ParkinsonFranceV1, PascalFrancis, Corpus, bibRecord, 001022

Manganese-induced apoptosis in PC12 cells

Identifieur interne : 001022 ( PascalFrancis/Corpus ); précédent : 001021; suivant : 001023

Manganese-induced apoptosis in PC12 cells

Auteurs : Yoko Hirata

Source :

Neurotoxicology and teratology [ 0892-0362 ] ; 2002.

RBID : Pascal:03-0018076

Descripteurs français

Pascal (Inist)
- Manganèse, Métal lourd, Toxicité, Parkinson maladie, In vitro, Apoptose, Catécholamine, Déficit, Dopamine, Pathogénie, Lignée PC12.

English descriptors

KwdEn :
- Apoptosis, Catecholamine, Deficiency, Dopamine, Heavy metal, In vitro, Manganese, Parkinson disease, Pathogenesis, Toxicity.

Abstract

Manganese has been known to induce neurological disorders similar to parkinsonisms for a long time. Dopamine deficiency has been demonstrated in Parkinson's disease and in chronic manganese poisoning, suggesting that the mechanisms underlying the neurotoxic effects of the metal ion are related to dysfunction of the extrapyramidal system. However, the details of the mechanisms have yet to be elucidated. In an effort to learn more about the toxicity of manganese, we have employed an in vitro model that uses the PC12 catecholaminergic cell line. In this model, manganese induces apoptosis in PC12 cells. In this paper, experiments conducted with this model, the cellular biochemical changes, and the mechanism of the cell death are reviewed.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

A01	`01`	`1`		`@0 0892-0362`
A02	`01`			`@0 NETEEC`
A03		`1`		`@0 Neurotoxicol. teratol.`
A05				`@2 24`
A06				`@2 5`
A08	`01`	`1`	`ENG`	`@1 Manganese-induced apoptosis in PC12 cells`
A09	`01`	`1`	`ENG`	`@1 Milestones in Research on Neurotoxins and Neuroprotection: A Tribute to Professor Toshiharu Nagatsu`
A11	`01`	`1`		`@1 HIRATA (Yoko)`
A12	`01`	`1`		`@1 NAOI (Makoto) @9 ed.`
A12	`02`	`1`		`@1 PARVEZ (Hasan) @9 ed.`
A12	`03`	`1`		`@1 MARUYAMA (Wakako) @9 ed.`
A12	`04`	`1`		`@1 COLLINS (Michel A.) @9 ed.`
A12	`05`	`1`		`@1 YOUDIM (Moussa B. H.) @9 ed.`
A14	`01`			`@1 Laboratory for Genes of Motor Systems, Bio-Mimetic Control Research Center, RIKEN, 2271-130, Anagahora, Shimoshidami @2 Moriyama, Nagoya 463-0003 @3 JPN @Z 1 aut.`
A14	`02`			`@1 Department of Biomolecular Science, Faculty of Engineering, Gifu University @2 Gifu 501-1193 @3 JPN @Z 1 aut.`
A15	`01`			`@1 Department of Brain Sciences, Institute of Applied Biochemistry, Yagi Memorial Park @2 Mitake, Gifu 505-0116 @3 JPN @Z 1 aut.`
A15	`02`			`@1 Unit of Neuroendocrinology, Bat. 5, Parc Chateau, CNRS @2 91190 Gif sur Yvette @3 FRA @Z 2 aut.`
A15	`03`			`@1 Laboratory of Biochemistry and Metabolism, Department of Basic Gerontology, National Institute of Longevity Sciences @2 Obu, Aichi 474-8622 @3 JPN @Z 3 aut.`
A15	`04`			`@1 Department of Molecular and Cellular Biochemistry, Loyola University of Chicago, Strich School of Medicine @2 Maywood, IL 60153 @3 USA @Z 4 aut.`
A15	`05`			`@1 Eve Topf and National Parkinson Foundation Neurodegenerative Diseases Centers, Department of Pharmacology, Rappaport Faculty of Medicine, Technion @2 Haifa 31096 @3 ISR @Z 5 aut.`
A20				`@1 639-653`
A21				`@1 2002`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 18910 @5 354000109244300090`
A44				`@0 0000 @1 © 2003 INIST-CNRS. All rights reserved.`
A45				`@0 68 ref.`
A47	`01`	`1`		`@0 03-0018076`
A60				`@1 P @2 C`
A61				`@0 A`
A64	`01`	`1`		`@0 Neurotoxicology and teratology`
A66	`01`			`@0 USA`
C01	`01`		`ENG`	@0 Manganese has been known to induce neurological disorders similar to parkinsonisms for a long time. Dopamine deficiency has been demonstrated in Parkinson's disease and in chronic manganese poisoning, suggesting that the mechanisms underlying the neurotoxic effects of the metal ion are related to dysfunction of the extrapyramidal system. However, the details of the mechanisms have yet to be elucidated. In an effort to learn more about the toxicity of manganese, we have employed an in vitro model that uses the PC12 catecholaminergic cell line. In this model, manganese induces apoptosis in PC12 cells. In this paper, experiments conducted with this model, the cellular biochemical changes, and the mechanism of the cell death are reviewed.
C02	`01`	`X`		`@0 002B17G`
C03	`01`	`X`	`FRE`	`@0 Manganèse @2 NC @5 01`
C03	`01`	`X`	`ENG`	`@0 Manganese @2 NC @5 01`
C03	`01`	`X`	`SPA`	`@0 Manganeso @2 NC @5 01`
C03	`02`	`X`	`FRE`	`@0 Métal lourd @5 04`
C03	`02`	`X`	`ENG`	`@0 Heavy metal @5 04`
C03	`02`	`X`	`SPA`	`@0 Metal pesado @5 04`
C03	`03`	`X`	`FRE`	`@0 Toxicité @5 07`
C03	`03`	`X`	`ENG`	`@0 Toxicity @5 07`
C03	`03`	`X`	`SPA`	`@0 Toxicidad @5 07`
C03	`04`	`X`	`FRE`	`@0 Parkinson maladie @5 10`
C03	`04`	`X`	`ENG`	`@0 Parkinson disease @5 10`
C03	`04`	`X`	`SPA`	`@0 Parkinson enfermedad @5 10`
C03	`05`	`X`	`FRE`	`@0 In vitro @5 11`
C03	`05`	`X`	`ENG`	`@0 In vitro @5 11`
C03	`05`	`X`	`SPA`	`@0 In vitro @5 11`
C03	`06`	`X`	`FRE`	`@0 Apoptose @5 12`
C03	`06`	`X`	`ENG`	`@0 Apoptosis @5 12`
C03	`06`	`X`	`SPA`	`@0 Apoptosis @5 12`
C03	`07`	`X`	`FRE`	`@0 Catécholamine @5 13`
C03	`07`	`X`	`ENG`	`@0 Catecholamine @5 13`
C03	`07`	`X`	`SPA`	`@0 Catecolamina @5 13`
C03	`08`	`X`	`FRE`	`@0 Déficit @5 14`
C03	`08`	`X`	`ENG`	`@0 Deficiency @5 14`
C03	`08`	`X`	`SPA`	`@0 Déficiencia @5 14`
C03	`09`	`X`	`FRE`	`@0 Dopamine @2 NK @2 FR @5 15`
C03	`09`	`X`	`ENG`	`@0 Dopamine @2 NK @2 FR @5 15`
C03	`09`	`X`	`SPA`	`@0 Dopamina @2 NK @2 FR @5 15`
C03	`10`	`X`	`FRE`	`@0 Pathogénie @5 16`
C03	`10`	`X`	`ENG`	`@0 Pathogenesis @5 16`
C03	`10`	`X`	`SPA`	`@0 Patogenia @5 16`
C03	`11`	`X`	`FRE`	`@0 Lignée PC12 @4 INC @5 86`
C07	`01`	`X`	`FRE`	`@0 Système nerveux pathologie @5 61`
C07	`01`	`X`	`ENG`	`@0 Nervous system diseases @5 61`
C07	`01`	`X`	`SPA`	`@0 Sistema nervioso patología @5 61`
C07	`02`	`X`	`FRE`	`@0 Système nerveux central pathologie @5 62`
C07	`02`	`X`	`ENG`	`@0 Central nervous system disease @5 62`
C07	`02`	`X`	`SPA`	`@0 Sistema nervosio central patología @5 62`
C07	`03`	`X`	`FRE`	`@0 Encéphale pathologie @5 63`
C07	`03`	`X`	`ENG`	`@0 Cerebral disorder @5 63`
C07	`03`	`X`	`SPA`	`@0 Encéfalo patología @5 63`
C07	`04`	`X`	`FRE`	`@0 Extrapyramidal syndrome @5 64`
C07	`04`	`X`	`ENG`	`@0 Extrapyramidal syndrome @5 64`
C07	`04`	`X`	`SPA`	`@0 Extrapiramidal síndrome @5 64`
C07	`05`	`X`	`FRE`	`@0 Maladie dégénérative @5 65`
C07	`05`	`X`	`ENG`	`@0 Degenerative disease @5 65`
C07	`05`	`X`	`SPA`	`@0 Enfermedad degenerativa @5 65`
N21				`@1 006`
N82				`@1 PSI`

