Interactions between antiparkinsonian drugs and ABCB1/P-glycoprotein at the blood-brain barrier in a rat brain endothelial cell model
Identifieur interne : 000752 ( PascalFrancis/Checkpoint ); précédent : 000751; suivant : 000753Interactions between antiparkinsonian drugs and ABCB1/P-glycoprotein at the blood-brain barrier in a rat brain endothelial cell model
Auteurs : Sarah Vautier [France] ; Aline Milane [France] ; Christine Fernandez [France] ; Marion Buyse [France] ; Helene Chacun [France] ; Robert Farinotti [France]Source :
- Neuroscience letters [ 0304-3940 ] ; 2008.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
Parkinson's disease is a neurodegenerative disorder that requires treatment by dopaminergic agonists, which may be responsible for central side effects. We hypothesized that the efflux transporter ABCB1/P-glycoprotein played a role in brain disposition ofantiparkinsonian drugs and could control central toxicity. We aimed to evaluate antiparkinsonian drugs as ABCB1 substrates and/or inhibitors in rat brain endothelial cells GPNT, in order to predict potential clinical drug-drug interactions. Among the antiparkinsonian drugs tested, levodopa, bromocriptine, pergolide and pramipexole were ABCB1 substrates. However, only bromocriptine could inhibit ABCB1 functionality with an ICso of 6.71 μM on Rhodamine 123 uptake and an IC50 of 1.71 μM on digoxine uptake. Thus, bromocriptine at 100 μM is responsible for an increase of levodopa intracellular transport of about 2.05-fold versus control. Therefore, we can conclude that bromocriptine is a potent drug for medicinal interactions in vitro. Hence, in patients with Parkinson's disease, these results may be considered to optimise treatments individually.
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
Pascal:08-0409295Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Interactions between antiparkinsonian drugs and ABCB1/P-glycoprotein at the blood-brain barrier in a rat brain endothelial cell model</title>
<author><name sortKey="Vautier, Sarah" sort="Vautier, Sarah" uniqKey="Vautier S" first="Sarah" last="Vautier">Sarah Vautier</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>University Paris-Sud XI, Department ofClinical Pharmacy, EA 2706, 5 rue Jean-Baptiste Clement</s1>
<s2>Châtenay-Malabry 92296</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Île-de-France</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Milane, Aline" sort="Milane, Aline" uniqKey="Milane A" first="Aline" last="Milane">Aline Milane</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>University Paris-Sud XI, Department ofClinical Pharmacy, EA 2706, 5 rue Jean-Baptiste Clement</s1>
<s2>Châtenay-Malabry 92296</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Île-de-France</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fernandez, Christine" sort="Fernandez, Christine" uniqKey="Fernandez C" first="Christine" last="Fernandez">Christine Fernandez</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>University Paris-Sud XI, Department ofClinical Pharmacy, EA 2706, 5 rue Jean-Baptiste Clement</s1>
<s2>Châtenay-Malabry 92296</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Île-de-France</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Pharmacy, Pitié-Salpêtrière Hospital, Assistance Publique -Hôpitaux de Paris, 47 Bd de l'Hôpital</s1>
<s2>Paris 75013</s2>
<s3>FRA</s3>
<sZ>3 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Île-de-France</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Buyse, Marion" sort="Buyse, Marion" uniqKey="Buyse M" first="Marion" last="Buyse">Marion Buyse</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>University Paris-Sud XI, Department ofClinical Pharmacy, EA 2706, 5 rue Jean-Baptiste Clement</s1>
<s2>Châtenay-Malabry 92296</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Île-de-France</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chacun, Helene" sort="Chacun, Helene" uniqKey="Chacun H" first="Helene" last="Chacun">Helene Chacun</name>
<affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Université Paris-Sud, Department of Galenic Pharmacy</s1>
<s2>Châtenay-Malabry 92296</s2>
<s3>FRA</s3>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Île-de-France</region>
</placeName>
<orgName type="university">Université Paris-Sud</orgName>
</affiliation>
</author>
<author><name sortKey="Farinotti, Robert" sort="Farinotti, Robert" uniqKey="Farinotti R" first="Robert" last="Farinotti">Robert Farinotti</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>University Paris-Sud XI, Department ofClinical Pharmacy, EA 2706, 5 rue Jean-Baptiste Clement</s1>
