Effects of internal clock and memory disorders on duration reproductions and duration productions in patients with Parkinson's disease
Identifieur interne : 000B29 ( PascalFrancis/Checkpoint ); précédent : 000B28; suivant : 000B30Effects of internal clock and memory disorders on duration reproductions and duration productions in patients with Parkinson's disease
Auteurs : Séverine Perbal [France] ; Bernard Deweer [France] ; Bernard Pillon [France] ; Marie Vidailhet [France] ; Bruno Dubois [France] ; Viviane Pouthas [France]Source :
- Brain and cognition : (Print) [ 0278-2626 ] ; 2005.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
Abstract
Patients with Parkinson's disease (PD) exhibit deficits in perceptual and motor timing as well as impairments in memory and attentional processes that are related to dysfunction of dopaminergic systems in the basal ganglia. The aim of the present study was to assess the relationships existing between impaired duration judgments and defective memory and attention in PD patients. We compared time performance of medicated PD patients and control subjects on a duration reproduction task that is highly memory-dependent, and on a duration production task that could reveal effects of changes in the speed of internal time-keeping mechanisms. Each task was performed in a control counting condition and in a condition requiring divided attention between the temporal task and a concurrent reading task. Moreover, PD patients and control subjects were assessed on memory and attention using a battery of neuropsychological tests. The results revealed that in the concurrent reading condition of the reproduction task, duration judgments tended to be more variable in PD patients than in control subjects. Moreover, variability of duration reproductions was correlated with both measures of memory and of disease severity. In the concurrent reading condition of the production task, duration judgments were significantly shorter in PD patients than in control subjects, and accuracy of duration productions was correlated with scores on sub-tests of short-term memory. The findings suggest that the administration of dopamine did not entirely remove the memory deficits in PD patients. Moreover, DA treatment would have abnormally accelerated the rate of the internal clock leading to shorter duration productions in PD patients. The whole results indicate that dopamine administration in patients might have overshadowed the slowing rate of the internal clock usually reported in non medicated PD patients, without entirely restoring all of the memory functions.
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wicri:step="Checkpoint">000B29</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Effects of internal clock and memory disorders on duration reproductions and duration productions in patients with Parkinson's disease</title><author><name sortKey="Perbal, Severine" sort="Perbal, Severine" uniqKey="Perbal S" first="Séverine" last="Perbal">Séverine Perbal</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Unité de Neurosciences Cognitives et Imagerie Cérébrale, CNRS UPR 640, Hôpital de la Salpêtrière</s1><s2>Paris</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Deweer, Bernard" sort="Deweer, Bernard" uniqKey="Deweer B" first="Bernard" last="Deweer">Bernard Deweer</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Neuropsycologie fonctionnelle, INSERM, EPI 007, Hôpital de la Salpêtrière</s1><s2>Paris</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Pillon, Bernard" sort="Pillon, Bernard" uniqKey="Pillon B" first="Bernard" last="Pillon">Bernard Pillon</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Neuropsycologie fonctionnelle, INSERM, EPI 007, Hôpital de la Salpêtrière</s1><s2>Paris</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Vidailhet, Marie" sort="Vidailhet, Marie" uniqKey="Vidailhet M" first="Marie" last="Vidailhet">Marie Vidailhet</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Service de Neurologie, Hôpital Saint Antoine</s1><s2>Paris</s2><s3>FRA</s3><sZ>4 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Dubois, Bruno" sort="Dubois, Bruno" uniqKey="Dubois B" first="Bruno" last="Dubois">Bruno Dubois</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Neuropsycologie fonctionnelle, INSERM, EPI 007, Hôpital de la Salpêtrière</s1><s2>Paris</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Pouthas, Viviane" sort="Pouthas, Viviane" uniqKey="Pouthas V" first="Viviane" last="Pouthas">Viviane Pouthas</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Unité de Neurosciences Cognitives et Imagerie Cérébrale, CNRS UPR 640, Hôpital de la Salpêtrière</s1><s2>Paris</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author></analytic><series><title level="j" type="main">Brain and cognition : (Print)</title><title level="j" type="abbreviated">Brain cogn. : (Print)</title><idno type="ISSN">0278-2626</idno><imprint><date when="2005">2005</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Brain and cognition : (Print)</title><title level="j" type="abbreviated">Brain cogn. : (Print)</title><idno type="ISSN">0278-2626</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Duration</term><term>Human</term><term>Internal clock</term><term>Memory disorder</term><term>Parkinson disease</term><term>Time perception</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Horloge interne</term><term>Trouble mémoire</term><term>Durée</term><term>Parkinson maladie</term><term>Perception temps</term><term>Homme</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Patients with Parkinson's disease (PD) exhibit deficits in perceptual