A30	`01`	`1`	`ENG`	`@1 International Catecholamine Symposium @2 9 @3 Kyoto JPN @4 2001-03-31`
A30	`02`	`1`	`ENG`	`@1 International Joint Congresses on Progress in Alzheimer's and Parkinson's Disease @2 5 @3 Kyoto JPN @4 2001-03-31`

Format Inist (serveur)

NO :	PASCAL 03-0018076 INIST
ET :	Manganese-induced apoptosis in PC12 cells
AU :	HIRATA (Yoko); NAOI (Makoto); PARVEZ (Hasan); MARUYAMA (Wakako); COLLINS (Michel A.); YOUDIM (Moussa B. H.)
AF :	Laboratory for Genes of Motor Systems, Bio-Mimetic Control Research Center, RIKEN, 2271-130, Anagahora, Shimoshidami/Moriyama, Nagoya 463-0003/Japon (1 aut.); Department of Biomolecular Science, Faculty of Engineering, Gifu University/Gifu 501-1193/Japon (1 aut.); Department of Brain Sciences, Institute of Applied Biochemistry, Yagi Memorial Park/Mitake, Gifu 505-0116/Japon (1 aut.); Unit of Neuroendocrinology, Bat. 5, Parc Chateau, CNRS/91190 Gif sur Yvette/France (2 aut.); Laboratory of Biochemistry and Metabolism, Department of Basic Gerontology, National Institute of Longevity Sciences/Obu, Aichi 474-8622/Japon (3 aut.); Department of Molecular and Cellular Biochemistry, Loyola University of Chicago, Strich School of Medicine/Maywood, IL 60153/Etats-Unis (4 aut.); Eve Topf and National Parkinson Foundation Neurodegenerative Diseases Centers, Department of Pharmacology, Rappaport Faculty of Medicine, Technion/Haifa 31096/Israël (5 aut.)
DT :	Publication en série; Congrès; Niveau analytique
SO :	Neurotoxicology and teratology; ISSN 0892-0362; Coden NETEEC; Etats-Unis; Da. 2002; Vol. 24; No. 5; Pp. 639-653; Bibl. 68 ref.
LA :	Anglais
EA :	Manganese has been known to induce neurological disorders similar to parkinsonisms for a long time. Dopamine deficiency has been demonstrated in Parkinson's disease and in chronic manganese poisoning, suggesting that the mechanisms underlying the neurotoxic effects of the metal ion are related to dysfunction of the extrapyramidal system. However, the details of the mechanisms have yet to be elucidated. In an effort to learn more about the toxicity of manganese, we have employed an in vitro model that uses the PC12 catecholaminergic cell line. In this model, manganese induces apoptosis in PC12 cells. In this paper, experiments conducted with this model, the cellular biochemical changes, and the mechanism of the cell death are reviewed.
CC :	002B17G
FD :	Manganèse; Métal lourd; Toxicité; Parkinson maladie; In vitro; Apoptose; Catécholamine; Déficit; Dopamine; Pathogénie; Lignée PC12
FG :	Système nerveux pathologie; Système nerveux central pathologie; Encéphale pathologie; Extrapyramidal syndrome; Maladie dégénérative
ED :	Manganese; Heavy metal; Toxicity; Parkinson disease; In vitro; Apoptosis; Catecholamine; Deficiency; Dopamine; Pathogenesis
EG :	Nervous system diseases; Central nervous system disease; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease
SD :	Manganeso; Metal pesado; Toxicidad; Parkinson enfermedad; In vitro; Apoptosis; Catecolamina; Déficiencia; Dopamina; Patogenia
LO :	INIST-18910.354000109244300090
ID :	03-0018076

