Parkinson's Disease Dementia Can Be Easily Detected in Routine Clinical Practice
Identifieur interne : 000444 ( PascalFrancis/Corpus ); précédent : 000443; suivant : 000445Parkinson's Disease Dementia Can Be Easily Detected in Routine Clinical Practice
Auteurs : Kathy Dujardin ; Bruno Dubois ; François Tison ; Franck Durif ; Isabelle Bourdeix ; Jean-Jacques Pere ; Alain DuhamelSource :
- Movement disorders [ 0885-3185 ] ; 2010.
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- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
Parkinson's disease (PD) is mainly characterized by its motor manifestations, but it is also frequently associated with dementia. Early diagnosis of PD dementia (PDD) is particularly important because effective cholinesterase inhibitor treatments are available. This study aimed at validating a short procedure for screening for PDD in routine clinical practice and which adopts recently published diagnostic criteria. One hundred eighty-eight patients with PD participated in the study. The examination procedure comprised three steps: standard clinical examination, a short cognitive function assessment fulfilling the requirements of the Movement Disorders Society (Mini Mental State Examination, five-word test, word generation task, and impact on daily life, including a questionnaire on compliance with medication) and an extensive evaluation of cognitive functions and behavior. After each step, the suspected presence or absence of dementia was recorded. After the short cognitive function assessment, PDD was suspected in 18.62% of the patients [95% confidence interval (CI): 13.32-24.93%]. After the extensive assessment, 21.81% (95% CI: 16.13-28.40%) met the criteria for probable PDD. The short battery's sensitivity and specificity were 65.85% (95% CI = 49.41-79.92%) and 94.56% (95% CI = 89.56-97.62%), respectively. A stepwise logistic regression analysis showed that use of a specific cutoff considerably enhanced the short battery's sensitivity (85.37%, 95% CI = 70.83-94.43%) without decreasing its specificity (83.67%, 95% CI = 76.69-89.25%). With an easy-to-use, short battery of tests that are commonly used in routine clinical practice, it is possible to diagnose PDD in accordance with reference criteria and with the same sensitivity and specificity as in a more extensive evaluation.
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Format Inist (serveur)
NO : | PASCAL 11-0065125 INIST |
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ET : | Parkinson's Disease Dementia Can Be Easily Detected in Routine Clinical Practice |
AU : | DUJARDIN (Kathy); DUBOIS (Bruno); TISON (François); DURIF (Franck); BOURDEIX (Isabelle); PERE (Jean-Jacques); DUHAMEL (Alain) |
AF : | Université Lille Nord de France, UDSL, CNRS FRE3291, Neurology and Movement Disorders Unit, Lille University Medical Center/Lille/France (1 aut.); INSERM-UPMC UMRS 610, Federation of Neurology, AP-HP, Salpêtrière Hospital; Université Paris 6/Paris/France (2 aut.); Department of Neurology, Bordeaux University Medical Center, Université de Bordeaux/Bordeaux/France (3 aut.); Department of Neurology, Clermont-Ferrand University Medical Center, Gabriel Montpied Hospital/Clermont-Ferrand/France (4 aut.); Novartis Pharma SAS/Rueil-Malmaison/France (5 aut., 6 aut.); Université Lille Nord de France, UDSL, EA2694, Biostatistics Department, Lille University Medical Center/Lille/France (7 aut.) |
DT : | Publication en série; Niveau analytique |
SO : | Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2010; Vol. 25; No. 16; Pp. 2769-2776; Bibl. 38 ref. |
LA : | Anglais |
EA : | Parkinson's disease (PD) is mainly characterized by its motor manifestations, but it is also frequently associated with dementia. Early diagnosis of PD dementia (PDD) is particularly important because effective cholinesterase inhibitor treatments are available. This study aimed at validating a short procedure for screening for PDD in routine clinical practice and which adopts recently published diagnostic criteria. One hundred eighty-eight patients with PD participated in the study. The examination procedure comprised three steps: standard clinical examination, a short cognitive function assessment fulfilling the requirements of the Movement Disorders Society (Mini Mental State Examination, five-word test, word generation task, and impact on daily life, including a questionnaire on compliance with medication) and an extensive evaluation of cognitive functions and behavior. After each step, the suspected presence or absence of dementia was recorded. After the short cognitive function assessment, PDD was suspected in 18.62% of the patients [95% confidence interval (CI): 13.32-24.93%]. After the extensive assessment, 21.81% (95% CI: 16.13-28.40%) met the criteria for probable PDD. The short battery's sensitivity and specificity were 65.85% (95% CI = 49.41-79.92%) and 94.56% (95% CI = 89.56-97.62%), respectively. A stepwise logistic regression analysis showed that use of a specific cutoff considerably enhanced the short battery's sensitivity (85.37%, 95% CI = 70.83-94.43%) without decreasing its specificity (83.67%, 95% CI = 76.69-89.25%). With an easy-to-use, short battery of tests that are commonly used in routine clinical practice, it is possible to diagnose PDD in accordance with reference criteria and with the same sensitivity and specificity as in a more extensive evaluation. |
CC : | 002B17; 002B17G |
FD : | Maladie de Parkinson; Démence; Pathologie du système nerveux; Cognition; Dépistage; Noyau gris central |
FG : | Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du système nerveux central; Encéphale; Système nerveux central |
ED : | Parkinson disease; Dementia; Nervous system diseases; Cognition; Medical screening; Basal ganglion |
