Neuroimaging in vascular cognitive impairment: a state-of-the-art review
Identifieur interne : 001B46 ( Ncbi/Merge ); précédent : 001B45; suivant : 001B47Neuroimaging in vascular cognitive impairment: a state-of-the-art review
Auteurs : Wolf-Dieter Heiss [Allemagne] ; Gary A. Rosenberg [États-Unis] ; Alexander Thiel ; Rok Berlot [Slovénie] ; Jacques De Reuck [France]Source :
- BMC Medicine [ 1741-7015 ] ; 2016.
Abstract
Imaging is critical in the diagnosis and treatment of dementia, particularly in vascular cognitive impairment, due to the visualization of ischemic and hemorrhagic injury of gray and white matter. Magnetic resonance imaging (MRI) and positron emission tomography (PET) provide structural and functional information. Clinical MRI is both generally available and versatile – T2-weighted images show infarcts, FLAIR shows white matter changes and lacunar infarcts, and susceptibility-weighted images reveal microbleeds. Diffusion MRI adds another dimension by showing graded damage to white matter, making it more sensitive to white matter injury than FLAIR. Regions of neuroinflammatory disruption of the blood–brain barrier with increased permeability can be quantified and visualized with dynamic contrast-enhanced MRI. PET shows metabolism of glucose and accumulation of amyloid and tau, which is useful in showing abnormal metabolism in Alzheimer’s disease. Combining MRI and PET allows identification of patients with mixed dementia, with MRI showing white matter injury and PET demonstrating regional impairment of glucose metabolism and deposition of amyloid. Excellent anatomical detail can be observed with 7.0-Tesla MRI. Imaging is the optimal method to follow the effect of treatments since changes in MRI scans are seen prior to those in cognition. This review describes the role of various imaging modalities in the diagnosis and treatment of vascular cognitive impairment.
Url:
DOI: 10.1186/s12916-016-0725-0
PubMed: 27806705
PubMed Central: 5094143
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000260
- to stream Pmc, to step Curation: 000258
- to stream Pmc, to step Checkpoint: 000055
Links to Exploration step
PMC:5094143Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Neuroimaging in vascular cognitive impairment: a state-of-the-art review</title><author><name sortKey="Heiss, Wolf Dieter" sort="Heiss, Wolf Dieter" uniqKey="Heiss W" first="Wolf-Dieter" last="Heiss">Wolf-Dieter Heiss</name><affiliation wicri:level="3"><nlm:aff id="Aff1">Max Planck Institute for Metabolism Research, Gleueler str. 50, D-50931 Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Max Planck Institute for Metabolism Research, Gleueler str. 50, D-50931 Cologne</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Cologne</settlement></placeName></affiliation></author><author><name sortKey="Rosenberg, Gary A" sort="Rosenberg, Gary A" uniqKey="Rosenberg G" first="Gary A." last="Rosenberg">Gary A. Rosenberg</name><affiliation wicri:level="2"><nlm:aff id="Aff2">Department of Neurology, UNM Memory and Aging Center, MSC 11 6035, University of New Mexico, Albuquerque, NM 87131 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Nouveau-Mexique</region></placeName><wicri:cityArea>Department of Neurology, UNM Memory and Aging Center, MSC 11 6035, University of New Mexico, Albuquerque</wicri:cityArea></affiliation></author><author><name sortKey="Thiel, Alexander" sort="Thiel, Alexander" uniqKey="Thiel A" first="Alexander" last="Thiel">Alexander Thiel</name><affiliation><nlm:aff id="Aff3">Department of Neurology & Neurosurgery, McGill University at SMBD Jewish General Hospital and Lady Davis Institute for Medical Research, Montreal, H3T 1E2 Québec Canada</nlm:aff><wicri:noCountry code="subfield">H3T 1E2 Québec Canada</wicri:noCountry></affiliation></author><author><name sortKey="Berlot, Rok" sort="Berlot, Rok" uniqKey="Berlot R" first="Rok" last="Berlot">Rok Berlot</name><affiliation wicri:level="1"><nlm:aff id="Aff4">Department of Neurology (R.B.), University Medical Centre Ljubljana, 1000 Ljubljana, Slovenia</nlm:aff><country xml:lang="fr">Slovénie</country><wicri:regionArea>Department of Neurology (R.B.), University Medical Centre Ljubljana, 1000 Ljubljana</wicri:regionArea><wicri:noRegion>1000 Ljubljana</wicri:noRegion></affiliation></author><author><name sortKey="De Reuck, Jacques" sort="De Reuck, Jacques" uniqKey="De Reuck J" first="Jacques" last="De Reuck">Jacques De Reuck</name><affiliation wicri:level="4"><nlm:aff id="Aff5">INSERM U1171, Degenerative and Vascular Cognitive Disorders, Université Lille 2, Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM U1171, Degenerative and Vascular Cognitive Disorders, Université Lille 2, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName><orgName type="university">Université Lille 2</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27806705</idno><idno type="pmc">5094143</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5094143</idno><idno type="RBID">PMC:5094143</idno><idno type="doi">10.1186/s12916-016-0725-0</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">000260</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000260</idno><idno type="wicri:Area/Pmc/Curation">000258</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000258</idno><idno type="wicri:Area/Pmc/Checkpoint">000055</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000055</idno><idno type="wicri:Area/Ncbi/Merge">001B46</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Neuroimaging in vascular cognitive impairment: a state-of-the-art review</title><author><name sortKey="Heiss, Wolf Dieter" sort="Heiss, Wolf Dieter" uniqKey="Heiss W" first="Wolf-Dieter" last="Heiss">Wolf-Dieter Heiss</name><affiliation wicri:level="3"><nlm:aff id="Aff1">Max Planck Institute for Metabolism Research, Gleueler str. 50, D-50931 Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Max Planck Institute for Metabolism Research, Gleueler str. 50, D-50931 Cologne</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Cologne</settlement></placeName></affiliation></author><author><name sortKey="Rosenberg, Gary A" sort="Rosenberg, Gary A" uniqKey="Rosenberg G" first="Gary A." last="Rosenberg">Gary A. Rosenberg</name><affiliation wicri:level="2"><nlm:aff id="Aff2">Department of Neurology, UNM Memory and Aging Center, MSC 11 6035, University of New Mexico, Albuquerque, NM 87131 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Nouveau-Mexique</region></placeName><wicri:cityArea>Department of Neurology, UNM Memory and Aging Center, MSC 11 6035, University of New Mexico, Albuquerque</wicri:cityArea></affiliation></author><author><name sortKey="Thiel, Alexander" sort="Thiel, Alexander" uniqKey="Thiel A" first="Alexander" last="Thiel">Alexander Thiel</name><affiliation><nlm:aff id="Aff3">Department of Neurology & Neurosurgery, McGill University at SMBD Jewish General Hospital and Lady Davis Institute for Medical Research, Montreal, H3T 1E2 Québec Canada</nlm:aff><wicri:noCountry code="subfield">H3T 1E2 Québec Canada</wicri:noCountry></affiliation></author><author><name sortKey="Berlot, Rok" sort="Berlot, Rok" uniqKey="Berlot R" first="Rok" last="Berlot">Rok Berlot</name><affiliation wicri:level="1"><nlm:aff id="Aff4">Department of Neurology (R.B.), University Medical Centre Ljubljana, 1000 Ljubljana, Slovenia</nlm:aff><country xml:lang="fr">Slovénie</country><wicri:regionArea>Department of Neurology (R.B.), University Medical Centre Ljubljana, 1000 Ljubljana</wicri:regionArea><wicri:noRegion>1000 Ljubljana</wicri:noRegion></affiliation></author><author><name sortKey="De Reuck, Jacques" sort="De Reuck, Jacques" uniqKey="De Reuck J" first="Jacques" last="De