Ventilatory Dysfunction in Parkinson’s Disease
Identifieur interne : 001A53 ( Ncbi/Merge ); précédent : 001A52; suivant : 001A54Ventilatory Dysfunction in Parkinson’s Disease
Auteurs : Guillaume Baille [France] ; Anna Maria De Jesus [France] ; Thierry Perez [France] ; David Devos [France] ; Kathy Dujardin [France] ; Christelle Monaca Charley [France] ; Luc Defebvre [France] ; Caroline Moreau [France]Source :
- Journal of Parkinson's Disease [ 1877-7171 ] ; ????.
Abstract
In contrast to some other neurodegenerative diseases, little is known about ventilatory dysfunction in Parkinson’s disease (PD). To assess the spectrum of ventilation disorders in PD, we searched for and reviewed studies of dyspnea, lung volumes, respiratory muscle function, sleep breathing disorders and the response to hypoxemia in PD. Among the studies, we identified some limitations: (i) small study populations (mainly composed of patients with advanced PD), (ii) the absence of long-term follow-up and (iii) the absence of functional evaluations under “off-drug” conditions. Although there are many reports of abnormal spirometry data in PD (mainly related to impairment of the inspiratory muscles), little is known about hypoventilation in PD. We conclude that ventilatory dysfunction in PD has been poorly studied and little is known about its frequency and clinical relevance. Hence, there is a need to characterize the different phenotypes of ventilation disorders in PD, study their relationships with disease progression and assess their prognostic value.
Url:
DOI: 10.3233/JPD-160804
PubMed: 27314755
PubMed Central: 5008229
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000978
- to stream Pmc, to step Curation: 000974
- to stream Pmc, to step Checkpoint: 000987
Links to Exploration step
PMC:5008229Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Ventilatory Dysfunction in Parkinson’s Disease</title><author><name sortKey="Baille, Guillaume" sort="Baille, Guillaume" uniqKey="Baille G" first="Guillaume" last="Baille">Guillaume Baille</name><affiliation wicri:level="1"><nlm:aff id="aff1">Service de Neurologie et Pathologie du Mouvement, Pôle de neurosciences et appareil locomoteur, CHRU de Lille, Lille, France / INSERM UMR 1171, LILLE France, Troubles cognitifs dégénératifs et vasculaires, Lille,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="De Jesus, Anna Maria" sort="De Jesus, Anna Maria" uniqKey="De Jesus A" first="Anna Maria" last="De Jesus">Anna Maria De Jesus</name><affiliation wicri:level="1"><nlm:aff id="aff2">Service d’Explorations Fonctionnelles Respiratoires, Hôpital Albert Calmette, CHRU de Lille, Lille,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Perez, Thierry" sort="Perez, Thierry" uniqKey="Perez T" first="Thierry" last="Perez">Thierry Perez</name><affiliation wicri:level="1"><nlm:aff id="aff2">Service d’Explorations Fonctionnelles Respiratoires, Hôpital Albert Calmette, CHRU de Lille, Lille,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Devos, David" sort="Devos, David" uniqKey="Devos D" first="David" last="Devos">David Devos</name><affiliation wicri:level="1"><nlm:aff id="aff3">Service de Pharmacologie Médicale, Université de Lille, CHRU de Lille, France / INSERM UMR 1171, Lille,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Dujardin, Kathy" sort="Dujardin, Kathy" uniqKey="Dujardin K" first="Kathy" last="Dujardin">Kathy Dujardin</name><affiliation wicri:level="1"><nlm:aff id="aff1">Service de Neurologie et Pathologie du Mouvement, Pôle de neurosciences et appareil locomoteur, CHRU de Lille, Lille, France / INSERM UMR 1171, LILLE France, Troubles cognitifs dégénératifs et vasculaires, Lille,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Charley, Christelle Monaca" sort="Charley, Christelle Monaca" uniqKey="Charley C" first="Christelle Monaca" last="Charley">Christelle Monaca Charley</name><affiliation wicri:level="1"><nlm:aff id="aff4">Unité des Troubles du Sommeil et de la Vigilance, CHRU de Lille/INSERM UMR 1171, Lille,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Defebvre, Luc" sort="Defebvre, Luc" uniqKey="Defebvre L" first="Luc" last="Defebvre">Luc Defebvre</name><affiliation wicri:level="1"><nlm:aff id="aff1">Service de Neurologie et Pathologie du Mouvement, Pôle de neurosciences et appareil locomoteur, CHRU de Lille, Lille, France / INSERM UMR 1171, LILLE France, Troubles cognitifs dégénératifs et vasculaires, Lille,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea><placeName><settlement type="city">Lille</settlement><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region></placeName><orgName type="university" n="3">Université Lille 2</orgName><orgName type="institution" wicri:auto="newGroup">Université Lille Nord de France</orgName></affiliation></author><author><name sortKey="Moreau, Caroline" sort="Moreau, Caroline" uniqKey="Moreau C" first="Caroline" last="Moreau">Caroline Moreau</name><affiliation wicri:level="1"><nlm:aff id="aff1">Service de Neurologie et Pathologie du Mouvement, Pôle de neurosciences et appareil locomoteur, CHRU de Lille, Lille, France / INSERM UMR 1171, LILLE France, Troubles cognitifs dégénératifs et vasculaires, Lille,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27314755</idno><idno type="pmc">5008229</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5008229</idno><idno type="RBID">PMC:5008229</idno><idno type="doi">10.3233/JPD-160804</idno><date when="????">????