EG : | Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease; Encephalon; Central nervous system |
SD : | Parkinson enfermedad; Demencia; Sistema nervioso patología; Cognición; Descubrimiento; Núcleo basal |
LO : | INIST-20953.354000193512620110 |
ID : | 11-0065125 |
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<front><div type="abstract" xml:lang="en">Parkinson's disease (PD) is mainly characterized by its motor manifestations, but it is also frequently associated with dementia. Early diagnosis of PD dementia (PDD) is particularly important because effective cholinesterase inhibitor treatments are available. This study aimed at validating a short procedure for screening for PDD in routine clinical practice and which adopts recently published diagnostic criteria. One hundred eighty-eight patients with PD participated in the study. The examination procedure comprised three steps: standard clinical examination, a short cognitive function assessment fulfilling the requirements of the Movement Disorders Society (Mini Mental State Examination, five-word test, word generation task, and impact on daily life, including a questionnaire on compliance with medication) and an extensive evaluation of cognitive functions and behavior. After each step, the suspected presence or absence of dementia was recorded. After the short cognitive function assessment, PDD was suspected in 18.62% of the patients [95% confidence interval (CI): 13.32-24.93%]. After the extensive assessment, 21.81% (95% CI: 16.13-28.40%) met the criteria for probable PDD. The short battery's sensitivity and specificity were 65.85% (95% CI = 49.41-79.92%) and 94.56% (95% CI = 89.56-97.62%), respectively. A stepwise logistic regression analysis showed that use of a specific cutoff considerably enhanced the short battery's sensitivity (85.37%, 95% CI = 70.83-94.43%) without decreasing its specificity (83.67%, 95% CI = 76.69-89.25%). With an easy-to-use, short battery of tests that are commonly used in routine clinical practice, it is possible to diagnose PDD in accordance with reference criteria and with the same sensitivity and specificity as in a more extensive evaluation.</div>
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<server><NO>PASCAL 11-0065125 INIST</NO>
<ET>Parkinson's Disease Dementia Can Be Easily Detected in Routine Clinical Practice</ET>
<AU>DUJARDIN (Kathy); DUBOIS (Bruno); TISON (François); DURIF (Franck); BOURDEIX (Isabelle); PERE (Jean-Jacques); DUHAMEL (Alain)</AU>
<AF>Université Lille Nord de France, UDSL, CNRS FRE3291, Neurology and Movement Disorders Unit, Lille University Medical Center/Lille/France (1 aut.); INSERM-UPMC UMRS 610, Federation of Neurology, AP-HP, Salpêtrière Hospital; Université Paris 6/Paris/France (2 aut.); Department of Neurology, Bordeaux University Medical Center, Université de Bordeaux/Bordeaux/France (3 aut.); Department of Neurology, Clermont-Ferrand University Medical Center, Gabriel Montpied Hospital/Clermont-Ferrand/France (4 aut.); Novartis Pharma SAS/Rueil-Malmaison/France (5 aut., 6 aut.); Université Lille Nord de France, UDSL, EA2694, Biostatistics Department, Lille University Medical Center/Lille/France (7 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2010; Vol. 25; No. 16; Pp. 2769-2776; Bibl. 38 ref.</SO>
<LA>Anglais</LA>
<EA>Parkinson's disease (PD) is mainly characterized by its motor manifestations, but it is also frequently associated with dementia. Early diagnosis of PD dementia (PDD) is particularly important because effective cholinesterase inhibitor treatments are available. This study aimed at validating a short procedure for screening for PDD in routine clinical practice and which adopts recently published diagnostic criteria. One hundred eighty-eight patients with PD participated in the study. The examination procedure comprised three steps: standard clinical examination, a short cognitive function assessment fulfilling the requirements of the Movement Disorders Society (Mini Mental State Examination, five-word test, word generation task, and impact on daily life, including a questionnaire on compliance with medication) and an extensive evaluation of cognitive functions and behavior. After each step, the suspected presence or absence of dementia was recorded. After the short cognitive function assessment, PDD was suspected in 18.62% of the patients [95% confidence interval (CI): 13.32-24.93%]. After the extensive assessment, 21.81% (95% CI: 16.13-28.40%) met the criteria for probable PDD. The short battery's sensitivity and specificity were 65.85% (95% CI = 49.41-79.92%) and 94.56% (95% CI = 89.56-97.62%), respectively. A stepwise logistic regression analysis showed that use of a specific cutoff considerably enhanced the short battery's sensitivity (85.37%, 95% CI = 70.83-94.43%) without decreasing its specificity (83.67%, 95% CI = 76.69-89.25%). With an easy-to-use, short battery of tests that are commonly used in routine clinical practice, it is possible to diagnose PDD in accordance with reference criteria and with the same sensitivity and specificity as in a more extensive evaluation.</EA>
<CC>002B17; 002B17G</CC>
<FD>Maladie de Parkinson; Démence; Pathologie du système nerveux; Cognition; Dépistage; Noyau gris central</FD>
<FG>Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du système nerveux central; Encéphale; Système nerveux central</FG>
<ED>Parkinson disease; Dementia; Nervous system diseases; Cognition; Medical screening; Basal ganglion</ED>
<EG>Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease; Encephalon; Central nervous system</EG>
<SD>Parkinson enfermedad; Demencia; Sistema nervioso patología; Cognición; Descubrimiento; Núcleo basal</SD>
<LO>INIST-20953.354000193512620110</LO>
<ID>11-0065125</ID>
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