In vitro and in vivo studies on chelation of manganese
Identifieur interne : 001281 ( PascalFrancis/Corpus ); précédent : 001280; suivant : 001282In vitro and in vivo studies on chelation of manganese
Auteurs : P. Missy ; M-C Lanhers ; Y. Grignon ; M. Joyeux ; D. BurnelSource :
- Human & experimental toxicology [ 0960-3271 ] ; 2000.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
This work deals with new chelating agents of manganese (Mn). Out of 24 compounds chosen for their chemical structure supposed to be favorable for Mn complexation, six polyaminopolycarboxylic acids proved to be efficient for displacing Mn bound to serum bovine proteins in vitro: TTHA, DTPA, DPTA, DPTA-OH, HBED, EDTA (mobilization >50%). The first five compounds were then tested in vivo on rats pre treated with MnCl2. They exhibited only slight to moderate efficacy to diminish Mn in tissues and were ineffective on increased Mn concentration in whole blood; in addition, they had different and specific mobilizing effects on other essential elements (Fe, Zn, Cu). Their limited efficacy in vivo could be due to the formation of very stable complexes between Mn2 + and different molecules such as hemoglobin and certain cytochromes, instead of Fe2+. This could disturb the functioning of the cellular respiratory chain, leading to an incomplete reduction of O2 with formation of free oxygenated radicals, reduction in the energy supply, and disturbance of the cytochromes renewal mechanism. All of these phenomena could accelerate cellular aging and explain the lack of efficacy ofthe chelating agents towards Mn neurotoxicity (Parkinson's syndrome).
Notice en format standard (ISO 2709)
Pour connaître la documentation sur le format Inist Standard.
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Format Inist (serveur)
NO : | PASCAL 01-0041987 INIST |
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ET : | In vitro and in vivo studies on chelation of manganese |
AU : | MISSY (P.); LANHERS (M-C); GRIGNON (Y.); JOYEUX (M.); BURNEL (D.) |
AF : | Laboratoire de Chimie et de Toxicologie des Métaux, Département Environnement et Santé Publique, Faculté de Médecine, Université Henry Poincaré, Nancy I/Vandoeuvre-lès-Nancy/France (1 aut., 2 aut., 5 aut.); Laboratoire d'Anatomie Pathologique, Faculté de Médecine, Université Henry Poincaré, Nancy I/Vandoeuvre-lès-Nancy/France (3 aut.); SERES, Département Environnement et Santé Publique, Faculté de Médecine, Université Henry Poincaré, Nancy I/Vandoeuvre-lès-Nancy/France (4 aut.) |
DT : | Publication en série; Niveau analytique |
SO : | Human & experimental toxicology; ISSN 0960-3271; Royaume-Uni; Da. 2000; Vol. 19; No. 8; Pp. 448-456; Bibl. 20 ref. |
LA : | Anglais |
EA : | This work deals with new chelating agents of manganese (Mn). Out of 24 compounds chosen for their chemical structure supposed to be favorable for Mn complexation, six polyaminopolycarboxylic acids proved to be efficient for displacing Mn bound to serum bovine proteins in vitro: TTHA, DTPA, DPTA, DPTA-OH, HBED, EDTA (mobilization >50%). The first five compounds were then tested in vivo on rats pre treated with MnCl2. They exhibited only slight to moderate efficacy to diminish Mn in tissues and were ineffective on increased Mn concentration in whole blood; in addition, they had different and specific mobilizing effects on other essential elements (Fe, Zn, Cu). Their limited efficacy in vivo could be due to the formation of very stable complexes between Mn2 + and different molecules such as hemoglobin and certain cytochromes, instead of Fe2+. This could disturb the functioning of the cellular respiratory chain, leading to an incomplete reduction of O2 with formation of free oxygenated radicals, reduction in the energy supply, and disturbance of the cytochromes renewal mechanism. All of these phenomena could accelerate cellular aging and explain the lack of efficacy ofthe chelating agents towards Mn neurotoxicity (Parkinson's syndrome). |
CC : | 002B03L05 |
FD : | Manganèse; Métal lourd; Chélateur; Intoxication; Antidote; Efficacité traitement; Chimiothérapie; In vivo; Rat; Animal; In vitro; Toxicité |
FG : | Rodentia; Mammalia; Vertebrata |
ED : | Manganese; Heavy metal; Chelating agent; Poisoning; Antidote; Treatment efficiency; Chemotherapy; In vivo; Rat; Animal; In vitro; Toxicity |
EG : | Rodentia; Mammalia; Vertebrata |
SD : | Manganeso; Metal pesado; Quelante; Intoxicación; Antídoto; Eficacia tratamiento; Quimioterapia; In vivo; Rata; Animal; In vitro; Toxicidad |
