In mice, production of plasma IL-1 and IL-6 in response to MPTP is related to behavioral lateralization
Identifieur interne : 000C86 ( PascalFrancis/Corpus ); précédent : 000C85; suivant : 000C87In mice, production of plasma IL-1 and IL-6 in response to MPTP is related to behavioral lateralization
Auteurs : Yan-Qin Shen ; Guillaume Hebert ; Yun Su ; Elizabeth Moze ; Pierre J. Neveu ; Kang-Sheng LiSource :
- Brain research [ 0006-8993 ] ; 2005.
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- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
l-Methyl-4-phenyl-l,2,3,6-tetrahydropyridine (MPTP) induces dopaminergic neuron death in substantia nigra and dopamine loss in striatum, similar to those observed in Parkinson disease. Given MPTP can also induce alterations in brain cytokines and in peripheral immune parameters, we hypothesize that MPTP can induce an elevation of plasma cytokines. We have previously shown that cytokine production depends on behavioral lateralization in certain conditions. Therefore, we further postulate that the MPTP-induced plasma cytokines are related to behavioral lateralization. To answer these questions, C57BL/6J male mice, selected for paw preference, were injected with 25 mg/ kg MPTP ip for five consecutive days and were decapitated at day 1, day 3, or day 14 after the last injection. Striatal DA and DOPAC concentration were measured by HPLC and plasma levels of IL-1β and IL-6 were quantified by ELISA. The results showed that after MPTP treatment, striatal DA content was dramatically decreased, IL-1β levels increased on day 3, while IL-6 levels increased on day 14. Interestingly, behavioral lateralization influenced DA/DOPAC ratio as well as plasma IL-1β and IL-6 levels. In left-pawed mice, MPTP induced a higher decrease of DA/DOPAC ratio than in right-pawed mice. The increase of IL-1β was observed in left-pawed but not in right-pawed mice. The elevation of IL-6 was higher in right-pawed mice than in left-pawed mice. These results have clearly demonstrated our hypotheses, that MPTP can induce increase of plasma IL-1β and IL-6 levels in mice, and this effect is shaped by behavioral lateralization.
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Format Inist (serveur)
| NO : | PASCAL 05-0267538 INIST |
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| ET : | In mice, production of plasma IL-1 and IL-6 in response to MPTP is related to behavioral lateralization |
| AU : | SHEN (Yan-Qin); HEBERT (Guillaume); SU (Yun); MOZE (Elizabeth); NEVEU (Pierre J.); LI (Kang-Sheng) |
| AF : | Department of Microbiology and Immunology, Shantou University Medical College. 22 Xinling Road/Shantou 515031, Guangdong/Chine (1 aut., 6 aut.); Neurobiologie Intégrative, UMR CNRS FRE2723, Institut François Magendie, Rue Camille Saint-Saëns/33077 Bordeaux/France (1 aut., 2 aut., 3 aut., 4 aut., 5 aut.) |
| DT : | Publication en série; Niveau analytique |
| SO : | Brain research; ISSN 0006-8993; Coden BRREAP; Pays-Bas; Da. 2005; Vol. 1045; No. 1-2; Pp. 31-37; Bibl. 38 ref. |
| LA : | Anglais |
| EA : | l-Methyl-4-phenyl-l,2,3,6-tetrahydropyridine (MPTP) induces dopaminergic neuron death in substantia nigra and dopamine loss in striatum, similar to those observed in Parkinson disease. Given MPTP can also induce alterations in brain cytokines and in peripheral immune parameters, we hypothesize that MPTP can induce an elevation of plasma cytokines. We have previously shown that cytokine production depends on behavioral lateralization in certain conditions. Therefore, we further postulate that the MPTP-induced plasma cytokines are related to behavioral lateralization. To answer these questions, C57BL/6J male mice, selected for paw preference, were injected with 25 mg/ kg MPTP ip for five consecutive days and were