Links to Exploration step

Pascal:03-0018076

Le document en format XML

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<front><div type="abstract" xml:lang="en">Manganese has been known to induce neurological disorders similar to parkinsonisms for a long time. Dopamine deficiency has been demonstrated in Parkinson's disease and in chronic manganese poisoning, suggesting that the mechanisms underlying the neurotoxic effects of the metal ion are related to dysfunction of the extrapyramidal system. However, the details of the mechanisms have yet to be elucidated. In an effort to learn more about the toxicity of manganese, we have employed an in vitro model that uses the PC12 catecholaminergic cell line. In this model, manganese induces apoptosis in PC12 cells. In this paper, experiments conducted with this model, the cellular biochemical changes, and the mechanism of the cell death are reviewed.</div>
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<s5>14</s5>
</fC03>
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<s2>FR</s2>
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</fC03>
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<s2>FR</s2>
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<s5>64</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0>
<s5>64</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0>
<s5>64</s5>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Maladie dégénérative</s0>
<s5>65</s5>
</fC07>
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<s5>65</s5>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0>
<s5>65</s5>
</fC07>
<fN21><s1>006</s1>
</fN21>
<fN82><s1>PSI</s1>
</fN82>
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<pR><fA30 i1="01" i2="1" l="ENG"><s1>International Catecholamine Symposium</s1>
<s2>9</s2>
<s3>Kyoto JPN</s3>
<s4>2001-03-31</s4>
</fA30>
<fA30 i1="02" i2="1" l="ENG"><s1>International Joint Congresses on Progress in Alzheimer's and Parkinson's Disease</s1>
<s2>5</s2>
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<s4>2001-03-31</s4>
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<server><NO>PASCAL 03-0018076 INIST</NO>
<ET>Manganese-induced apoptosis in PC12 cells</ET>
<AU>HIRATA (Yoko); NAOI (Makoto); PARVEZ (Hasan); MARUYAMA (Wakako); COLLINS (Michel A.); YOUDIM (Moussa B. H.)</AU>
<AF>Laboratory for Genes of Motor Systems, Bio-Mimetic Control Research Center, RIKEN, 2271-130, Anagahora, Shimoshidami/Moriyama, Nagoya 463-0003/Japon (1 aut.); Department of Biomolecular Science, Faculty of Engineering, Gifu University/Gifu 501-1193/Japon (1 aut.); Department of Brain Sciences, Institute of Applied Biochemistry, Yagi Memorial Park/Mitake, Gifu 505-0116/Japon (1 aut.); Unit of Neuroendocrinology, Bat. 5, Parc Chateau, CNRS/91190 Gif sur Yvette/France (2 aut.); Laboratory of Biochemistry and Metabolism, Department of Basic Gerontology, National Institute of Longevity Sciences/Obu, Aichi 474-8622/Japon (3 aut.); Department of Molecular and Cellular Biochemistry, Loyola University of Chicago, Strich School of Medicine/Maywood, IL 60153/Etats-Unis (4 aut.); Eve Topf and National Parkinson Foundation Neurodegenerative Diseases Centers, Department of Pharmacology, Rappaport Faculty of Medicine, Technion/Haifa 31096/Israël (5 aut.)</AF>
<DT>Publication en série; Congrès; Niveau analytique</DT>
<SO>Neurotoxicology and teratology; ISSN 0892-0362; Coden NETEEC; Etats-Unis; Da. 2002; Vol. 24; No. 5; Pp. 639-653; Bibl. 68 ref.</SO>
<LA>Anglais</LA>
<EA>Manganese has been known to induce neurological disorders similar to parkinsonisms for a long time. Dopamine deficiency has been demonstrated in Parkinson's disease and in chronic manganese poisoning, suggesting that the mechanisms underlying the neurotoxic effects of the metal ion are related to dysfunction of the extrapyramidal system. However, the details of the mechanisms have yet to be elucidated. In an effort to learn more about the toxicity of manganese, we have employed an in vitro model that uses the PC12 catecholaminergic cell line. In this model, manganese induces apoptosis in PC12 cells. In this paper, experiments conducted with this model, the cellular biochemical changes, and the mechanism of the cell death are reviewed.</EA>
<CC>002B17G</CC>
<FD>Manganèse; Métal lourd; Toxicité; Parkinson maladie; In vitro; Apoptose; Catécholamine; Déficit; Dopamine; Pathogénie; Lignée PC12</FD>
<FG>Système nerveux pathologie; Système nerveux central pathologie; Encéphale pathologie; Extrapyramidal syndrome; Maladie dégénérative</FG>
<ED>Manganese; Heavy metal; Toxicity; Parkinson disease; In vitro; Apoptosis; Catecholamine; Deficiency; Dopamine; Pathogenesis</ED>
<EG>Nervous system diseases; Central nervous system disease; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease</EG>
<SD>Manganeso; Metal pesado; Toxicidad; Parkinson enfermedad; In vitro; Apoptosis; Catecolamina; Déficiencia; Dopamina; Patogenia</SD>
<LO>INIST-18910.354000109244300090</LO>
<ID>03-0018076</ID>
</server>
</inist>
</record>

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	La maladie de Parkinson en France (serveur d'exploration)
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La maladie de Parkinson en France (serveur d'exploration)

Manganese-induced apoptosis in PC12 cells

Manganese-induced apoptosis in PC12 cells

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