ParkinsonFranceV1, PascalFrancis, Corpus, bibRecord, 001293

Chemical and pharmacological aspects of heteroaryl-nitrones

Identifieur interne : 001293 ( PascalFrancis/Corpus ); précédent : 001292; suivant : 001294

Chemical and pharmacological aspects of heteroaryl-nitrones

Auteurs : Solo Goldstein ; Pierre Lestage

Source :

Current medicinal chemistry [ 0929-8673 ] ; 2000.

RBID : Pascal:01-0009153

Descripteurs français

Pascal (Inist)
- Article synthèse, Recherche développement, Antioxydant, Intercepteur radical, Nitrone, Composé aromatique, Benzène dérivé, Hétérocycle azote, Hétérocycle oxygène, Imidazole dérivé, Synthèse chimique, Pyridine dérivé, Furane dérivé, Thiophène dérivé.

English descriptors

KwdEn :
- Antioxidant, Aromatic compound, Benzene derivatives, Chemical synthesis, Furan derivatives, Imidazole derivatives, Nitrogen heterocycle, Nitrone, Oxygen heterocycle, Pyridine derivatives, Radical scavenger, Research and development, Review, Thiophene derivatives.

Abstract

Radical induced oxidative damage is extremely harmful to tissues and organs due to molecular modifications brought to polyunsaturated membrane lipids, proteins and nucleic acids. Oxidative stress is believed to be one of the pathophysiological mechanisms that operate in neurodegenerative disorders such as cerebral ischemias, amyotrophic lateral sclerosis, Parkinson's and Alzheimer's diseases. Nitrones oppose oxidative challenges by virtue of their ability to trap very rapidly oxygen or carbon centered radicals thus generating nitroxide radical species which are more stable and biochemically less harmful than the original radical. However the operational mechanism of nitrones might also go beyond direct scavenging of radicals. The chemical and pharmacological properties of nitrones depend strongly on the connectivity as well as on the type and position of the substituents in the compound's architecture. Heteroaryl-nitrones are known, but except for a few cases (for example pyridyl-nitrones) no particular attention has been given to this class of molecules. The following review is a survey of the literature reports on this subject from 1980 to 1999. The structures were classified according to the heterocyclic substituent on the nitrone double bond, and documented pharmaceutical features were emphasized. Whenever possible heteroaromatic and related aromatic nitrones were compared.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A08	`01`	`1`	`ENG`	`@1 Chemical and pharmacological aspects of heteroaryl-nitrones`
A11	`01`	`1`		`@1 GOLDSTEIN (Solo)`
A11	`02`	`1`		`@1 LESTAGE (Pierre)`
A14	`01`			`@1 Institut de Recherches Servier Chemistry Research Division A, 11 rue des Moulineaux @2 92150 Suresnes @3 FRA @Z 1 aut.`
A14	`02`			`@1 Division of Cerebral Pathology, 125 Chemin de Ronde @2 78290 Croissy sur Seine @3 FRA @Z 2 aut.`
A20				`@1 1255-1267`
A21				`@1 2000`
A23	`01`			`@0 ENG`
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A44				`@0 0000 @1 © 2001 INIST-CNRS. All rights reserved.`
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A47	`01`	`1`		`@0 01-0009153`
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A61				`@0 A`
