ParkinsonFranceV1, PascalFrancis, Corpus, bibRecord, 000F41

Neuroinflammatory processes in Parkinson's disease. Discussion

Identifieur interne : 000F41 ( PascalFrancis/Corpus ); précédent : 000F40; suivant : 000F42

Neuroinflammatory processes in Parkinson's disease. Discussion

Auteurs : Stephane Hunot ; E. C. Hirsch

Source :

Annals of neurology [ 0364-5134 ] ; 2003.

RBID : Pascal:03-0328800

Descripteurs français

Pascal (Inist)
- Parkinson maladie, Inflammation, Prostaglandin-endoperoxide synthase, Nitric-oxide synthase, Cytokine, Apoptose, Neurone dopaminergique, Névroglie, Pathogénie, Physiopathologie, Homme, Cyclooxygenase 2.

English descriptors

KwdEn :
- Apoptosis, Cytokine, Dopaminergic neuron, Human, Inflammation, Neuroglia, Nitric-oxide synthase, Parkinson disease, Pathogenesis, Pathophysiology, Prostaglandin-endoperoxide synthase.

Abstract

Parkinson's disease (PD) is a movement disorder characterized by the progressive degeneration of dopaminergic neurons in the midbrain. To date, its cause remains unknown and the mechanism of nerve cell death uncertain. Apart from the massive loss of dopaminergic neurons, PD brains also show a conspicuous glial reaction together with signs of a neuroinflammatory reaction manifested by elevated cytokine levels and upregulation of inflammatory-associated factors such as cyclooxygenase-2 and inducible nitric oxide synthase. Mounting evidence also suggests a possible deleterious effect of these neuroinflammatory processes in experimental models of the disease. We propose that, in PD, neuroinflammation plays a role in the cascade of events leading to nerve cell death, thus propagating the neurodegenerative process. In this review, we summarize and discuss the latest findings regarding neuroinflammatory aspects in PD.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A02	`01`			`@0 ANNED3`
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A05				`@2 53`
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A08	`01`	`1`	`ENG`	`@1 Neuroinflammatory processes in Parkinson's disease. Discussion`
A09	`01`	`1`	`ENG`	`@1 Neurodegeneration and prospects for neuroprotection and rescue in Parkinson's disease`
A11	`01`	`1`		`@1 HUNOT (Stephane)`
A11	`02`	`1`		`@1 HIRSCH (E. C.)`
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A12	`02`	`1`		`@1 SCHPIRA (Anthony H. V.) @9 ed.`
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A14	`01`			`@1 INSERM U289, Hôpital de la Salpêtrière @2 Paris @3 FRA @Z 1 aut. @Z 2 aut.`
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C01	`01`		`ENG`	@0 Parkinson's disease (PD) is a movement disorder characterized by the progressive degeneration of dopaminergic neurons in the midbrain. To date, its cause remains unknown and the mechanism of nerve cell death uncertain. Apart from the massive loss of dopaminergic neurons, PD brains also show a conspicuous glial reaction together with signs of a neuroinflammatory reaction manifested by elevated cytokine levels and upregulation of inflammatory-associated factors such as cyclooxygenase-2 and inducible nitric oxide synthase. Mounting evidence also suggests a possible deleterious effect of these neuroinflammatory processes in experimental models of the disease. We propose that, in PD, neuroinflammation plays a role in the cascade of events leading to nerve cell death, thus propagating the neurodegenerative process. In this review, we summarize and discuss the latest findings regarding neuroinflammatory aspects in PD.
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C03	`03`	`X`	`ENG`	`@0 Prostaglandin-endoperoxide synthase @2 FE @5 07`
C03	`03`	`X`	`SPA`	`@0 Prostaglandin-endoperoxide synthase @2 FE @5 07`
C03	`04`	`X`	`FRE`	`@0 Nitric-oxide synthase @2 FE @5 08`
C03	`04`	`X`	`ENG`	`@0 Nitric-oxide synthase @2 FE @5 08`
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C03	`11`	`X`	`FRE`	`@0 Homme @5 20`
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C03	`12`	`X`	`FRE`	`@0 Cyclooxygenase 2 @2 FE @4 INC @5 86`
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C07	`02`	`X`	`FRE`	`@0 Enzyme`
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C07	`03`	`X`	`FRE`	`@0 Système nerveux pathologie @5 37`
C07	`03`	`X`	`ENG`	`@0 Nervous system diseases @5 37`
C07	`03`	`X`	`SPA`	`@0 Sistema nervioso patología @5 37`
C07	`04`	`X`	`FRE`	`@0 Système nerveux central pathologie @5 38`
C07	`04`	`X`	`ENG`	`@0 Central nervous system disease @5 38`
C07	`04`	`X`	`SPA`	`@0 Sistema nervosio central patología @5 38`
C07	`05`	`X`	`FRE`	`@0 Encéphale pathologie @5 39`
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N21				`@1 223`
N82				`@1 PSI`

