Overactivity of cervical premotor neurons in Parkinson's disease
Identifieur interne : 001427 ( PascalFrancis/Checkpoint ); précédent : 001426; suivant : 001428Overactivity of cervical premotor neurons in Parkinson's disease
Auteurs : S. Pol [France] ; M. Vidailhet [France] ; S. Meunier [France] ; D. Mazevet [France] ; Yves Agid [France] ; E. Pierrot-Deseilligny [France]Source :
- Journal of neurology, neurosurgery and psychiatry [ 0022-3050 ] ; 1998.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
Abstract
Objective-Cortical command to upper limb motor neurons is transmitted, in humans, not only through the monosynaptic corticomotor neuronal pathway, but also through cervical premotor neurons. Whether activity in this non-monosynaptic corticospinal pathway is modified in Parkinson's disease was explored. Methods-Ongoing EMG activity recorded in wrist extensors during tonic extension of the wrist is suppressed by a volley evoked by stimulating the superficial radial nerve. It has been shown that this cutaneous induced suppression is due to inhibition of transmission of the cortical command at a premotor neuronal level. By comparing the cutaneous induced EMG depression between 45 de novo parkinsonian patients and 23 age matched controls it has been possible to appreciate if and to what extent the "non-monosynaptic" part of the cortical command is modified in these patients. Result-At the early stage of the illness the EMG depression, reflecting the "non-monosynaptic" part of the cortical command, was bilaterally increased despite very asymmetric clinical status. When the duration of the disease was more than 36 months, EMG depression returned to its control level. No correlation was found between the amount of the EMG depression and parkinsonian symptoms before and after levodopa treatment. Conclusion-Increase of the relative "non-monosynaptic" part of the cortical command could reflect a compensatory motor mechanism elaborated upstream from the motor cortex.
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Pascal:98-0128145Le document en format XML
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Pierrot-Deseilligny</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Laboratoire de Neurophysiologie Clinique, Réeducation, Hôpital de la Salpêtrière, 47 Boulevard de l'Hôpital</s1><s2>75651, Paris</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">98-0128145</idno><date when="1998">1998</date><idno type="stanalyst">PASCAL 98-0128145 INIST</idno><idno type="RBID">Pascal:98-0128145</idno><idno type="wicri:Area/PascalFrancis/Corpus">001645</idno><idno type="wicri:Area/PascalFrancis/Curation">001A01</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">001427</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">001427</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Overactivity of cervical premotor neurons in Parkinson's disease</title><author><name sortKey="Pol, S" sort="Pol, S" uniqKey="Pol S" first="S." last="Pol">S. Pol</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Laboratoire de Neurophysiologie Clinique, Réeducation, Hôpital de la Salpêtrière, 47 Boulevard de l'Hôpital</s1><s2>75651, Paris</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Vidailhet, M" sort="Vidailhet, M" uniqKey="Vidailhet M" first="M." last="Vidailhet">M. Vidailhet</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Laboratoire de Neurophysiologie Clinique, Réeducation, Fédération de Neurologie Hôpital de la Salpêtrière, 47 Boulevard de l'Hôpital</s1><s2>75651, Paris</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Meunier, S" sort="Meunier, S" uniqKey="Meunier S" first="S." last="Meunier">S. Meunier</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Laboratoire de Neurophysiologie Clinique, Réeducation, Hôpital de la Salpêtrière, 47 Boulevard de l'Hôpital</s1><s2>75651, Paris</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Mazevet, D" sort="Mazevet, D" uniqKey="Mazevet D" first="D." last="Mazevet">D. Mazevet</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Laboratoire de Neurophysiologie Clinique, Réeducation, Hôpital de la Salpêtrière, 47 Boulevard de l'Hôpital</s1><s2>75651, Paris</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Agid, Y" sort="Agid, Y" uniqKey="Agid Y" first="Y." last="Agid">Yves Agid</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Laboratoire de Neurophysiologie Clinique, Réeducation, Fédération de Neurologie Hôpital de la Salpêtrière, 47 Boulevard de l'Hôpital</s1><s2>75651, Paris</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName><placeName><settlement type="city">Paris</settlement><region type="region" nuts="2">Île-de-France</region></placeName><orgName type="hospital" n="4">Hôpital de la Salpêtrière</orgName></affiliation></author><author><name sortKey="Pierrot Deseilligny, E" sort="Pierrot Deseilligny, E" uniqKey="Pierrot Deseilligny E" first="E." last="Pierrot-Deseilligny">E. Pierrot-Deseilligny</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Laboratoire