At which steps of spatial working memory processing do striatofrontal circuits intervene in humans?
Identifieur interne : 001F57 ( Ncbi/Merge ); précédent : 001F56; suivant : 001F58At which steps of spatial working memory processing do striatofrontal circuits intervene in humans?
Auteurs : C. Le Bras [France] ; B. Pillon ; P. Damier ; B. DuboisSource :
- Neuropsychologia [ 0028-3932 ] ; 1999.
English descriptors
- KwdEn :
- Antiparkinson Agents (therapeutic use), Female, Humans, Levodopa (therapeutic use), Male, Memory, Short-Term (physiology), Mental Processes (physiology), Middle Aged, Neostriatum (physiology), Parkinson Disease (drug therapy), Parkinson Disease (psychology), Prefrontal Cortex (physiology), Psychomotor Performance (drug effects), Space Perception (physiology).
- MESH :
- chemical , therapeutic use : Antiparkinson Agents, Levodopa.
- drug effects : Psychomotor Performance.
- drug therapy : Parkinson Disease.
- physiology : Memory, Short-Term, Mental Processes, Neostriatum, Prefrontal Cortex, Space Perception.
- psychology : Parkinson Disease.
- Female, Humans, Male, Middle Aged.
Abstract
Striatofrontal circuits have been implicated in spatial working memory in non-human and human primates. To determine at which steps of information processing (stimulus encoding, storage or response programming) they intervene, we compared 32 levodopa-treated patients with idiopathic Parkinson's disease (PD) and 32 matched control subjects in a visuo-spatial pattern span paradigm. Our testing procedure allowed us to evaluate the influence of: (1) the type of encoding (controlled vs free); (2) the nature of interference during a 10 s delay (spatial vs verbal); and (3) response elaboration (reproduction vs error detection). As expected, the performance of control subjects was significantly better in controlled than in free encoding, in verbal than in spatial interference and in detection than in reproduction, clearly demonstrating the sensitivity of the procedure to these factors. Compared to controls, PD patients were impaired in all conditions and the severity of the deficit was significantly correlated with that observed in tests of executive functions. The global pattern of performance, however, was identical to that of controls. These data confirm the involvement of striatofrontal circuits in spatial working memory in humans and suggest that the executive working memory component intervenes at all steps of working memory processing.
PubMed: 9920474
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Damier</name></author><author><name sortKey="Dubois, B" sort="Dubois, B" uniqKey="Dubois B" first="B" last="Dubois">B. 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Le Bras</name><affiliation wicri:level="3"><nlm:affiliation>Inserm U289 and Fédération de Neurologie, Hôpital de la Salpêtrière, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Inserm U289 and Fédération de Neurologie, Hôpital de la Salpêtrière, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Pillon, B" sort="Pillon, B" uniqKey="Pillon B" first="B" last="Pillon">B. Pillon</name></author><author><name sortKey="Damier, P" sort="Damier, P" uniqKey="Damier P" first="P" last="Damier">P. Damier</name></author><author><name sortKey="Dubois, B" sort="Dubois, B" uniqKey="Dubois B" first="B" last="Dubois">B. Dubois</name></author></analytic><series><title level="j">Neuropsychologia</title><idno type="ISSN">0028-3932</idno><imprint><date when="1999" type="published">1999</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antiparkinson Agents (therapeutic use)</term><term>Female</term><term>Humans</term><term>Levodopa (therapeutic use)</term><term>Male</term><term>Memory, Short-Term (physiology)</term><term>Mental Processes (physiology)</term><term>Middle Aged</term><term>Neostriatum (physiology)</term><term>Parkinson Disease (drug therapy)</term><term>Parkinson Disease (psychology)</term><term>Prefrontal Cortex (physiology)</term><term>Psychomotor Performance (drug effects)</term><term>Space Perception (physiology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiparkinson Agents</term><term>Levodopa</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Psychomotor Performance</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Memory, Short-Term</term><term>Mental Processes</term><term>Neostriatum</term><term>Prefrontal Cortex</term><term>Space Perception</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Striatofrontal circuits have been implicated in spatial working memory in non-human and human primates. To determine at which steps of information processing (stimulus encoding, storage or response programming) they intervene, we compared 32 levodopa-treated patients with idiopathic Parkinson's disease (PD) and 32 matched control subjects in a visuo-spatial pattern span paradigm. Our testing procedure allowed us to evaluate the influence of: (1) the type of encoding (controlled vs free); (2) the nature of interference during a 10 s delay (spatial vs verbal); and (3) response elaboration (reproduction vs error detection). As expected, the performance of control subjects was significantly better in controlled than in free encoding, in verbal than in spatial interference and in detection than in reproduction, clearly demonstrating the sensitivity of the procedure to these factors. Compared to controls, PD patients were impaired in all conditions and the severity of the deficit was significantly correlated with that observed in tests of executive functions. The global pattern of performance, however, was identical to that of controls. These data confirm the involvement of striatofrontal circuits in spatial working memory in humans and suggest that the executive working memory component intervenes at all steps of working memory processing.