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C01	`01`		`ENG`	@0 Radical induced oxidative damage is extremely harmful to tissues and organs due to molecular modifications brought to polyunsaturated membrane lipids, proteins and nucleic acids. Oxidative stress is believed to be one of the pathophysiological mechanisms that operate in neurodegenerative disorders such as cerebral ischemias, amyotrophic lateral sclerosis, Parkinson's and Alzheimer's diseases. Nitrones oppose oxidative challenges by virtue of their ability to trap very rapidly oxygen or carbon centered radicals thus generating nitroxide radical species which are more stable and biochemically less harmful than the original radical. However the operational mechanism of nitrones might also go beyond direct scavenging of radicals. The chemical and pharmacological properties of nitrones depend strongly on the connectivity as well as on the type and position of the substituents in the compound's architecture. Heteroaryl-nitrones are known, but except for a few cases (for example pyridyl-nitrones) no particular attention has been given to this class of molecules. The following review is a survey of the literature reports on this subject from 1980 to 1999. The structures were classified according to the heterocyclic substituent on the nitrone double bond, and documented pharmaceutical features were emphasized. Whenever possible heteroaromatic and related aromatic nitrones were compared.
C02	`01`	`X`		`@0 002B02N`
C03	`01`	`X`	`FRE`	`@0 Article synthèse @5 01`
C03	`01`	`X`	`ENG`	`@0 Review @5 01`
C03	`01`	`X`	`SPA`	`@0 Artículo síntesis @5 01`
C03	`02`	`X`	`FRE`	`@0 Recherche développement @5 02`
C03	`02`	`X`	`ENG`	`@0 Research and development @5 02`
C03	`02`	`X`	`SPA`	`@0 Investigación desarrollo @5 02`
C03	`03`	`X`	`FRE`	`@0 Antioxydant @5 03`
C03	`03`	`X`	`ENG`	`@0 Antioxidant @5 03`
C03	`03`	`X`	`SPA`	`@0 Antioxidante @5 03`
C03	`04`	`X`	`FRE`	`@0 Intercepteur radical @5 04`
C03	`04`	`X`	`ENG`	`@0 Radical scavenger @5 04`
C03	`04`	`X`	`SPA`	`@0 Interceptor radical @5 04`
C03	`05`	`X`	`FRE`	`@0 Nitrone @5 06`
C03	`05`	`X`	`ENG`	`@0 Nitrone @5 06`
C03	`05`	`X`	`SPA`	`@0 Nitrona @5 06`
C03	`06`	`X`	`FRE`	`@0 Composé aromatique @5 07`
C03	`06`	`X`	`ENG`	`@0 Aromatic compound @5 07`
C03	`06`	`X`	`SPA`	`@0 Compuesto aromático @5 07`
C03	`07`	`X`	`FRE`	`@0 Benzène dérivé @5 08`
C03	`07`	`X`	`ENG`	`@0 Benzene derivatives @5 08`
C03	`07`	`X`	`SPA`	`@0 Benceno derivado @5 08`
C03	`08`	`X`	`FRE`	`@0 Hétérocycle azote @5 09`
C03	`08`	`X`	`ENG`	`@0 Nitrogen heterocycle @5 09`
C03	`08`	`X`	`SPA`	`@0 Heterociclo nitrógeno @5 09`
C03	`09`	`X`	`FRE`	`@0 Hétérocycle oxygène @5 10`
C03	`09`	`X`	`ENG`	`@0 Oxygen heterocycle @5 10`
C03	`09`	`X`	`SPA`	`@0 Heterociclo oxígeno @5 10`
C03	`10`	`X`	`FRE`	`@0 Imidazole dérivé @5 11`
C03	`10`	`X`	`ENG`	`@0 Imidazole derivatives @5 11`
C03	`10`	`X`	`SPA`	`@0 Imidazol derivado @5 11`
C03	`11`	`X`	`FRE`	`@0 Synthèse chimique @5 12`
C03	`11`	`X`	`ENG`	`@0 Chemical synthesis @5 12`
C03	`11`	`X`	`SPA`	`@0 Síntesis química @5 12`
C03	`12`	`X`	`FRE`	`@0 Pyridine dérivé @5 16`
C03	`12`	`X`	`ENG`	`@0 Pyridine derivatives @5 16`
C03	`12`	`X`	`SPA`	`@0 Piridina derivado @5 16`
C03	`13`	`X`	`FRE`	`@0 Furane dérivé @5 17`
C03	`13`	`X`	`ENG`	`@0 Furan derivatives @5 17`
C03	`13`	`X`	`SPA`	`@0 Furano derivado @5 17`
C03	`14`	`X`	`FRE`	`@0 Thiophène dérivé @5 18`
C03	`14`	`X`	`ENG`	`@0 Thiophene derivatives @5 18`
C03	`14`	`X`	`SPA`	`@0 Tiofeno derivado @5 18`
N21				`@1 001`