de Neurophysiologie Clinique, Réeducation, Hôpital de la Salpêtrière, 47 Boulevard de l'Hôpital</s1><s2>75651, Paris</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author></analytic><series><title level="j" type="main">Journal of neurology, neurosurgery and psychiatry</title><title level="j" type="abbreviated">J. neurol. neurosurg. psychiatry</title><idno type="ISSN">0022-3050</idno><imprint><date when="1998">1998</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Journal of neurology, neurosurgery and psychiatry</title><title level="j" type="abbreviated">J. neurol. neurosurg. psychiatry</title><idno type="ISSN">0022-3050</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cerebral cortex</term><term>Cervical spinal cord</term><term>Control</term><term>Electromyography</term><term>Exploration</term><term>Human</term><term>Parkinson disease</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Parkinson maladie</term><term>Moelle épinière cervicale</term><term>Electromyographie</term><term>Commande</term><term>Cortex cérébral</term><term>Exploration</term><term>Homme</term><term>Neurone prémoteur</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Objective-Cortical command to upper limb motor neurons is transmitted, in humans, not only through the monosynaptic corticomotor neuronal pathway, but also through cervical premotor neurons. Whether activity in this non-monosynaptic corticospinal pathway is modified in Parkinson's disease was explored. Methods-Ongoing EMG activity recorded in wrist extensors during tonic extension of the wrist is suppressed by a volley evoked by stimulating the superficial radial nerve. It has been shown that this cutaneous induced suppression is due to inhibition of transmission of the cortical command at a premotor neuronal level. By comparing the cutaneous induced EMG depression between 45 de novo parkinsonian patients and 23 age matched controls it has been possible to appreciate if and to what extent the "non-monosynaptic" part of the cortical command is modified in these patients. Result-At the early stage of the illness the EMG depression, reflecting the "non-monosynaptic" part of the cortical command, was bilaterally increased despite very asymmetric clinical status. When the duration of the disease was more than 36 months, EMG depression returned to its control level. No correlation was found between the amount of the EMG depression and parkinsonian symptoms before and after levodopa treatment. Conclusion-Increase of the relative "non-monosynaptic" part of the cortical command could reflect a compensatory motor mechanism elaborated upstream from the motor cortex.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0022-3050</s0></fA01><fA02 i1="01"><s0>JNNPAU</s0></fA02><fA03 i2="1"><s0>J. neurol. neurosurg. psychiatry</s0></fA03><fA05><s2>64</s2></fA05><fA06><s2>2</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Overactivity of cervical premotor neurons in Parkinson's disease</s1></fA08><fA11 i1="01" i2="1"><s1>POL (S.)</s1></fA11><fA11 i1="02" i2="1"><s1>VIDAILHET (M.)</s1></fA11><fA11 i1="03" i2="1"><s1>MEUNIER (S.)</s1></fA11><fA11 i1="04" i2="1"><s1>MAZEVET (D.)</s1></fA11><fA11 i1="05" i2="1"><s1>AGID (Y.)</s1></fA11><fA11 i1="06" i2="1"><s1>PIERROT-DESEILLIGNY (E.)</s1></fA11><fA14 i1="01"><s1>Laboratoire de Neurophysiologie Clinique, Réeducation, Hôpital de la Salpêtrière, 47 Boulevard de l'Hôpital</s1><s2>75651, Paris</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ></fA14><fA14 i1="02"><s1>Laboratoire de Neurophysiologie Clinique, Réeducation, Fédération de Neurologie Hôpital de la Salpêtrière, 47 Boulevard de l'Hôpital</s1><s2>75651, Paris</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ></fA14><fA20><s1>166-171</s1></fA20><fA21><s1>1998</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>6015</s2><s5>354000078670890060</s5></fA43><fA44><s0>0000</s0><s1>© 1998 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>22 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>98-0128145</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i2="1"><s0>Journal of neurology, neurosurgery and psychiatry</s0></fA64><fA66 i1="01"><s0>GBR</s0></fA66><fC01 i1="01" l="ENG"><s0>Objective-Cortical command to upper limb motor neurons is transmitted, in humans, not only through the monosynaptic corticomotor neuronal pathway, but also through cervical premotor neurons. Whether activity in this non-monosynaptic corticospinal pathway is modified in Parkinson's disease was explored. Methods-Ongoing EMG activity recorded in wrist extensors during tonic extension of the wrist is suppressed by a volley evoked by stimulating the superficial radial nerve. It has been shown that this cutaneous induced suppression is due to inhibition of transmission of the cortical command at a premotor neuronal level. By comparing the cutaneous induced EMG depression between 45 de novo parkinsonian patients and 23 age matched controls it has been possible to appreciate if and to what extent the "non-monosynaptic" part of the cortical command is modified in these patients. Result-At the early stage of the illness the EMG depression, reflecting the "non-monosynaptic" part of the cortical command, was bilaterally increased despite very asymmetric clinical status. When the duration of the disease was more than 36 months, EMG depression returned to its control level. No correlation was found between the amount of the EMG depression and parkinsonian symptoms before and after levodopa treatment. Conclusion-Increase of the relative "non-monosynaptic" part of the cortical command could reflect a compensatory motor mechanism elaborated upstream from the motor cortex.