BDNF controls dopamine D3 receptor expression and triggers behavioural sensitization
Identifieur interne : 001090 ( PascalFrancis/Checkpoint ); précédent : 001089; suivant : 001091BDNF controls dopamine D3 receptor expression and triggers behavioural sensitization
Auteurs : Olivier Guillin [France] ; Jorge Diaz [France] ; Patrick Carroll [France] ; Nathalie Griffon [France] ; Jean-Charles Schwartz [France] ; Pierre Sokoloff [France]Source :
- Nature : (London) [ 0028-0836 ] ; 2001.
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Abstract
Brain-derived neurotrophic factor (BDNF), like other neurotrophins, is a polypeptidic factor initially regarded to be responsible for neuron proliferation, differentiation and survival, through its uptake at nerve terminals and retrograde transport to the cell body1. A more diverse role for BDNF has emerged progressively from observations showing that it is also transported anterogradely2,3, is released on neuron depolarization1, and triggers rapid intracellular signals4 and action potentials in central neurons5. Here we report that BDNF elicits long-term neuronal adaptations by controlling the responsiveness of its target neurons to the important neurotransmitter, dopamine. Using lesions and gene-targeted mice lacking BDNF, we show that BDNF from dopamine neurons is responsible for inducing normal expression of the dopamine D3 receptor in nucleus accumbens6-8 both during development and in adulthood. BDNF from corticostriatal neurons3also induces behavioural sensitization, by triggering overexpression of the D3 receptor in striatum of hemiparkinsonian rats9. Our results suggest that BDNF may be an important determinant of pathophysiological conditions such as drug addiction10, schizophrenia" or Parkinson's disease12, in which D3 receptor expression is abnormal.
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type="wicri:source">INIST</idno><idno type="inist">01-0282005</idno><date when="2001">2001</date><idno type="stanalyst">PASCAL 01-0282005 INIST</idno><idno type="RBID">Pascal:01-0282005</idno><idno type="wicri:Area/PascalFrancis/Corpus">001229</idno><idno type="wicri:Area/PascalFrancis/Curation">000209</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">001090</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">001090</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">BDNF controls dopamine D<sub>3</sub> receptor expression and triggers behavioural sensitization</title><author><name sortKey="Guillin, Olivier" sort="Guillin, Olivier" uniqKey="Guillin O" first="Olivier" last="Guillin">Olivier Guillin</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Unité de Neurobiologie et Pharmacologie Moléculaire, INSERM U 109, Centre Paul Broca, 2ter rue d'Alésia</s1><s2>75014 Paris</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Diaz, Jorge" sort="Diaz, Jorge" uniqKey="Diaz J" first="Jorge" last="Diaz">Jorge Diaz</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Laboratoire de Physiologie, Université René Descartes, Avenue de l'Observatoire</s1><s2>75006 Paris</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Carroll, Patrick" sort="Carroll, Patrick" uniqKey="Carroll P" first="Patrick" last="Carroll">Patrick Carroll</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Unité de Développement et Pathologie du Motoneurone Spinal, INSERM U 382, IBDM, Campus de Luminy, Case 907</s1><s2>13288 Marseille</s2><s3>FRA</s3><sZ>3 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Griffon, Nathalie" sort="Griffon, Nathalie" uniqKey="Griffon N" first="Nathalie" last="Griffon">Nathalie Griffon</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Unité de Neurobiologie et Pharmacologie Moléculaire, INSERM U 109, Centre Paul Broca, 2ter rue d'Alésia</s1><s2>75014 Paris</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Schwartz, Jean Charles" sort="Schwartz, Jean Charles" uniqKey="Schwartz J" first="Jean-Charles" last="Schwartz">Jean-Charles Schwartz</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Unité de Neurobiologie et Pharmacologie Moléculaire, INSERM U 109, Centre Paul Broca, 2ter rue d'Alésia</s1><s2>75014 Paris</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Laboratoire de Physiologie, Université René Descartes, Avenue de l'Observatoire</s1><s2>75006 Paris</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Sokoloff, Pierre" sort="Sokoloff, Pierre" uniqKey="Sokoloff P" first="Pierre" last="Sokoloff">Pierre Sokoloff</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Unité de Neurobiologie et Pharmacologie Moléculaire, INSERM U 109, Centre Paul Broca, 2ter rue d'Alésia</s1><s2>75014 Paris</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author></analytic><series><title level="j" type="main">Nature : (London)</title><title level="j" type="abbreviated">Nature : (Lond.)</title><idno type="ISSN">0028-0836</idno><imprint><date when="2001">2001</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Nature : (London)</title><title level="j" type="abbreviated">Nature : (Lond.)