LO : | INIST-19290.354000093665510040 |
ID : | 01-0041987 |
Links to Exploration step
Pascal:01-0041987Le document en format XML
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<front><div type="abstract" xml:lang="en">This work deals with new chelating agents of manganese (Mn). Out of 24 compounds chosen for their chemical structure supposed to be favorable for Mn complexation, six polyaminopolycarboxylic acids proved to be efficient for displacing Mn bound to serum bovine proteins in vitro: TTHA, DTPA, DPTA, DPTA-OH, HBED, EDTA (mobilization >50%). The first five compounds were then tested in vivo on rats pre treated with MnCl<sub>2</sub>
. They exhibited only slight to moderate efficacy to diminish Mn in tissues and were ineffective on increased Mn concentration in whole blood; in addition, they had different and specific mobilizing effects on other essential elements (Fe, Zn, Cu). Their limited efficacy in vivo could be due to the formation of very stable complexes between Mn<sup>2</sup>
+ and different molecules such as hemoglobin and certain cytochromes, instead of Fe<sup>2+</sup>
. This could disturb the functioning of the cellular respiratory chain, leading to an incomplete reduction of O<sub>2</sub>
with formation of free oxygenated radicals, reduction in the energy supply, and disturbance of the cytochromes renewal mechanism. All of these phenomena could accelerate cellular aging and explain the lack of efficacy ofthe chelating agents towards Mn neurotoxicity (Parkinson's syndrome).</div>
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<server><NO>PASCAL 01-0041987 INIST</NO>
<ET>In vitro and in vivo studies on chelation of manganese</ET>
<AU>MISSY (P.); LANHERS (M-C); GRIGNON (Y.); JOYEUX (M.); BURNEL (D.)</AU>
<AF>Laboratoire de Chimie et de Toxicologie des Métaux, Département Environnement et Santé Publique, Faculté de Médecine, Université Henry Poincaré, Nancy I/Vandoeuvre-lès-Nancy/France (1 aut., 2 aut., 5 aut.); Laboratoire d'Anatomie Pathologique, Faculté de Médecine, Université Henry Poincaré, Nancy I/Vandoeuvre-lès-Nancy/France (3 aut.); SERES, Département Environnement et Santé Publique, Faculté de Médecine, Université Henry Poincaré, Nancy I/Vandoeuvre-lès-Nancy/France (4 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Human & experimental toxicology; ISSN 0960-3271; Royaume-Uni; Da. 2000; Vol. 19; No. 8; Pp. 448-456; Bibl. 20 ref.</SO>
<LA>Anglais</LA>
<EA>This work deals with new chelating agents of manganese (Mn). Out of 24 compounds chosen for their chemical structure supposed to be favorable for Mn complexation, six polyaminopolycarboxylic acids proved to be efficient for displacing Mn bound to serum bovine proteins in vitro: TTHA, DTPA, DPTA, DPTA-OH, HBED, EDTA (mobilization >50%). The first five compounds were then tested in vivo on rats pre treated with MnCl<sub>2</sub>
. They exhibited only slight to moderate efficacy to diminish Mn in tissues and were ineffective on increased Mn concentration in whole blood; in addition, they had different and specific mobilizing effects on other essential elements (Fe, Zn, Cu). Their limited efficacy in vivo could be due to the formation of very stable complexes between Mn<sup>2</sup>
+ and different molecules such as hemoglobin and certain cytochromes, instead of Fe<sup>2+</sup>
. This could disturb the functioning of the cellular respiratory chain, leading to an incomplete reduction of O<sub>2</sub>
with formation of free oxygenated radicals, reduction in the energy supply, and disturbance of the cytochromes renewal mechanism. All of these phenomena could accelerate cellular aging and explain the lack of efficacy ofthe chelating agents towards Mn neurotoxicity (Parkinson's syndrome).</EA>
<CC>002B03L05</CC>
<FD>Manganèse; Métal lourd; Chélateur; Intoxication; Antidote; Efficacité traitement; Chimiothérapie; In vivo; Rat; Animal; In vitro; Toxicité</FD>
<FG>Rodentia; Mammalia; Vertebrata</FG>
<ED>Manganese; Heavy metal; Chelating agent; Poisoning; Antidote; Treatment efficiency; Chemotherapy; In vivo; Rat; Animal; In vitro; Toxicity</ED>
<EG>Rodentia; Mammalia; Vertebrata</EG>
<SD>Manganeso; Metal pesado; Quelante; Intoxicación; Antídoto; Eficacia tratamiento; Quimioterapia; In vivo; Rata; Animal; In vitro; Toxicidad</SD>
<LO>INIST-19290.354000093665510040</LO>
<ID>01-0041987</ID>
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