ParkinsonFranceV1, PascalFrancis, Corpus, bibRecord, 000D76

Subthalamic nucleus stimulation modulates motor cortex oscillatory activity in Parkinson's disease

Identifieur interne : 000D76 ( PascalFrancis/Corpus ); précédent : 000D75; suivant : 000D77

Subthalamic nucleus stimulation modulates motor cortex oscillatory activity in Parkinson's disease

Auteurs : D. Devos ; E. Labyt ; P. Derambure ; J. L. Bourriez ; F. Cassim ; N. Reyns ; S. Blond ; J. D. Guieu ; A. Destee ; L. Defebvre

Source :

Brain [ 0006-8950 ] ; 2004.

RBID : Pascal:04-0453729

Descripteurs français

Pascal (Inist)
- Parkinson maladie, Noyau sousthalamique, Noyau moteur, Système nerveux pathologie, Cortex moteur, Electroencéphalographie, Désynchronisation.

English descriptors

KwdEn :
- Desynchronization, Electroencephalography, Motor cortex, Motor nucleus, Nervous system diseases, Parkinson disease, Subthalamic nucleus.

Abstract

In Parkinson's disease, impaired motor preparation has been related to an increased latency in the appearance of movement-related desynchronization (MRD) throughout the contralateral primary sensorimotor (PSM) cortex. Internal globus pallidus (GPi) stimulation improved movement desynchronization over the PSM cortex during movement execution but failed to improve impaired motor preparation. PET studies indicate that subthalamic nucleus (STN) stimulation partly reverses the abnormal premotor pattern of brain activation during movement. By monitoring MRD, we aimed to assess changes in premotor and PSM cortex oscillatory activity induced by bilateral STN stimulation and to compare these changes with those induced by L-dopa. Ten Parkinson's disease patients and a group of healthy, age-matched controls performed self-paced wrist flexions in each of four conditions: without either stimulation or L-dopa (the 'off' condition), with stimulation and without L-dopa (On Stim), with L-dopa and without stimulation ('on drug'), and with both stimulation and L-dopa (On Both). Compared with the Off condition, in both the On Stim and the On Drug condition the Unified Parkinson's Disease Rating Scale (UPDRS) III score decreased by about 60% and in the On Both condition it decreased by 80%. The desynchronization latency over central regions contralateral to movement and the movement desynchronization over bilateral central regions were significantly increased by stimulation and by L-dopa, with a maximal effect when the two were associated. Furthermore, desynchronization latency significantly decreased over bilateral frontocentral regions in the three treatment conditions compared with the Off condition. In Parkinson's disease, STN stimulation may induce a change in abnormal cortical oscillatory activity patterns (similar to that produced by L-dopa) by decreasing the abnormal spreading of desynchronization over frontocentral regions and increasing PSM cortex activity during movement preparation and execution, with a correlated improvement in bradykinesia. Parkinsonians under treatment displayed a desynchronization pattern close to that seen in healthy, age-matched controls, although central latencies remained shorter. The study indicates that it is possible to influence cortical reactivity related to the planning and execution of voluntary movement through the basal ganglia, and furthermore that the oscillatory activity of the PSM cortex (in addition to that of premotor areas) could be of major importance in the control of movement-associated, neural activity in Parkinson's disease.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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Format Inist (serveur)