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">9920474</PMID><DateCreated><Year>1999</Year><Month>04</Month><Day>13</Day></DateCreated><DateCompleted><Year>1999</Year><Month>04</Month><Day>13</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0028-3932</ISSN><JournalIssue CitedMedium="Print"><Volume>37</Volume><Issue>1</Issue><PubDate><Year>1999</Year><Month>Jan</Month></PubDate></JournalIssue><Title>Neuropsychologia</Title><ISOAbbreviation>Neuropsychologia</ISOAbbreviation></Journal><ArticleTitle>At which steps of spatial working memory processing do striatofrontal circuits intervene in humans?</ArticleTitle><Pagination><MedlinePgn>83-90</MedlinePgn></Pagination><Abstract><AbstractText>Striatofrontal circuits have been implicated in spatial working memory in non-human and human primates. To determine at which steps of information processing (stimulus encoding, storage or response programming) they intervene, we compared 32 levodopa-treated patients with idiopathic Parkinson's disease (PD) and 32 matched control subjects in a visuo-spatial pattern span paradigm. Our testing procedure allowed us to evaluate the influence of: (1) the type of encoding (controlled vs free); (2) the nature of interference during a 10 s delay (spatial vs verbal); and (3) response elaboration (reproduction vs error detection). As expected, the performance of control subjects was significantly better in controlled than in free encoding, in verbal than in spatial interference and in detection than in reproduction, clearly demonstrating the sensitivity of the procedure to these factors. Compared to controls, PD patients were impaired in all conditions and the severity of the deficit was significantly correlated with that observed in tests of executive functions. The global pattern of performance, however, was identical to that of controls. These data confirm the involvement of striatofrontal circuits in spatial working memory in humans and suggest that the executive working memory component intervenes at all steps of working memory processing.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Le Bras</LastName><ForeName>C</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Inserm U289 and Fédération de Neurologie, Hôpital de la Salpêtrière, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pillon</LastName><ForeName>B</ForeName><Initials>B</Initials></Author><Author ValidYN="Y"><LastName>Damier</LastName><ForeName>P</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Dubois</LastName><ForeName>B</ForeName><Initials>B</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016430">Clinical Trial</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Neuropsychologia</MedlineTA><NlmUniqueID>0020713</NlmUniqueID><ISSNLinking>0028-3932</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000978">Antiparkinson Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>46627O600J</RegistryNumber><NameOfSubstance UI="D007980">Levodopa</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CitationSubset>S</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000978" MajorTopicYN="N">Antiparkinson Agents</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007980" MajorTopicYN="N">Levodopa</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008570" MajorTopicYN="N">Memory, Short-Term</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008606" MajorTopicYN="N">Mental Processes</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017072" MajorTopicYN="N">Neostriatum</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName><QualifierName UI="Q000523" MajorTopicYN="N">psychology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017397" MajorTopicYN="N">Prefrontal Cortex</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011597" MajorTopicYN="N">Psychomotor Performance</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013028" MajorTopicYN="N">Space Perception</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1999</Year><Month>1</Month><Day>27</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1999</Year><Month>1</Month><Day>27</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1999</Year><Month>1</Month><Day>27</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">9920474</ArticleId><ArticleId IdType="pii">S0028393298000414</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>France</li></country><region><li>Île-de-France</li></region><settlement><li>Paris</li></settlement></list><tree><noCountry><name sortKey="Damier, P" sort="Damier, P" uniqKey="Damier P" first="P" last="Damier">P. Damier</name><name sortKey="Dubois, B" sort="Dubois, B" uniqKey="Dubois B" first="B" last="Dubois">B. Dubois</name><name sortKey="Pillon, B" sort="Pillon, B" uniqKey="Pillon B" first="B" last="Pillon">B. Pillon</name></noCountry><country name="France"><region name="Île-de-France"><name sortKey="Le Bras, C" sort="Le Bras, C" uniqKey="Le Bras C" first="C" last="Le Bras">C. Le Bras</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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