Comparative analysis of gait and speech in Parkinson's disease: hypokinetic or dysrhythmic disorders?
Identifieur interne : 000613 ( PascalFrancis/Corpus ); précédent : 000612; suivant : 000614Comparative analysis of gait and speech in Parkinson's disease: hypokinetic or dysrhythmic disorders?
Auteurs : Stéphanie Cantiniaux ; Marianne Vaugoyeau ; Danièle Robert ; Christine Horrelou-Pitek ; Julien Mancini ; Tatiana Witjas ; Jean-Philippe AzulaySource :
- Journal of neurology, neurosurgery and psychiatry [ 0022-3050 ] ; 2010.
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- Pascal (Inist)
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Abstract
Gait and speech are automatic motor activities which are frequently impaired in Parkinson's disease. Obvious clinical similarities exist between these disorders but were never investigated. We propose to determine whether there exist any common features in Parkinson's disease between spatiotemporal gait disorders and temporal speech disorders. Gait and speech were analysed on 11 Parkinsonian patients (PP) undergoing deep-brain stimulation of the subthalamic nucleus (STN-DBS) and 11 control subjects under three conditions of velocity (natural, slow and speed). The patients were tested with and without L-dopa and stimulator ON or OFF. Locomotor parameters were recorded using an optoelectronic system. Speech parameters were recorded with a headphone while subjects were reading a short paragraph. The results confirmed that PP walk and read more slowly than controls. Patient's difficulties in modulating walking and speech velocities seem to be due mainly to an inability to internally control the step length and the interpause-speech duration (ISD). STN-DBS and levodopa increased patients' walking velocity by increasing the step length. STN-DBS and levodopa had no effect on speech velocity but restored the patients' ability to modulate the ISD. The walking cadence and speech index of rythmicity tended to be lower in patients and were not significantly improved by STN-DBS or levodopa. Speech and walking velocity as well as ISD and step length were correlated in both groups. Negative correlations between speech index of and walking cadence were observed in both groups. Similar fundamental hypokinetic impairment and probably a similar rhythmic factor similarly affected the patients' speech and gait. These results suggest a similar physiopathological process in both walking and speaking dysfunction.
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| NO : | PASCAL 10-0079693 INIST |
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| ET : | Comparative analysis of gait and speech in Parkinson's disease: hypokinetic or dysrhythmic disorders? |
| AU : | CANTINIAUX (Stéphanie); VAUGOYEAU (Marianne); ROBERT (Danièle); HORRELOU-PITEK (Christine); MANCINI (Julien); WITJAS (Tatiana); AZULAY (Jean-Philippe) |
| AF : | Department of Neurological Sciences, Movement Disorders Unit, hôpital de la Timone/Marseille/France (1 aut., 6 aut., 7 aut.); CNRS-Université Provence, Site Saint Charles/Marseille/France (1 aut., 2 aut., 7 aut.); Department of Otorhinolaryngology, Hôpital de la Timone/Marseille/France (3 aut., 4 aut.); Aix Marseille Université, LERTIM/Marseille/France (5 aut.); Department of Public Health and Medical Information t, hôpital de la Timone/Marseille/France (5 aut.) |
| DT : | Publication en série; Papier de recherche; Niveau analytique |
| SO : | Journal of neurology, neurosurgery and psychiatry; ISSN 0022-3050; Coden JNNPAU; Royaume-Uni; Da. 2010; Vol. 81; No. 2; Pp. 177-184; Bibl. 32 ref. |
| LA : | Anglais |
| EA : | Gait and speech are automatic motor activities which are frequently impaired in Parkinson's disease. Obvious clinical similarities exist between these disorders but were never investigated. We propose to determine whether there exist any common features in Parkinson's disease between spatiotemporal gait disorders and temporal speech disorders. Gait and speech were analysed on 11 Parkinsonian patients (PP) undergoing deep-brain stimulation of the subthalamic nucleus (STN-DBS) and 11 control subjects under three conditions of velocity (natural, slow and speed). The patients were tested with and without L-dopa and stimulator ON or OFF. Locomotor parameters were recorded using an optoelectronic system. Speech parameters were recorded with a headphone while subjects were reading a short paragraph. The results confirmed that PP walk and read more slowly than controls. Patient's difficulties in modulating walking and speech velocities seem to be due mainly to an inability to internally control the step length and the interpause-speech duration (ISD). STN-DBS and levodopa increased patients' walking velocity by increasing the step length. STN-DBS and levodopa had no effect on speech velocity but restored the patients' ability to modulate the ISD. The walking cadence and speech index of rythmicity tended to be lower in patients and were not significantly improved by STN-DBS or levodopa. Speech and walking velocity as well as ISD and step length were correlated in both groups. Negative correlations between speech index of and walking cadence were observed in both groups. Similar fundamental hypokinetic impairment and probably a similar rhythmic factor similarly affected the patients' speech and gait. These results suggest a similar physiopathological process in both walking and speaking dysfunction. |
| CC : | 002B17; 002B17G |
| FD : | Maladie de Parkinson; Pathologie du système nerveux; Parole |
| FG : | Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du système nerveux central |
| ED : | Parkinson disease; Nervous system diseases; Speech |
| EG : | Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease |
| SD : | Parkinson enfermedad; Sistema nervioso patología; Habla |
| LO : | INIST-6015.354000189992770130 |
| ID : | 10-0079693 |
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aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Horrelou Pitek, Christine" sort="Horrelou Pitek, Christine" uniqKey="Horrelou Pitek C" first="Christine" last="Horrelou-Pitek">Christine Horrelou-Pitek</name><affiliation><inist:fA14 i1="03"><s1>Department of Otorhinolaryngology, Hôpital de la Timone</s1><s2>Marseille</s2><s3>FRA</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Mancini, Julien" sort="Mancini, Julien" uniqKey="Mancini J" first="Julien" last="Mancini">Julien Mancini</name><affiliation><inist:fA14 i1="04"><s1>Aix Marseille Université, LERTIM</s1><s2>Marseille</s2><s3>FRA</s3><sZ>5 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="05"><s1>Department of Public Health and Medical Information t, hôpital de la Timone</s1><s2>Marseille</s2><s3>FRA</s3><sZ>5 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Witjas, Tatiana" sort="Witjas, Tatiana" uniqKey="Witjas T" first="Tatiana" last="Witjas">Tatiana Witjas</name><affiliation><inist:fA14 i1="01"><s1>Department of Neurological Sciences, Movement Disorders Unit, hôpital de la Timone</s1><s2>Marseille</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Azulay, Jean Philippe" sort="Azulay, Jean Philippe" uniqKey="Azulay J" first="Jean-Philippe" last="Azulay">Jean-Philippe Azulay</name><affiliation><inist:fA14 i1="01"><s1>Department of Neurological Sciences, Movement Disorders Unit, hôpital de la Timone</s1><s2>Marseille</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="02"><s1>CNRS-Université Provence, Site Saint Charles</s1><s2>Marseille</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>7 aut.</sZ></inist:fA14></affiliation></author></analytic><series><title level="j" type="main">Journal of neurology, neurosurgery and psychiatry</title><title level="j" type="abbreviated">J. neurol. neurosurg. psychiatry</title><idno type="ISSN">0022-3050</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Journal of neurology, neurosurgery and psychiatry</title><title level="j" type="abbreviated">J. neurol. neurosurg. psychiatry</title><idno type="ISSN">0022-3050</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Nervous system diseases</term><term>Parkinson disease</term><term>Speech</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Maladie de Parkinson</term><term>Pathologie du système nerveux</term><term>Parole</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Gait and speech are automatic motor activities which are frequently impaired in Parkinson's disease. Obvious clinical similarities exist between these disorders but were never investigated. We propose to determine whether there exist any common features in Parkinson's disease between spatiotemporal gait disorders and temporal speech disorders. Gait and speech were analysed on 11 Parkinsonian patients (PP) undergoing deep-brain stimulation of the subthalamic nucleus (STN-DBS) and 11 control subjects under three conditions of velocity (natural, slow and speed). The patients were tested with and without L-dopa and stimulator ON or OFF. Locomotor parameters were recorded using an optoelectronic system. Speech parameters were recorded with a headphone while subjects were reading a short paragraph. The results confirmed that PP walk and read more slowly than controls. Patient's difficulties in modulating walking and speech velocities seem to be due mainly to an inability to internally control the step length and the interpause-speech duration (ISD). STN-DBS and levodopa increased patients' walking velocity by increasing the step length. STN-DBS and levodopa had no effect on speech velocity but restored the patients' ability to modulate the ISD. The walking cadence and speech index of rythmicity tended to be lower in patients and were not significantly improved by STN-DBS or levodopa. Speech and walking velocity as well as ISD and step length were correlated in both groups. Negative correlations between speech index of and walking cadence were observed in both groups. Similar fundamental hypokinetic impairment and probably a similar rhythmic factor similarly affected the patients' speech and gait. These results suggest a similar physiopathological process in both walking and speaking dysfunction.