<s2>Châtenay-Malabry 92296</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Île-de-France</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Pharmacy, Pitié-Salpêtrière Hospital, Assistance Publique -Hôpitaux de Paris, 47 Bd de l'Hôpital</s1>
<s2>Paris 75013</s2>
<s3>FRA</s3>
<sZ>3 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Île-de-France</region>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">08-0409295</idno>
<date when="2008">2008</date>
<idno type="stanalyst">PASCAL 08-0409295 INIST</idno>
<idno type="RBID">Pascal:08-0409295</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000862</idno>
<idno type="wicri:Area/PascalFrancis/Curation">000B47</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">000752</idno>
<idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000752</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Interactions between antiparkinsonian drugs and ABCB1/P-glycoprotein at the blood-brain barrier in a rat brain endothelial cell model</title>
<author><name sortKey="Vautier, Sarah" sort="Vautier, Sarah" uniqKey="Vautier S" first="Sarah" last="Vautier">Sarah Vautier</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>University Paris-Sud XI, Department ofClinical Pharmacy, EA 2706, 5 rue Jean-Baptiste Clement</s1>
<s2>Châtenay-Malabry 92296</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Île-de-France</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Milane, Aline" sort="Milane, Aline" uniqKey="Milane A" first="Aline" last="Milane">Aline Milane</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>University Paris-Sud XI, Department ofClinical Pharmacy, EA 2706, 5 rue Jean-Baptiste Clement</s1>
<s2>Châtenay-Malabry 92296</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Île-de-France</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fernandez, Christine" sort="Fernandez, Christine" uniqKey="Fernandez C" first="Christine" last="Fernandez">Christine Fernandez</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>University Paris-Sud XI, Department ofClinical Pharmacy, EA 2706, 5 rue Jean-Baptiste Clement</s1>
<s2>Châtenay-Malabry 92296</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Île-de-France</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Pharmacy, Pitié-Salpêtrière Hospital, Assistance Publique -Hôpitaux de Paris, 47 Bd de l'Hôpital</s1>
<s2>Paris 75013</s2>
<s3>FRA</s3>
<sZ>3 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Île-de-France</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Buyse, Marion" sort="Buyse, Marion" uniqKey="Buyse M" first="Marion" last="Buyse">Marion Buyse</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>University Paris-Sud XI, Department ofClinical Pharmacy, EA 2706, 5 rue Jean-Baptiste Clement</s1>
<s2>Châtenay-Malabry 92296</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Île-de-France</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chacun, Helene" sort="Chacun, Helene" uniqKey="Chacun H" first="Helene" last="Chacun">Helene Chacun</name>
<affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Université Paris-Sud, Department of Galenic Pharmacy</s1>
<s2>Châtenay-Malabry 92296</s2>
<s3>FRA</s3>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Île-de-France</region>
</placeName>
<orgName type="university">Université Paris-Sud</orgName>
</affiliation>
</author>
<author><name sortKey="Farinotti, Robert" sort="Farinotti, Robert" uniqKey="Farinotti R" first="Robert" last="Farinotti">Robert Farinotti</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>University Paris-Sud XI, Department ofClinical Pharmacy, EA 2706, 5 rue Jean-Baptiste Clement</s1>
<s2>Châtenay-Malabry 92296</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Île-de-France</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Pharmacy, Pitié-Salpêtrière Hospital, Assistance Publique -Hôpitaux de Paris, 47 Bd de l'Hôpital</s1>
<s2>Paris 75013</s2>
<s3>FRA</s3>
<sZ>3 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Île-de-France</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Neuroscience letters</title>
<title level="j" type="abbreviated">Neurosci. lett.</title>
<idno type="ISSN">0304-3940</idno>
<imprint><date when="2008">2008</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Neuroscience letters</title>
<title level="j" type="abbreviated">Neurosci. lett.</title>
<idno type="ISSN">0304-3940</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animal</term>
<term>Antiparkinson agent</term>
<term>Blood brain barrier</term>
<term>Bromocriptine</term>
<term>Drug interaction</term>
<term>Encephalon</term>
<term>Endothelial cell</term>
<term>Glycoprotein</term>
<term>Models</term>
<term>Rat</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Antiparkinsonien</term>
<term>Glycoprotéine</term>
<term>Barrière hématoencéphalique</term>