Format Inist (serveur)

NO :	PASCAL 03-0328800 INIST
ET :	Neuroinflammatory processes in Parkinson's disease. Discussion
AU :	HUNOT (Stephane); HIRSCH (E. C.); OLANOW (C. Warren); SCHPIRA (Anthony H. V.); AGID (Yves)
AF :	INSERM U289, Hôpital de la Salpêtrière/Paris/France (1 aut., 2 aut.); Department of Neurology, Mount Sinai School of Medicine/New York, NY/Etats-Unis (1 aut.)
DT :	Publication en série; Article; Commentaire; Niveau analytique
SO :	Annals of neurology; ISSN 0364-5134; Coden ANNED3; Etats-Unis; Da. 2003; Vol. 53; No. SUP3; S49-S60; Bibl. 83 ref.
LA :	Anglais
EA :	Parkinson's disease (PD) is a movement disorder characterized by the progressive degeneration of dopaminergic neurons in the midbrain. To date, its cause remains unknown and the mechanism of nerve cell death uncertain. Apart from the massive loss of dopaminergic neurons, PD brains also show a conspicuous glial reaction together with signs of a neuroinflammatory reaction manifested by elevated cytokine levels and upregulation of inflammatory-associated factors such as cyclooxygenase-2 and inducible nitric oxide synthase. Mounting evidence also suggests a possible deleterious effect of these neuroinflammatory processes in experimental models of the disease. We propose that, in PD, neuroinflammation plays a role in the cascade of events leading to nerve cell death, thus propagating the neurodegenerative process. In this review, we summarize and discuss the latest findings regarding neuroinflammatory aspects in PD.
CC :	002B17G
FD :	Parkinson maladie; Inflammation; Prostaglandin-endoperoxide synthase; Nitric-oxide synthase; Cytokine; Apoptose; Neurone dopaminergique; Névroglie; Pathogénie; Physiopathologie; Homme; Cyclooxygenase 2
FG :	Oxidoreductases; Enzyme; Système nerveux pathologie; Système nerveux central pathologie; Encéphale pathologie; Extrapyramidal syndrome; Maladie dégénérative
ED :	Parkinson disease; Inflammation; Prostaglandin-endoperoxide synthase; Nitric-oxide synthase; Cytokine; Apoptosis; Dopaminergic neuron; Neuroglia; Pathogenesis; Pathophysiology; Human
EG :	Oxidoreductases; Enzyme; Nervous system diseases; Central nervous system disease; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease
SD :	Parkinson enfermedad; Inflamación; Prostaglandin-endoperoxide synthase; Nitric-oxide synthase; Citoquina; Apoptosis; Neurona dopaminérgica; Neuroglia; Patogenia; Fisiopatología; Hombre
LO :	INIST-16555.354000109554000050
ID :	03-0328800

