ParkinsonFranceV1, PascalFrancis, Corpus, bibRecord, 000E14

The neurobiology of dopamine signaling

Identifieur interne : 000E14 ( PascalFrancis/Corpus ); précédent : 000E13; suivant : 000E15

The neurobiology of dopamine signaling

Auteurs : Jean-Antoine Girault ; Paul Greengard

Source :

Archives of neurology : (Chicago) [ 0003-9942 ] ; 2004.

RBID : Pascal:04-0308072

Descripteurs français

Pascal (Inist)
- Système nerveux pathologie, Dopamine.

English descriptors

KwdEn :
- Dopamine, Nervous system diseases.

Abstract

The brain contains 2 major groups of dopamine neurons. One is located in the arcuate nucleus of the hypothalamic median eminence and is involved in neuroendocrine regulation. The other, which is the subject of this article, is located in the ventral mesencephalon and projects to the forebrain. Although dopamine neurons are few (<1/ 100000 brain neurons), they play an important role in regulating several aspects of basic brain function. They are necessary for the normal tasks of the regions they innervate, including motor behavior, motivation, and working memory. Dopamine neurons are also a central element in the brain reward system that controls the learning of many behaviors. Disappearance of nigrostriatal neurons results in Parkinson disease, whereas blockade of dopamine receptors has therapeutic effects in psychosis. Finally, artificial increase in dopamine transmission is the common mechanism of action of drugs of abuse that leads to addiction. Understanding how dopamine works is a major goal of neurobiology. Much progress has been accomplished in identifying the intracellular signaling pathways that underlie the immediate actions of dopamine and account for its long-term effects on brain properties. Recent findings allow us to identify molecules that may represent future therapeutic targets in neurology and psychiatry.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A08	`01`	`1`	`ENG`	`@1 The neurobiology of dopamine signaling`
A11	`01`	`1`		`@1 GIRAULT (Jean-Antoine)`
A11	`02`	`1`		`@1 GREENGARD (Paul)`
A14	`01`			`@1 Institut National de la Santé et de la Recherche Médicale and Université Pierre et Marie Curie Unit 536, Institut du Fer à Moulin @2 Paris @3 FRA @Z 1 aut.`
A14	`02`			`@1 Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University @2 New York, NY @3 USA @Z 2 aut.`
A20				`@1 641-644`
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A23	`01`			`@0 ENG`
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A44				`@0 0000 @1 © 2004 INIST-CNRS. All rights reserved.`
A45				`@0 13 ref.`
A47	`01`	`1`		`@0 04-0308072`
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A64	`01`	`1`		`@0 Archives of neurology : (Chicago)`
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C01	`01`		`ENG`	@0 The brain contains 2 major groups of dopamine neurons. One is located in the arcuate nucleus of the hypothalamic median eminence and is involved in neuroendocrine regulation. The other, which is the subject of this article, is located in the ventral mesencephalon and projects to the forebrain. Although dopamine neurons are few (<1/ 100000 brain neurons), they play an important role in regulating several aspects of basic brain function. They are necessary for the normal tasks of the regions they innervate, including motor behavior, motivation, and working memory. Dopamine neurons are also a central element in the brain reward system that controls the learning of many behaviors. Disappearance of nigrostriatal neurons results in Parkinson disease, whereas blockade of dopamine receptors has therapeutic effects in psychosis. Finally, artificial increase in dopamine transmission is the common mechanism of action of drugs of abuse that leads to addiction. Understanding how dopamine works is a major goal of neurobiology. Much progress has been accomplished in identifying the intracellular signaling pathways that underlie the immediate actions of dopamine and account for its long-term effects on brain properties. Recent findings allow us to identify molecules that may represent future therapeutic targets in neurology and psychiatry.
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C03	`01`	`X`	`SPA`	`@0 Sistema nervioso patología @5 01`
C03	`02`	`X`	`FRE`	`@0 Dopamine @2 NK @2 FR @5 02`
C03	`02`	`X`	`ENG`	`@0 Dopamine @2 NK @2 FR @5 02`
C03	`02`	`X`	`SPA`	`@0 Dopamina @2 NK @2 FR @5 02`
C07	`01`	`X`	`FRE`	`@0 Catécholamine @5 37`
C07	`01`	`X`	`ENG`	`@0 Catecholamine @5 37`
C07	`01`	`X`	`SPA`	`@0 Catecolamina @5 37`
C07	`02`	`X`	`FRE`	`@0 Neurotransmetteur @5 38`
C07	`02`	`X`	`ENG`	`@0 Neurotransmitter @5 38`
C07	`02`	`X`	`SPA`	`@0 Neurotransmisor @5 38`
N21				`@1 187`
N44	`01`			`@1 OTO`
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Format Inist (serveur)

NO :	PASCAL 04-0308072 INIST
ET :	The neurobiology of dopamine signaling
AU :	GIRAULT (Jean-Antoine); GREENGARD (Paul)
AF :	Institut National de la Santé et de la Recherche Médicale and Université Pierre et Marie Curie Unit 536, Institut du Fer à Moulin/Paris/France (1 aut.); Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University/New York, NY/Etats-Unis (2 aut.)
DT :	Publication en série; Niveau analytique
SO :	Archives of neurology : (Chicago); ISSN 0003-9942; Coden ARNEAS; Etats-Unis; Da. 2004; Vol. 61; No. 5; Pp. 641-644; Bibl. 13 ref.
LA :	Anglais
EA :	The brain contains 2 major groups of dopamine neurons. One is located in the arcuate nucleus of the hypothalamic median eminence and is involved in neuroendocrine regulation. The other, which is the subject of this article, is located in the ventral mesencephalon and projects to the forebrain. Although dopamine neurons are few (<1/ 100000 brain neurons), they play an important role in regulating several aspects of basic brain function. They are necessary for the normal tasks of the regions they innervate, including motor behavior, motivation, and working memory. Dopamine neurons are also a central element in the brain reward system that controls the learning of many behaviors. Disappearance of nigrostriatal neurons results in Parkinson disease, whereas blockade of dopamine receptors has therapeutic effects in psychosis. Finally, artificial increase in dopamine transmission is the common mechanism of action of drugs of abuse that leads to addiction. Understanding how dopamine works is a major goal of neurobiology. Much progress has been accomplished in identifying the intracellular signaling pathways that underlie the immediate actions of dopamine and account for its long-term effects on brain properties. Recent findings allow us to identify molecules that may represent future therapeutic targets in neurology and psychiatry.
CC :	002B17
FD :	Système nerveux pathologie; Dopamine
FG :	Catécholamine; Neurotransmetteur
ED :	Nervous system diseases; Dopamine
EG :	Catecholamine; Neurotransmitter
SD :	Sistema nervioso patología; Dopamina
LO :	INIST-2048B.354000111998340040
ID :	04-0308072

Links to Exploration step

Pascal:04-0308072

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	La maladie de Parkinson en France (serveur d'exploration)
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La maladie de Parkinson en France (serveur d'exploration)

The neurobiology of dopamine signaling

The neurobiology of dopamine signaling

Source :

Descripteurs français

English descriptors

Abstract

Notice en format standard (ISO 2709)

Format Inist (serveur)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri