Potential neurotoxic "agents provocateurs" in Parkinson's disease
Identifieur interne : 001028 ( PascalFrancis/Corpus ); précédent : 001027; suivant : 001029Potential neurotoxic "agents provocateurs" in Parkinson's disease
Auteurs : Michael A. Collins ; Edward J. NeafseySource :
- Neurotoxicology and teratology [ 0892-0362 ] ; 2002.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
Idiopathic Parkinson's disease (PD), one of the most common neurodegenerative disorders associated with aging, is characterized neurochemically by abnormal and profound loss of nigrostriatal dopamine (DA) neurons. A prominent current view is that the excessive degeneration of the dopaminergic system is the outcome of extended insults by environmental neurotoxins or endogenous neurotoxic factors in genetically vulnerable or susceptible individuals. Recent insights into the identities and mechanisms of potential neurotoxic species, which span pesticides, environmental contaminants including heterocyclic amines with β-carboline (βC) and isoquinoline (IQ) structures, endogenous DA metabolites or intermediates, neuromelanin, metals, and infectious agents, are presented.
Notice en format standard (ISO 2709)
Pour connaître la documentation sur le format Inist Standard.
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Format Inist (serveur)
NO : | PASCAL 03-0017996 INIST |
---|---|
ET : | Potential neurotoxic "agents provocateurs" in Parkinson's disease |
AU : | COLLINS (Michael A.); NEAFSEY (Edward J.); NAOI (Makoto); PARVEZ (Hasan); MARUYAMA (Wakako); COLLINS (Michel A.); YOUDIM (Moussa B. H.) |
AF : | Department of Cell Biology, Neurobiology, and Anatomy, Division of Biochemistry, Loyola University School of Medicine, 2160 South First Avenue/Maywood, IL 60153/Etats-Unis (1 aut., 2 aut.); Department of Brain Sciences, Institute of Applied Biochemistry, Yagi Memorial Park/Mitake, Gifu 505-0116/Japon (1 aut.); Unit of Neuroendocrinology, Bat. 5, Parc Chateau, CNRS/91190 Gif sur Yvette/France (2 aut.); Laboratory of Biochemistry and Metabolism, Department of Basic Gerontology, National Institute of Longevity Sciences/Obu, Aichi 474-8622/Japon (3 aut.); Department of Molecular and Cellular Biochemistry, Loyola University of Chicago, Strich School of Medicine/Maywood, IL 60153/Etats-Unis (4 aut.); Eve Topf and National Parkinson Foundation Neurodegenerative Diseases Centers, Department of Pharmacology, Rappaport Faculty of Medicine, Technion/Haifa 31096/Israël (5 aut.) |
DT : | Publication en série; Congrès; Niveau analytique |
SO : | Neurotoxicology and teratology; ISSN 0892-0362; Coden NETEEC; Etats-Unis; Da. 2002; Vol. 24; No. 5; Pp. 571-577; Bibl. 97 ref. |
LA : | Anglais |
EA : | Idiopathic Parkinson's disease (PD), one of the most common neurodegenerative disorders associated with aging, is characterized neurochemically by abnormal and profound loss of nigrostriatal dopamine (DA) neurons. A prominent current view is that the excessive degeneration of the dopaminergic system is the outcome of extended insults by environmental neurotoxins or endogenous neurotoxic factors in genetically vulnerable or susceptible individuals. Recent insights into the identities and mechanisms of potential neurotoxic species, which span pesticides, environmental contaminants including heterocyclic amines with β-carboline (βC) and isoquinoline (IQ) structures, endogenous DA metabolites or intermediates, neuromelanin, metals, and infectious agents, are presented. |
CC : | 002B17G |
FD : | Voie dopaminergique; Etiologie; Amine; Parkinson maladie; Pesticide; Carboline dérivé; Isoquinoléine dérivé; Homme; Animal; Toxicité |
FG : | Système nerveux pathologie; Système nerveux central pathologie; Encéphale pathologie; Extrapyramidal syndrome; Maladie dégénérative |
ED : | Dopaminergic pathway; Etiology; Amine; Parkinson disease; Pesticides; Carboline derivatives; Isoquinoline derivatives; Human; Animal; Toxicity |
EG : | Nervous system diseases; Central nervous system disease; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease |
SD : | Vía dopaminérgica; Etiología; Amina; Parkinson enfermedad; Plaguicida; Isoquinoleína; Hombre; Animal; Toxicidad |
LO : | INIST-18910.354000109244300020 |
ID : | 03-0017996 |
Links to Exploration step
Pascal:03-0017996Le document en format XML
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<front><div type="abstract" xml:lang="en">Idiopathic Parkinson's disease (PD), one of the most common neurodegenerative disorders associated with aging, is characterized neurochemically by abnormal and profound loss of nigrostriatal dopamine (DA) neurons. A prominent current view is that the excessive degeneration of the dopaminergic system is the outcome of extended insults by environmental neurotoxins or endogenous neurotoxic factors in genetically vulnerable or susceptible individuals. Recent insights into the identities and mechanisms of potential neurotoxic species, which span pesticides, environmental contaminants including heterocyclic amines with β-carboline (βC) and isoquinoline (IQ) structures, endogenous DA metabolites or intermediates, neuromelanin, metals, and infectious agents, are presented.</div>
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<server><NO>PASCAL 03-0017996 INIST</NO>
<ET>Potential neurotoxic "agents provocateurs" in Parkinson's disease</ET>
<AU>COLLINS (Michael A.); NEAFSEY (Edward J.); NAOI (Makoto); PARVEZ (Hasan); MARUYAMA (Wakako); COLLINS (Michel A.); YOUDIM (Moussa B. H.)</AU>
<AF>Department of Cell Biology, Neurobiology, and Anatomy, Division of Biochemistry, Loyola University School of Medicine, 2160 South First Avenue/Maywood, IL 60153/Etats-Unis (1 aut., 2 aut.); Department of Brain Sciences, Institute of Applied Biochemistry, Yagi Memorial Park/Mitake, Gifu 505-0116/Japon (1 aut.); Unit of Neuroendocrinology, Bat. 5, Parc Chateau, CNRS/91190 Gif sur Yvette/France (2 aut.); Laboratory of Biochemistry and Metabolism, Department of Basic Gerontology, National Institute of Longevity Sciences/Obu, Aichi 474-8622/Japon (3 aut.); Department of Molecular and Cellular Biochemistry, Loyola University of Chicago, Strich School of Medicine/Maywood, IL 60153/Etats-Unis (4 aut.); Eve Topf and National Parkinson Foundation Neurodegenerative Diseases Centers, Department of Pharmacology, Rappaport Faculty of Medicine, Technion/Haifa 31096/Israël (5 aut.)</AF>
<DT>Publication en série; Congrès; Niveau analytique</DT>
<SO>Neurotoxicology and teratology; ISSN 0892-0362; Coden NETEEC; Etats-Unis; Da. 2002; Vol. 24; No. 5; Pp. 571-577; Bibl. 97 ref.</SO>
<LA>Anglais</LA>
<EA>Idiopathic Parkinson's disease (PD), one of the most common neurodegenerative disorders associated with aging, is characterized neurochemically by abnormal and profound loss of nigrostriatal dopamine (DA) neurons. A prominent current view is that the excessive degeneration of the dopaminergic system is the outcome of extended insults by environmental neurotoxins or endogenous neurotoxic factors in genetically vulnerable or susceptible individuals. Recent insights into the identities and mechanisms of potential neurotoxic species, which span pesticides, environmental contaminants including heterocyclic amines with β-carboline (βC) and isoquinoline (IQ) structures, endogenous DA metabolites or intermediates, neuromelanin, metals, and infectious agents, are presented.</EA>
<CC>002B17G</CC>
<FD>Voie dopaminergique; Etiologie; Amine; Parkinson maladie; Pesticide; Carboline dérivé; Isoquinoléine dérivé; Homme; Animal; Toxicité</FD>
<FG>Système nerveux pathologie; Système nerveux central pathologie; Encéphale pathologie; Extrapyramidal syndrome; Maladie dégénérative</FG>
<ED>Dopaminergic pathway; Etiology; Amine; Parkinson disease; Pesticides; Carboline derivatives; Isoquinoline derivatives; Human; Animal; Toxicity</ED>
<EG>Nervous system diseases; Central nervous system disease; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease</EG>
<SD>Vía dopaminérgica; Etiología; Amina; Parkinson enfermedad; Plaguicida; Isoquinoleína; Hombre; Animal; Toxicidad</SD>
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