ParkinsonFranceV1, PascalFrancis, Corpus, bibRecord, 000C82

Saccadic eye movement changes in Parkinson's disease dementia and dementia with Lewy bodies

Identifieur interne : 000C82 ( PascalFrancis/Corpus ); précédent : 000C81; suivant : 000C83

Saccadic eye movement changes in Parkinson's disease dementia and dementia with Lewy bodies

Auteurs : Urs P. Mosimann ; René M. Müri ; David J. Burn ; Jacques Felblinger ; John T. O'Brien ; Ian G. Mckeith

Source :

Brain [ 0006-8950 ] ; 2005.

RBID : Pascal:05-0284095

Descripteurs français

Pascal (Inist)
- Système nerveux pathologie, Parkinson maladie, Démence Alzheimer, Mouvement oculaire saccadé, Démence corps Lewy, Corps Lewy maladie.

English descriptors

KwdEn :
- Alzheimer disease, Lewy body dementia, Lewy body disease, Nervous system diseases, Parkinson disease, Saccadic eye movement.

Abstract

Neurodegeneration in Parkinson's disease dementia (PDD) and dementia with Lewy bodies (DLB) affect cortical and subcortical networks involved in saccade generation. We therefore expected impairments in saccade performance in both disorders. In order to improve the pathophysiological understanding and to investigate the usefulness of saccades for differential diagnosis, saccades were tested in age- and education-matched patients with PDD (n = 20) and DLB (n = 20), Alzheimer's disease (n = 22) and Parkinson's disease (n = 24), and controls (n = 24). Reflexive (gap, overlap) and complex saccades (prediction, decision and antisaccade) were tested with electro-oculography. PDD and DLB patients had similar impairment in all tasks (P > 0.05, not significant). Compared with controls, they were impaired in both reflexive saccade execution (gap and overlap latencies, P < 0.0001; gains, P < 0.004) and complex saccade performance (target prediction, P < 0.0001; error decisions, P < 0.003; error antisaccades: P < 0.0001). Patients with Alzheimer's disease were only impaired in complex saccade performance (Alzheimer's disease versus controls, target prediction P < 0.001, error decisions P < 0.0001, error antisaccades P < 0.0001), but not reflexive saccade execution (for all, P > 0.05). Patients with Parkinson's disease had, compared with controls, similar complex saccade performance (for all, P > 0.05) and only minimal impairment in reflexive tasks, i.e. hypometric gain in the gap task (P = 0.04). Impaired saccade execution in reflexive tasks allowed discrimination between DLB versus Alzheimer's disease (sensitivity ≥60%, specificity ≥77%) and between PDD versus Parkinson's disease (sensitivity ≥60%, specificity ≥88%) when ±1.5 standard deviations was used for group discrimination. We conclude that impairments in reflexive saccades may be helpful for differential diagnosis and are minimal when either cortical (Alzheimer's disease) or nigrostriatal neurodegeneration (Parkinson's disease) exists solely; however, they become prominent with combined cortical and subcortical neurodegeneration in PDD and DLB. The similarities in saccade performance in PDD and DLB underline the overlap between these conditions and underscore differences from Alzheimer's disease and Parkinson's disease.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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Format Inist (serveur)

NO :	PASCAL 05-0284095 INIST
ET :	Saccadic eye movement changes in Parkinson's disease dementia and dementia with Lewy bodies
AU :	MOSIMANN (Urs P.); MÜRI (René M.); BURN (David J.); FELBLINGER (Jacques); O'BRIEN (John T.); MCKEITH (Ian G.)
AF :	Institute for Ageing and Health, Newcastle General Hospital/Newcastle upon Tyne/Royaume-Uni (1 aut., 3 aut., 5 aut., 6 aut.); Perception and Eye Movement Laboratory, Departments of Neurology and Clinical Research, Inselspital/Bern/Suisse (1 aut., 2 aut.); Department of Radiology, University Hospital of Nancy/Vandoeuvre/France (4 aut.)
DT :	Publication en série; Niveau analytique
SO :	Brain; ISSN 0006-8950; Royaume-Uni; Da. 2005; Vol. 128; No. p.6; Pp. 1267-1276; Bibl. 1 p.1/4
LA :	Anglais
EA :	Neurodegeneration in Parkinson's disease dementia (PDD) and dementia with Lewy bodies (DLB) affect cortical and subcortical networks involved in saccade generation. We therefore expected impairments in saccade performance in both disorders. In order to improve the pathophysiological understanding and to investigate the usefulness of saccades for differential diagnosis, saccades were tested in age- and education-matched patients with PDD (n = 20) and DLB (n = 20), Alzheimer's disease (n = 22) and Parkinson's disease (n = 24), and controls (n = 24). Reflexive (gap, overlap) and complex saccades (prediction, decision and antisaccade) were tested with electro-oculography. PDD and DLB patients had similar impairment in all tasks (P > 0.05, not significant). Compared with controls, they were impaired in both reflexive saccade execution (gap and overlap latencies, P < 0.0001; gains, P < 0.004) and complex saccade performance (target prediction, P < 0.0001; error decisions, P < 0.003; error antisaccades: P < 0.0001). Patients with Alzheimer's disease were only impaired in complex saccade performance (Alzheimer's disease versus controls, target prediction P < 0.001, error decisions P < 0.0001, error antisaccades P < 0.0001), but not reflexive saccade execution (for all, P > 0.05). Patients with Parkinson's disease had, compared with controls, similar complex saccade performance (for all, P > 0.05) and only minimal impairment in reflexive tasks, i.e. hypometric gain in the gap task (P = 0.04). Impaired saccade execution in reflexive tasks allowed discrimination between DLB versus Alzheimer's disease (sensitivity ≥60%, specificity ≥77%) and between PDD versus Parkinson's disease (sensitivity ≥60%, specificity ≥88%) when ±1.5 standard deviations was used for group discrimination. We conclude that impairments in reflexive saccades may be helpful for differential diagnosis and are minimal when either cortical (Alzheimer's disease) or nigrostriatal neurodegeneration (Parkinson's disease) exists solely; however, they become prominent with combined cortical and subcortical neurodegeneration in PDD and DLB. The similarities in saccade performance in PDD and DLB underline the overlap between these conditions and underscore differences from Alzheimer's disease and Parkinson's disease.
CC :	002B17; 002B17G; 002B17A02
FD :	Système nerveux pathologie; Parkinson maladie; Démence Alzheimer; Mouvement oculaire saccadé; Démence corps Lewy; Corps Lewy maladie
FG :	Encéphale pathologie; Extrapyramidal syndrome; Maladie dégénérative; Système nerveux central pathologie
ED :	Nervous system diseases; Parkinson disease; Alzheimer disease; Saccadic eye movement; Lewy body dementia; Lewy body disease
EG :	Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease
SD :	Sistema nervioso patología; Parkinson enfermedad; Demencia Alzheimer; Movimiento ocular brusco; Demencia cuerpos Lewy; Cuerpo Lewy enfermedad
LO :	INIST-998.354000124801340050
ID :	05-0284095

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Pascal:05-0284095

Le document en format XML

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<front><div type="abstract" xml:lang="en">Neurodegeneration in Parkinson's disease dementia (PDD) and dementia with Lewy bodies (DLB) affect cortical and subcortical networks involved in saccade generation. We therefore expected impairments in saccade performance in both disorders. In order to improve the pathophysiological understanding and to investigate the usefulness of saccades for differential diagnosis, saccades were tested in age- and education-matched patients with PDD (n = 20) and DLB (n = 20), Alzheimer's disease (n = 22) and Parkinson's disease (n = 24), and controls (n = 24). Reflexive (gap, overlap) and complex saccades (prediction, decision and antisaccade) were tested with electro-oculography. PDD and DLB patients had similar impairment in all tasks (P > 0.05, not significant). Compared with controls, they were impaired in both reflexive saccade execution (gap and overlap latencies, P < 0.0001; gains, P < 0.004) and complex saccade performance (target prediction, P < 0.0001; error decisions, P < 0.003; error antisaccades: P < 0.0001). Patients with Alzheimer's disease were only impaired in complex saccade performance (Alzheimer's disease versus controls, target prediction P < 0.001, error decisions P < 0.0001, error antisaccades P < 0.0001), but not reflexive saccade execution (for all, P > 0.05). Patients with Parkinson's disease had, compared with controls, similar complex saccade performance (for all, P > 0.05) and only minimal impairment in reflexive tasks, i.e. hypometric gain in the gap task (P = 0.04). Impaired saccade execution in reflexive tasks allowed discrimination between DLB versus Alzheimer's disease (sensitivity ≥60%, specificity ≥77%) and between PDD versus Parkinson's disease (sensitivity ≥60%, specificity ≥88%) when ±1.5 standard deviations was used for group discrimination. We conclude that impairments in reflexive saccades may be helpful for differential diagnosis and are minimal when either cortical (Alzheimer's disease) or nigrostriatal neurodegeneration (Parkinson's disease) exists solely; however, they become prominent with combined cortical and subcortical neurodegeneration in PDD and DLB. The similarities in saccade performance in PDD and DLB underline the overlap between these conditions and underscore differences from Alzheimer's disease and Parkinson's disease.</div>
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<ET>Saccadic eye movement changes in Parkinson's disease dementia and dementia with Lewy bodies</ET>
<AU>MOSIMANN (Urs P.); MÜRI (René M.); BURN (David J.); FELBLINGER (Jacques); O'BRIEN (John T.); MCKEITH (Ian G.)</AU>
<AF>Institute for Ageing and Health, Newcastle General Hospital/Newcastle upon Tyne/Royaume-Uni (1 aut., 3 aut., 5 aut., 6 aut.); Perception and Eye Movement Laboratory, Departments of Neurology and Clinical Research, Inselspital/Bern/Suisse (1 aut., 2 aut.); Department of Radiology, University Hospital of Nancy/Vandoeuvre/France (4 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Brain; ISSN 0006-8950; Royaume-Uni; Da. 2005; Vol. 128; No. p.6; Pp. 1267-1276; Bibl. 1 p.1/4</SO>
<LA>Anglais</LA>
<EA>Neurodegeneration in Parkinson's disease dementia (PDD) and dementia with Lewy bodies (DLB) affect cortical and subcortical networks involved in saccade generation. We therefore expected impairments in saccade performance in both disorders. In order to improve the pathophysiological understanding and to investigate the usefulness of saccades for differential diagnosis, saccades were tested in age- and education-matched patients with PDD (n = 20) and DLB (n = 20), Alzheimer's disease (n = 22) and Parkinson's disease (n = 24), and controls (n = 24). Reflexive (gap, overlap) and complex saccades (prediction, decision and antisaccade) were tested with electro-oculography. PDD and DLB patients had similar impairment in all tasks (P > 0.05, not significant). Compared with controls, they were impaired in both reflexive saccade execution (gap and overlap latencies, P < 0.0001; gains, P < 0.004) and complex saccade performance (target prediction, P < 0.0001; error decisions, P < 0.003; error antisaccades: P < 0.0001). Patients with Alzheimer's disease were only impaired in complex saccade performance (Alzheimer's disease versus controls, target prediction P < 0.001, error decisions P < 0.0001, error antisaccades P < 0.0001), but not reflexive saccade execution (for all, P > 0.05). Patients with Parkinson's disease had, compared with controls, similar complex saccade performance (for all, P > 0.05) and only minimal impairment in reflexive tasks, i.e. hypometric gain in the gap task (P = 0.04). Impaired saccade execution in reflexive tasks allowed discrimination between DLB versus Alzheimer's disease (sensitivity ≥60%, specificity ≥77%) and between PDD versus Parkinson's disease (sensitivity ≥60%, specificity ≥88%) when ±1.5 standard deviations was used for group discrimination. We conclude that impairments in reflexive saccades may be helpful for differential diagnosis and are minimal when either cortical (Alzheimer's disease) or nigrostriatal neurodegeneration (Parkinson's disease) exists solely; however, they become prominent with combined cortical and subcortical neurodegeneration in PDD and DLB. The similarities in saccade performance in PDD and DLB underline the overlap between these conditions and underscore differences from Alzheimer's disease and Parkinson's disease.</EA>
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<ED>Nervous system diseases; Parkinson disease; Alzheimer disease; Saccadic eye movement; Lewy body dementia; Lewy body disease</ED>
<EG>Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease</EG>
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	La maladie de Parkinson en France (serveur d'exploration)
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La maladie de Parkinson en France (serveur d'exploration)

Saccadic eye movement changes in Parkinson's disease dementia and dementia with Lewy bodies

Saccadic eye movement changes in Parkinson's disease dementia and dementia with Lewy bodies

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