</title><idno type="ISSN">0028-0836</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Basal ganglion</term><term>Brain (vertebrata)</term><term>Brain derived neurotrophic factor</term><term>D3 Dopamine receptor</term><term>Dopaminergic neuron</term><term>Dopaminergic pathway</term><term>Gene expression</term><term>Gene overexpression</term><term>Rat</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Encéphale</term><term>Voie dopaminergique</term><term>Noyau gris central</term><term>Neurone dopaminergique</term><term>Expression génique</term><term>Récepteur dopaminergique D3</term><term>Facteur BDNF</term><term>Surexpression génique</term><term>Rat</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Brain-derived neurotrophic factor (BDNF), like other neurotrophins, is a polypeptidic factor initially regarded to be responsible for neuron proliferation, differentiation and survival, through its uptake at nerve terminals and retrograde transport to the cell body<sup>1</sup>. A more diverse role for BDNF has emerged progressively from observations showing that it is also transported anterogradely<sup>2,3</sup>, is released on neuron depolarization<sup>1</sup>, and triggers rapid intracellular signals<sup>4</sup> and action potentials in central neurons<sup>5</sup>. Here we report that BDNF elicits long-term neuronal adaptations by controlling the responsiveness of its target neurons to the important neurotransmitter, dopamine. Using lesions and gene-targeted mice lacking BDNF, we show that BDNF from dopamine neurons is responsible for inducing normal expression of the dopamine D<sub>3</sub> receptor in nucleus accumbens<sup>6-8</sup> both during development and in adulthood. BDNF from corticostriatal neurons<sup>3</sup>also induces behavioural sensitization, by triggering overexpression of the D<sub>3</sub> receptor in striatum of hemiparkinsonian rats<sup>9</sup>. Our results suggest that BDNF may be an important determinant of pathophysiological conditions such as drug addiction<sup>10</sup>, schizophrenia" or Parkinson's disease<sup>12</sup>, in which D<sub>3</sub> receptor expression is abnormal.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0028-0836</s0></fA01><fA02 i1="01"><s0>NATUAS</s0></fA02><fA03 i2="1"><s0>Nature : (Lond.)</s0></fA03><fA05><s2>411</s2></fA05><fA06><s2>6833</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>BDNF controls dopamine D<sub>3</sub> receptor expression and triggers behavioural sensitization</s1></fA08><fA11 i1="01" i2="1"><s1>GUILLIN (Olivier)</s1></fA11><fA11 i1="02" i2="1"><s1>DIAZ (Jorge)</s1></fA11><fA11 i1="03" i2="1"><s1>CARROLL (Patrick)</s1></fA11><fA11 i1="04" i2="1"><s1>GRIFFON (Nathalie)</s1></fA11><fA11 i1="05" i2="1"><s1>SCHWARTZ (Jean-Charles)</s1></fA11><fA11 i1="06" i2="1"><s1>SOKOLOFF (Pierre)</s1></fA11><fA14 i1="01"><s1>Unité de Neurobiologie et Pharmacologie Moléculaire, INSERM U 109, Centre Paul Broca, 2ter rue d'Alésia</s1><s2>75014 Paris</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></fA14><fA14 i1="02"><s1>Laboratoire de Physiologie, Université René Descartes, Avenue de l'Observatoire</s1><s2>75006 Paris</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ></fA14><fA14 i1="03"><s1>Unité de Développement et Pathologie du Motoneurone Spinal, INSERM U 382, IBDM, Campus de Luminy, Case 907</s1><s2>13288 Marseille</s2><s3>FRA</s3><sZ>3 aut.</sZ></fA14><fA20><s1>86-89</s1></fA20><fA21><s1>2001</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>142</s2><s5>354000095222450240</s5></fA43><fA44><s0>0000</s0><s1>© 2001 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>30 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>01-0282005</s0></fA47><fA60><s1>P</s1><s3>LT</s3></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Nature : (London)</s0></fA64><fA66 i1="01"><s0>GBR</s0></fA66><fC01 i1="01" l="ENG"><s0>Brain-derived neurotrophic factor (BDNF), like other neurotrophins, is a polypeptidic factor initially regarded to be responsible for neuron proliferation, differentiation and survival, through its uptake at nerve terminals and retrograde transport to the cell body<sup>1</sup>. A more diverse role for BDNF has emerged progressively from observations showing that it is also transported anterogradely<sup>2,3</sup>, is released on neuron depolarization<sup>1</sup>, and triggers rapid intracellular signals<sup>4</sup> and action potentials in central neurons<sup>5</sup>. Here we report that BDNF elicits long-term neuronal adaptations by controlling the responsiveness of its target neurons to the important neurotransmitter, dopamine. Using lesions and gene-targeted mice lacking BDNF, we show that BDNF from dopamine neurons is responsible for inducing normal expression of the dopamine D<sub>3</sub> receptor in nucleus accumbens<sup>6-8</sup> both during development and in adulthood. BDNF from corticostriatal neurons<sup>3</sup>also induces behavioural sensitization, by triggering overexpression of the D<sub>3</sub> receptor in striatum of hemiparkinsonian rats<sup>9</sup>. Our results suggest that BDNF may be an important determinant of pathophysiological conditions such as drug addiction<sup>10</sup>, schizophrenia" or Parkinson's disease<sup>12</sup>, in which D<sub>3</sub> receptor expression is abnormal.