-Rorer @2 Vitry sur Seine @3 FRA @Z 5 aut.`
A20				`@1 703-713`
A21				`@1 1997`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 17194 @5 354000065142780080`
A44				`@0 0000 @1 © 1997 INIST-CNRS. All rights reserved.`
A45				`@0 50 ref.`
A47	`01`	`1`		`@0 97-0287749`
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A61				`@0 A`
A64	`01`	`1`		`@0 Neuroscience`
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C01	`01`		`ENG`	@0 Intrastriatal grafting of embryonic dopamine-containing neurons is a promising approach for treating clinical and experimental Parkinson's disease. However, neuropathological analyses of grafted patients and transplanted rats have demonstrated that the survival of grafted dopamine neurons is relatively poor. In the present study, we pursued a strategy of transferring a potentially neuroprotective gene into rat embryonic mesencephalic rat cells in vitro, before grafting them into the denervated striatum of 6-hydroxydopamine-lesioned rats. We performed intrastriatal grafts of embryonic day 14 mesencephalic cells infected with replication-defective adenoviruses bearing either the human copper-zinc superoxide dismutase gene or, as a control, the E. coli lac Z marker gene. The transgenes were expressed in the grafts four days after transplantation and the expression persisted for at least five weeks thereafter. After five weeks postgrafting, there was more extensive functional recovery in the superoxide dismutase group as compared to the control (uninfected cells) and β-galactosidase groups. The functional recovery was significantly correlated with the number of tyrosine hydroxylase-positive cells in the grafts, although the clear trend to increased survival of the dopamine neurons in the superoxide dismutase grafts did not reach statistical significance. Only a moderate inflammatory reaction was revealed by OX-42 immunostaining in all groups. suggesting that ex vivo gene transfer using adenoviral vectors is a promising method for delivering functional proteins into brain grafts.
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C03	`01`	`X`	`ENG`	`@0 Graft @5 01`
C03	`01`	`X`	`SPA`	`@0 Injerto @5 01`
C03	`02`	`X`	`FRE`	`@0 Corps strié @5 02`
C03	`02`	`X`	`ENG`	`@0 Corpus striatum @5 02`
C03	`02`	`X`	`SPA`	`@0 Cuerpo estriado @5 02`
C03	`03`	`X`	`FRE`	`@0 Mésencéphale @5 03`
C03	`03`	`X`	`ENG`	`@0 Midbrain @5 03`
C03	`03`	`X`	`SPA`	`@0 Mesencéfalo @5 03`
C03	`04`	`X`	`FRE`	`@0 Homme @5 04`
C03	`04`	`X`	`ENG`	`@0 Human @5 04`
C03	`04`	`X`	`SPA`	`@0 Hombre @5 04`
C03	`05`	`X`	`FRE`	`@0 Superoxide dismutase @2 FE @5 05`
C03	`05`	`X`	`ENG`	`@0 Superoxide dismutase @2 FE @5 05`
C03	`05`	`X`	`SPA`	`@0 Superoxide dismutase @2 FE @5 05`
C03	`06`	`X`	`FRE`	`@0 Parkinson maladie @5 07`
C03	`06`	`X`	`ENG`	`@0 Parkinson disease @5 07`
C03	`06`	`X`	`SPA`	`@0 Parkinson enfermedad @5 07`
C03	`07`	`X`	`FRE`	`@0 Rat @5 54`
C03	`07`	`X`	`ENG`	`@0 Rat @5 54`
C03	`07`	`X`	`SPA`	`@0 Rata @5 54`
C07	`01`	`X`	`FRE`	`@0 Oxidoreductases @2 FE`
C07	`01`	`X`	`ENG`	`@0 Oxidoreductases @2 FE`
C07	`01`	`X`	`SPA`	`@0 Oxidoreductases @2 FE`
C07	`02`	`X`	`FRE`	`@0 Enzyme`
C07	`02`	`X`	`ENG`	`@0 Enzyme`
C07	`02`	`X`	`SPA`	`@0 Enzima`
C07	`03`	`X`	`FRE`	`@0 Noyau gris central @5 23`
C07	`03`	`X`	`ENG`	`@0 Basal ganglion @5 23`
C07	`03`	`X`	`SPA`	`@0 Núcleo basal @5 23`
C07	`04`	`X`	`FRE`	`@0 Encéphale @5 24`
C07	`04`	`X`	`ENG`	`@0 Brain (vertebrata) @5 24`
C07	`04`	`X`	`SPA`	`@0 Encéfalo @5 24`
C07	`05`	`X`	`FRE`	`@0 Système nerveux central @5 25`
C07	`05`	`X`	`ENG`	`@0 Central nervous system @5 25`
C07	`05`	`X`	`SPA`	`@0 Sistema nervioso central @5 25`
C07	`06`	`X`	`FRE`	`@0 Rodentia @2 NS`
C07	`06`	`X`	`ENG`	`@0 Rodentia @2 NS`
C07	`06`	`X`	`SPA`	`@0 Rodentia @2 NS`
C07	`07`	`X`	`FRE`	`@0 Mammalia @2 NS`
C07	`07`	`X`	`ENG`	`@0 Mammalia @2 NS`
C07	`07`	`X`	`SPA`	`@0 Mammalia @2 NS`
C07	`08`	`X`	`FRE`	`@0 Vertebrata @2 NS`
C07	`08`	`X`	`ENG`	`@0 Vertebrata @2 NS`
C07	`08`	`X`	`SPA`	`@0 Vertebrata @2 NS`
N21				`@1 160`