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0022-3050</s0></fA01><fA02 i1="01"><s0>JNNPAU</s0></fA02><fA03 i2="1"><s0>J. neurol. neurosurg. psychiatry</s0></fA03><fA05><s2>81</s2></fA05><fA06><s2>2</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Comparative analysis of gait and speech in Parkinson's disease: hypokinetic or dysrhythmic disorders?</s1></fA08><fA11 i1="01" i2="1"><s1>CANTINIAUX (Stéphanie)</s1></fA11><fA11 i1="02" i2="1"><s1>VAUGOYEAU (Marianne)</s1></fA11><fA11 i1="03" i2="1"><s1>ROBERT (Danièle)</s1></fA11><fA11 i1="04" i2="1"><s1>HORRELOU-PITEK (Christine)</s1></fA11><fA11 i1="05" i2="1"><s1>MANCINI (Julien)</s1></fA11><fA11 i1="06" i2="1"><s1>WITJAS (Tatiana)</s1></fA11><fA11 i1="07" i2="1"><s1>AZULAY (Jean-Philippe)</s1></fA11><fA14 i1="01"><s1>Department of Neurological Sciences, Movement Disorders Unit, hôpital de la Timone</s1><s2>Marseille</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></fA14><fA14 i1="02"><s1>CNRS-Université Provence, Site Saint Charles</s1><s2>Marseille</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>7 aut.</sZ></fA14><fA14 i1="03"><s1>Department of Otorhinolaryngology, Hôpital de la Timone</s1><s2>Marseille</s2><s3>FRA</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ></fA14><fA14 i1="04"><s1>Aix Marseille Université, LERTIM</s1><s2>Marseille</s2><s3>FRA</s3><sZ>5 aut.</sZ></fA14><fA14 i1="05"><s1>Department of Public Health and Medical Information t, hôpital de la Timone</s1><s2>Marseille</s2><s3>FRA</s3><sZ>5 aut.</sZ></fA14><fA20><s1>177-184</s1></fA20><fA21><s1>2010</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>6015</s2><s5>354000189992770130</s5></fA43><fA44><s0>0000</s0><s1>© 2010 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>32 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>10-0079693</s0></fA47><fA60><s1>P</s1><s3>PR</s3></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Journal of neurology, neurosurgery and psychiatry</s0></fA64><fA66 i1="01"><s0>GBR</s0></fA66><fC01 i1="01" l="ENG"><s0>Gait and speech are automatic motor activities which are frequently impaired in Parkinson's disease. Obvious clinical similarities exist between these disorders but were never investigated. We propose to determine whether there exist any common features in Parkinson's disease between spatiotemporal gait disorders and temporal speech disorders. Gait and speech were analysed on 11 Parkinsonian patients (PP) undergoing deep-brain stimulation of the subthalamic nucleus (STN-DBS) and 11 control subjects under three conditions of velocity (natural, slow and speed). The patients were tested with and without L-dopa and stimulator ON or OFF. Locomotor parameters were recorded using an optoelectronic system. Speech parameters were recorded with a headphone while subjects were reading a short paragraph. The results confirmed that PP walk and read more slowly than controls. Patient's difficulties in modulating walking and speech velocities seem to be due mainly to an inability to internally control the step length and the interpause-speech duration (ISD). STN-DBS and levodopa increased patients' walking velocity by increasing the step length. STN-DBS and levodopa had no effect on speech velocity but restored the patients' ability to modulate the ISD. The walking cadence and speech index of rythmicity tended to be lower in patients and were not significantly improved by STN-DBS or levodopa. Speech and walking velocity as well as ISD and step length were correlated in both groups. Negative correlations between speech index of and walking cadence were observed in both groups. Similar fundamental hypokinetic impairment and probably a similar rhythmic factor similarly affected the patients' speech and gait. These results suggest a similar physiopathological process in both walking and speaking dysfunction.