Reuck">Jacques De Reuck</name><affiliation wicri:level="4"><nlm:aff id="Aff5">INSERM U1171, Degenerative and Vascular Cognitive Disorders, Université Lille 2, Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM U1171, Degenerative and Vascular Cognitive Disorders, Université Lille 2, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName><orgName type="university">Université Lille 2</orgName></affiliation></author></analytic><series><title level="j">BMC Medicine</title><idno type="eISSN">1741-7015</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Imaging is critical in the diagnosis and treatment of dementia, particularly in vascular cognitive impairment, due to the visualization of ischemic and hemorrhagic injury of gray and white matter. Magnetic resonance imaging (MRI) and positron emission tomography (PET) provide structural and functional information. Clinical MRI is both generally available and versatile – T2-weighted images show infarcts, FLAIR shows white matter changes and lacunar infarcts, and susceptibility-weighted images reveal microbleeds. Diffusion MRI adds another dimension by showing graded damage to white matter, making it more sensitive to white matter injury than FLAIR. Regions of neuroinflammatory disruption of the blood–brain barrier with increased permeability can be quantified and visualized with dynamic contrast-enhanced MRI. PET shows metabolism of glucose and accumulation of amyloid and tau, which is useful in showing abnormal metabolism in Alzheimer’s disease. Combining MRI and PET allows identification of patients with mixed dementia, with MRI showing white matter injury and PET demonstrating regional impairment of glucose metabolism and deposition of amyloid. Excellent anatomical detail can be observed with 7.0-Tesla MRI. Imaging is the optimal method to follow the effect of treatments since changes in MRI scans are seen prior to those in cognition. This review describes the role of various imaging modalities in the diagnosis and treatment of vascular cognitive impairment.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Rockwood, K" uniqKey="Rockwood K">K Rockwood</name></author><author><name sortKey="Wentzel, C" uniqKey="Wentzel C">C Wentzel</name></author><author><name sortKey="Hachinski, V" uniqKey="Hachinski V">V Hachinski</name></author><author><name sortKey="Hogan, Db" uniqKey="Hogan D">DB Hogan</name></author><author><name sortKey="Macknight, C" uniqKey="Macknight C">C MacKnight</name></author><author><name sortKey="Mcdowell, I" uniqKey="Mcdowell I">I McDowell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Reuck, J" uniqKey="De Reuck J">J De Reuck</name></author><author><name sortKey="Deramecourt, V" uniqKey="Deramecourt V">V Deramecourt</name></author><author><name sortKey="Cordonnier, C" uniqKey="Cordonnier C">C Cordonnier</name></author><author><name sortKey="Pasquier, F" uniqKey="Pasquier F">F Pasquier</name></author><author><name sortKey="Leys, D" uniqKey="Leys D">D Leys</name></author><author><name sortKey="Maurage, Ca" uniqKey="Maurage C">CA Maurage</name></author><author><name sortKey="Bordet, R" uniqKey="Bordet R">R Bordet</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jellinger, Ka" uniqKey="Jellinger K">KA Jellinger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Knopman, Ds" uniqKey="Knopman D">DS Knopman</name></author><author><name sortKey="Parisi, Je" uniqKey="Parisi J">JE Parisi</name></author><author><name sortKey="Boeve, Bf" uniqKey="Boeve B">BF Boeve</name></author><author><name sortKey="Cha, Rh" uniqKey="Cha R">RH Cha</name></author><author><name sortKey="Apaydin, H" uniqKey="Apaydin H">H Apaydin</name></author><author><name sortKey="Salviati, A" uniqKey="Salviati A">A Salviati</name></author><author><name sortKey="Edland, Sd" uniqKey="Edland S">SD Edland</name></author><author><name sortKey="Rocca, Wa" uniqKey="Rocca W">WA Rocca</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Korczyn, Ad" uniqKey="Korczyn A">AD Korczyn</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rosenberg, Ga" uniqKey="Rosenberg G">GA Rosenberg</name></author><author><name sortKey="Bjerke, M" uniqKey="Bjerke M">M Bjerke</name></author><author><name sortKey="Wallin, A" uniqKey="Wallin A">A Wallin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gorelick, Pb" uniqKey="Gorelick P">PB Gorelick</name></author><author><name sortKey="Scuteri, A" uniqKey="Scuteri A">A Scuteri</name></author><author><name sortKey="Black, Se" uniqKey="Black S">SE Black</name></author><author><name sortKey="Decarli, C" uniqKey="Decarli C">C Decarli</name></author><author><name sortKey="Greenberg, Sm" uniqKey="Greenberg S">SM Greenberg</name></author><author><name sortKey="Iadecola, C" uniqKey="Iadecola C">C Iadecola</name></author><author><name sortKey="Launer, Lj" uniqKey="Launer L">LJ Launer</name></author><author><name sortKey="Laurent, S" uniqKey="Laurent S">S Laurent</name></author><author><name sortKey="Lopez, Ol" uniqKey="Lopez O">OL Lopez</name></author><author><name sortKey="Nyenhuis, D" uniqKey="Nyenhuis D">D Nyenhuis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Roman, Gc" uniqKey="Roman G">GC Roman</name></author><author><name sortKey="Erkinjuntti, T" uniqKey="Erkinjuntti T">T Erkinjuntti</name></author><author><name sortKey="Wallin, A" uniqKey="Wallin A">A Wallin</name></author><author><name sortKey="Pantoni, L" uniqKey="Pantoni L">L Pantoni</name></author><author><name sortKey="Chui, Hc" uniqKey="Chui H">HC Chui</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vermeer, Se" uniqKey="Vermeer S">SE Vermeer</name></author><author><name sortKey="Longstreth, Wt" uniqKey="Longstreth W">WT Longstreth</name></author><author><name sortKey="Koudstaal, Pj" uniqKey="Koudstaal P">PJ Koudstaal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hunt, Al" uniqKey="Hunt A">AL Hunt</name></author><author><name sortKey="Orrison, Ww" uniqKey="Orrison W">WW Orrison</name></author><author><name sortKey="Yeo, Ra" uniqKey="Yeo R">RA Yeo</name></author><author><name sortKey="Haaland, Ky" uniqKey="Haaland K">KY Haaland</name></author><author><name sortKey="Rhyne, Rl" uniqKey="Rhyne R">RL Rhyne</name></author><author><name sortKey="Garry, Pj" uniqKey="Garry P">PJ Garry</name></author><author><name sortKey="Rosenberg, Ga" uniqKey="Rosenberg G">GA Rosenberg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hachinski, Vc" uniqKey="Hachinski V">VC Hachinski</name></author><author><name sortKey="Potter, P" uniqKey="Potter P">P Potter</name></author><author><name sortKey="Merskey, H" uniqKey="Merskey H">H Merskey</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wattjes, Mp" uniqKey="Wattjes M">MP Wattjes</name></author><author><name sortKey="Henneman, Wj" uniqKey="Henneman W">WJ Henneman</name></author><author><name sortKey="Van Der Flier, Wm" uniqKey="Van Der Flier W">WM van der Flier</name></author><author><name sortKey="De Vries, O" uniqKey="De Vries O">O de Vries</name></author><author><name sortKey="Traber, F" uniqKey="Traber F">F Traber</name></author><author><name sortKey="Geurts, Jj" uniqKey="Geurts J">JJ Geurts</name></author><author><name sortKey="Scheltens, P" uniqKey="Scheltens P">P Scheltens</name></author><author><name sortKey="Vrenken, H" uniqKey="Vrenken H">H Vrenken</name></author><author><name sortKey="Barkhof, F" uniqKey="Barkhof F">F Barkhof</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wahlund, Lo" uniqKey="Wahlund L">LO Wahlund</name></author><author><name sortKey="Barkhof, F" uniqKey="Barkhof F">F Barkhof</name></author><author><name sortKey="Fazekas, F" uniqKey="Fazekas F">F Fazekas</name></author><author><name sortKey="Bronge, L" uniqKey="Bronge L">L