</s0></fC01><fC02 i1="01" i2="X"><s0>002B17G</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Parkinson maladie</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Parkinson disease</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Parkinson enfermedad</s0><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Moelle épinière cervicale</s0><s5>04</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Cervical spinal cord</s0><s5>04</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Médula espinal cervical</s0><s5>04</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Electromyographie</s0><s5>07</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Electromyography</s0><s5>07</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Electromiografía</s0><s5>07</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Commande</s0><s5>10</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Control</s0><s5>10</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Control</s0><s5>10</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Cortex cérébral</s0><s5>13</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Cerebral cortex</s0><s5>13</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Corteza cerebral</s0><s5>13</s5></fC03><fC03 i1="06" i2="X" l="FRE"><s0>Exploration</s0><s5>17</s5></fC03><fC03 i1="06" i2="X" l="ENG"><s0>Exploration</s0><s5>17</s5></fC03><fC03 i1="06" i2="X" l="SPA"><s0>Exploración</s0><s5>17</s5></fC03><fC03 i1="07" i2="X" l="FRE"><s0>Homme</s0><s5>20</s5></fC03><fC03 i1="07" i2="X" l="ENG"><s0>Human</s0><s5>20</s5></fC03><fC03 i1="07" i2="X" l="SPA"><s0>Hombre</s0><s5>20</s5></fC03><fC03 i1="08" i2="X" l="FRE"><s0>Neurone prémoteur</s0><s4>INC</s4><s5>86</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Système nerveux pathologie</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Nervous system diseases</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Sistema nervioso patología</s0><s5>37</s5></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Système nerveux central pathologie</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Central nervous system disease</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0><s5>38</s5></fC07><fC07 i1="03" i2="X" l="FRE"><s0>Encéphale pathologie</s0><s5>39</s5></fC07><fC07 i1="03" i2="X" l="ENG"><s0>Cerebral disorder</s0><s5>39</s5></fC07><fC07 i1="03" i2="X" l="SPA"><s0>Encéfalo patología</s0><s5>39</s5></fC07><fC07 i1="04" i2="X" l="FRE"><s0>Extrapyramidal syndrome</s0><s5>40</s5></fC07><fC07 i1="04" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0><s5>40</s5></fC07><fC07 i1="04" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0><s5>40</s5></fC07><fC07 i1="05" i2="X" l="FRE"><s0>Maladie dégénérative</s0><s5>41</s5></fC07><fC07 i1="05" i2="X" l="ENG"><s0>Degenerative disease</s0><s5>41</s5></fC07><fC07 i1="05" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0><s5>41</s5></fC07><fC07 i1="06" i2="X" l="FRE"><s0>Electrodiagnostic</s0><s5>53</s5></fC07><fC07 i1="06" i2="X" l="ENG"><s0>Electrodiagnosis</s0><s5>53</s5></fC07><fC07 i1="06" i2="X" l="SPA"><s0>Electrodiagnóstico</s0><s5>53</s5></fC07><fN21><s1>082</s1></fN21></pA></standard></inist><affiliations><list><country><li>France</li></country><region><li>Île-de-France</li></region><settlement><li>Paris</li></settlement><orgName><li>Hôpital de la Salpêtrière</li></orgName></list><tree><country name="France"><region name="Île-de-France"><name sortKey="Pol, S" sort="Pol, S" uniqKey="Pol S" first="S." last="Pol">S. Pol</name></region><name sortKey="Agid, Y" sort="Agid, Y" uniqKey="Agid Y" first="Y." last="Agid">Yves Agid</name><name sortKey="Mazevet, D" sort="Mazevet, D" uniqKey="Mazevet D" first="D." last="Mazevet">D. Mazevet</name><name sortKey="Meunier, S" sort="Meunier, S" uniqKey="Meunier S" first="S." last="Meunier">S. Meunier</name><name sortKey="Pierrot Deseilligny, E" sort="Pierrot Deseilligny, E" uniqKey="Pierrot Deseilligny E" first="E." last="Pierrot-Deseilligny">E. Pierrot-Deseilligny</name><name sortKey="Vidailhet, M" sort="Vidailhet, M" uniqKey="Vidailhet M" first="M." last="Vidailhet">M. Vidailhet</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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