and motor timing as well as impairments in memory and attentional processes that are related to dysfunction of dopaminergic systems in the basal ganglia. The aim of the present study was to assess the relationships existing between impaired duration judgments and defective memory and attention in PD patients. We compared time performance of medicated PD patients and control subjects on a duration reproduction task that is highly memory-dependent, and on a duration production task that could reveal effects of changes in the speed of internal time-keeping mechanisms. Each task was performed in a control counting condition and in a condition requiring divided attention between the temporal task and a concurrent reading task. Moreover, PD patients and control subjects were assessed on memory and attention using a battery of neuropsychological tests. The results revealed that in the concurrent reading condition of the reproduction task, duration judgments tended to be more variable in PD patients than in control subjects. Moreover, variability of duration reproductions was correlated with both measures of memory and of disease severity. In the concurrent reading condition of the production task, duration judgments were significantly shorter in PD patients than in control subjects, and accuracy of duration productions was correlated with scores on sub-tests of short-term memory. The findings suggest that the administration of dopamine did not entirely remove the memory deficits in PD patients. Moreover, DA treatment would have abnormally accelerated the rate of the internal clock leading to shorter duration productions in PD patients. The whole results indicate that dopamine administration in patients might have overshadowed the slowing rate of the internal clock usually reported in non medicated PD patients, without entirely restoring all of the memory functions.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0278-2626</s0></fA01><fA02 i1="01"><s0>BRCOEI</s0></fA02><fA03 i2="1"><s0>Brain cogn. : (Print)</s0></fA03><fA05><s2>58</s2></fA05><fA06><s2>1</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Effects of internal clock and memory disorders on duration reproductions and duration productions in patients with Parkinson's disease</s1></fA08><fA09 i1="01" i2="1" l="ENG"><s1>Neuropsychology of timing and time perception</s1></fA09><fA11 i1="01" i2="1"><s1>PERBAL (Séverine)</s1></fA11><fA11 i1="02" i2="1"><s1>DEWEER (Bernard)</s1></fA11><fA11 i1="03" i2="1"><s1>PILLON (Bernard)</s1></fA11><fA11 i1="04" i2="1"><s1>VIDAILHET (Marie)</s1></fA11><fA11 i1="05" i2="1"><s1>DUBOIS (Bruno)</s1></fA11><fA11 i1="06" i2="1"><s1>POUTHAS (Viviane)</s1></fA11><fA12 i1="01" i2="1"><s1>MECK (Warren)</s1><s9>ed.</s9></fA12><fA14 i1="01"><s1>Unité de Neurosciences Cognitives et Imagerie Cérébrale, CNRS UPR 640, Hôpital de la Salpêtrière</s1><s2>Paris</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>6 aut.</sZ></fA14><fA14 i1="02"><s1>Neuropsycologie fonctionnelle, INSERM, EPI 007, Hôpital de la Salpêtrière</s1><s2>Paris</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ></fA14><fA14 i1="03"><s1>Service de Neurologie, Hôpital Saint Antoine</s1><s2>Paris</s2><s3>FRA</s3><sZ>4 aut.</sZ></fA14><fA15 i1="01"><s1>Department of Psychological and Brain Sciences, Genome Sciences Research Building II, 3rd Floor, 103 Research Drive, Box 91050, Duke University</s1><s2>Durham, NC 27708</s2><s3>USA</s3><sZ>1 aut.</sZ></fA15><fA20><s1>35-48</s1></fA20><fA21><s1>2005</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>19677</s2><s5>354000124917760030</s5></fA43><fA44><s0>0000</s0><s1>© 2005 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>1 p.1/4</s0></fA45><fA47 i1="01" i2="1"><s0>05-0273420</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Brain and cognition : (Print)</s0></fA64><fA66 i1="01"><s0>USA</s0></fA66><fC01 i1="01" l="ENG"><s0>Patients with Parkinson's disease (PD) exhibit deficits in perceptual and motor timing as well as impairments in memory and attentional processes that are related to dysfunction of dopaminergic systems in the basal ganglia. The aim of the present study was to assess the relationships existing between impaired duration judgments and defective memory and attention in PD patients. We compared time performance of medicated PD patients and control subjects on a duration reproduction task that is highly memory-dependent, and on a duration production task that could reveal effects of changes in the speed of internal time-keeping mechanisms. Each task was performed in a control counting condition and in a condition requiring divided attention between the temporal task and a concurrent reading task. Moreover, PD patients and control subjects were assessed on memory and attention using a battery of neuropsychological tests. The results revealed that in the concurrent reading condition of the reproduction task, duration judgments tended to be more variable in PD patients than in control subjects. Moreover, variability of duration reproductions was correlated with both measures of memory and of disease severity. In the concurrent reading condition of the production task, duration judgments were significantly shorter in PD patients than in control subjects, and accuracy of duration productions was correlated with scores on sub-tests of short-term memory. The findings suggest that the administration of dopamine did not entirely remove the memory deficits in PD patients. Moreover, DA treatment would have abnormally accelerated the rate of the internal clock leading to shorter duration productions in PD patients. 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