Older Candidates for Subthalamic Deep Brain Stimulation in Parkinson's Disease Have a Higher Incidence of Psychiatric Serious Adverse Events
Identifieur interne : 001A63 ( Ncbi/Merge ); précédent : 001A62; suivant : 001A64Older Candidates for Subthalamic Deep Brain Stimulation in Parkinson's Disease Have a Higher Incidence of Psychiatric Serious Adverse Events
Auteurs : Vitalii V. Cozac [Suisse] ; Michael M. Ehrensperger [Suisse] ; Ute Gschwandtner [Suisse] ; Florian Hatz [Suisse] ; Antonia Meyer [Suisse] ; Andreas U. Monsch [Suisse] ; Michael Schuepbach [Suisse, France] ; Ethan Taub [Suisse] ; Peter Fuhr [Suisse]Source :
- Frontiers in Aging Neuroscience [ 1663-4365 ] ; 2016.
Abstract
Url:
DOI: 10.3389/fnagi.2016.00132
PubMed: 27375478
PubMed Central: 4896943
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Cozac</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Neurology, Hospital of the University of Basel</institution><country>Basel, Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Ehrensperger, Michael M" sort="Ehrensperger, Michael M" uniqKey="Ehrensperger M" first="Michael M." last="Ehrensperger">Michael M. Ehrensperger</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Memory Clinic, Felix Platter Hospital, University Center for Medicine of Aging</institution><country>Basel, Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Gschwandtner, Ute" sort="Gschwandtner, Ute" uniqKey="Gschwandtner U" first="Ute" last="Gschwandtner">Ute Gschwandtner</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Neurology, Hospital of the University of Basel</institution><country>Basel, Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Hatz, Florian" sort="Hatz, Florian" uniqKey="Hatz F" first="Florian" last="Hatz">Florian Hatz</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Neurology, Hospital of the University of Basel</institution><country>Basel, Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Meyer, Antonia" sort="Meyer, Antonia" uniqKey="Meyer A" first="Antonia" last="Meyer">Antonia Meyer</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Neurology, Hospital of the University of Basel</institution><country>Basel, Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Monsch, Andreas U" sort="Monsch, Andreas U" uniqKey="Monsch A" first="Andreas U." last="Monsch">Andreas U. Monsch</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Memory Clinic, Felix Platter Hospital, University Center for Medicine of Aging</institution><country>Basel, Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Schuepbach, Michael" sort="Schuepbach, Michael" uniqKey="Schuepbach M" first="Michael" last="Schuepbach">Michael Schuepbach</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Department of Neurology, University Hospital Bern and University of Bern</institution><country>Bern, Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea></wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Département de Neurologie, Assistance-Publique Hôpitaux de Paris, Centre d'Investigation Clinique 9503, Institut du Cerveau et de la Moelle épinière, Université Pierre et Marie Curie, Paris 6 et Institut National de la Santé et de la Recherche Médicale, Centre Hospitalier Universitaire (CHU) Pitié-Salpêtrière</institution><country>Paris, France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Taub, Ethan" sort="Taub, Ethan" uniqKey="Taub E" first="Ethan" last="Taub">Ethan Taub</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Neurology, Hospital of the University of Basel</institution><country>Basel, Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Fuhr, Peter" sort="Fuhr, Peter" uniqKey="Fuhr P" first="Peter" last="Fuhr">Peter Fuhr</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Neurology, Hospital of the University of Basel</institution><country>Basel, Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea></wicri:regionArea></affiliation></author></analytic><series><title level="j">Frontiers in Aging Neuroscience</title><idno type="eISSN">1663-4365</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><bold>Objective:</bold> To investigate the incidence of serious adverse events (SAE) of subthalamic deep brain stimulation (STN-DBS) in elderly patients with Parkinson's disease (PD).</p><p><bold>Methods:</bold> We investigated a group of 26 patients with PD who underwent STN-DBS at mean age 63.2 ± 3.3 years. The operated patients from the EARLYSTIM study (mean age 52.9 ± 6.6) were used as a comparison group. Incidences of SAE were compared between these groups.</p><p><bold>Results:</bold> A higher incidence of psychosis and hallucinations was found in these elderly patients compared to the younger patients in the EARLYSTIM study (<italic>p</italic> < 0.01).</p><p><bold>Conclusions:</bold> The higher incidence of STN-DBS-related psychiatric complications underscores the need for comprehensive psychiatric pre- and postoperative assessment in older DBS candidates. However, these psychiatric SAE were transient, and the benefits of DBS clearly outweighed its adverse effects.