Manganese-induced apoptosis in PC12 cells
Identifieur interne : 001022 ( PascalFrancis/Corpus ); précédent : 001021; suivant : 001023Manganese-induced apoptosis in PC12 cells
Auteurs : Yoko HirataSource :
- Neurotoxicology and teratology [ 0892-0362 ] ; 2002.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
Manganese has been known to induce neurological disorders similar to parkinsonisms for a long time. Dopamine deficiency has been demonstrated in Parkinson's disease and in chronic manganese poisoning, suggesting that the mechanisms underlying the neurotoxic effects of the metal ion are related to dysfunction of the extrapyramidal system. However, the details of the mechanisms have yet to be elucidated. In an effort to learn more about the toxicity of manganese, we have employed an in vitro model that uses the PC12 catecholaminergic cell line. In this model, manganese induces apoptosis in PC12 cells. In this paper, experiments conducted with this model, the cellular biochemical changes, and the mechanism of the cell death are reviewed.
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Pour connaître la documentation sur le format Inist Standard.
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Format Inist (serveur)
NO : | PASCAL 03-0018076 INIST |
---|---|
ET : | Manganese-induced apoptosis in PC12 cells |
AU : | HIRATA (Yoko); NAOI (Makoto); PARVEZ (Hasan); MARUYAMA (Wakako); COLLINS (Michel A.); YOUDIM (Moussa B. H.) |
AF : | Laboratory for Genes of Motor Systems, Bio-Mimetic Control Research Center, RIKEN, 2271-130, Anagahora, Shimoshidami/Moriyama, Nagoya 463-0003/Japon (1 aut.); Department of Biomolecular Science, Faculty of Engineering, Gifu University/Gifu 501-1193/Japon (1 aut.); Department of Brain Sciences, Institute of Applied Biochemistry, Yagi Memorial Park/Mitake, Gifu 505-0116/Japon (1 aut.); Unit of Neuroendocrinology, Bat. 5, Parc Chateau, CNRS/91190 Gif sur Yvette/France (2 aut.); Laboratory of Biochemistry and Metabolism, Department of Basic Gerontology, National Institute of Longevity Sciences/Obu, Aichi 474-8622/Japon (3 aut.); Department of Molecular and Cellular Biochemistry, Loyola University of Chicago, Strich School of Medicine/Maywood, IL 60153/Etats-Unis (4 aut.); Eve Topf and National Parkinson Foundation Neurodegenerative Diseases Centers, Department of Pharmacology, Rappaport Faculty of Medicine, Technion/Haifa 31096/Israël (5 aut.) |
DT : | Publication en série; Congrès; Niveau analytique |
SO : | Neurotoxicology and teratology; ISSN 0892-0362; Coden NETEEC; Etats-Unis; Da. 2002; Vol. 24; No. 5; Pp. 639-653; Bibl. 68 ref. |
LA : | Anglais |
EA : | Manganese has been known to induce neurological disorders similar to parkinsonisms for a long time. Dopamine deficiency has been demonstrated in Parkinson's disease and in chronic manganese poisoning, suggesting that the mechanisms underlying the neurotoxic effects of the metal ion are related to dysfunction of the extrapyramidal system. However, the details of the mechanisms have yet to be elucidated. In an effort to learn more about the toxicity of manganese, we have employed an in vitro model that uses the PC12 catecholaminergic cell line. In this model, manganese induces apoptosis in PC12 cells. In this paper, experiments conducted with this model, the cellular biochemical changes, and the mechanism of the cell death are reviewed. |
CC : | 002B17G |
FD : | Manganèse; Métal lourd; Toxicité; Parkinson maladie; In vitro; Apoptose; Catécholamine; Déficit; Dopamine; Pathogénie; Lignée PC12 |