</date><idno type="wicri:Area/Pmc/Corpus">000978</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000978</idno><idno type="wicri:Area/Pmc/Curation">000974</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000974</idno><idno type="wicri:Area/Pmc/Checkpoint">000987</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000987</idno><idno type="wicri:Area/Ncbi/Merge">001A53</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Ventilatory Dysfunction in Parkinson’s Disease</title><author><name sortKey="Baille, Guillaume" sort="Baille, Guillaume" uniqKey="Baille G" first="Guillaume" last="Baille">Guillaume Baille</name><affiliation wicri:level="1"><nlm:aff id="aff1">Service de Neurologie et Pathologie du Mouvement, Pôle de neurosciences et appareil locomoteur, CHRU de Lille, Lille, France / INSERM UMR 1171, LILLE France, Troubles cognitifs dégénératifs et vasculaires, Lille,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="De Jesus, Anna Maria" sort="De Jesus, Anna Maria" uniqKey="De Jesus A" first="Anna Maria" last="De Jesus">Anna Maria De Jesus</name><affiliation wicri:level="1"><nlm:aff id="aff2">Service d’Explorations Fonctionnelles Respiratoires, Hôpital Albert Calmette, CHRU de Lille, Lille,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Perez, Thierry" sort="Perez, Thierry" uniqKey="Perez T" first="Thierry" last="Perez">Thierry Perez</name><affiliation wicri:level="1"><nlm:aff id="aff2">Service d’Explorations Fonctionnelles Respiratoires, Hôpital Albert Calmette, CHRU de Lille, Lille,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Devos, David" sort="Devos, David" uniqKey="Devos D" first="David" last="Devos">David Devos</name><affiliation wicri:level="1"><nlm:aff id="aff3">Service de Pharmacologie Médicale, Université de Lille, CHRU de Lille, France / INSERM UMR 1171, Lille,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Dujardin, Kathy" sort="Dujardin, Kathy" uniqKey="Dujardin K" first="Kathy" last="Dujardin">Kathy Dujardin</name><affiliation wicri:level="1"><nlm:aff id="aff1">Service de Neurologie et Pathologie du Mouvement, Pôle de neurosciences et appareil locomoteur, CHRU de Lille, Lille, France / INSERM UMR 1171, LILLE France, Troubles cognitifs dégénératifs et vasculaires, Lille,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Charley, Christelle Monaca" sort="Charley, Christelle Monaca" uniqKey="Charley C" first="Christelle Monaca" last="Charley">Christelle Monaca Charley</name><affiliation wicri:level="1"><nlm:aff id="aff4">Unité des Troubles du Sommeil et de la Vigilance, CHRU de Lille/INSERM UMR 1171, Lille,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Defebvre, Luc" sort="Defebvre, Luc" uniqKey="Defebvre L" first="Luc" last="Defebvre">Luc Defebvre</name><affiliation wicri:level="1"><nlm:aff id="aff1">Service de Neurologie et Pathologie du Mouvement, Pôle de neurosciences et appareil locomoteur, CHRU de Lille, Lille, France / INSERM UMR 1171, LILLE France, Troubles cognitifs dégénératifs et vasculaires, Lille,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea><placeName><settlement type="city">Lille</settlement><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region></placeName><orgName type="university" n="3">Université Lille 2</orgName><orgName type="institution" wicri:auto="newGroup">Université Lille Nord de France</orgName></affiliation></author><author><name sortKey="Moreau, Caroline" sort="Moreau, Caroline" uniqKey="Moreau C" first="Caroline" last="Moreau">Caroline Moreau</name><affiliation wicri:level="1"><nlm:aff id="aff1">Service de Neurologie et Pathologie du Mouvement, Pôle de neurosciences et appareil locomoteur, CHRU de Lille, Lille, France / INSERM UMR 1171, LILLE France, Troubles cognitifs dégénératifs et vasculaires, Lille,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Journal of Parkinson's Disease</title><idno type="ISSN">1877-7171</idno><idno type="eISSN">1877-718X</idno><imprint><date when="????">????</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>In contrast to some other neurodegenerative diseases, little is known about ventilatory dysfunction in Parkinson’s disease (PD). To assess the spectrum of ventilation disorders in PD, we searched for and reviewed studies of dyspnea, lung volumes, respiratory muscle function, sleep breathing disorders and the response to hypoxemia in PD. Among the studies, we identified some limitations: (i) small study populations (mainly composed of patients with advanced PD), (ii) the absence of long-term follow-up and (iii) the absence of functional evaluations under “off-drug” conditions. Although there are many reports of abnormal spirometry data in PD (mainly related to impairment of the inspiratory muscles), little is known about hypoventilation in PD. We conclude that ventilatory dysfunction in PD has been poorly studied and little is known about its frequency and clinical relevance. Hence, there is a need to characterize the different phenotypes of ventilation disorders in PD, study their relationships with disease progression and assess their prognostic value.