Bronge</name></author><author><name sortKey="Augustin, M" uniqKey="Augustin M">M Augustin</name></author><author><name sortKey="Sjogren, M" uniqKey="Sjogren M">M Sjogren</name></author><author><name sortKey="Wallin, A" uniqKey="Wallin A">A Wallin</name></author><author><name sortKey="Ader, H" uniqKey="Ader H">H Ader</name></author><author><name sortKey="Leys, D" uniqKey="Leys D">D Leys</name></author><author><name sortKey="Pantoni, L" uniqKey="Pantoni L">L Pantoni</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vitali, P" uniqKey="Vitali P">P Vitali</name></author><author><name sortKey="Migliaccio, R" uniqKey="Migliaccio R">R Migliaccio</name></author><author><name sortKey="Agosta, F" uniqKey="Agosta F">F Agosta</name></author><author><name sortKey="Rosen, Hj" uniqKey="Rosen H">HJ Rosen</name></author><author><name sortKey="Geschwind, Md" uniqKey="Geschwind M">MD Geschwind</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brainin, M" uniqKey="Brainin M">M Brainin</name></author><author><name sortKey="Tuomilehto, J" uniqKey="Tuomilehto J">J Tuomilehto</name></author><author><name sortKey="Heiss, Wd" uniqKey="Heiss W">WD Heiss</name></author><author><name sortKey="Bornstein, Nm" uniqKey="Bornstein N">NM Bornstein</name></author><author><name sortKey="Bath, Pm" uniqKey="Bath P">PM Bath</name></author><author><name sortKey="Teuschl, Y" uniqKey="Teuschl Y">Y Teuschl</name></author><author><name sortKey="Richard, E" uniqKey="Richard E">E Richard</name></author><author><name sortKey="Guekht, A" uniqKey="Guekht A">A Guekht</name></author><author><name sortKey="Quinn, T" uniqKey="Quinn T">T Quinn</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wardlaw, Jm" uniqKey="Wardlaw J">JM Wardlaw</name></author><author><name sortKey="Smith, Ee" uniqKey="Smith E">EE Smith</name></author><author><name sortKey="Biessels, Gj" uniqKey="Biessels G">GJ Biessels</name></author><author><name sortKey="Cordonnier, C" uniqKey="Cordonnier C">C Cordonnier</name></author><author><name sortKey="Fazekas, F" uniqKey="Fazekas F">F Fazekas</name></author><author><name sortKey="Frayne, R" uniqKey="Frayne R">R Frayne</name></author><author><name sortKey="Lindley, Ri" uniqKey="Lindley R">RI Lindley</name></author><author><name sortKey="O Rien, Jt" uniqKey="O Rien J">JT O’Brien</name></author><author><name sortKey="Barkhof, F" uniqKey="Barkhof F">F Barkhof</name></author><author><name sortKey="Benavente, Or" uniqKey="Benavente O">OR Benavente</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Grysiewicz, R" uniqKey="Grysiewicz R">R Grysiewicz</name></author><author><name sortKey="Gorelick, Pb" uniqKey="Gorelick P">PB Gorelick</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Roman, Gc" uniqKey="Roman G">GC Roman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Boone, Kb" uniqKey="Boone K">KB Boone</name></author><author><name sortKey="Miller, Bl" uniqKey="Miller B">BL Miller</name></author><author><name sortKey="Lesser, Im" uniqKey="Lesser I">IM Lesser</name></author><author><name sortKey="Mehringer, Cm" uniqKey="Mehringer C">CM Mehringer</name></author><author><name sortKey="Hill Gutierrez, E" uniqKey="Hill Gutierrez E">E Hill Gutierrez</name></author><author><name sortKey="Goldberg, Ma" uniqKey="Goldberg M">MA Goldberg</name></author><author><name sortKey="Berman, Ng" uniqKey="Berman N">NG Berman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Straaten, Ec" uniqKey="Van Straaten E">EC van Straaten</name></author><author><name sortKey="Scheltens, P" uniqKey="Scheltens P">P Scheltens</name></author><author><name sortKey="Knol, Dl" uniqKey="Knol D">DL Knol</name></author><author><name sortKey="Van Buchem, Ma" uniqKey="Van Buchem M">MA van Buchem</name></author><author><name sortKey="Van Dijk, Ej" uniqKey="Van Dijk E">EJ van Dijk</name></author><author><name sortKey="Hofman, Pa" uniqKey="Hofman P">PA Hofman</name></author><author><name sortKey="Karas, G" uniqKey="Karas G">G Karas</name></author><author><name sortKey="Kjartansson, O" uniqKey="Kjartansson O">O Kjartansson</name></author><author><name sortKey="De Leeuw, Fe" uniqKey="De Leeuw F">FE de Leeuw</name></author><author><name sortKey="Prins, Nd" uniqKey="Prins N">ND Prins</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cordonnier, C" uniqKey="Cordonnier C">C Cordonnier</name></author><author><name sortKey="Van Der Flier, Wm" uniqKey="Van Der Flier W">WM van der Flier</name></author><author><name sortKey="Sluimer, Jd" uniqKey="Sluimer J">JD Sluimer</name></author><author><name sortKey="Leys, D" uniqKey="Leys D">D Leys</name></author><author><name sortKey="Barkhof, F" uniqKey="Barkhof F">F Barkhof</name></author><author><name sortKey="Scheltens, P" uniqKey="Scheltens P">P Scheltens</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Koennecke, Hc" uniqKey="Koennecke H">HC Koennecke</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Reuck, J" uniqKey="De Reuck J">J De Reuck</name></author><author><name sortKey="Deramecourt, V" uniqKey="Deramecourt V">V Deramecourt</name></author><author><name sortKey="Cordonnier, C" uniqKey="Cordonnier C">C Cordonnier</name></author><author><name sortKey="Leys, D" uniqKey="Leys D">D Leys</name></author><author><name sortKey="Pasquier, F" uniqKey="Pasquier F">F Pasquier</name></author><author><name sortKey="Maurage, Ca" uniqKey="Maurage C">CA Maurage</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Reuck, Jl" uniqKey="De Reuck J">JL De Reuck</name></author><author><name sortKey="Auger, F" uniqKey="Auger F">F Auger</name></author><author><name sortKey="Durieux, N" uniqKey="Durieux N">N Durieux</name></author><author><name sortKey="Cordonnier, C" uniqKey="Cordonnier C">C Cordonnier</name></author><author><name sortKey="Deramecourt, V" uniqKey="Deramecourt V">V Deramecourt</name></author><author><name sortKey="Pasquier, F" uniqKey="Pasquier F">F Pasquier</name></author><author><name sortKey="Maurage, Ca" uniqKey="Maurage C">CA Maurage</name></author><author><name sortKey="Leys, D" uniqKey="Leys D">D Leys</name></author><author><name sortKey="Bordet, R" uniqKey="Bordet R">R Bordet</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wardlaw, Jm" uniqKey="Wardlaw J">JM Wardlaw</name></author><author><name sortKey="Allerhand, M" uniqKey="Allerhand M">M Allerhand</name></author><author><name sortKey="Doubal, Fn" uniqKey="Doubal F">FN Doubal</name></author><author><name sortKey="Valdes Hernandez, M" uniqKey="Valdes Hernandez M">M Valdes Hernandez</name></author><author><name sortKey="Morris, Z" uniqKey="Morris Z">Z Morris</name></author><author><name sortKey="Gow, Aj" uniqKey="Gow A">AJ Gow</name></author><author><name sortKey="Bastin, M" uniqKey="Bastin M">M Bastin</name></author><author><name sortKey="Starr, Jm" uniqKey="Starr J">JM Starr</name></author><author><name sortKey="Dennis, Ms" uniqKey="Dennis M">MS Dennis</name></author><author><name sortKey="Deary, Ij" uniqKey="Deary I">IJ Deary</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ihara, M" uniqKey="Ihara M">M Ihara</name></author><author><name sortKey="Yamamoto, Y" uniqKey="Yamamoto Y">Y Yamamoto</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wardlaw, Jm" uniqKey="Wardlaw J">JM Wardlaw</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Veluw, Sj" uniqKey="Van Veluw S">SJ van Veluw</name></author><author><name sortKey="Zwanenburg, Jj" uniqKey="Zwanenburg J">JJ Zwanenburg</name></author><author><name sortKey="Engelen Lee, J" uniqKey="Engelen Lee J">J Engelen-Lee</name></author><author><name sortKey="Spliet, Wg" uniqKey="Spliet W">WG Spliet</name></author><author><name sortKey="Hendrikse, J" uniqKey="Hendrikse J">J Hendrikse</name></author><author><name sortKey="Luijten, Pr" uniqKey="Luijten P">PR Luijten</name></author><author><name sortKey="Biessels, Gj" uniqKey="Biessels G">GJ Biessels</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ii, Y" uniqKey="Ii Y">Y Ii</name></author><author><name sortKey="Maeda, M" uniqKey="Maeda M">M Maeda</name></author><author><name sortKey="Kida, H" uniqKey="Kida H">H Kida</name></author><author><name sortKey="Matsuo, K" uniqKey="Matsuo K">K Matsuo</name></author><author><name sortKey="Shindo, A" uniqKey="Shindo A">A Shindo</name></author><author><name sortKey="Taniguchi, A" uniqKey="Taniguchi A">A Taniguchi</name></author><author><name sortKey="Tomimoto, H" uniqKey="Tomimoto H">H Tomimoto</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Landi, D" uniqKey="Landi D">D Landi</name></author><author><name sortKey="Maggio, P" uniqKey="Maggio P">P Maggio</name></author><author><name sortKey="Lupoi, D" uniqKey="Lupoi D">D Lupoi</name></author><author><name sortKey="Palazzo, P" uniqKey="Palazzo P">P Palazzo</name></author><author><name sortKey="Altamura, C" uniqKey="Altamura C">C Altamura</name></author><author><name sortKey="Falato, E" uniqKey="Falato E">E Falato</name></author><author><name sortKey="Altavilla, R" uniqKey="Altavilla R">R Altavilla</name></author><author><name sortKey="Vollaro, S" uniqKey="Vollaro S">S Vollaro</name></author><author><name sortKey="Coniglio, Ad" uniqKey="Coniglio A">AD Coniglio</name></author><author><name sortKey="Tibuzzi, F" uniqKey="Tibuzzi F">F Tibuzzi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Reuck, J" uniqKey="De Reuck J">J De Reuck</name></author><author><name sortKey="Auger, F" uniqKey="Auger F">F Auger</name></author><author><name sortKey="Cordonnier, C" uniqKey="Cordonnier C">C Cordonnier</name></author><author><name sortKey="Deramecourt, V" uniqKey="Deramecourt V">V Deramecourt</name></author><author><name sortKey="Durieux, N" uniqKey="Durieux N">N Durieux</name></author><author><name sortKey="Pasquier, F" uniqKey="Pasquier F">F Pasquier</name></author><author><name sortKey="Bordet, R" uniqKey="Bordet R">R Bordet</name></author><author><name sortKey="Maurage, Ca" uniqKey="Maurage C">CA Maurage</name></author><author><name sortKey="Leys, D" uniqKey="Leys D">D Leys</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Reuck, J" uniqKey="De Reuck J">J De Reuck</name></author><author><name sortKey="Auger, F" uniqKey="Auger F">F Auger</name></author><author><name sortKey="Durieux, N" uniqKey="Durieux N">N Durieux</name></author><author><name sortKey="Deramecourt, V" uniqKey="Deramecourt V">V Deramecourt</name></author><author><name sortKey="Cordonnier, C" uniqKey="Cordonnier C">C Cordonnier</name></author><author><name sortKey="Pasquier, F" uniqKey="Pasquier F">F Pasquier</name></author><author><name sortKey="Maurage, Ca" uniqKey="Maurage C">CA Maurage</name></author><author><name sortKey="Leys, D" uniqKey="Leys D">D Leys</name></author><author><name sortKey="Bordet, R" uniqKey="Bordet R">R Bordet</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Reuck, J" uniqKey="De Reuck J">J De Reuck</name></author><author><name sortKey="Deramecourt, V" uniqKey="Deramecourt V">V Deramecourt</name></author><author><name sortKey="Auger, F" uniqKey="Auger F">F Auger</name></author><author><name sortKey="Durieux, N" uniqKey="Durieux N">N Durieux</name></author><author><name sortKey="Cordonnier, C" uniqKey="Cordonnier C">C Cordonnier</name></author><author><name sortKey="Devos, D" uniqKey="Devos D">D Devos</name></author><author><name sortKey="Defebvre, L" uniqKey="Defebvre L">L Defebvre</name></author><author><name sortKey="Moreau, C" uniqKey="Moreau C">C Moreau</name></author><author><name sortKey="Caparros Lefebvre, D" uniqKey="Caparros Lefebvre D">D Caparros-Lefebvre</name></author><author><name sortKey="Bordet, R" uniqKey="Bordet R">R Bordet</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Reuck, Jl" uniqKey="De Reuck J">JL De Reuck</name></author><author><name sortKey="Deramecourt, V" uniqKey="Deramecourt V">V Deramecourt</name></author><author><name sortKey="Auger, F" uniqKey="Auger F">F Auger</name></author><author><name sortKey="Durieux, N" uniqKey="Durieux N">N Durieux</name></author><author><name sortKey="Cordonnier, C" uniqKey="Cordonnier C">C Cordonnier</name></author><author><name sortKey="Devos, D" uniqKey="Devos D">D Devos</name></author><author><name sortKey="Defebvre, L" uniqKey="Defebvre L">L Defebvre</name></author><author><name sortKey="Moreau, C" uniqKey="Moreau C">C Moreau</name></author><author><name sortKey="Capparos Lefebvre, D" uniqKey="Capparos Lefebvre D">D Capparos-Lefebvre</name></author><author><name sortKey="Pasquier, F" uniqKey="Pasquier F">F Pasquier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Reuck, J" uniqKey="De Reuck J">J De Reuck</name></author><author><name sortKey="Deramecourt, V" uniqKey="Deramecourt V">V Deramecourt</name></author><author><name sortKey="Cordonnier, C" uniqKey="Cordonnier C">C Cordonnier</name></author><author><name sortKey="Auger, F" uniqKey="Auger F">F Auger</name></author><author><name sortKey="Durieux, N" uniqKey="Durieux N">N Durieux</name></author><author><name sortKey="Bordet, R" uniqKey="Bordet R">R Bordet</name></author><author><name sortKey="Maurage, Ca" uniqKey="Maurage C">CA Maurage</name></author><author><name sortKey="Leys, D" uniqKey="Leys D">D Leys</name></author><author><name sortKey="Pasquier, F" uniqKey="Pasquier F">F Pasquier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Reuck, J" uniqKey="De Reuck J">J De Reuck</name></author><author><name sortKey="Deramecourt, V" uniqKey="Deramecourt V">V Deramecourt</name></author><author><name sortKey="Cordonnier, C" uniqKey="Cordonnier C">C Cordonnier</name></author><author><name sortKey="Auger, F" uniqKey="Auger F">F Auger</name></author><author><name sortKey="Durieux, N" uniqKey="Durieux N">N Durieux</name></author><author><name sortKey="Pasquier, F" uniqKey="Pasquier F">F Pasquier</name></author><author><name sortKey="Bordet, R" uniqKey="Bordet R">R Bordet</name></author><author><name sortKey="Defebvre, L" uniqKey="Defebvre L">L Defebvre</name></author><author><name sortKey="Caparros Lefebvre, D" uniqKey="Caparros Lefebvre D">D Caparros-Lefebvre</name></author><author><name sortKey="Maurage, Ca" uniqKey="Maurage C">CA Maurage</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Reuck, Jl" uniqKey="De Reuck J">JL De Reuck</name></author><author><name sortKey="Deramecourt, V" uniqKey="Deramecourt V">V Deramecourt</name></author><author><name sortKey="Auger, F" uniqKey="Auger F">F Auger</name></author><author><name sortKey="Durieux, N" uniqKey="Durieux N">N Durieux</name></author><author><name sortKey="Cordonnier, C" uniqKey="Cordonnier C">C Cordonnier</name></author><author><name sortKey="Devos, D" uniqKey="Devos D">D Devos</name></author><author><name sortKey="Defebvre, L" uniqKey="Defebvre L">L Defebvre</name></author><author><name sortKey="Moreau, C" uniqKey="Moreau C">C Moreau</name></author><author><name sortKey="Caparros Lefebvre, D" uniqKey="Caparros Lefebvre D">D Caparros-Lefebvre</name></author><author><name sortKey="Leys, D" uniqKey="Leys D">D Leys</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="O Ullivan, M" uniqKey="O Ullivan M">M O’Sullivan</name></author><author><name sortKey="Jones, Dk" uniqKey="Jones D">DK Jones</name></author><author><name sortKey="Summers, Pe" uniqKey="Summers P">PE Summers</name></author><author><name sortKey="Morris, Rg" uniqKey="Morris R">RG Morris</name></author><author><name sortKey="Williams, Sc" uniqKey="Williams S">SC Williams</name></author><author><name sortKey="Markus, Hs" uniqKey="Markus H">HS Markus</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sabri, O" uniqKey="Sabri O">O Sabri</name></author><author><name sortKey="Ringelstein, Eb" uniqKey="Ringelstein E">EB Ringelstein</name></author><author><name sortKey="Hellwig, D" uniqKey="Hellwig D">D Hellwig</name></author><author><name sortKey="Schneider, R" uniqKey="Schneider R">R Schneider</name></author><author><name sortKey="Schreckenberger, M" uniqKey="Schreckenberger M">M Schreckenberger</name></author><author><name sortKey="Kaiser, Hj" uniqKey="Kaiser H">HJ Kaiser</name></author><author><name sortKey="Mull, M" uniqKey="Mull M">M Mull</name></author><author><name sortKey="Buell, U" uniqKey="Buell U">U Buell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="O Ullivan, M" uniqKey="O Ullivan M">M O’Sullivan</name></author><author><name sortKey="Morris, Rg" uniqKey="Morris R">RG Morris</name></author><author><name sortKey="Huckstep, B" uniqKey="Huckstep B">B Huckstep</name></author><author><name sortKey="Jones, Dk" uniqKey="Jones D">DK Jones</name></author><author><name sortKey="Williams, Sc" uniqKey="Williams S">SC Williams</name></author><author><name sortKey="Markus, Hs" uniqKey="Markus H">HS Markus</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pierpaoli, C" uniqKey="Pierpaoli C">C Pierpaoli</name></author><author><name sortKey="Basser, Pj" uniqKey="Basser P">PJ Basser</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Beaulieu, C" uniqKey="Beaulieu C">C Beaulieu</name></author><author><name sortKey="Allen, Ps" uniqKey="Allen P">PS Allen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jones, Dk" uniqKey="Jones D">DK Jones</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wheeler Kingshott, Ca" uniqKey="Wheeler Kingshott C">CA Wheeler-Kingshott</name></author><author><name sortKey="Cercignani, M" uniqKey="Cercignani M">M Cercignani</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jones, Dk" uniqKey="Jones D">DK Jones</name></author><author><name sortKey="Knosche, Tr" uniqKey="Knosche T">TR Knosche</name></author><author><name sortKey="Turner, R" uniqKey="Turner R">R Turner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nitkunan, A" uniqKey="Nitkunan A">A Nitkunan</name></author><author><name sortKey="Barrick, Tr" uniqKey="Barrick T">TR Barrick</name></author><author><name sortKey="Charlton, Ra" uniqKey="Charlton R">RA Charlton</name></author><author><name sortKey="Clark, Ca" uniqKey="Clark C">CA Clark</name></author><author><name sortKey="Markus, Hs" uniqKey="Markus H">HS Markus</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Molko, N" uniqKey="Molko N">N Molko</name></author><author><name sortKey="Pappata, S" uniqKey="Pappata S">S Pappata</name></author><author><name sortKey="Mangin, Jf" uniqKey="Mangin J">JF Mangin</name></author><author><name sortKey="Poupon, F" uniqKey="Poupon F">F Poupon</name></author><author><name sortKey="Lebihan, D" uniqKey="Lebihan D">D LeBihan</name></author><author><name sortKey="Bousser, Mg" uniqKey="Bousser M">MG Bousser</name></author><author><name sortKey="Chabriat, H" uniqKey="Chabriat H">H Chabriat</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Holtmannspotter, M" uniqKey="Holtmannspotter M">M Holtmannspotter</name></author><author><name sortKey="Peters, N" uniqKey="Peters N">N Peters</name></author><author><name sortKey="Opherk, C" uniqKey="Opherk C">C Opherk</name></author><author><name sortKey="Martin, D" uniqKey="Martin D">D Martin</name></author><author><name sortKey="Herzog, J" uniqKey="Herzog J">J Herzog</name></author><author><name sortKey="Bruckmann, H" uniqKey="Bruckmann H">H Bruckmann</name></author><author><name sortKey="Samann, P" uniqKey="Samann P">P Samann</name></author><author><name sortKey="Gschwendtner, A" uniqKey="Gschwendtner A">A Gschwendtner</name></author><author><name sortKey="Dichgans, M" uniqKey="Dichgans M">M Dichgans</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="O Ullivan, M" uniqKey="O Ullivan M">M O’Sullivan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Berlot, R" uniqKey="Berlot R">R Berlot</name></author><author><name sortKey="Metzler Baddeley, C" uniqKey="Metzler Baddeley C">C Metzler-Baddeley</name></author><author><name sortKey="Jones, Dk" uniqKey="Jones D">DK Jones</name></author><author><name sortKey="O Ullivan, Mj" uniqKey="O Ullivan M">MJ O’Sullivan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="O Ullivan, M" uniqKey="O Ullivan M">M O’Sullivan</name></author><author><name sortKey="Barrick, Tr" uniqKey="Barrick T">TR Barrick</name></author><author><name sortKey="Morris, Rg" uniqKey="Morris R">RG Morris</name></author><author><name sortKey="Clark, Ca" uniqKey="Clark C">CA Clark</name></author><author><name sortKey="Markus, Hs" uniqKey="Markus H">HS Markus</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Der Holst, Hm" uniqKey="Van Der Holst H">HM van der Holst</name></author><author><name sortKey="Tuladhar, Am" uniqKey="Tuladhar A">AM Tuladhar</name></author><author><name sortKey="Van Norden, Ag" uniqKey="Van Norden A">AG van Norden</name></author><author><name sortKey="De Laat, Kf" uniqKey="De Laat K">KF de Laat</name></author><author><name sortKey="Van Uden, Iw" uniqKey="Van Uden I">IW van Uden</name></author><author><name sortKey="Van Oudheusden, Lj" uniqKey="Van Oudheusden L">LJ van Oudheusden</name></author><author><name sortKey="Zwiers, Mp" uniqKey="Zwiers M">MP Zwiers</name></author><author><name sortKey="Norris, Dg" uniqKey="Norris D">DG Norris</name></author><author><name sortKey="Kessels, Rp" uniqKey="Kessels R">RP Kessels</name></author><author><name sortKey="De Leeuw, Fe" uniqKey="De Leeuw F">FE de Leeuw</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Correia, S" uniqKey="Correia S">S Correia</name></author><author><name sortKey="Lee, Sy" uniqKey="Lee S">SY Lee</name></author><author><name sortKey="Voorn, T" uniqKey="Voorn T">T Voorn</name></author><author><name sortKey="Tate, Df" uniqKey="Tate D">DF Tate</name></author><author><name sortKey="Paul, Rh" uniqKey="Paul R">RH Paul</name></author><author><name sortKey="Zhang, S" uniqKey="Zhang S">S Zhang</name></author><author><name sortKey="Salloway, Sp" uniqKey="Salloway S">SP Salloway</name></author><author><name sortKey="Malloy, Pf" uniqKey="Malloy P">PF Malloy</name></author><author><name sortKey="Laidlaw, Dh" uniqKey="Laidlaw D">DH Laidlaw</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lawrence, Aj" uniqKey="Lawrence A">AJ Lawrence</name></author><author><name sortKey="Chung, Aw" uniqKey="Chung A">AW Chung</name></author><author><name sortKey="Morris, Rg" uniqKey="Morris R">RG Morris</name></author><author><name sortKey="Markus, Hs" uniqKey="Markus H">HS Markus</name></author><author><name sortKey="Barrick, Tr" uniqKey="Barrick T">TR Barrick</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Reijmer, Yd" uniqKey="Reijmer Y">YD Reijmer</name></author><author><name sortKey="Fotiadis, P" uniqKey="Fotiadis P">P Fotiadis</name></author><author><name sortKey="Martinez Ramirez, S" uniqKey="Martinez Ramirez S">S Martinez-Ramirez</name></author><author><name sortKey="Salat, Dh" uniqKey="Salat D">DH Salat</name></author><author><name sortKey="Schultz, A" uniqKey="Schultz A">A Schultz</name></author><author><name sortKey="Shoamanesh, A" uniqKey="Shoamanesh A">A Shoamanesh</name></author><author><name sortKey="Ayres, Am" uniqKey="Ayres A">AM Ayres</name></author><author><name sortKey="Vashkevich, A" uniqKey="Vashkevich A">A Vashkevich</name></author><author><name sortKey="Rosas, D" uniqKey="Rosas D">D Rosas</name></author><author><name sortKey="Schwab, K" uniqKey="Schwab K">K Schwab</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sappey Marinier, D" uniqKey="Sappey Marinier D">D Sappey Marinier</name></author><author><name sortKey="Calabrese, G" uniqKey="Calabrese