</s0></fC01><fC02 i1="01" i2="X"><s0>002B17</s0></fC02><fC02 i1="02" i2="X"><s0>002B17G</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Maladie de Parkinson</s0><s2>NM</s2><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Parkinson disease</s0><s2>NM</s2><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Parkinson enfermedad</s0><s2>NM</s2><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Pathologie du système nerveux</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Nervous system diseases</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Sistema nervioso patología</s0><s5>02</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Parole</s0><s5>09</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Speech</s0><s5>09</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Habla</s0><s5>09</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Pathologie de l'encéphale</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Cerebral disorder</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Encéfalo patología</s0><s5>37</s5></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Syndrome extrapyramidal</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0><s5>38</s5></fC07><fC07 i1="03" i2="X" l="FRE"><s0>Maladie dégénérative</s0><s5>39</s5></fC07><fC07 i1="03" i2="X" l="ENG"><s0>Degenerative disease</s0><s5>39</s5></fC07><fC07 i1="03" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0><s5>39</s5></fC07><fC07 i1="04" i2="X" l="FRE"><s0>Pathologie du système nerveux central</s0><s5>40</s5></fC07><fC07 i1="04" i2="X" l="ENG"><s0>Central nervous system disease</s0><s5>40</s5></fC07><fC07 i1="04" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0><s5>40</s5></fC07><fN21><s1>053</s1></fN21><fN44 i1="01"><s1>OTO</s1></fN44><fN82><s1>OTO</s1></fN82></pA></standard><server><NO>PASCAL 10-0079693 INIST</NO><ET>Comparative analysis of gait and speech in Parkinson's disease: hypokinetic or dysrhythmic disorders?</ET><AU>CANTINIAUX (Stéphanie); VAUGOYEAU (Marianne); ROBERT (Danièle); HORRELOU-PITEK (Christine); MANCINI (Julien); WITJAS (Tatiana); AZULAY (Jean-Philippe)</AU><AF>Department of Neurological Sciences, Movement Disorders Unit, hôpital de la Timone/Marseille/France (1 aut., 6 aut., 7 aut.); CNRS-Université Provence, Site Saint Charles/Marseille/France (1 aut., 2 aut., 7 aut.); Department of Otorhinolaryngology, Hôpital de la Timone/Marseille/France (3 aut., 4 aut.); Aix Marseille Université, LERTIM/Marseille/France (5 aut.); Department of Public Health and Medical Information t, hôpital de la Timone/Marseille/France (5 aut.)</AF><DT>Publication en série; Papier de recherche; Niveau analytique</DT><SO>Journal of neurology, neurosurgery and psychiatry; ISSN 0022-3050; Coden JNNPAU; Royaume-Uni; Da. 2010; Vol. 81; No. 2; Pp. 177-184; Bibl. 32 ref.</SO><LA>Anglais</LA><EA>Gait and speech are automatic motor activities which are frequently impaired in Parkinson's disease. Obvious clinical similarities exist between these disorders but were never investigated. We propose to determine whether there exist any common features in Parkinson's disease between spatiotemporal gait disorders and temporal speech disorders. Gait and speech were analysed on 11 Parkinsonian patients (PP) undergoing deep-brain stimulation of the subthalamic nucleus (STN-DBS) and 11 control subjects under three conditions of velocity (natural, slow and speed). The patients were tested with and without L-dopa and stimulator ON or OFF. Locomotor parameters were recorded using an optoelectronic system. Speech parameters were recorded with a headphone while subjects were reading a short paragraph. The results confirmed that PP walk and read more slowly than controls. Patient's difficulties in modulating walking and speech velocities seem to be due mainly to an inability to internally control the step length and the interpause-speech duration (ISD). STN-DBS and levodopa increased patients' walking velocity by increasing the step length. STN-DBS and levodopa had no effect on speech velocity but restored the patients' ability to modulate the ISD. The walking cadence and speech index of rythmicity tended to be lower in patients and were not significantly improved by STN-DBS or levodopa. Speech and walking velocity as well as ISD and step length were correlated in both groups. Negative correlations between speech index of and walking cadence were observed in both groups. Similar fundamental hypokinetic impairment and probably a similar rhythmic factor similarly affected the patients' speech and gait. These results suggest a similar physiopathological process in both walking and speaking dysfunction.</EA><CC>002B17; 002B17G</CC><FD>Maladie de Parkinson; Pathologie du système nerveux; Parole</FD><FG>Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du système nerveux central</FG><ED>Parkinson disease; Nervous system diseases; Speech</ED><EG>Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease</EG><SD>Parkinson enfermedad; Sistema nervioso patología; Habla</SD><LO>INIST-6015.354000189992770130</LO><ID>10-0079693</ID></server></inist></record>Pour manipuler ce document sous Unix (Dilib)
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