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Appleby, B S" uniqKey="Appleby B">B. S. Appleby</name></author><author><name sortKey="Duggan, P S" uniqKey="Duggan P">P. S. Duggan</name></author><author><name sortKey="Regenberg, A" uniqKey="Regenberg A">A. 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Ferrando</name></author></analytic></biblStruct></listBibl></div1></back></TEI><double pmid="27375478"><pmc><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Older Candidates for Subthalamic Deep Brain Stimulation in Parkinson's Disease Have a Higher Incidence of Psychiatric Serious Adverse Events</title><author><name sortKey="Cozac, Vitalii V" sort="Cozac, Vitalii V" uniqKey="Cozac V" first="Vitalii V." last="Cozac">Vitalii V. Cozac</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Neurology, Hospital of the University of Basel</institution><country>Basel, Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Ehrensperger, Michael M" sort="Ehrensperger, Michael M" uniqKey="Ehrensperger M" first="Michael M." last="Ehrensperger">Michael M. Ehrensperger</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Memory Clinic, Felix Platter Hospital, University Center for Medicine of Aging</institution><country>Basel, Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Gschwandtner, Ute" sort="Gschwandtner, Ute" uniqKey="Gschwandtner U" first="Ute" last="Gschwandtner">Ute Gschwandtner</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Neurology, Hospital of the University of Basel</institution><country>Basel, Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Hatz, Florian" sort="Hatz, Florian" uniqKey="Hatz F" first="Florian" last="Hatz">Florian Hatz</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Neurology, Hospital of the University of Basel</institution><country>Basel, Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Meyer, Antonia" sort="Meyer, Antonia" uniqKey="Meyer A" first="Antonia" last="Meyer">Antonia Meyer</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Neurology, Hospital of the University of Basel</institution><country>Basel, Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Monsch, Andreas U" sort="Monsch, Andreas U" uniqKey="Monsch A" first="Andreas U." last="Monsch">Andreas U. Monsch</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Memory Clinic, Felix Platter Hospital, University Center for Medicine of Aging</institution><country>Basel, Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Schuepbach, Michael" sort="Schuepbach, Michael" uniqKey="Schuepbach M" first="Michael" last="Schuepbach">Michael Schuepbach</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Department of Neurology, University Hospital Bern and University of Bern</institution><country>Bern, Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea></wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Département de Neurologie, Assistance-Publique Hôpitaux de Paris, Centre d'Investigation Clinique 9503, Institut du Cerveau et de la Moelle épinière, Université Pierre et Marie Curie, Paris 6 et Institut National de la Santé et de la Recherche Médicale, Centre Hospitalier Universitaire (CHU) Pitié-Salpêtrière</institution><country>Paris, France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Taub, Ethan" sort="Taub, Ethan" uniqKey="Taub E" first="Ethan" last="Taub">Ethan Taub</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Neurology, Hospital of the University of Basel</institution><country>Basel, Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Fuhr, Peter" sort="Fuhr, Peter" uniqKey="Fuhr P" first="Peter" last="Fuhr">Peter Fuhr</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Neurology, Hospital of the University of Basel</institution><country>Basel, Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea></wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27375478</idno><idno type="pmc">4896943</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4896943</idno><idno type="RBID">PMC:4896943</idno><idno type="doi">10.3389/fnagi.2016.00132</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">000134</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000134</idno><idno type="wicri:Area/Pmc/Curation">000134</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000134</idno><idno type="wicri:Area/Pmc/Checkpoint">000051</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000051</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Older Candidates for Subthalamic Deep Brain Stimulation in Parkinson's Disease Have a Higher Incidence of Psychiatric Serious Adverse Events</title><author><name sortKey="Cozac, Vitalii V" sort="Cozac, Vitalii V" uniqKey="Cozac V" first="Vitalii V." last="Cozac">Vitalii V. Cozac</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Neurology, Hospital of the University of Basel</institution><country>Basel, Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Ehrensperger, Michael M" sort="Ehrensperger, Michael M" uniqKey="Ehrensperger M" first="Michael M." last="Ehrensperger">Michael M. Ehrensperger</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Memory Clinic, Felix Platter Hospital, University Center for Medicine of