G">G Calabrese</name></author><author><name sortKey="Hetherington, Hp" uniqKey="Hetherington H">HP Hetherington</name></author><author><name sortKey="Fisher, Sn" uniqKey="Fisher S">SN Fisher</name></author><author><name sortKey="Deicken, R" uniqKey="Deicken R">R Deicken</name></author><author><name sortKey="Van Dyke, C" uniqKey="Van Dyke C">C Van Dyke</name></author><author><name sortKey="Fein, G" uniqKey="Fein G">G Fein</name></author><author><name sortKey="Weiner, Mw" uniqKey="Weiner M">MW Weiner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brooks, Wm" uniqKey="Brooks W">WM Brooks</name></author><author><name sortKey="Wesley, Mh" uniqKey="Wesley M">MH Wesley</name></author><author><name sortKey="Kodituwakku, Pw" uniqKey="Kodituwakku P">PW Kodituwakku</name></author><author><name sortKey="Garry, Pj" uniqKey="Garry P">PJ Garry</name></author><author><name sortKey="Rosenberg, Ga" uniqKey="Rosenberg G">GA Rosenberg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Maillard, P" uniqKey="Maillard P">P Maillard</name></author><author><name sortKey="Fletcher, E" uniqKey="Fletcher E">E Fletcher</name></author><author><name sortKey="Lockhart, Sn" uniqKey="Lockhart S">SN Lockhart</name></author><author><name sortKey="Roach, Ae" uniqKey="Roach A">AE Roach</name></author><author><name sortKey="Reed, B" uniqKey="Reed B">B Reed</name></author><author><name sortKey="Mungas, D" uniqKey="Mungas D">D Mungas</name></author><author><name sortKey="Decarli, C" uniqKey="Decarli C">C DeCarli</name></author><author><name sortKey="Carmichael, Ot" uniqKey="Carmichael O">OT Carmichael</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Taheri, S" uniqKey="Taheri S">S Taheri</name></author><author><name sortKey="Gasparovic, C" uniqKey="Gasparovic C">C Gasparovic</name></author><author><name sortKey="Huisa, Bn" uniqKey="Huisa B">BN Huisa</name></author><author><name sortKey="Adair, Jc" uniqKey="Adair J">JC Adair</name></author><author><name sortKey="Edmonds, E" uniqKey="Edmonds E">E Edmonds</name></author><author><name sortKey="Prestopnik, J" uniqKey="Prestopnik J">J Prestopnik</name></author><author><name sortKey="Grossetete, M" uniqKey="Grossetete M">M Grossetete</name></author><author><name sortKey="Shah, Nj" uniqKey="Shah N">NJ Shah</name></author><author><name sortKey="Wills, J" uniqKey="Wills J">J Wills</name></author><author><name sortKey="Qualls, C" uniqKey="Qualls C">C Qualls</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huisa, Bn" uniqKey="Huisa B">BN Huisa</name></author><author><name sortKey="Caprihan, A" uniqKey="Caprihan A">A Caprihan</name></author><author><name sortKey="Thompson, J" uniqKey="Thompson J">J Thompson</name></author><author><name sortKey="Prestopnik, J" uniqKey="Prestopnik J">J Prestopnik</name></author><author><name sortKey="Qualls, Cr" uniqKey="Qualls C">CR Qualls</name></author><author><name sortKey="Rosenberg, Ga" uniqKey="Rosenberg G">GA Rosenberg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rosenberg, Ga" uniqKey="Rosenberg G">GA Rosenberg</name></author><author><name sortKey="Wallin, A" uniqKey="Wallin A">A Wallin</name></author><author><name sortKey="Wardlaw, Jm" uniqKey="Wardlaw J">JM Wardlaw</name></author><author><name sortKey="Markus, Hs" uniqKey="Markus H">HS Markus</name></author><author><name sortKey="Montaner, J" uniqKey="Montaner J">J Montaner</name></author><author><name sortKey="Wolfson, L" uniqKey="Wolfson L">L Wolfson</name></author><author><name sortKey="Iadecola, C" uniqKey="Iadecola C">C Iadecola</name></author><author><name sortKey="Zlokovic, Bv" uniqKey="Zlokovic B">BV Zlokovic</name></author><author><name sortKey="Joutel, A" uniqKey="Joutel A">A Joutel</name></author><author><name sortKey="Dichgans, M" uniqKey="Dichgans M">M Dichgans</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Heiss, Wd" uniqKey="Heiss W">WD Heiss</name></author><author><name sortKey="Zimmermann Meinzingen, S" uniqKey="Zimmermann Meinzingen S">S Zimmermann-Meinzingen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Benson, Df" uniqKey="Benson D">DF Benson</name></author><author><name sortKey="Kuhl, De" uniqKey="Kuhl D">DE Kuhl</name></author><author><name sortKey="Hawkins, Ra" uniqKey="Hawkins R">RA Hawkins</name></author><author><name sortKey="Phelps, Me" uniqKey="Phelps M">ME Phelps</name></author><author><name sortKey="Cummings, Jl" uniqKey="Cummings J">JL Cummings</name></author><author><name sortKey="Tsai, Sy" uniqKey="Tsai S">SY Tsai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mielke, R" uniqKey="Mielke R">R Mielke</name></author><author><name sortKey="Herholz, K" uniqKey="Herholz K">K Herholz</name></author><author><name sortKey="Grond, M" uniqKey="Grond M">M Grond</name></author><author><name sortKey="Kessler, J" uniqKey="Kessler J">J Kessler</name></author><author><name sortKey="Heiss, Wd" uniqKey="Heiss W">WD Heiss</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Herholz, K" uniqKey="Herholz K">K Herholz</name></author><author><name sortKey="Salmon, E" uniqKey="Salmon E">E Salmon</name></author><author><name sortKey="Perani, D" uniqKey="Perani D">D Perani</name></author><author><name sortKey="Baron, Jc" uniqKey="Baron J">JC Baron</name></author><author><name sortKey="Holthoff, V" uniqKey="Holthoff V">V Holthoff</name></author><author><name sortKey="Frolich, L" uniqKey="Frolich L">L Frolich</name></author><author><name sortKey="Schonknecht, P" uniqKey="Schonknecht P">P Schonknecht</name></author><author><name sortKey="Ito, K" uniqKey="Ito K">K Ito</name></author><author><name sortKey="Mielke, R" uniqKey="Mielke R">R Mielke</name></author><author><name sortKey="Kalbe, E" uniqKey="Kalbe E">E Kalbe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bohnen, Ni" uniqKey="Bohnen N">NI Bohnen</name></author><author><name sortKey="Djang, Ds" uniqKey="Djang D">DS Djang</name></author><author><name sortKey="Herholz, K" uniqKey="Herholz K">K Herholz</name></author><author><name sortKey="Anzai, Y" uniqKey="Anzai Y">Y Anzai</name></author><author><name sortKey="Minoshima, S" uniqKey="Minoshima S">S Minoshima</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Su, L" uniqKey="Su L">L Su</name></author><author><name sortKey="Cai, Y" uniqKey="Cai Y">Y Cai</name></author><author><name sortKey="Xu, Y" uniqKey="Xu Y">Y Xu</name></author><author><name sortKey="Dutt, A" uniqKey="Dutt A">A Dutt</name></author><author><name sortKey="Shi, S" uniqKey="Shi S">S Shi</name></author><author><name sortKey="Bramon, E" uniqKey="Bramon E">E Bramon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Herholz, K" uniqKey="Herholz K">K Herholz</name></author><author><name sortKey="Weisenbach, S" uniqKey="Weisenbach S">S Weisenbach</name></author><author><name sortKey="Kalbe, E" uniqKey="Kalbe E">E Kalbe</name></author><author><name sortKey="Diederich, Nj" uniqKey="Diederich N">NJ Diederich</name></author><author><name sortKey="Heiss, Wd" uniqKey="Heiss W">WD Heiss</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hilker, R" uniqKey="Hilker R">R Hilker</name></author><author><name sortKey="Thomas, Av" uniqKey="Thomas A">AV Thomas</name></author><author><name sortKey="Klein, Jc" uniqKey="Klein J">JC Klein</name></author><author><name sortKey="Weisenbach, S" uniqKey="Weisenbach S">S Weisenbach</name></author><author><name sortKey="Kalbe, E" uniqKey="Kalbe E">E Kalbe</name></author><author><name sortKey="Burghaus, L" uniqKey="Burghaus L">L Burghaus</name></author><author><name sortKey="Jacobs, Ah" uniqKey="Jacobs A">AH Jacobs</name></author><author><name sortKey="Herholz, K" uniqKey="Herholz K">K Herholz</name></author><author><name sortKey="Heiss, Wd" uniqKey="Heiss W">WD Heiss</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Braak, H" uniqKey="Braak