NO :	PASCAL 04-0453729 INIST
ET :	Subthalamic nucleus stimulation modulates motor cortex oscillatory activity in Parkinson's disease
AU :	DEVOS (D.); LABYT (E.); DERAMBURE (P.); BOURRIEZ (J. L.); CASSIM (F.); REYNS (N.); BLOND (S.); GUIEU (J. D.); DESTEE (A.); DEFEBVRE (L.)
AF :	Department of Neurology, EA2683, Lille University Medical Centre/Lille/France (1 aut., 9 aut., 10 aut.); Department of Clinical Neurophysiology, EA2683, Lille University Medical Centre/Lille/France (2 aut., 3 aut., 4 aut., 5 aut., 8 aut.); Department of Neurosurgery, EA2683, Lille University Medical Centre/Lille/France (6 aut., 7 aut.)
DT :	Publication en série; Niveau analytique
SO :	Brain; ISSN 0006-8950; Royaume-Uni; Da. 2004; Vol. 127; No. p.2; Pp. 408-419; Bibl. 1 p.3/4
LA :	Anglais
EA :	In Parkinson's disease, impaired motor preparation has been related to an increased latency in the appearance of movement-related desynchronization (MRD) throughout the contralateral primary sensorimotor (PSM) cortex. Internal globus pallidus (GPi) stimulation improved movement desynchronization over the PSM cortex during movement execution but failed to improve impaired motor preparation. PET studies indicate that subthalamic nucleus (STN) stimulation partly reverses the abnormal premotor pattern of brain activation during movement. By monitoring MRD, we aimed to assess changes in premotor and PSM cortex oscillatory activity induced by bilateral STN stimulation and to compare these changes with those induced by L-dopa. Ten Parkinson's disease patients and a group of healthy, age-matched controls performed self-paced wrist flexions in each of four conditions: without either stimulation or L-dopa (the 'off' condition), with stimulation and without L-dopa (On Stim), with L-dopa and without stimulation ('on drug'), and with both stimulation and L-dopa (On Both). Compared with the Off condition, in both the On Stim and the On Drug condition the Unified Parkinson's Disease Rating Scale (UPDRS) III score decreased by about 60% and in the On Both condition it decreased by 80%. The desynchronization latency over central regions contralateral to movement and the movement desynchronization over bilateral central regions were significantly increased by stimulation and by L-dopa, with a maximal effect when the two were associated. Furthermore, desynchronization latency significantly decreased over bilateral frontocentral regions in the three treatment conditions compared with the Off condition. In Parkinson's disease, STN stimulation may induce a change in abnormal cortical oscillatory activity patterns (similar to that produced by L-dopa) by decreasing the abnormal spreading of desynchronization over frontocentral regions and increasing PSM cortex activity during movement preparation and execution, with a correlated improvement in bradykinesia. Parkinsonians under treatment displayed a desynchronization pattern close to that seen in healthy, age-matched controls, although central latencies remained shorter. The study indicates that it is possible to influence cortical reactivity related to the planning and execution of voluntary movement through the basal ganglia, and furthermore that the oscillatory activity of the PSM cortex (in addition to that of premotor areas) could be of major importance in the control of movement-associated, neural activity in Parkinson's disease.
CC :	002B17
FD :	Parkinson maladie; Noyau sousthalamique; Noyau moteur; Système nerveux pathologie; Cortex moteur; Electroencéphalographie; Désynchronisation
FG :	Encéphale pathologie; Système nerveux central; Voie motrice; Extrapyramidal syndrome; Maladie dégénérative; Système nerveux central pathologie; Electrophysiologie; Electrodiagnostic
ED :	Parkinson disease; Subthalamic nucleus; Motor nucleus; Nervous system diseases; Motor cortex; Electroencephalography; Desynchronization
EG :	Cerebral disorder; Central nervous system; Motor pathway; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease; Electrophysiology; Electrodiagnosis
SD :	Parkinson enfermedad; Núcleo subtalámico; Núcleo motor; Sistema nervioso patología; Corteza motora; Electroencefalografía; Desincronización
LO :	INIST-998.354000116430960170
ID :	04-0453729