Aging</institution><country>Basel, Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Gschwandtner, Ute" sort="Gschwandtner, Ute" uniqKey="Gschwandtner U" first="Ute" last="Gschwandtner">Ute Gschwandtner</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Neurology, Hospital of the University of Basel</institution><country>Basel, Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Hatz, Florian" sort="Hatz, Florian" uniqKey="Hatz F" first="Florian" last="Hatz">Florian Hatz</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Neurology, Hospital of the University of Basel</institution><country>Basel, Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Meyer, Antonia" sort="Meyer, Antonia" uniqKey="Meyer A" first="Antonia" last="Meyer">Antonia Meyer</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Neurology, Hospital of the University of Basel</institution><country>Basel, Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Monsch, Andreas U" sort="Monsch, Andreas U" uniqKey="Monsch A" first="Andreas U." last="Monsch">Andreas U. Monsch</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Memory Clinic, Felix Platter Hospital, University Center for Medicine of Aging</institution><country>Basel, Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Schuepbach, Michael" sort="Schuepbach, Michael" uniqKey="Schuepbach M" first="Michael" last="Schuepbach">Michael Schuepbach</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Department of Neurology, University Hospital Bern and University of Bern</institution><country>Bern, Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea></wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Département de Neurologie, Assistance-Publique Hôpitaux de Paris, Centre d'Investigation Clinique 9503, Institut du Cerveau et de la Moelle épinière, Université Pierre et Marie Curie, Paris 6 et Institut National de la Santé et de la Recherche Médicale, Centre Hospitalier Universitaire (CHU) Pitié-Salpêtrière</institution><country>Paris, France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Taub, Ethan" sort="Taub, Ethan" uniqKey="Taub E" first="Ethan" last="Taub">Ethan Taub</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Neurology, Hospital of the University of Basel</institution><country>Basel, Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Fuhr, Peter" sort="Fuhr, Peter" uniqKey="Fuhr P" first="Peter" last="Fuhr">Peter Fuhr</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Neurology, Hospital of the University of Basel</institution><country>Basel, Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea></wicri:regionArea></affiliation></author></analytic><series><title level="j">Frontiers in Aging Neuroscience</title><idno type="eISSN">1663-4365</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><bold>Objective:</bold> To investigate the incidence of serious adverse events (SAE) of subthalamic deep brain stimulation (STN-DBS) in elderly patients with Parkinson's disease (PD).</p><p><bold>Methods:</bold> We investigated a group of 26 patients with PD who underwent STN-DBS at mean age 63.2 ± 3.3 years. The operated patients from the EARLYSTIM study (mean age 52.9 ± 6.6) were used as a comparison group. Incidences of SAE were compared between these groups.</p><p><bold>Results:</bold> A higher incidence of psychosis and hallucinations was found in these elderly patients compared to the younger patients in the EARLYSTIM study (<italic>p</italic> < 0.01).</p><p><bold>Conclusions:</bold> The higher incidence of STN-DBS-related psychiatric complications underscores the need for comprehensive psychiatric pre- and postoperative assessment in older DBS candidates. However, these psychiatric SAE were transient, and the benefits of DBS clearly outweighed its adverse effects.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Appleby, B S" uniqKey="Appleby B">B. S. Appleby</name></author><author><name sortKey="Duggan, P S" uniqKey="Duggan P">P. S. Duggan</name></author><author><name sortKey="Regenberg, A" uniqKey="Regenberg A">A. 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Ferrando</name></author></analytic></biblStruct></listBibl></div1></back></TEI></pmc><pubmed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Older Candidates for Subthalamic Deep Brain Stimulation in Parkinson's Disease Have a Higher Incidence of Psychiatric Serious Adverse Events.</title><author><name sortKey="Cozac, Vitalii V" sort="Cozac, Vitalii V" uniqKey="Cozac V" first="Vitalii V" last="Cozac">Vitalii V. Cozac</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Hospital of the University of Basel Basel, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Neurology, Hospital of the University of Basel Basel</wicri:regionArea><wicri:noRegion>Hospital of the University of Basel Basel</wicri:noRegion></affiliation></author><author><name sortKey="Ehrensperger, Michael M" sort="Ehrensperger, Michael M" uniqKey="Ehrensperger M" first="Michael M" last="Ehrensperger">Michael M. Ehrensperger</name><affiliation wicri:level="1"><nlm:affiliation>Memory Clinic, Felix Platter Hospital, University Center for Medicine of Aging