H">H Braak</name></author><author><name sortKey="Braak, E" uniqKey="Braak E">E Braak</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Klunk, We" uniqKey="Klunk W">WE Klunk</name></author><author><name sortKey="Engler, H" uniqKey="Engler H">H Engler</name></author><author><name sortKey="Nordberg, A" uniqKey="Nordberg A">A Nordberg</name></author><author><name sortKey="Wang, Y" uniqKey="Wang Y">Y Wang</name></author><author><name sortKey="Blomqvist, G" uniqKey="Blomqvist G">G Blomqvist</name></author><author><name sortKey="Holt, Dp" uniqKey="Holt D">DP Holt</name></author><author><name sortKey="Bergstrom, M" uniqKey="Bergstrom M">M Bergstrom</name></author><author><name sortKey="Savitcheva, I" uniqKey="Savitcheva I">I Savitcheva</name></author><author><name sortKey="Huang, Gf" uniqKey="Huang G">GF Huang</name></author><author><name sortKey="Estrada, S" uniqKey="Estrada S">S Estrada</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Villemagne, Vl" uniqKey="Villemagne V">VL Villemagne</name></author><author><name sortKey="Mulligan, Rs" uniqKey="Mulligan R">RS Mulligan</name></author><author><name sortKey="Pejoska, S" uniqKey="Pejoska S">S Pejoska</name></author><author><name sortKey="Ong, K" uniqKey="Ong K">K Ong</name></author><author><name sortKey="Jones, G" uniqKey="Jones G">G Jones</name></author><author><name sortKey="O Eefe, G" uniqKey="O Eefe G">G O’Keefe</name></author><author><name sortKey="Chan, Jg" uniqKey="Chan J">JG Chan</name></author><author><name sortKey="Young, K" uniqKey="Young K">K Young</name></author><author><name sortKey="Tochon Danguy, H" uniqKey="Tochon Danguy H">H Tochon-Danguy</name></author><author><name sortKey="Masters, Cl" uniqKey="Masters C">CL Masters</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Aizenstein, Hj" uniqKey="Aizenstein H">HJ Aizenstein</name></author><author><name sortKey="Nebes, Rd" uniqKey="Nebes R">RD Nebes</name></author><author><name sortKey="Saxton, Ja" uniqKey="Saxton J">JA Saxton</name></author><author><name sortKey="Price, Jc" uniqKey="Price J">JC Price</name></author><author><name sortKey="Mathis, Ca" uniqKey="Mathis C">CA Mathis</name></author><author><name sortKey="Tsopelas, Nd" uniqKey="Tsopelas N">ND Tsopelas</name></author><author><name sortKey="Ziolko, Sk" uniqKey="Ziolko S">SK Ziolko</name></author><author><name sortKey="James, Ja" uniqKey="James J">JA James</name></author><author><name sortKey="Snitz, Be" uniqKey="Snitz B">BE Snitz</name></author><author><name sortKey="Houck, Pr" uniqKey="Houck P">PR Houck</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Herholz, K" uniqKey="Herholz K">K Herholz</name></author><author><name sortKey="Ebmeier, K" uniqKey="Ebmeier K">K Ebmeier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yotter, Ra" uniqKey="Yotter R">RA Yotter</name></author><author><name sortKey="Doshi, J" uniqKey="Doshi J">J Doshi</name></author><author><name sortKey="Clark, V" uniqKey="Clark V">V Clark</name></author><author><name sortKey="Sojkova, J" uniqKey="Sojkova J">J Sojkova</name></author><author><name sortKey="Zhou, Y" uniqKey="Zhou Y">Y Zhou</name></author><author><name sortKey="Wong, Df" uniqKey="Wong D">DF Wong</name></author><author><name sortKey="Ferrucci, L" uniqKey="Ferrucci L">L Ferrucci</name></author><author><name sortKey="Resnick, Sm" uniqKey="Resnick S">SM Resnick</name></author><author><name sortKey="Davatzikos, C" uniqKey="Davatzikos C">C Davatzikos</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Maruyama, M" uniqKey="Maruyama M">M Maruyama</name></author><author><name sortKey="Shimada, H" uniqKey="Shimada H">H Shimada</name></author><author><name sortKey="Suhara, T" uniqKey="Suhara T">T Suhara</name></author><author><name sortKey="Shinotoh, H" uniqKey="Shinotoh H">H Shinotoh</name></author><author><name sortKey="Ji, B" uniqKey="Ji B">B Ji</name></author><author><name sortKey="Maeda, J" uniqKey="Maeda J">J Maeda</name></author><author><name sortKey="Zhang, Mr" uniqKey="Zhang M">MR Zhang</name></author><author><name sortKey="Trojanowski, Jq" uniqKey="Trojanowski J">JQ Trojanowski</name></author><author><name sortKey="Lee, Vm" uniqKey="Lee V">VM Lee</name></author><author><name sortKey="Ono, M" uniqKey="Ono M">M Ono</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Small, Gw" uniqKey="Small G">GW Small</name></author><author><name sortKey="Bookheimer, Sy" uniqKey="Bookheimer S">SY Bookheimer</name></author><author><name sortKey="Thompson, Pm" uniqKey="Thompson P">PM Thompson</name></author><author><name sortKey="Cole, Gm" uniqKey="Cole G">GM Cole</name></author><author><name sortKey="Huang, Sc" uniqKey="Huang S">SC Huang</name></author><author><name sortKey="Kepe, V" uniqKey="Kepe V">V Kepe</name></author><author><name sortKey="Barrio, Jr" uniqKey="Barrio J">JR Barrio</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Spillantini, Mg" uniqKey="Spillantini M">MG Spillantini</name></author><author><name sortKey="Goedert, M" uniqKey="Goedert M">M Goedert</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Snowdon, Da" uniqKey="Snowdon D">DA Snowdon</name></author><author><name sortKey="Greiner, Lh" uniqKey="Greiner L">LH Greiner</name></author><author><name sortKey="Mortimer, Ja" uniqKey="Mortimer J">JA Mortimer</name></author><author><name sortKey="Riley, Kp" uniqKey="Riley K">KP Riley</name></author><author><name sortKey="Greiner, Pa" uniqKey="Greiner P">PA Greiner</name></author><author><name sortKey="Markesbery, Wr" uniqKey="Markesbery W">WR Markesbery</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pendlebury, St" uniqKey="Pendlebury S">ST Pendlebury</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Whitehead, Sn" uniqKey="Whitehead S">SN Whitehead</name></author><author><name sortKey="Hachinski, Vc" uniqKey="Hachinski V">VC Hachinski</name></author><author><name sortKey="Cechetto, Df" uniqKey="Cechetto D">DF Cechetto</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Thiel, A" uniqKey="Thiel A">A Thiel</name></author><author><name sortKey="Heiss, Wd" uniqKey="Heiss W">WD Heiss</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stefaniak, J" uniqKey="Stefaniak J">J Stefaniak</name></author><author><name sortKey="O Rien, J" uniqKey="O Rien J">J O’Brien</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schmitt, Ab" uniqKey="Schmitt A">AB Schmitt</name></author><author><name sortKey="Brook, Ga" uniqKey="Brook G">GA Brook</name></author><author><name sortKey="Buss, A" uniqKey="Buss A">A Buss</name></author><author><name sortKey="Nacimiento, W" uniqKey="Nacimiento W">W Nacimiento</name></author><author><name sortKey="Noth, J" uniqKey="Noth J">J Noth</name></author><author><name sortKey="Kreutzberg, Gw" uniqKey="Kreutzberg G">GW Kreutzberg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Thiel, A" uniqKey="Thiel A">A Thiel</name></author><author><name sortKey="Radlinska, Ba" uniqKey="Radlinska B">BA Radlinska</name></author><author><name sortKey="Paquette, C" uniqKey="Paquette C">C Paquette</name></author><author><name sortKey="Sidel, M" uniqKey="Sidel M">M Sidel</name></author><author><name sortKey="Soucy, Jp" uniqKey="Soucy J">JP Soucy</name></author><author><name sortKey="Schirrmacher, R" uniqKey="Schirrmacher R">R Schirrmacher</name></author><author><name sortKey="Minuk, J" uniqKey="Minuk J">J Minuk</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Radlinska, Ba" uniqKey="Radlinska B">BA Radlinska</name></author><author><name sortKey="Blunk, Y" uniqKey="Blunk Y">Y Blunk</name></author><author><name sortKey="Leppert, Ir" uniqKey="Leppert I">IR Leppert</name></author><author><name sortKey="Minuk, J" uniqKey="Minuk J">J Minuk</name></author><author><name