Format Inist (serveur)

NO :	PASCAL 01-0009153 INIST
ET :	Chemical and pharmacological aspects of heteroaryl-nitrones
AU :	GOLDSTEIN (Solo); LESTAGE (Pierre)
AF :	Institut de Recherches Servier Chemistry Research Division A, 11 rue des Moulineaux/92150 Suresnes/France (1 aut.); Division of Cerebral Pathology, 125 Chemin de Ronde/78290 Croissy sur Seine/France (2 aut.)
DT :	Publication en série; Niveau analytique
SO :	Current medicinal chemistry; ISSN 0929-8673; Pays-Bas; Da. 2000; Vol. 7; No. 12; Pp. 1255-1267; Bibl. 60 ref.
LA :	Anglais
EA :	Radical induced oxidative damage is extremely harmful to tissues and organs due to molecular modifications brought to polyunsaturated membrane lipids, proteins and nucleic acids. Oxidative stress is believed to be one of the pathophysiological mechanisms that operate in neurodegenerative disorders such as cerebral ischemias, amyotrophic lateral sclerosis, Parkinson's and Alzheimer's diseases. Nitrones oppose oxidative challenges by virtue of their ability to trap very rapidly oxygen or carbon centered radicals thus generating nitroxide radical species which are more stable and biochemically less harmful than the original radical. However the operational mechanism of nitrones might also go beyond direct scavenging of radicals. The chemical and pharmacological properties of nitrones depend strongly on the connectivity as well as on the type and position of the substituents in the compound's architecture. Heteroaryl-nitrones are known, but except for a few cases (for example pyridyl-nitrones) no particular attention has been given to this class of molecules. The following review is a survey of the literature reports on this subject from 1980 to 1999. The structures were classified according to the heterocyclic substituent on the nitrone double bond, and documented pharmaceutical features were emphasized. Whenever possible heteroaromatic and related aromatic nitrones were compared.
CC :	002B02N
FD :	Article synthèse; Recherche développement; Antioxydant; Intercepteur radical; Nitrone; Composé aromatique; Benzène dérivé; Hétérocycle azote; Hétérocycle oxygène; Imidazole dérivé; Synthèse chimique; Pyridine dérivé; Furane dérivé; Thiophène dérivé
ED :	Review; Research and development; Antioxidant; Radical scavenger; Nitrone; Aromatic compound; Benzene derivatives; Nitrogen heterocycle; Oxygen heterocycle; Imidazole derivatives; Chemical synthesis; Pyridine derivatives; Furan derivatives; Thiophene derivatives
SD :	Artículo síntesis; Investigación desarrollo; Antioxidante; Interceptor radical; Nitrona; Compuesto aromático; Benceno derivado; Heterociclo nitrógeno; Heterociclo oxígeno; Imidazol derivado; Síntesis química; Piridina derivado; Furano derivado; Tiofeno derivado
LO :	INIST-22999.354000093013500050
ID :	01-0009153