Format Inist (serveur)

NO :	PASCAL 97-0287749 INIST
ET :	Intrastriatal grafts of embryonic mesencephalic rat neurons genetically modified using an adenovirus encoding human Cu/Zn superoxide dismutase
AU :	BARKATS (M.); NAKAO (N.); GRASBON-FRODL (E. M.); BILANG-BLEUEL (A.); REVAH (F.); MALLET (J.); BRUNDIN (P.)
AF :	Laboratoire de Génétique Moléculaire de la Neurotransmission et des Processus Neurodégénératifs, UMR CNRS C9923, Hôpital de la Pitié Salpêtrière/Paris/France (1 aut., 4 aut., 6 aut.); Section for Neuronal Survival, Department of Physiology and Neuroscience, University of Lund/Lund/Suède (2 aut., 3 aut., 7 aut.); Gencell Rhône-Poulenc-Rorer/Vitry sur Seine/France (5 aut.)
DT :	Publication en série; Niveau analytique
SO :	Neuroscience; ISSN 0306-4522; Coden NRSCDN; Royaume-Uni; Da. 1997; Vol. 78; No. 3; Pp. 703-713; Bibl. 50 ref.
LA :	Anglais
EA :	Intrastriatal grafting of embryonic dopamine-containing neurons is a promising approach for treating clinical and experimental Parkinson's disease. However, neuropathological analyses of grafted patients and transplanted rats have demonstrated that the survival of grafted dopamine neurons is relatively poor. In the present study, we pursued a strategy of transferring a potentially neuroprotective gene into rat embryonic mesencephalic rat cells in vitro, before grafting them into the denervated striatum of 6-hydroxydopamine-lesioned rats. We performed intrastriatal grafts of embryonic day 14 mesencephalic cells infected with replication-defective adenoviruses bearing either the human copper-zinc superoxide dismutase gene or, as a control, the E. coli lac Z marker gene. The transgenes were expressed in the grafts four days after transplantation and the expression persisted for at least five weeks thereafter. After five weeks postgrafting, there was more extensive functional recovery in the superoxide dismutase group as compared to the control (uninfected cells) and β-galactosidase groups. The functional recovery was significantly correlated with the number of tyrosine hydroxylase-positive cells in the grafts, although the clear trend to increased survival of the dopamine neurons in the superoxide dismutase grafts did not reach statistical significance. Only a moderate inflammatory reaction was revealed by OX-42 immunostaining in all groups. suggesting that ex vivo gene transfer using adenoviral vectors is a promising method for delivering functional proteins into brain grafts.
CC :	002A25L
FD :	Greffe; Corps strié; Mésencéphale; Homme; Superoxide dismutase; Parkinson maladie; Rat
FG :	Oxidoreductases; Enzyme; Noyau gris central; Encéphale; Système nerveux central; Rodentia; Mammalia; Vertebrata
ED :	Graft; Corpus striatum; Midbrain; Human; Superoxide dismutase; Parkinson disease; Rat
EG :	Oxidoreductases; Enzyme; Basal ganglion; Brain (vertebrata); Central nervous system; Rodentia; Mammalia; Vertebrata
SD :	Injerto; Cuerpo estriado; Mesencéfalo; Hombre; Superoxide dismutase; Parkinson enfermedad; Rata
LO :	INIST-17194.354000065142780080
ID :	97-0287749