FG : | Système nerveux pathologie; Système nerveux central pathologie; Encéphale pathologie; Extrapyramidal syndrome; Maladie dégénérative |
ED : | Manganese; Heavy metal; Toxicity; Parkinson disease; In vitro; Apoptosis; Catecholamine; Deficiency; Dopamine; Pathogenesis |
EG : | Nervous system diseases; Central nervous system disease; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease |
SD : | Manganeso; Metal pesado; Toxicidad; Parkinson enfermedad; In vitro; Apoptosis; Catecolamina; Déficiencia; Dopamina; Patogenia |
LO : | INIST-18910.354000109244300090 |
ID : | 03-0018076 |
Links to Exploration step
Pascal:03-0018076Le document en format XML
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<server><NO>PASCAL 03-0018076 INIST</NO>
<ET>Manganese-induced apoptosis in PC12 cells</ET>
<AU>HIRATA (Yoko); NAOI (Makoto); PARVEZ (Hasan); MARUYAMA (Wakako); COLLINS (Michel A.); YOUDIM (Moussa B. H.)</AU>
<AF>Laboratory for Genes of Motor Systems, Bio-Mimetic Control Research Center, RIKEN, 2271-130, Anagahora, Shimoshidami/Moriyama, Nagoya 463-0003/Japon (1 aut.); Department of Biomolecular Science, Faculty of Engineering, Gifu University/Gifu 501-1193/Japon (1 aut.); Department of Brain Sciences, Institute of Applied Biochemistry, Yagi Memorial Park/Mitake, Gifu 505-0116/Japon (1 aut.); Unit of Neuroendocrinology, Bat. 5, Parc Chateau, CNRS/91190 Gif sur Yvette/France (2 aut.); Laboratory of Biochemistry and Metabolism, Department of Basic Gerontology, National Institute of Longevity Sciences/Obu, Aichi 474-8622/Japon (3 aut.); Department of Molecular and Cellular Biochemistry, Loyola University of Chicago, Strich School of Medicine/Maywood, IL 60153/Etats-Unis (4 aut.); Eve Topf and National Parkinson Foundation Neurodegenerative Diseases Centers, Department of Pharmacology, Rappaport Faculty of Medicine, Technion/Haifa 31096/Israël (5 aut.)</AF>
<DT>Publication en série; Congrès; Niveau analytique</DT>
<SO>Neurotoxicology and teratology; ISSN 0892-0362; Coden NETEEC; Etats-Unis; Da. 2002; Vol. 24; No. 5; Pp. 639-653; Bibl. 68 ref.</SO>
<LA>Anglais</LA>
<EA>Manganese has been known to induce neurological disorders similar to parkinsonisms for a long time. Dopamine deficiency has been demonstrated in Parkinson's disease and in chronic manganese poisoning, suggesting that the mechanisms underlying the neurotoxic effects of the metal ion are related to dysfunction of the extrapyramidal system. However, the details of the mechanisms have yet to be elucidated. In an effort to learn more about the toxicity of manganese, we have employed an in vitro model that uses the PC12 catecholaminergic cell line. In this model, manganese induces apoptosis in PC12 cells. In this paper, experiments conducted with this model, the cellular biochemical changes, and the mechanism of the cell death are reviewed.</EA>
<CC>002B17G</CC>
<FD>Manganèse; Métal lourd; Toxicité; Parkinson maladie; In vitro; Apoptose; Catécholamine; Déficit; Dopamine; Pathogénie; Lignée PC12</FD>
<FG>Système nerveux pathologie; Système nerveux central pathologie; Encéphale pathologie; Extrapyramidal syndrome; Maladie dégénérative</FG>
<ED>Manganese; Heavy metal; Toxicity; Parkinson disease; In vitro; Apoptosis; Catecholamine; Deficiency; Dopamine; Pathogenesis</ED>
<EG>Nervous system diseases; Central nervous system disease; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease</EG>
<SD>Manganeso; Metal pesado; Toxicidad; Parkinson enfermedad; In vitro; Apoptosis; Catecolamina; Déficiencia; Dopamina; Patogenia</SD>
<LO>INIST-18910.354000109244300090</LO>
<ID>03-0018076</ID>
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