Neuroinflammatory processes in Parkinson's disease. Discussion
Identifieur interne : 000F41 ( PascalFrancis/Corpus ); précédent : 000F40; suivant : 000F42Neuroinflammatory processes in Parkinson's disease. Discussion
Auteurs : Stephane Hunot ; E. C. HirschSource :
- Annals of neurology [ 0364-5134 ] ; 2003.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
Parkinson's disease (PD) is a movement disorder characterized by the progressive degeneration of dopaminergic neurons in the midbrain. To date, its cause remains unknown and the mechanism of nerve cell death uncertain. Apart from the massive loss of dopaminergic neurons, PD brains also show a conspicuous glial reaction together with signs of a neuroinflammatory reaction manifested by elevated cytokine levels and upregulation of inflammatory-associated factors such as cyclooxygenase-2 and inducible nitric oxide synthase. Mounting evidence also suggests a possible deleterious effect of these neuroinflammatory processes in experimental models of the disease. We propose that, in PD, neuroinflammation plays a role in the cascade of events leading to nerve cell death, thus propagating the neurodegenerative process. In this review, we summarize and discuss the latest findings regarding neuroinflammatory aspects in PD.
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Format Inist (serveur)
NO : | PASCAL 03-0328800 INIST |
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ET : | Neuroinflammatory processes in Parkinson's disease. Discussion |
AU : | HUNOT (Stephane); HIRSCH (E. C.); OLANOW (C. Warren); SCHPIRA (Anthony H. V.); AGID (Yves) |
AF : | INSERM U289, Hôpital de la Salpêtrière/Paris/France (1 aut., 2 aut.); Department of Neurology, Mount Sinai School of Medicine/New York, NY/Etats-Unis (1 aut.) |
DT : | Publication en série; Article; Commentaire; Niveau analytique |
SO : | Annals of neurology; ISSN 0364-5134; Coden ANNED3; Etats-Unis; Da. 2003; Vol. 53; No. SUP3; S49-S60; Bibl. 83 ref. |
LA : | Anglais |
EA : | Parkinson's disease (PD) is a movement disorder characterized by the progressive degeneration of dopaminergic neurons in the midbrain. To date, its cause remains unknown and the mechanism of nerve cell death uncertain. Apart from the massive loss of dopaminergic neurons, PD brains also show a conspicuous glial reaction together with signs of a neuroinflammatory reaction manifested by elevated cytokine levels and upregulation of inflammatory-associated factors such as cyclooxygenase-2 and inducible nitric oxide synthase. Mounting evidence also suggests a possible deleterious effect of these neuroinflammatory processes in experimental models of the disease. We propose that, in PD, neuroinflammation plays a role in the cascade of events leading to nerve cell death, thus propagating the neurodegenerative process. In this review, we summarize and discuss the latest findings regarding neuroinflammatory aspects in PD. |
CC : | 002B17G |
FD : | Parkinson maladie; Inflammation; Prostaglandin-endoperoxide synthase; Nitric-oxide synthase; Cytokine; Apoptose; Neurone dopaminergique; Névroglie; Pathogénie; Physiopathologie; Homme; Cyclooxygenase 2 |
FG : | Oxidoreductases; Enzyme; Système nerveux pathologie; Système nerveux central pathologie; Encéphale pathologie; Extrapyramidal syndrome; Maladie dégénérative |
ED : | Parkinson disease; Inflammation; Prostaglandin-endoperoxide synthase; Nitric-oxide synthase; Cytokine; Apoptosis; Dopaminergic neuron; Neuroglia; Pathogenesis; Pathophysiology; Human |
EG : | Oxidoreductases; Enzyme; Nervous system diseases; Central nervous system disease; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease |
SD : | Parkinson enfermedad; Inflamación; Prostaglandin-endoperoxide synthase; Nitric-oxide synthase; Citoquina; Apoptosis; Neurona dopaminérgica; Neuroglia; Patogenia; Fisiopatología; Hombre |
LO : | INIST-16555.354000109554000050 |
ID : | 03-0328800 |
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Pascal:03-0328800Le document en format XML
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<front><div type="abstract" xml:lang="en">Parkinson's disease (PD) is a movement disorder characterized by the progressive degeneration of dopaminergic neurons in the midbrain. To date, its cause remains unknown and the mechanism of nerve cell death uncertain. Apart from the massive loss of dopaminergic neurons, PD brains also show a conspicuous glial reaction together with signs of a neuroinflammatory reaction manifested by elevated cytokine levels and upregulation of inflammatory-associated factors such as cyclooxygenase-2 and inducible nitric oxide synthase. Mounting evidence also suggests a possible deleterious effect of these neuroinflammatory processes in experimental models of the disease. We propose that, in PD, neuroinflammation plays a role in the cascade of events leading to nerve cell death, thus propagating the neurodegenerative process. In this review, we summarize and discuss the latest findings regarding neuroinflammatory aspects in PD.</div>
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<ET>Neuroinflammatory processes in Parkinson's disease. Discussion</ET>
<AU>HUNOT (Stephane); HIRSCH (E. C.); OLANOW (C. Warren); SCHPIRA (Anthony H. V.); AGID (Yves)</AU>
<AF>INSERM U289, Hôpital de la Salpêtrière/Paris/France (1 aut., 2 aut.); Department of Neurology, Mount Sinai School of Medicine/New York, NY/Etats-Unis (1 aut.)</AF>
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<EA>Parkinson's disease (PD) is a movement disorder characterized by the progressive degeneration of dopaminergic neurons in the midbrain. To date, its cause remains unknown and the mechanism of nerve cell death uncertain. Apart from the massive loss of dopaminergic neurons, PD brains also show a conspicuous glial reaction together with signs of a neuroinflammatory reaction manifested by elevated cytokine levels and upregulation of inflammatory-associated factors such as cyclooxygenase-2 and inducible nitric oxide synthase. Mounting evidence also suggests a possible deleterious effect of these neuroinflammatory processes in experimental models of the disease. We propose that, in PD, neuroinflammation plays a role in the cascade of events leading to nerve cell death, thus propagating the neurodegenerative process. In this review, we summarize and discuss the latest findings regarding neuroinflammatory aspects in PD.</EA>
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