Links to Exploration step

Pascal:97-0287749

Le document en format XML

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<front><div type="abstract" xml:lang="en">Intrastriatal grafting of embryonic dopamine-containing neurons is a promising approach for treating clinical and experimental Parkinson's disease. However, neuropathological analyses of grafted patients and transplanted rats have demonstrated that the survival of grafted dopamine neurons is relatively poor. In the present study, we pursued a strategy of transferring a potentially neuroprotective gene into rat embryonic mesencephalic rat cells in vitro, before grafting them into the denervated striatum of 6-hydroxydopamine-lesioned rats. We performed intrastriatal grafts of embryonic day 14 mesencephalic cells infected with replication-defective adenoviruses bearing either the human copper-zinc superoxide dismutase gene or, as a control, the E. coli lac Z marker gene. The transgenes were expressed in the grafts four days after transplantation and the expression persisted for at least five weeks thereafter. After five weeks postgrafting, there was more extensive functional recovery in the superoxide dismutase group as compared to the control (uninfected cells) and β-galactosidase groups. The functional recovery was significantly correlated with the number of tyrosine hydroxylase-positive cells in the grafts, although the clear trend to increased survival of the dopamine neurons in the superoxide dismutase grafts did not reach statistical significance. Only a moderate inflammatory reaction was revealed by OX-42 immunostaining in all groups. suggesting that ex vivo gene transfer using adenoviral vectors is a promising method for delivering functional proteins into brain grafts.</div>
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<fA14 i1="01"><s1>Laboratoire de Génétique Moléculaire de la Neurotransmission et des Processus Neurodégénératifs, UMR CNRS C9923, Hôpital de la Pitié Salpêtrière</s1>
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<fA14 i1="02"><s1>Section for Neuronal Survival, Department of Physiology and Neuroscience, University of Lund</s1>
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</fA20>
<fA21><s1>1997</s1>
</fA21>
<fA23 i1="01"><s0>ENG</s0>
</fA23>
<fA43 i1="01"><s1>INIST</s1>
<s2>17194</s2>
<s5>354000065142780080</s5>
</fA43>
<fA44><s0>0000</s0>
<s1>© 1997 INIST-CNRS. All rights reserved.</s1>
</fA44>
<fA45><s0>50 ref.</s0>
</fA45>
<fA47 i1="01" i2="1"><s0>97-0287749</s0>
</fA47>
<fA60><s1>P</s1>
</fA60>
<fA61><s0>A</s0>
</fA61>
<fA64 i1="01" i2="1"><s0>Neuroscience</s0>
</fA64>
<fA66 i1="01"><s0>GBR</s0>
</fA66>
<fC01 i1="01" l="ENG"><s0>Intrastriatal grafting of embryonic dopamine-containing neurons is a promising approach for treating clinical and experimental Parkinson's disease. However, neuropathological analyses of grafted patients and transplanted rats have demonstrated that the survival of grafted dopamine neurons is relatively poor. In the present study, we pursued a strategy of transferring a potentially neuroprotective gene into rat embryonic mesencephalic rat cells in vitro, before grafting them into the denervated striatum of 6-hydroxydopamine-lesioned rats. We performed intrastriatal grafts of embryonic day 14 mesencephalic cells infected with replication-defective adenoviruses bearing either the human copper-zinc superoxide dismutase gene or, as a control, the E. coli lac Z marker gene. The transgenes were expressed in the grafts four days after transplantation and the expression persisted for at least five weeks thereafter. After five weeks postgrafting, there was more extensive functional recovery in the superoxide dismutase group as compared to the control (uninfected cells) and β-galactosidase groups. The functional recovery was significantly correlated with the number of tyrosine hydroxylase-positive cells in the grafts, although the clear trend to increased survival of the dopamine neurons in the superoxide dismutase grafts did not reach statistical significance. Only a moderate inflammatory reaction was revealed by OX-42 immunostaining in all groups. suggesting that ex vivo gene transfer using adenoviral vectors is a promising method for delivering functional proteins into brain grafts.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002A25L</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Greffe</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Graft</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Injerto</s0>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Corps strié</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Corpus striatum</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Cuerpo estriado</s0>
<s5>02</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Mésencéphale</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Midbrain</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Mesencéfalo</s0>
<s5>03</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Homme</s0>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Human</s0>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Hombre</s0>
<s5>04</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Superoxide dismutase</s0>
<s2>FE</s2>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Superoxide dismutase</s0>
<s2>FE</s2>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Superoxide dismutase</s0>
<s2>FE</s2>
<s5>05</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Parkinson maladie</s0>
<s5>07</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Parkinson disease</s0>
<s5>07</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Parkinson enfermedad</s0>
<s5>07</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Rat</s0>
