Clinical pharmacology of MAO inhibitors: Safety and future
Identifieur interne : 000E47 ( PascalFrancis/Corpus ); précédent : 000E46; suivant : 000E48Clinical pharmacology of MAO inhibitors: Safety and future
Auteurs : Mitsuhiko Yamada ; Hajime YasuharaSource :
- Neurotoxicology : (Park Forest South) [ 0161-813X ] ; 2004.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
In this article, we review the clinical pharmacology of monoamine oxidase inhibitors (MAOIs). Now, MAOIs are used for the treatment of depressive disorders, anxiety disorders, Parkinson's disease, and Alzheimer's disease. The selective monoamine oxidase-B inhibitor selegiline and the selective and reversible inhibitor of monoamine oxidase-A (RIMA) moclobemide are free from the hypertensive crisis, the so-called cheese effect. Therefore, selective MAO-B inhibitors and RIMAs hold promise as safer alternatives to classical MAOIs. It is clear that much remains to be investigated with regard to the clinical pharmacology of MAOIs. It seems obvious that a greater understanding of the pharmacodynamics and pharmacokinetics of MAOIs could result in improved treatment of the patients in the future.
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Format Inist (serveur)
NO : | PASCAL 04-0190285 INIST |
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ET : | Clinical pharmacology of MAO inhibitors: Safety and future |
AU : | YAMADA (Mitsuhiko); YASUHARA (Hajime); NICOTRA (A.); PARVEZ (S. H.); GLOVER (V.); SANDLER (M.); PARVEZ (S.); MINAMI (M.) |
AF : | Department of Psychiatry, Showa University Karasuyama Hospital, 6-11-11 Kitakarasuyama/Setagaya, Tokyo 157-8577/Japon (1 aut.); Department of Pharmacology, Showa University School of Medicine/Tokyo 142-8555/Japon (2 aut.); Dept. Animal and Human Biology, University of Rome I, Viale dell'Università 32/00198 Rome/Italie (1 aut.); Institut Alfred Fressard of Neuroscience, Bât5 Parc Chateau, CNRS/91190 Gif sur Yvette/France (2 aut., 5 aut.); Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Campus, Du Cane Road/London, W12 ONN/Royaume-Uni (3 aut., 4 aut.); The Research Institute of Personalized Health, Health Sciences University of Hokkaido/061-0293 Ishikari-Tobetsu/Japon (6 aut.) |
DT : | Publication en série; Niveau analytique |
SO : | Neurotoxicology : (Park Forest South); ISSN 0161-813X; Etats-Unis; Da. 2004; Vol. 25; No. 1-2; Pp. 215-221; Bibl. 1 p.1/4 |
LA : | Anglais |
EA : | In this article, we review the clinical pharmacology of monoamine oxidase inhibitors (MAOIs). Now, MAOIs are used for the treatment of depressive disorders, anxiety disorders, Parkinson's disease, and Alzheimer's disease. The selective monoamine oxidase-B inhibitor selegiline and the selective and reversible inhibitor of monoamine oxidase-A (RIMA) moclobemide are free from the hypertensive crisis, the so-called cheese effect. Therefore, selective MAO-B inhibitors and RIMAs hold promise as safer alternatives to classical MAOIs. It is clear that much remains to be investigated with regard to the clinical pharmacology of MAOIs. It seems obvious that a greater understanding of the pharmacodynamics and pharmacokinetics of MAOIs could result in improved treatment of the patients in the future. |
CC : | 002A25; 002B03; 002B17 |
FD : | Pharmacologie clinique; IMAO; Toxicité; Neurologie; Toxicologie |
ED : | Clinical pharmacology; MAO inhibitor; Toxicity; Neurology; Toxicology |
SD : | Farmacología clinica; IMAO; Toxicidad; Neurología; Toxicología |
LO : | INIST-18397.354000119285470220 |
ID : | 04-0190285 |
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Pascal:04-0190285Le document en format XML
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<ET>Clinical pharmacology of MAO inhibitors: Safety and future</ET>
<AU>YAMADA (Mitsuhiko); YASUHARA (Hajime); NICOTRA (A.); PARVEZ (S. H.); GLOVER (V.); SANDLER (M.); PARVEZ (S.); MINAMI (M.)</AU>
<AF>Department of Psychiatry, Showa University Karasuyama Hospital, 6-11-11 Kitakarasuyama/Setagaya, Tokyo 157-8577/Japon (1 aut.); Department of Pharmacology, Showa University School of Medicine/Tokyo 142-8555/Japon (2 aut.); Dept. Animal and Human Biology, University of Rome I, Viale dell'Università 32/00198 Rome/Italie (1 aut.); Institut Alfred Fressard of Neuroscience, Bât5 Parc Chateau, CNRS/91190 Gif sur Yvette/France (2 aut., 5 aut.); Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Campus, Du Cane Road/London, W12 ONN/Royaume-Uni (3 aut., 4 aut.); The Research Institute of Personalized Health, Health Sciences University of Hokkaido/061-0293 Ishikari-Tobetsu/Japon (6 aut.)</AF>
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<EA>In this article, we review the clinical pharmacology of monoamine oxidase inhibitors (MAOIs). Now, MAOIs are used for the treatment of depressive disorders, anxiety disorders, Parkinson's disease, and Alzheimer's disease. The selective monoamine oxidase-B inhibitor selegiline and the selective and reversible inhibitor of monoamine oxidase-A (RIMA) moclobemide are free from the hypertensive crisis, the so-called cheese effect. Therefore, selective MAO-B inhibitors and RIMAs hold promise as safer alternatives to classical MAOIs. It is clear that much remains to be investigated with regard to the clinical pharmacology of MAOIs. It seems obvious that a greater understanding of the pharmacodynamics and pharmacokinetics of MAOIs could result in improved treatment of the patients in the future.</EA>
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