<term>Encéphale</term>
<term>Cellule endothéliale</term>
<term>Modèle</term>
<term>Bromocriptine</term>
<term>Interaction médicamenteuse</term>
<term>Rat</term>
<term>Animal</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Parkinson's disease is a neurodegenerative disorder that requires treatment by dopaminergic agonists, which may be responsible for central side effects. We hypothesized that the efflux transporter ABCB1/P-glycoprotein played a role in brain disposition ofantiparkinsonian drugs and could control central toxicity. We aimed to evaluate antiparkinsonian drugs as ABCB1 substrates and/or inhibitors in rat brain endothelial cells GPNT, in order to predict potential clinical drug-drug interactions. Among the antiparkinsonian drugs tested, levodopa, bromocriptine, pergolide and pramipexole were ABCB1 substrates. However, only bromocriptine could inhibit ABCB1 functionality with an ICso of 6.71 μM on Rhodamine 123 uptake and an IC<sub>50</sub>
of 1.71 μM on digoxine uptake. Thus, bromocriptine at 100 μM is responsible for an increase of levodopa intracellular transport of about 2.05-fold versus control. Therefore, we can conclude that bromocriptine is a potent drug for medicinal interactions in vitro. Hence, in patients with Parkinson's disease, these results may be considered to optimise treatments individually.</div>
</front>
</TEI>
<inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0304-3940</s0>
</fA01>
<fA02 i1="01"><s0>NELED5</s0>
</fA02>
<fA03 i2="1"><s0>Neurosci. lett.</s0>
</fA03>
<fA05><s2>442</s2>
</fA05>
<fA06><s2>1</s2>
</fA06>
<fA08 i1="01" i2="1" l="ENG"><s1>Interactions between antiparkinsonian drugs and ABCB1/P-glycoprotein at the blood-brain barrier in a rat brain endothelial cell model</s1>
</fA08>
<fA11 i1="01" i2="1"><s1>VAUTIER (Sarah)</s1>
</fA11>
<fA11 i1="02" i2="1"><s1>MILANE (Aline)</s1>
</fA11>
<fA11 i1="03" i2="1"><s1>FERNANDEZ (Christine)</s1>
</fA11>
<fA11 i1="04" i2="1"><s1>BUYSE (Marion)</s1>
</fA11>
<fA11 i1="05" i2="1"><s1>CHACUN (Helene)</s1>
</fA11>
<fA11 i1="06" i2="1"><s1>FARINOTTI (Robert)</s1>
</fA11>
<fA14 i1="01"><s1>University Paris-Sud XI, Department ofClinical Pharmacy, EA 2706, 5 rue Jean-Baptiste Clement</s1>
<s2>Châtenay-Malabry 92296</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
</fA14>
<fA14 i1="02"><s1>Department of Pharmacy, Pitié-Salpêtrière Hospital, Assistance Publique -Hôpitaux de Paris, 47 Bd de l'Hôpital</s1>
<s2>Paris 75013</s2>
<s3>FRA</s3>
<sZ>3 aut.</sZ>
<sZ>6 aut.</sZ>
</fA14>
<fA14 i1="03"><s1>Université Paris-Sud, Department of Galenic Pharmacy</s1>
<s2>Châtenay-Malabry 92296</s2>
<s3>FRA</s3>
<sZ>5 aut.</sZ>
</fA14>
<fA20><s1>19-23</s1>
</fA20>
<fA21><s1>2008</s1>
</fA21>
<fA23 i1="01"><s0>ENG</s0>
</fA23>
<fA43 i1="01"><s1>INIST</s1>
<s2>17240</s2>
<s5>354000196252020050</s5>
</fA43>
<fA44><s0>0000</s0>
<s1>© 2008 INIST-CNRS. All rights reserved.</s1>
</fA44>
<fA45><s0>22 ref.</s0>
</fA45>
<fA47 i1="01" i2="1"><s0>08-0409295</s0>
</fA47>
<fA60><s1>P</s1>
</fA60>
<fA61><s0>A</s0>
</fA61>
<fA64 i1="01" i2="1"><s0>Neuroscience letters</s0>
</fA64>
<fA66 i1="01"><s0>IRL</s0>
</fA66>
<fC01 i1="01" l="ENG"><s0>Parkinson's disease is a neurodegenerative disorder that requires treatment by dopaminergic agonists, which may be responsible for central side effects. We hypothesized that the efflux transporter ABCB1/P-glycoprotein played a role in brain disposition ofantiparkinsonian drugs and could control central toxicity. We aimed to evaluate antiparkinsonian drugs as ABCB1 substrates and/or inhibitors in rat brain endothelial cells GPNT, in order to predict potential clinical drug-drug interactions. Among the antiparkinsonian drugs tested, levodopa, bromocriptine, pergolide and pramipexole were ABCB1 substrates. However, only bromocriptine could inhibit ABCB1 functionality with an ICso of 6.71 μM on Rhodamine 123 uptake and an IC<sub>50</sub>
of 1.71 μM on digoxine uptake. Thus, bromocriptine at 100 μM is responsible for an increase of levodopa intracellular transport of about 2.05-fold versus control. Therefore, we can conclude that bromocriptine is a potent drug for medicinal interactions in vitro. Hence, in patients with Parkinson's disease, these results may be considered to optimise treatments individually.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002A25B</s0>
</fC02>
<fC02 i1="02" i2="X"><s0>002B02B06</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Antiparkinsonien</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Antiparkinson agent</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Antiparkinsoniano</s0>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Glycoprotéine</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Glycoprotein</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Glicoproteína</s0>