Basel, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Memory Clinic, Felix Platter Hospital, University Center for Medicine of Aging Basel</wicri:regionArea><wicri:noRegion>University Center for Medicine of Aging Basel</wicri:noRegion></affiliation></author><author><name sortKey="Gschwandtner, Ute" sort="Gschwandtner, Ute" uniqKey="Gschwandtner U" first="Ute" last="Gschwandtner">Ute Gschwandtner</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Hospital of the University of Basel Basel, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Neurology, Hospital of the University of Basel Basel</wicri:regionArea><wicri:noRegion>Hospital of the University of Basel Basel</wicri:noRegion></affiliation></author><author><name sortKey="Hatz, Florian" sort="Hatz, Florian" uniqKey="Hatz F" first="Florian" last="Hatz">Florian Hatz</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Hospital of the University of Basel Basel, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Neurology, Hospital of the University of Basel Basel</wicri:regionArea><wicri:noRegion>Hospital of the University of Basel Basel</wicri:noRegion></affiliation></author><author><name sortKey="Meyer, Antonia" sort="Meyer, Antonia" uniqKey="Meyer A" first="Antonia" last="Meyer">Antonia Meyer</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Hospital of the University of Basel Basel, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Neurology, Hospital of the University of Basel Basel</wicri:regionArea><wicri:noRegion>Hospital of the University of Basel Basel</wicri:noRegion></affiliation></author><author><name sortKey="Monsch, Andreas U" sort="Monsch, Andreas U" uniqKey="Monsch A" first="Andreas U" last="Monsch">Andreas U. Monsch</name><affiliation wicri:level="1"><nlm:affiliation>Memory Clinic, Felix Platter Hospital, University Center for Medicine of Aging Basel, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Memory Clinic, Felix Platter Hospital, University Center for Medicine of Aging Basel</wicri:regionArea><wicri:noRegion>University Center for Medicine of Aging Basel</wicri:noRegion></affiliation></author><author><name sortKey="Schuepbach, Michael" sort="Schuepbach, Michael" uniqKey="Schuepbach M" first="Michael" last="Schuepbach">Michael Schuepbach</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, University Hospital Bern and University of BernBern, Switzerland; Département de Neurologie, Assistance-Publique Hôpitaux de Paris, Centre d'Investigation Clinique 9503, Institut du Cerveau et de la Moelle épinière, Université Pierre et Marie Curie, Paris 6 et Institut National de la Santé et de la Recherche Médicale, Centre Hospitalier Universitaire (CHU) Pitié-SalpêtrièreParis, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Neurology, University Hospital Bern and University of BernBern, Switzerland; Département de Neurologie, Assistance-Publique Hôpitaux de Paris, Centre d'Investigation Clinique 9503, Institut du Cerveau et de la Moelle épinière, Université Pierre et Marie Curie, Paris 6 et Institut National de la Santé et de la Recherche Médicale, Centre Hospitalier Universitaire (CHU) Pitié-SalpêtrièreParis</wicri:regionArea><wicri:noRegion>Centre Hospitalier Universitaire (CHU) Pitié-SalpêtrièreParis</wicri:noRegion><wicri:noRegion>Centre Hospitalier Universitaire (CHU) Pitié-SalpêtrièreParis</wicri:noRegion></affiliation></author><author><name sortKey="Taub, Ethan" sort="Taub, Ethan" uniqKey="Taub E" first="Ethan" last="Taub">Ethan Taub</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Hospital of the University of Basel Basel, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Neurology, Hospital of the University of Basel Basel</wicri:regionArea><wicri:noRegion>Hospital of the University of Basel Basel</wicri:noRegion></affiliation></author><author><name sortKey="Fuhr, Peter" sort="Fuhr, Peter" uniqKey="Fuhr P" first="Peter" last="Fuhr">Peter Fuhr</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Hospital of the University of Basel Basel, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Neurology, Hospital of the University of Basel Basel</wicri:regionArea><wicri:noRegion>Hospital of the University of Basel Basel</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:27375478</idno><idno type="pmid">27375478</idno><idno type="doi">10.3389/fnagi.2016.00132</idno><idno type="wicri:Area/PubMed/Corpus">000132</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000132</idno><idno type="wicri:Area/PubMed/Curation">000132</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000132</idno><idno type="wicri:Area/PubMed/Checkpoint">000132</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000132</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Older Candidates for Subthalamic Deep Brain Stimulation in Parkinson's Disease Have a Higher Incidence of Psychiatric Serious Adverse Events.