<s5>54</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Rat</s0>
<s5>54</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Rata</s0>
<s5>54</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Oxidoreductases</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Oxidoreductases</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Oxidoreductases</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Enzyme</s0>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Enzyme</s0>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Enzima</s0>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Noyau gris central</s0>
<s5>23</s5>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Basal ganglion</s0>
<s5>23</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Núcleo basal</s0>
<s5>23</s5>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Encéphale</s0>
<s5>24</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Brain (vertebrata)</s0>
<s5>24</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Encéfalo</s0>
<s5>24</s5>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Système nerveux central</s0>
<s5>25</s5>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Central nervous system</s0>
<s5>25</s5>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Sistema nervioso central</s0>
<s5>25</s5>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Rodentia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Rodentia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Rodentia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="07" i2="X" l="FRE"><s0>Mammalia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="07" i2="X" l="ENG"><s0>Mammalia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="07" i2="X" l="SPA"><s0>Mammalia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="08" i2="X" l="FRE"><s0>Vertebrata</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="08" i2="X" l="ENG"><s0>Vertebrata</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="08" i2="X" l="SPA"><s0>Vertebrata</s0>
<s2>NS</s2>
</fC07>
<fN21><s1>160</s1>
</fN21>
</pA>
</standard>
<server><NO>PASCAL 97-0287749 INIST</NO>
<ET>Intrastriatal grafts of embryonic mesencephalic rat neurons genetically modified using an adenovirus encoding human Cu/Zn superoxide dismutase</ET>
<AU>BARKATS (M.); NAKAO (N.); GRASBON-FRODL (E. M.); BILANG-BLEUEL (A.); REVAH (F.); MALLET (J.); BRUNDIN (P.)</AU>
<AF>Laboratoire de Génétique Moléculaire de la Neurotransmission et des Processus Neurodégénératifs, UMR CNRS C9923, Hôpital de la Pitié Salpêtrière/Paris/France (1 aut., 4 aut., 6 aut.); Section for Neuronal Survival, Department of Physiology and Neuroscience, University of Lund/Lund/Suède (2 aut., 3 aut., 7 aut.); Gencell Rhône-Poulenc-Rorer/Vitry sur Seine/France (5 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Neuroscience; ISSN 0306-4522; Coden NRSCDN; Royaume-Uni; Da. 1997; Vol. 78; No. 3; Pp. 703-713; Bibl. 50 ref.</SO>
<LA>Anglais</LA>
<EA>Intrastriatal grafting of embryonic dopamine-containing neurons is a promising approach for treating clinical and experimental Parkinson's disease. However, neuropathological analyses of grafted patients and transplanted rats have demonstrated that the survival of grafted dopamine neurons is relatively poor. In the present study, we pursued a strategy of transferring a potentially neuroprotective gene into rat embryonic mesencephalic rat cells in vitro, before grafting them into the denervated striatum of 6-hydroxydopamine-lesioned rats. We performed intrastriatal grafts of embryonic day 14 mesencephalic cells infected with replication-defective adenoviruses bearing either the human copper-zinc superoxide dismutase gene or, as a control, the E. coli lac Z marker gene. The transgenes were expressed in the grafts four days after transplantation and the expression persisted for at least five weeks thereafter. After five weeks postgrafting, there was more extensive functional recovery in the superoxide dismutase group as compared to the control (uninfected cells) and β-galactosidase groups. The functional recovery was significantly correlated with the number of tyrosine hydroxylase-positive cells in the grafts, although the clear trend to increased survival of the dopamine neurons in the superoxide dismutase grafts did not reach statistical significance. Only a moderate inflammatory reaction was revealed by OX-42 immunostaining in all groups. suggesting that ex vivo gene transfer using adenoviral vectors is a promising method for delivering functional proteins into brain grafts.</EA>
<CC>002A25L</CC>
<FD>Greffe; Corps strié; Mésencéphale; Homme; Superoxide dismutase; Parkinson maladie; Rat</FD>
<FG>Oxidoreductases; Enzyme; Noyau gris central; Encéphale; Système nerveux central; Rodentia; Mammalia; Vertebrata</FG>
<ED>Graft; Corpus striatum; Midbrain; Human; Superoxide dismutase; Parkinson disease; Rat</ED>
<EG>Oxidoreductases; Enzyme; Basal ganglion; Brain (vertebrata); Central nervous system; Rodentia; Mammalia; Vertebrata</EG>
<SD>Injerto; Cuerpo estriado; Mesencéfalo; Hombre; Superoxide dismutase; Parkinson enfermedad; Rata</SD>
<LO>INIST-17194.354000065142780080</LO>
<ID>97-0287749</ID>
</server>
</inist>
</record>

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	La maladie de Parkinson en France (serveur d'exploration)
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La maladie de Parkinson en France (serveur d'exploration)

Intrastriatal grafts of embryonic mesencephalic rat neurons genetically modified using an adenovirus encoding human Cu/Zn superoxide dismutase

Intrastriatal grafts of embryonic mesencephalic rat neurons genetically modified using an adenovirus encoding human Cu/Zn superoxide dismutase

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