decapitated at day 1, day 3, or day 14 after the last injection. Striatal DA and DOPAC concentration were measured by HPLC and plasma levels of IL-1β and IL-6 were quantified by ELISA. The results showed that after MPTP treatment, striatal DA content was dramatically decreased, IL-1β levels increased on day 3, while IL-6 levels increased on day 14. Interestingly, behavioral lateralization influenced DA/DOPAC ratio as well as plasma IL-1β and IL-6 levels. In left-pawed mice, MPTP induced a higher decrease of DA/DOPAC ratio than in right-pawed mice. The increase of IL-1β was observed in left-pawed but not in right-pawed mice. The elevation of IL-6 was higher in right-pawed mice than in left-pawed mice. These results have clearly demonstrated our hypotheses, that MPTP can induce increase of plasma IL-1β and IL-6 levels in mice, and this effect is shaped by behavioral lateralization. |
| CC : | 002B17G |
| FD : | Animal; Interleukine 1; Interleukine 6; Neurotoxine; Comportement; Spécialisation hémisphérique; Latéralité; Interleukine 1β; Encéphale; Asymétrie; Souris; Parkinson maladie; MPTP |
| FG : | Toxine; Cytokine; Système nerveux central; Maladie dégénérative; Système nerveux pathologie; Encéphale pathologie; Extrapyramidal syndrome; Système nerveux central pathologie; Rodentia; Mammalia; Vertebrata |
| ED : | Animal; Interleukin 1; Interleukin 6; Neurotoxin; Behavior; Hemispheric specialization; Laterality; Interleukin 1β; Encephalon; Asymmetry; Mouse; Parkinson disease |
| EG : | Toxin; Cytokine; Central nervous system; Degenerative disease; Nervous system diseases; Cerebral disorder; Extrapyramidal syndrome; Central nervous system disease; Rodentia; Mammalia; Vertebrata |
| SD : | Animal; Interleuquina 1; Interleuquina 6; Neurotoxina; Conducta; Especialización hemisférica; Lateralidad; Interleuquina 1β; Encéfalo; Asimetría; Ratón; Parkinson enfermedad |
| LO : | INIST-12895.354000124650690040 |
| ID : | 05-0267538 |
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Neveu</name><affiliation><inist:fA14 i1="02"><s1>Neurobiologie Intégrative, UMR CNRS FRE2723, Institut François Magendie, Rue Camille Saint-Saëns</s1><s2>33077 Bordeaux</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Li, Kang Sheng" sort="Li, Kang Sheng" uniqKey="Li K" first="Kang-Sheng" last="Li">Kang-Sheng Li</name><affiliation><inist:fA14 i1="01"><s1>Department of Microbiology and Immunology, Shantou University Medical College. 22 Xinling Road</s1><s2>Shantou 515031, Guangdong</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>6 aut.</sZ></inist:fA14></affiliation></author></analytic><series><title level="j" type="main">Brain research</title><title level="j" type="abbreviated">Brain res.</title><idno type="ISSN">0006-8993</idno><imprint><date when="2005">2005</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Brain research</title><title level="j" type="abbreviated">Brain res.</title><idno type="ISSN">0006-8993</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animal</term><term>Asymmetry</term><term>Behavior</term><term>Encephalon</term><term>Hemispheric specialization</term><term>Interleukin 1</term><term>Interleukin 1β</term><term>Interleukin 6</term><term>Laterality</term><term>Mouse</term><term>Neurotoxin</term><term>Parkinson disease</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Animal</term><term>Interleukine 1</term><term>Interleukine 6</term><term>Neurotoxine</term><term>Comportement</term><term>Spécialisation hémisphérique</term><term>Latéralité</term><term>Interleukine 1β</term><term>Encéphale</term><term>Asymétrie</term><term>Souris</term><term>Parkinson maladie</term><term>MPTP</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">l-Methyl-4-phenyl-l,2,3,6-tetrahydropyridine (MPTP) induces dopaminergic neuron death in