</title><author><name sortKey="Cozac, Vitalii V" sort="Cozac, Vitalii V" uniqKey="Cozac V" first="Vitalii V" last="Cozac">Vitalii V. Cozac</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Hospital of the University of Basel Basel, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Neurology, Hospital of the University of Basel Basel</wicri:regionArea><wicri:noRegion>Hospital of the University of Basel Basel</wicri:noRegion></affiliation></author><author><name sortKey="Ehrensperger, Michael M" sort="Ehrensperger, Michael M" uniqKey="Ehrensperger M" first="Michael M" last="Ehrensperger">Michael M. Ehrensperger</name><affiliation wicri:level="1"><nlm:affiliation>Memory Clinic, Felix Platter Hospital, University Center for Medicine of Aging Basel, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Memory Clinic, Felix Platter Hospital, University Center for Medicine of Aging Basel</wicri:regionArea><wicri:noRegion>University Center for Medicine of Aging Basel</wicri:noRegion></affiliation></author><author><name sortKey="Gschwandtner, Ute" sort="Gschwandtner, Ute" uniqKey="Gschwandtner U" first="Ute" last="Gschwandtner">Ute Gschwandtner</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Hospital of the University of Basel Basel, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Neurology, Hospital of the University of Basel Basel</wicri:regionArea><wicri:noRegion>Hospital of the University of Basel Basel</wicri:noRegion></affiliation></author><author><name sortKey="Hatz, Florian" sort="Hatz, Florian" uniqKey="Hatz F" first="Florian" last="Hatz">Florian Hatz</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Hospital of the University of Basel Basel, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Neurology, Hospital of the University of Basel Basel</wicri:regionArea><wicri:noRegion>Hospital of the University of Basel Basel</wicri:noRegion></affiliation></author><author><name sortKey="Meyer, Antonia" sort="Meyer, Antonia" uniqKey="Meyer A" first="Antonia" last="Meyer">Antonia Meyer</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Hospital of the University of Basel Basel, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Neurology, Hospital of the University of Basel Basel</wicri:regionArea><wicri:noRegion>Hospital of the University of Basel Basel</wicri:noRegion></affiliation></author><author><name sortKey="Monsch, Andreas U" sort="Monsch, Andreas U" uniqKey="Monsch A" first="Andreas U" last="Monsch">Andreas U. Monsch</name><affiliation wicri:level="1"><nlm:affiliation>Memory Clinic, Felix Platter Hospital, University Center for Medicine of Aging Basel, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Memory Clinic, Felix Platter Hospital, University Center for Medicine of Aging Basel</wicri:regionArea><wicri:noRegion>University Center for Medicine of Aging Basel</wicri:noRegion></affiliation></author><author><name sortKey="Schuepbach, Michael" sort="Schuepbach, Michael" uniqKey="Schuepbach M" first="Michael" last="Schuepbach">Michael Schuepbach</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, University Hospital Bern and University of BernBern, Switzerland; Département de Neurologie, Assistance-Publique Hôpitaux de Paris, Centre d'Investigation Clinique 9503, Institut du Cerveau et de la Moelle épinière, Université Pierre et Marie Curie, Paris 6 et Institut National de la Santé et de la Recherche Médicale, Centre Hospitalier Universitaire (CHU) Pitié-SalpêtrièreParis, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Neurology, University Hospital Bern and University of BernBern, Switzerland; Département de Neurologie, Assistance-Publique Hôpitaux de Paris, Centre d'Investigation Clinique 9503, Institut du Cerveau et de la Moelle épinière, Université Pierre et Marie Curie, Paris 6 et Institut National de la Santé et de la Recherche Médicale, Centre Hospitalier Universitaire (CHU) Pitié-SalpêtrièreParis</wicri:regionArea><wicri:noRegion>Centre Hospitalier Universitaire (CHU) Pitié-SalpêtrièreParis</wicri:noRegion><wicri:noRegion>Centre Hospitalier Universitaire (CHU) Pitié-SalpêtrièreParis</wicri:noRegion></affiliation></author><author><name sortKey="Taub, Ethan" sort="Taub, Ethan" uniqKey="Taub E" first="Ethan" last="Taub">Ethan Taub</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Hospital of the University of Basel Basel, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Neurology, Hospital of the University of Basel Basel</wicri:regionArea><wicri:noRegion>Hospital of the University of Basel Basel</wicri:noRegion></affiliation></author><author><name sortKey="Fuhr, Peter" sort="Fuhr, Peter" uniqKey="Fuhr P" first="Peter" last="Fuhr">Peter Fuhr</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Hospital of the University of Basel Basel, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Neurology, Hospital of the University of Basel Basel</wicri:regionArea><wicri:noRegion>Hospital of the University of Basel Basel</wicri:noRegion></affiliation></author></analytic><series><title level="j">Frontiers in aging neuroscience</title><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To investigate the incidence of serious adverse events (SAE) of subthalamic deep brain stimulation (STN-DBS) in elderly patients with Parkinson's disease (PD).</div></front></TEI></pubmed></double></record>Pour manipuler ce document sous Unix (Dilib)
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