sortKey="Pike, Gb" uniqKey="Pike G">GB Pike</name></author><author><name sortKey="Thiel, A" uniqKey="Thiel A">A Thiel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Thiel, A" uniqKey="Thiel A">A Thiel</name></author><author><name sortKey="Cechetto, Df" uniqKey="Cechetto D">DF Cechetto</name></author><author><name sortKey="Heiss, Wd" uniqKey="Heiss W">WD Heiss</name></author><author><name sortKey="Hachinski, V" uniqKey="Hachinski V">V Hachinski</name></author><author><name sortKey="Whitehead, Sn" uniqKey="Whitehead S">SN Whitehead</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="review-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">BMC Med</journal-id><journal-id journal-id-type="iso-abbrev">BMC Med</journal-id><journal-title-group><journal-title>BMC Medicine</journal-title></journal-title-group><issn pub-type="epub">1741-7015</issn><publisher><publisher-name>BioMed Central</publisher-name><publisher-loc>London</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">27806705</article-id><article-id pub-id-type="pmc">5094143</article-id><article-id pub-id-type="publisher-id">725</article-id><article-id pub-id-type="doi">10.1186/s12916-016-0725-0</article-id><article-categories><subj-group subj-group-type="heading"><subject>Review</subject></subj-group></article-categories><title-group><article-title>Neuroimaging in vascular cognitive impairment: a state-of-the-art review</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Heiss</surname><given-names>Wolf-Dieter</given-names></name><address><email>wdh@sf.mpg.de</email></address><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Rosenberg</surname><given-names>Gary A.</given-names></name><xref ref-type="aff" rid="Aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>Thiel</surname><given-names>Alexander</given-names></name><xref ref-type="aff" rid="Aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>Berlot</surname><given-names>Rok</given-names></name><xref ref-type="aff" rid="Aff4">4</xref></contrib><contrib contrib-type="author"><name><surname>de Reuck</surname><given-names>Jacques</given-names></name><xref ref-type="aff" rid="Aff5">5</xref></contrib><aff id="Aff1"><label>1</label>Max Planck Institute for Metabolism Research, Gleueler str. 50, D-50931 Cologne, Germany</aff><aff id="Aff2"><label>2</label>Department of Neurology, UNM Memory and Aging Center, MSC 11 6035, University of New Mexico, Albuquerque, NM 87131 USA</aff><aff id="Aff3"><label>3</label>Department of Neurology & Neurosurgery, McGill University at SMBD Jewish General Hospital and Lady Davis Institute for Medical Research, Montreal, H3T 1E2 Québec Canada</aff><aff id="Aff4"><label>4</label>Department of Neurology (R.B.), University Medical Centre Ljubljana, 1000 Ljubljana, Slovenia</aff><aff id="Aff5"><label>5</label>INSERM U1171, Degenerative and Vascular Cognitive Disorders, Université Lille 2, Lille, France</aff></contrib-group><pub-date pub-type="epub"><day>3</day><month>11</month><year>2016</year></pub-date><pub-date pub-type="pmc-release"><day>3</day><month>11</month><year>2016</year></pub-date><pub-date pub-type="collection"><year>2016</year></pub-date><volume>14</volume><elocation-id>174</elocation-id><history><date date-type="received"><day>28</day><month>5</month><year>2016</year></date><date date-type="accepted"><day>25</day><month>10</month><year>2016</year></date></history><permissions><copyright-statement>© The Author(s). 2016</copyright-statement><license license-type="OpenAccess"><license-p><bold>Open Access</bold>This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</ext-link>), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/publicdomain/zero/1.0/">http://creativecommons.org/publicdomain/zero/1.0/</ext-link>) applies to the data made available in this article, unless otherwise stated.</license-p></license></permissions><abstract id="Abs1"><p>Imaging is critical in the diagnosis and treatment of dementia, particularly in vascular cognitive impairment, due to the visualization of ischemic and hemorrhagic injury of gray and white matter. Magnetic resonance imaging (MRI) and positron emission tomography (PET) provide structural and functional information. Clinical MRI is both generally available and versatile – T2-weighted images show infarcts, FLAIR shows white matter changes and lacunar infarcts, and susceptibility-weighted images reveal microbleeds. Diffusion MRI adds another dimension by showing graded damage to white matter, making it more sensitive to white matter injury than FLAIR. Regions of neuroinflammatory disruption of the blood–brain barrier with increased permeability can be quantified and visualized with dynamic contrast-enhanced MRI. PET shows metabolism of glucose and accumulation of amyloid and tau, which is useful in showing abnormal metabolism in Alzheimer’s disease. Combining MRI and PET allows identification of patients with mixed dementia, with MRI showing white matter injury and PET demonstrating regional impairment of glucose metabolism and deposition of amyloid. Excellent anatomical detail can be observed with 7.0-Tesla MRI. Imaging is the optimal method to follow the effect of treatments since changes in MRI scans are seen prior to those in cognition. This review describes the role of various imaging modalities in the diagnosis and treatment of vascular cognitive impairment.</p></abstract><kwd-group xml:lang="en"><title>Keywords</title><kwd>Neuroimaging</kwd><kwd>CT</kwd><kwd>MRI</kwd><kwd>PET</kwd><kwd>Vascular cognitive impairment</kwd><kwd>Cerebral small vessel disease</kwd><kwd>Molecular imaging</kwd></kwd-group><custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name><meta-value>© The Author(s) 2016</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc><affiliations><list><country><li>Allemagne</li><li>France</li><li>Slovénie</li><li>États-Unis</li></country><region><li>District de Cologne</li><li>Hauts-de-France</li><li>Nord-Pas-de-Calais</li><li>Nouveau-Mexique</li><li>Rhénanie-du-Nord-Westphalie</li></region><settlement><li>Cologne</li><li>Lille</li></settlement><orgName><li>Université Lille 2</li></orgName></list><tree><noCountry><name sortKey="Thiel, Alexander" sort="Thiel, Alexander" uniqKey="Thiel A" first="Alexander" last="Thiel">Alexander Thiel</name></noCountry><country name="Allemagne"><region name="Rhénanie-du-Nord-Westphalie"><name sortKey="Heiss, Wolf Dieter" sort="Heiss, Wolf Dieter" uniqKey="Heiss W" first="Wolf-Dieter" last="Heiss">Wolf-Dieter Heiss</name></region></country><country name="États-Unis"><region name="Nouveau-Mexique"><name sortKey="Rosenberg, Gary A" sort="Rosenberg, Gary A" uniqKey="Rosenberg G" first="Gary A." last="Rosenberg">Gary A. Rosenberg</name></region></country><country name="Slovénie"><noRegion><name sortKey="Berlot, Rok" sort="Berlot, Rok" uniqKey="Berlot R" first="Rok" last="Berlot">Rok Berlot</name></noRegion></country><country name="France"><region name="Hauts-de-France"><name sortKey="De Reuck, Jacques" sort="De Reuck, Jacques" uniqKey="De Reuck J" first="Jacques" last="De Reuck">Jacques De Reuck</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/Ncbi/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001B46 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd -nk 001B46 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonFranceV1
|flux= Ncbi
|étape= Merge
|type= RBID
|clé= PMC:5094143
|texte= Neuroimaging in vascular cognitive impairment: a state-of-the-art review
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/RBID.i -Sk "pubmed:27806705" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd \
| NlmPubMed2Wicri -a ParkinsonFranceV1
| This area was generated with Dilib version V0.6.29. |  |