Links to Exploration step

Pascal:01-0009153

Le document en format XML

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<front><div type="abstract" xml:lang="en">Radical induced oxidative damage is extremely harmful to tissues and organs due to molecular modifications brought to polyunsaturated membrane lipids, proteins and nucleic acids. Oxidative stress is believed to be one of the pathophysiological mechanisms that operate in neurodegenerative disorders such as cerebral ischemias, amyotrophic lateral sclerosis, Parkinson's and Alzheimer's diseases. Nitrones oppose oxidative challenges by virtue of their ability to trap very rapidly oxygen or carbon centered radicals thus generating nitroxide radical species which are more stable and biochemically less harmful than the original radical. However the operational mechanism of nitrones might also go beyond direct scavenging of radicals. The chemical and pharmacological properties of nitrones depend strongly on the connectivity as well as on the type and position of the substituents in the compound's architecture. Heteroaryl-nitrones are known, but except for a few cases (for example pyridyl-nitrones) no particular attention has been given to this class of molecules. The following review is a survey of the literature reports on this subject from 1980 to 1999. The structures were classified according to the heterocyclic substituent on the nitrone double bond, and documented pharmaceutical features were emphasized. Whenever possible heteroaromatic and related aromatic nitrones were compared.</div>
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<fC03 i1="05" i2="X" l="ENG"><s0>Nitrone</s0>
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<s5>12</s5>
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<s5>16</s5>
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<fC03 i1="12" i2="X" l="ENG"><s0>Pyridine derivatives</s0>
<s5>16</s5>
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<s5>16</s5>
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<s5>17</s5>
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<s5>17</s5>
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<fC03 i1="14" i2="X" l="FRE"><s0>Thiophène dérivé</s0>
<s5>18</s5>
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<fC03 i1="14" i2="X" l="SPA"><s0>Tiofeno derivado</s0>
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<server><NO>PASCAL 01-0009153 INIST</NO>
<ET>Chemical and pharmacological aspects of heteroaryl-nitrones</ET>
<AU>GOLDSTEIN (Solo); LESTAGE (Pierre)</AU>
<AF>Institut de Recherches Servier Chemistry Research Division A, 11 rue des Moulineaux/92150 Suresnes/France (1 aut.); Division of Cerebral Pathology, 125 Chemin de Ronde/78290 Croissy sur Seine/France (2 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Current medicinal chemistry; ISSN 0929-8673; Pays-Bas; Da. 2000; Vol. 7; No. 12; Pp. 1255-1267; Bibl. 60 ref.</SO>
<LA>Anglais</LA>
<EA>Radical induced oxidative damage is extremely harmful to tissues and organs due to molecular modifications brought to polyunsaturated membrane lipids, proteins and nucleic acids. Oxidative stress is believed to be one of the pathophysiological mechanisms that operate in neurodegenerative disorders such as cerebral ischemias, amyotrophic lateral sclerosis, Parkinson's and Alzheimer's diseases. Nitrones oppose oxidative challenges by virtue of their ability to trap very rapidly oxygen or carbon centered radicals thus generating nitroxide radical species which are more stable and biochemically less harmful than the original radical. However the operational mechanism of nitrones might also go beyond direct scavenging of radicals. The chemical and pharmacological properties of nitrones depend strongly on the connectivity as well as on the type and position of the substituents in the compound's architecture. Heteroaryl-nitrones are known, but except for a few cases (for example pyridyl-nitrones) no particular attention has been given to this class of molecules. The following review is a survey of the literature reports on this subject from 1980 to 1999. The structures were classified according to the heterocyclic substituent on the nitrone double bond, and documented pharmaceutical features were emphasized. Whenever possible heteroaromatic and related aromatic nitrones were compared.</EA>
<CC>002B02N</CC>
<FD>Article synthèse; Recherche développement; Antioxydant; Intercepteur radical; Nitrone; Composé aromatique; Benzène dérivé; Hétérocycle azote; Hétérocycle oxygène; Imidazole dérivé; Synthèse chimique; Pyridine dérivé; Furane dérivé; Thiophène dérivé</FD>
<ED>Review; Research and development; Antioxidant; Radical scavenger; Nitrone; Aromatic compound; Benzene derivatives; Nitrogen heterocycle; Oxygen heterocycle; Imidazole derivatives; Chemical synthesis; Pyridine derivatives; Furan derivatives; Thiophene derivatives</ED>
<SD>Artículo síntesis; Investigación desarrollo; Antioxidante; Interceptor radical; Nitrona; Compuesto aromático; Benceno derivado; Heterociclo nitrógeno; Heterociclo oxígeno; Imidazol derivado; Síntesis química; Piridina derivado; Furano derivado; Tiofeno derivado</SD>
<LO>INIST-22999.354000093013500050</LO>
<ID>01-0009153</ID>
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Chemical and pharmacological aspects of heteroaryl-nitrones

Chemical and pharmacological aspects of heteroaryl-nitrones

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