substantia nigra and dopamine loss in striatum, similar to those observed in Parkinson disease. Given MPTP can also induce alterations in brain cytokines and in peripheral immune parameters, we hypothesize that MPTP can induce an elevation of plasma cytokines. We have previously shown that cytokine production depends on behavioral lateralization in certain conditions. Therefore, we further postulate that the MPTP-induced plasma cytokines are related to behavioral lateralization. To answer these questions, C57BL/6J male mice, selected for paw preference, were injected with 25 mg/ kg MPTP ip for five consecutive days and were decapitated at day 1, day 3, or day 14 after the last injection. Striatal DA and DOPAC concentration were measured by HPLC and plasma levels of IL-1β and IL-6 were quantified by ELISA. The results showed that after MPTP treatment, striatal DA content was dramatically decreased, IL-1β levels increased on day 3, while IL-6 levels increased on day 14. Interestingly, behavioral lateralization influenced DA/DOPAC ratio as well as plasma IL-1β and IL-6 levels. In left-pawed mice, MPTP induced a higher decrease of DA/DOPAC ratio than in right-pawed mice. The increase of IL-1β was observed in left-pawed but not in right-pawed mice. The elevation of IL-6 was higher in right-pawed mice than in left-pawed mice. These results have clearly demonstrated our hypotheses, that MPTP can induce increase of plasma IL-1β and IL-6 levels in mice, and this effect is shaped by behavioral lateralization.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0006-8993</s0></fA01><fA02 i1="01"><s0>BRREAP</s0></fA02><fA03 i2="1"><s0>Brain res.</s0></fA03><fA05><s2>1045</s2></fA05><fA06><s2>1-2</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>In mice, production of plasma IL-1 and IL-6 in response to MPTP is related to behavioral lateralization</s1></fA08><fA11 i1="01" i2="1"><s1>SHEN (Yan-Qin)</s1></fA11><fA11 i1="02" i2="1"><s1>HEBERT (Guillaume)</s1></fA11><fA11 i1="03" i2="1"><s1>SU (Yun)</s1></fA11><fA11 i1="04" i2="1"><s1>MOZE (Elizabeth)</s1></fA11><fA11 i1="05" i2="1"><s1>NEVEU (Pierre J.)</s1></fA11><fA11 i1="06" i2="1"><s1>LI (Kang-Sheng)</s1></fA11><fA14 i1="01"><s1>Department of Microbiology and Immunology, Shantou University Medical College. 22 Xinling Road</s1><s2>Shantou 515031, Guangdong</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>6 aut.</sZ></fA14><fA14 i1="02"><s1>Neurobiologie Intégrative, UMR CNRS FRE2723, Institut François Magendie, Rue Camille Saint-Saëns</s1><s2>33077 Bordeaux</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></fA14><fA20><s1>31-37</s1></fA20><fA21><s1>2005</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>12895</s2><s5>354000124650690040</s5></fA43><fA44><s0>0000</s0><s1>© 2005 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>38 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>05-0267538</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Brain research</s0></fA64><fA66 i1="01"><s0>NLD</s0></fA66><fC01 i1="01" l="ENG"><s0>l-Methyl-4-phenyl-l,2,3,6-tetrahydropyridine (MPTP) induces dopaminergic neuron death in substantia nigra and dopamine loss in striatum, similar to those observed in Parkinson disease. Given MPTP can also induce alterations in brain cytokines and in peripheral immune parameters, we hypothesize that MPTP can induce an elevation of plasma cytokines. We have previously shown that cytokine production depends on behavioral lateralization in certain conditions. Therefore, we further postulate that the MPTP-induced plasma cytokines are related to behavioral lateralization. To answer these questions, C57BL/6J male mice, selected for paw preference, were injected with 25 mg/ kg MPTP ip for five consecutive days and were decapitated at day 1, day 3, or day 