</s0></fC01><fC02 i1="01" i2="X"><s0>002A25D04</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Encéphale</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Brain (vertebrata)</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Encéfalo</s0><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Voie dopaminergique</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Dopaminergic pathway</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Vía dopaminérgica</s0><s5>02</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Noyau gris central</s0><s5>03</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Basal ganglion</s0><s5>03</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Núcleo basal</s0><s5>03</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Neurone dopaminergique</s0><s5>04</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Dopaminergic neuron</s0><s5>04</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Neurona dopaminérgica</s0><s5>04</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Expression génique</s0><s5>05</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Gene expression</s0><s5>05</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Expresión genética</s0><s5>05</s5></fC03><fC03 i1="06" i2="X" l="FRE"><s0>Récepteur dopaminergique D3</s0><s5>06</s5></fC03><fC03 i1="06" i2="X" l="ENG"><s0>D3 Dopamine receptor</s0><s5>06</s5><s6>«D3» Dopamine receptor</s6></fC03><fC03 i1="06" i2="X" l="SPA"><s0>Receptor dopaminérgico D3</s0><s5>06</s5></fC03><fC03 i1="07" i2="X" l="FRE"><s0>Facteur BDNF</s0><s5>07</s5></fC03><fC03 i1="07" i2="X" l="ENG"><s0>Brain derived neurotrophic factor</s0><s5>07</s5></fC03><fC03 i1="07" i2="X" l="SPA"><s0>Factor BDNF</s0><s5>07</s5></fC03><fC03 i1="08" i2="X" l="FRE"><s0>Surexpression génique</s0><s5>08</s5></fC03><fC03 i1="08" i2="X" l="ENG"><s0>Gene overexpression</s0><s5>08</s5></fC03><fC03 i1="08" i2="X" l="SPA"><s0>Sobreexpressión genética</s0><s5>08</s5></fC03><fC03 i1="09" i2="X" l="FRE"><s0>Rat</s0><s5>54</s5></fC03><fC03 i1="09" i2="X" l="ENG"><s0>Rat</s0><s5>54</s5></fC03><fC03 i1="09" i2="X" l="SPA"><s0>Rata</s0><s5>54</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Système nerveux central</s0><s5>20</s5></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Central nervous system</s0><s5>20</s5></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Sistema nervioso central</s0><s5>20</s5></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Facteur neurotrophique</s0><s5>29</s5></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Neurotrophic factor</s0><s5>29</s5></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Factor neurotrófico</s0><s5>29</s5></fC07><fC07 i1="03" i2="X" l="FRE"><s0>Rodentia</s0><s2>NS</s2></fC07><fC07 i1="03" i2="X" l="ENG"><s0>Rodentia</s0><s2>NS</s2></fC07><fC07 i1="03" i2="X" l="SPA"><s0>Rodentia</s0><s2>NS</s2></fC07><fC07 i1="04" i2="X" l="FRE"><s0>Mammalia</s0><s2>NS</s2></fC07><fC07 i1="04" i2="X" l="ENG"><s0>Mammalia</s0><s2>NS</s2></fC07><fC07 i1="04" i2="X" l="SPA"><s0>Mammalia</s0><s2>NS</s2></fC07><fC07 i1="05" i2="X" l="FRE"><s0>Vertebrata</s0><s2>NS</s2></fC07><fC07 i1="05" i2="X" l="ENG"><s0>Vertebrata</s0><s2>NS</s2></fC07><fC07 i1="05" i2="X" l="SPA"><s0>Vertebrata</s0><s2>NS</s2></fC07><fN21><s1>190</s1></fN21></pA></standard></inist><affiliations><list><country><li>France</li></country><region><li>Provence-Alpes-Côte d'Azur</li><li>Île-de-France</li></region><settlement><li>Marseille</li><li>Paris</li></settlement></list><tree><country name="France"><region name="Île-de-France"><name sortKey="Guillin, Olivier" sort="Guillin, Olivier" uniqKey="Guillin O" first="Olivier" last="Guillin">Olivier Guillin</name></region><name sortKey="Carroll, Patrick" sort="Carroll, Patrick" uniqKey="Carroll P" first="Patrick" last="Carroll">Patrick Carroll</name><name sortKey="Diaz, Jorge" sort="Diaz, Jorge" uniqKey="Diaz J" first="Jorge" last="Diaz">Jorge Diaz</name><name sortKey="Griffon, Nathalie" sort="Griffon, Nathalie" uniqKey="Griffon N" first="Nathalie" last="Griffon">Nathalie Griffon</name><name sortKey="Schwartz, Jean Charles" sort="Schwartz, Jean Charles" uniqKey="Schwartz J" first="Jean-Charles" last="Schwartz">Jean-Charles Schwartz</name><name sortKey="Schwartz, Jean Charles" sort="Schwartz, Jean Charles" uniqKey="Schwartz J" first="Jean-Charles" last="Schwartz">Jean-Charles Schwartz</name><name sortKey="Sokoloff, Pierre" sort="Sokoloff, Pierre" uniqKey="Sokoloff P" first="Pierre" last="Sokoloff">Pierre Sokoloff</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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