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Pascal:03-0328800

Le document en format XML

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<front><div type="abstract" xml:lang="en">Parkinson's disease (PD) is a movement disorder characterized by the progressive degeneration of dopaminergic neurons in the midbrain. To date, its cause remains unknown and the mechanism of nerve cell death uncertain. Apart from the massive loss of dopaminergic neurons, PD brains also show a conspicuous glial reaction together with signs of a neuroinflammatory reaction manifested by elevated cytokine levels and upregulation of inflammatory-associated factors such as cyclooxygenase-2 and inducible nitric oxide synthase. Mounting evidence also suggests a possible deleterious effect of these neuroinflammatory processes in experimental models of the disease. We propose that, in PD, neuroinflammation plays a role in the cascade of events leading to nerve cell death, thus propagating the neurodegenerative process. In this review, we summarize and discuss the latest findings regarding neuroinflammatory aspects in PD.</div>
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<s5>39</s5>
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<s5>40</s5>
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<fC07 i1="06" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0>
<s5>40</s5>
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<server><NO>PASCAL 03-0328800 INIST</NO>
<ET>Neuroinflammatory processes in Parkinson's disease. Discussion</ET>
<AU>HUNOT (Stephane); HIRSCH (E. C.); OLANOW (C. Warren); SCHPIRA (Anthony H. V.); AGID (Yves)</AU>
<AF>INSERM U289, Hôpital de la Salpêtrière/Paris/France (1 aut., 2 aut.); Department of Neurology, Mount Sinai School of Medicine/New York, NY/Etats-Unis (1 aut.)</AF>
<DT>Publication en série; Article; Commentaire; Niveau analytique</DT>
<SO>Annals of neurology; ISSN 0364-5134; Coden ANNED3; Etats-Unis; Da. 2003; Vol. 53; No. SUP3; S49-S60; Bibl. 83 ref.</SO>
<LA>Anglais</LA>
<EA>Parkinson's disease (PD) is a movement disorder characterized by the progressive degeneration of dopaminergic neurons in the midbrain. To date, its cause remains unknown and the mechanism of nerve cell death uncertain. Apart from the massive loss of dopaminergic neurons, PD brains also show a conspicuous glial reaction together with signs of a neuroinflammatory reaction manifested by elevated cytokine levels and upregulation of inflammatory-associated factors such as cyclooxygenase-2 and inducible nitric oxide synthase. Mounting evidence also suggests a possible deleterious effect of these neuroinflammatory processes in experimental models of the disease. We propose that, in PD, neuroinflammation plays a role in the cascade of events leading to nerve cell death, thus propagating the neurodegenerative process. In this review, we summarize and discuss the latest findings regarding neuroinflammatory aspects in PD.</EA>
<CC>002B17G</CC>
<FD>Parkinson maladie; Inflammation; Prostaglandin-endoperoxide synthase; Nitric-oxide synthase; Cytokine; Apoptose; Neurone dopaminergique; Névroglie; Pathogénie; Physiopathologie; Homme; Cyclooxygenase 2</FD>
<FG>Oxidoreductases; Enzyme; Système nerveux pathologie; Système nerveux central pathologie; Encéphale pathologie; Extrapyramidal syndrome; Maladie dégénérative</FG>
<ED>Parkinson disease; Inflammation; Prostaglandin-endoperoxide synthase; Nitric-oxide synthase; Cytokine; Apoptosis; Dopaminergic neuron; Neuroglia; Pathogenesis; Pathophysiology; Human</ED>
<EG>Oxidoreductases; Enzyme; Nervous system diseases; Central nervous system disease; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease</EG>
<SD>Parkinson enfermedad; Inflamación; Prostaglandin-endoperoxide synthase; Nitric-oxide synthase; Citoquina; Apoptosis; Neurona dopaminérgica; Neuroglia; Patogenia; Fisiopatología; Hombre</SD>
<LO>INIST-16555.354000109554000050</LO>
<ID>03-0328800</ID>
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	La maladie de Parkinson en France (serveur d'exploration)
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La maladie de Parkinson en France (serveur d'exploration)

Neuroinflammatory processes in Parkinson's disease. Discussion

Neuroinflammatory processes in Parkinson's disease. Discussion

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