<s5>02</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Barrière hématoencéphalique</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Blood brain barrier</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Barrera hematoencefálica</s0>
<s5>03</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Encéphale</s0>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Encephalon</s0>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Encéfalo</s0>
<s5>04</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Cellule endothéliale</s0>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Endothelial cell</s0>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Célula endotelial</s0>
<s5>05</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Modèle</s0>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Models</s0>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Modelo</s0>
<s5>06</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Bromocriptine</s0>
<s2>NK</s2>
<s2>FR</s2>
<s5>07</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Bromocriptine</s0>
<s2>NK</s2>
<s2>FR</s2>
<s5>07</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Bromocriptina</s0>
<s2>NK</s2>
<s2>FR</s2>
<s5>07</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE"><s0>Interaction médicamenteuse</s0>
<s5>08</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG"><s0>Drug interaction</s0>
<s5>08</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA"><s0>Interacción medicamentosa</s0>
<s5>08</s5>
</fC03>
<fC03 i1="09" i2="X" l="FRE"><s0>Rat</s0>
<s5>54</s5>
</fC03>
<fC03 i1="09" i2="X" l="ENG"><s0>Rat</s0>
<s5>54</s5>
</fC03>
<fC03 i1="09" i2="X" l="SPA"><s0>Rata</s0>
<s5>54</s5>
</fC03>
<fC03 i1="10" i2="X" l="FRE"><s0>Animal</s0>
<s5>69</s5>
</fC03>
<fC03 i1="10" i2="X" l="ENG"><s0>Animal</s0>
<s5>69</s5>
</fC03>
<fC03 i1="10" i2="X" l="SPA"><s0>Animal</s0>
<s5>69</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Système nerveux central</s0>
<s5>20</s5>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Central nervous system</s0>
<s5>20</s5>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Sistema nervioso central</s0>
<s5>20</s5>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Rodentia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Rodentia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Rodentia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Mammalia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Mammalia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Mammalia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Vertebrata</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Vertebrata</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Vertebrata</s0>
<s2>NS</s2>
</fC07>
<fN21><s1>266</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
</inist>
<affiliations><list><country><li>France</li>
</country>
<region><li>Île-de-France</li>
</region>
<orgName><li>Université Paris-Sud</li>
</orgName>
</list>
<tree><country name="France"><region name="Île-de-France"><name sortKey="Vautier, Sarah" sort="Vautier, Sarah" uniqKey="Vautier S" first="Sarah" last="Vautier">Sarah Vautier</name>
</region>
<name sortKey="Buyse, Marion" sort="Buyse, Marion" uniqKey="Buyse M" first="Marion" last="Buyse">Marion Buyse</name>
<name sortKey="Chacun, Helene" sort="Chacun, Helene" uniqKey="Chacun H" first="Helene" last="Chacun">Helene Chacun</name>
<name sortKey="Farinotti, Robert" sort="Farinotti, Robert" uniqKey="Farinotti R" first="Robert" last="Farinotti">Robert Farinotti</name>
<name sortKey="Farinotti, Robert" sort="Farinotti, Robert" uniqKey="Farinotti R" first="Robert" last="Farinotti">Robert Farinotti</name>
<name sortKey="Fernandez, Christine" sort="Fernandez, Christine" uniqKey="Fernandez C" first="Christine" last="Fernandez">Christine Fernandez</name>
<name sortKey="Fernandez, Christine" sort="Fernandez, Christine" uniqKey="Fernandez C" first="Christine" last="Fernandez">Christine Fernandez</name>
<name sortKey="Milane, Aline" sort="Milane, Aline" uniqKey="Milane A" first="Aline" last="Milane">Aline Milane</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/PascalFrancis/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000752 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PascalFrancis/Checkpoint/biblio.hfd -nk 000752 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= ParkinsonFranceV1 |flux= PascalFrancis |étape= Checkpoint |type= RBID |clé= Pascal:08-0409295 |texte= Interactions between antiparkinsonian drugs and ABCB1/P-glycoprotein at the blood-brain barrier in a rat brain endothelial cell model }}
![]() | This area was generated with Dilib version V0.6.29. | ![]() |