14 after the last injection. Striatal DA and DOPAC concentration were measured by HPLC and plasma levels of IL-1β and IL-6 were quantified by ELISA. The results showed that after MPTP treatment, striatal DA content was dramatically decreased, IL-1β levels increased on day 3, while IL-6 levels increased on day 14. Interestingly, behavioral lateralization influenced DA/DOPAC ratio as well as plasma IL-1β and IL-6 levels. In left-pawed mice, MPTP induced a higher decrease of DA/DOPAC ratio than in right-pawed mice. The increase of IL-1β was observed in left-pawed but not in right-pawed mice. The elevation of IL-6 was higher in right-pawed mice than in left-pawed mice. These results have clearly demonstrated our hypotheses, that MPTP can induce increase of plasma IL-1β and IL-6 levels in mice, and this effect is shaped by behavioral lateralization.</s0></fC01><fC02 i1="01" i2="X"><s0>002B17G</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Animal</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Animal</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Animal</s0><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Interleukine 1</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Interleukin 1</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Interleuquina 1</s0><s5>02</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Interleukine 6</s0><s5>03</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Interleukin 6</s0><s5>03</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Interleuquina 6</s0><s5>03</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Neurotoxine</s0><s5>04</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Neurotoxin</s0><s5>04</s5></fC03><fC03 i1="04" i2="X" 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l="FRE"><s0>Cytokine</s0><s5>20</s5></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Cytokine</s0><s5>20</s5></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Citoquina</s0><s5>20</s5></fC07><fC07 i1="03" i2="X" l="FRE"><s0>Système nerveux central</s0><s5>21</s5></fC07><fC07 i1="03" i2="X" l="ENG"><s0>Central nervous system</s0><s5>21</s5></fC07><fC07 i1="03" i2="X" l="SPA"><s0>Sistema nervioso central</s0><s5>21</s5></fC07><fC07 i1="04" i2="X" l="FRE"><s0>Maladie dégénérative</s0><s5>22</s5></fC07><fC07 i1="04" i2="X" l="ENG"><s0>Degenerative disease</s0><s5>22</s5></fC07><fC07 i1="04" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0><s5>22</s5></fC07><fC07 i1="05" i2="X" l="FRE"><s0>Système nerveux pathologie</s0><s5>23</s5></fC07><fC07 i1="05" i2="X" l="ENG"><s0>Nervous system diseases</s0><s5>23</s5></fC07><fC07 i1="05" i2="X" l="SPA"><s0>Sistema nervioso patología</s0><s5>23</s5></fC07><fC07 i1="06" i2="X" l="FRE"><s0>Encéphale pathologie</s0><s5>24</s5></fC07><fC07 i1="06" i2="X" l="ENG"><s0>Cerebral disorder</s0><s5>24</s5></fC07><fC07 i1="06" i2="X" l="SPA"><s0>Encéfalo patología</s0><s5>24</s5></fC07><fC07 i1="07" i2="X" l="FRE"><s0>Extrapyramidal syndrome</s0><s5>25</s5></fC07><fC07 i1="07" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0><s5>25</s5></fC07><fC07 i1="07" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0><s5>25</s5></fC07><fC07 i1="08" i2="X" l="FRE"><s0>Système nerveux central pathologie</s0><s5>26</s5></fC07><fC07 i1="08" i2="X" l="ENG"><s0>Central nervous system disease</s0><s5>26</s5></fC07><fC07 i1="08" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0><s5>26</s5></fC07><fC07 i1="09" i2="X" l="FRE"><s0>Rodentia</s0><s2>NS</s2></fC07><fC07 i1="09" i2="X" l="ENG"><s0>Rodentia</s0><s2>NS</s2></fC07><fC07 i1="09" i2="X" l="SPA"><s0>Rodentia</s0><s2>NS</s2></fC07><fC07 i1="10" i2="X" l="FRE"><s0>Mammalia</s0><s2>NS</s2></fC07><fC07 i1="10" i2="X" l="ENG"><s0>Mammalia</s0><s2>NS</s2></fC07><fC07 i1="10" i2="X" l="SPA"><s0>Mammalia</s0><s2>NS</s2></fC07><fC07 