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Pascal:04-0453729

Le document en format XML

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<author><name sortKey="Defebvre, L" sort="Defebvre, L" uniqKey="Defebvre L" first="L." last="Defebvre">L. Defebvre</name>
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<term>Motor nucleus</term>
<term>Nervous system diseases</term>
<term>Parkinson disease</term>
<term>Subthalamic nucleus</term>
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<keywords scheme="Pascal" xml:lang="fr"><term>Parkinson maladie</term>
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<term>Noyau moteur</term>
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<front><div type="abstract" xml:lang="en">In Parkinson's disease, impaired motor preparation has been related to an increased latency in the appearance of movement-related desynchronization (MRD) throughout the contralateral primary sensorimotor (PSM) cortex. Internal globus pallidus (GPi) stimulation improved movement desynchronization over the PSM cortex during movement execution but failed to improve impaired motor preparation. PET studies indicate that subthalamic nucleus (STN) stimulation partly reverses the abnormal premotor pattern of brain activation during movement. By monitoring MRD, we aimed to assess changes in premotor and PSM cortex oscillatory activity induced by bilateral STN stimulation and to compare these changes with those induced by L-dopa. Ten Parkinson's disease patients and a group of healthy, age-matched controls performed self-paced wrist flexions in each of four conditions: without either stimulation or L-dopa (the 'off' condition), with stimulation and without L-dopa (On Stim), with L-dopa and without stimulation ('on drug'), and with both stimulation and L-dopa (On Both). Compared with the Off condition, in both the On Stim and the On Drug condition the Unified Parkinson's Disease Rating Scale (UPDRS) III score decreased by about 60% and in the On Both condition it decreased by 80%. The desynchronization latency over central regions contralateral to movement and the movement desynchronization over bilateral central regions were significantly increased by stimulation and by L-dopa, with a maximal effect when the two were associated. Furthermore, desynchronization latency significantly decreased over bilateral frontocentral regions in the three treatment conditions compared with the Off condition. In Parkinson's disease, STN stimulation may induce a change in abnormal cortical oscillatory activity patterns (similar to that produced by L-dopa) by decreasing the abnormal spreading of desynchronization over frontocentral regions and increasing PSM cortex activity during movement preparation and execution, with a correlated improvement in bradykinesia. Parkinsonians under treatment displayed a desynchronization pattern close to that seen in healthy, age-matched controls, although central latencies remained shorter. The study indicates that it is possible to influence cortical reactivity related to the planning and execution of voluntary movement through the basal ganglia, and furthermore that the oscillatory activity of the PSM cortex (in addition to that of premotor areas) could be of major importance in the control of movement-associated, neural activity in Parkinson's disease.</div>
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<ET>Subthalamic nucleus stimulation modulates motor cortex oscillatory activity in Parkinson's disease</ET>
<AU>DEVOS (D.); LABYT (E.); DERAMBURE (P.); BOURRIEZ (J. L.); CASSIM (F.); REYNS (N.); BLOND (S.); GUIEU (J. D.); DESTEE (A.); DEFEBVRE (L.)</AU>
<AF>Department of Neurology, EA2683, Lille University Medical Centre/Lille/France (1 aut., 9 aut., 10 aut.); Department of Clinical Neurophysiology, EA2683, Lille University Medical Centre/Lille/France (2 aut., 3 aut., 4 aut., 5 aut., 8 aut.); Department of Neurosurgery, EA2683, Lille University Medical Centre/Lille/France (6 aut., 7 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Brain; ISSN 0006-8950; Royaume-Uni; Da. 2004; Vol. 127; No. p.2; Pp. 408-419; Bibl. 1 p.3/4</SO>
<LA>Anglais</LA>
<EA>In Parkinson's disease, impaired motor preparation has been related to an increased latency in the appearance of movement-related desynchronization (MRD) throughout the contralateral primary sensorimotor (PSM) cortex. Internal globus pallidus (GPi) stimulation improved movement desynchronization over the PSM cortex during movement execution but failed to improve impaired motor preparation. PET studies indicate that subthalamic nucleus (STN) stimulation partly reverses the abnormal premotor pattern of brain activation during movement. By monitoring MRD, we aimed to assess changes in premotor and PSM cortex oscillatory activity induced by bilateral STN stimulation and to compare these changes with those induced by L-dopa. Ten Parkinson's disease patients and a group of healthy, age-matched controls performed self-paced wrist flexions in each of four conditions: without either stimulation or L-dopa (the 'off' condition), with stimulation and without L-dopa (On Stim), with L-dopa and without stimulation ('on drug'), and with both stimulation and L-dopa (On Both). Compared with the Off condition, in both the On Stim and the On Drug condition the Unified Parkinson's Disease Rating Scale (UPDRS) III score decreased by about 60% and in the On Both condition it decreased by 80%. The desynchronization latency over central regions contralateral to movement and the movement desynchronization over bilateral central regions were significantly increased by stimulation and by L-dopa, with a maximal effect when the two were associated. Furthermore, desynchronization latency significantly decreased over bilateral frontocentral regions in the three treatment conditions compared with the Off condition. In Parkinson's disease, STN stimulation may induce a change in abnormal cortical oscillatory activity patterns (similar to that produced by L-dopa) by decreasing the abnormal spreading of desynchronization over frontocentral regions and increasing PSM cortex activity during movement preparation and execution, with a correlated improvement in bradykinesia. Parkinsonians under treatment displayed a desynchronization pattern close to that seen in healthy, age-matched controls, although central latencies remained shorter. The study indicates that it is possible to influence cortical reactivity related to the planning and execution of voluntary movement through the basal ganglia, and furthermore that the oscillatory activity of the PSM cortex (in addition to that of premotor areas) could be of major importance in the control of movement-associated, neural activity in Parkinson's disease.</EA>
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<FD>Parkinson maladie; Noyau sousthalamique; Noyau moteur; Système nerveux pathologie; Cortex moteur; Electroencéphalographie; Désynchronisation</FD>
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<ED>Parkinson disease; Subthalamic nucleus; Motor nucleus; Nervous system diseases; Motor cortex; Electroencephalography; Desynchronization</ED>
<EG>Cerebral disorder; Central nervous system; Motor pathway; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease; Electrophysiology; Electrodiagnosis</EG>
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	La maladie de Parkinson en France (serveur d'exploration)
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La maladie de Parkinson en France (serveur d'exploration)

Subthalamic nucleus stimulation modulates motor cortex oscillatory activity in Parkinson's disease

Subthalamic nucleus stimulation modulates motor cortex oscillatory activity in Parkinson's disease

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