i1="11" i2="X" l="FRE"><s0>Vertebrata</s0><s2>NS</s2></fC07><fC07 i1="11" i2="X" l="ENG"><s0>Vertebrata</s0><s2>NS</s2></fC07><fC07 i1="11" i2="X" l="SPA"><s0>Vertebrata</s0><s2>NS</s2></fC07><fN21><s1>185</s1></fN21></pA></standard><server><NO>PASCAL 05-0267538 INIST</NO><ET>In mice, production of plasma IL-1 and IL-6 in response to MPTP is related to behavioral lateralization</ET><AU>SHEN (Yan-Qin); HEBERT (Guillaume); SU (Yun); MOZE (Elizabeth); NEVEU (Pierre J.); LI (Kang-Sheng)</AU><AF>Department of Microbiology and Immunology, Shantou University Medical College. 22 Xinling Road/Shantou 515031, Guangdong/Chine (1 aut., 6 aut.); Neurobiologie Intégrative, UMR CNRS FRE2723, Institut François Magendie, Rue Camille Saint-Saëns/33077 Bordeaux/France (1 aut., 2 aut., 3 aut., 4 aut., 5 aut.)</AF><DT>Publication en série; Niveau analytique</DT><SO>Brain research; ISSN 0006-8993; Coden BRREAP; Pays-Bas; Da. 2005; Vol. 1045; No. 1-2; Pp. 31-37; Bibl. 38 ref.</SO><LA>Anglais</LA><EA>l-Methyl-4-phenyl-l,2,3,6-tetrahydropyridine (MPTP) induces dopaminergic neuron death in substantia nigra and dopamine loss in striatum, similar to those observed in Parkinson disease. Given MPTP can also induce alterations in brain cytokines and in peripheral immune parameters, we hypothesize that MPTP can induce an elevation of plasma cytokines. We have previously shown that cytokine production depends on behavioral lateralization in certain conditions. Therefore, we further postulate that the MPTP-induced plasma cytokines are related to behavioral lateralization. To answer these questions, C57BL/6J male mice, selected for paw preference, were injected with 25 mg/ kg MPTP ip for five consecutive days and were decapitated at day 1, day 3, or day 14 after the last injection. Striatal DA and DOPAC concentration were measured by HPLC and plasma levels of IL-1β and IL-6 were quantified by ELISA. The results showed that after MPTP treatment, striatal DA content was dramatically decreased, IL-1β levels increased on day 3, while IL-6 levels increased on day 14. Interestingly, behavioral lateralization influenced DA/DOPAC ratio as well as plasma IL-1β and IL-6 levels. In left-pawed mice, MPTP induced a higher decrease of DA/DOPAC ratio than in right-pawed mice. The increase of IL-1β was observed in left-pawed but not in right-pawed mice. The elevation of IL-6 was higher in right-pawed mice than in left-pawed mice. These results have clearly demonstrated our hypotheses, that MPTP can induce increase of plasma IL-1β and IL-6 levels in mice, and this effect is shaped by behavioral lateralization.</EA><CC>002B17G</CC><FD>Animal; Interleukine 1; Interleukine 6; Neurotoxine; Comportement; Spécialisation hémisphérique; Latéralité; Interleukine 1β; Encéphale; Asymétrie; Souris; Parkinson maladie; MPTP</FD><FG>Toxine; Cytokine; Système nerveux central; Maladie dégénérative; Système nerveux pathologie; Encéphale pathologie; Extrapyramidal syndrome; Système nerveux central pathologie; Rodentia; Mammalia; Vertebrata</FG><ED>Animal; Interleukin 1; Interleukin 6; Neurotoxin; Behavior; Hemispheric specialization; Laterality; Interleukin 1β; Encephalon; Asymmetry; Mouse; Parkinson disease</ED><EG>Toxin; Cytokine; Central nervous system; Degenerative disease; Nervous system diseases; Cerebral disorder; Extrapyramidal syndrome; Central nervous system disease; Rodentia; Mammalia; Vertebrata</EG><SD>Animal; Interleuquina 1; Interleuquina 6; Neurotoxina; Conducta; Especialización hemisférica; Lateralidad; Interleuquina 1β; Encéfalo; Asimetría; Ratón; Parkinson enfermedad</SD><LO>INIST-12895.354000124650690040</LO><ID>05-0267538</ID></server></inist></record>Pour manipuler ce document sous Unix (Dilib)
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