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><pmc article-type="review-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Parkinsons Dis</journal-id><journal-id journal-id-type="iso-abbrev">J Parkinsons Dis</journal-id><journal-id journal-id-type="publisher-id">JPD</journal-id><journal-title-group><journal-title>Journal of Parkinson's Disease</journal-title></journal-title-group><issn pub-type="ppub">1877-7171</issn><issn pub-type="epub">1877-718X</issn><issn-l>1877-7171</issn-l><publisher><publisher-name>IOS Press</publisher-name><publisher-loc>Nieuwe Hemweg 6B, 1013 BG Amsterdam, The Netherlands</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">27314755</article-id><article-id pub-id-type="pmc">5008229</article-id><article-id pub-id-type="publisher-id">JPD160804</article-id><article-id pub-id-type="doi">10.3233/JPD-160804</article-id><article-categories><subj-group subj-group-type="heading"><subject>Review</subject></subj-group></article-categories><title-group><article-title>Ventilatory Dysfunction in Parkinson’s Disease</article-title><alt-title alt-title-type="left-running-head">G. Baille et al.</alt-title><alt-title alt-title-type="right-running-head">Ventilatory Dysfunction in Parkinson’s Disease</alt-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Baille</surname><given-names>Guillaume</given-names></name><xref ref-type="aff" rid="aff1">a</xref></contrib><contrib contrib-type="author"><name><surname>De Jesus</surname><given-names>Anna Maria</given-names></name><xref ref-type="aff" rid="aff2">b</xref></contrib><contrib contrib-type="author"><name><surname>Perez</surname><given-names>Thierry</given-names></name><xref ref-type="aff" rid="aff2">b</xref></contrib><contrib contrib-type="author"><name><surname>Devos</surname><given-names>David</given-names></name><xref ref-type="aff" rid="aff3">c</xref></contrib><contrib contrib-type="author"><name><surname>Dujardin</surname><given-names>Kathy</given-names></name><xref ref-type="aff" rid="aff1">a</xref></contrib><contrib contrib-type="author"><name><surname>Charley</surname><given-names>Christelle Monaca</given-names></name><xref ref-type="aff" rid="aff4">d</xref></contrib><contrib contrib-type="author"><name><surname>Defebvre</surname><given-names>Luc</given-names></name><xref ref-type="aff" rid="aff1">a</xref></contrib><contrib contrib-type="author"><name><surname>Moreau</surname><given-names>Caroline</given-names></name><xref ref-type="aff" rid="aff1">a</xref><xref ref-type="corresp" rid="cor1">*</xref></contrib><aff id="aff1"><label>a</label>Service de Neurologie et Pathologie du Mouvement, Pôle de neurosciences et appareil locomoteur, CHRU de Lille, Lille, France / INSERM UMR 1171, LILLE France, Troubles cognitifs dégénératifs et vasculaires, Lille,<country>France</country></aff><aff id="aff2"><label>b</label>Service d’Explorations Fonctionnelles Respiratoires, Hôpital Albert Calmette, CHRU de Lille, Lille,<country>France</country></aff><aff id="aff3"><label>c</label>Service de Pharmacologie Médicale, Université de Lille, CHRU de Lille, France / INSERM UMR 1171, Lille,<country>France</country></aff><aff id="aff4"><label>d</label>Unité des Troubles du Sommeil et de la Vigilance, CHRU de Lille/INSERM UMR 1171, Lille,<country>France</country></aff></contrib-group><author-notes><corresp id="cor1"><label>*</label>Correspondence to: Caroline Moreau, MD, PhD, Service de Neurologie et Pathologie du Mouvement, Pôle de neurosciences et appareil locomoteur, CHRU de Lille/INSERM UMR 1171,F-59037 Lille, France. Tel.: +003320446752; Fax: +003320446680; E-mail: <email>caroline.moreau@chru-lille.fr</email>.
</corresp></author-notes><pub-date date-type="preprint" publication-format="electronic"><day>16</day><month>6</month><year>2016</year></pub-date><pub-date date-type="pub" publication-format="electronic"><day>20</day><month>8</month><year>2016</year></pub-date><pub-date date-type="collection" publication-format="electronic"><year>2016</year></pub-date><volume>6</volume><issue>3</issue><fpage>463</fpage><lpage>471</lpage><history><date date-type="accepted"><day>16</day><month>5</month><year>2016</year></date></history><permissions><copyright-statement>IOS Press and the authors. All rights reserved</copyright-statement><copyright-year>2016</copyright-year><license xlink:href="https://creativecommons.org/licenses/by-nc/4.0/" license-type="open-access"><license-p>This is an open access article distributed under the terms of the <ext-link ext-link-type="uri" xlink:href="https://creativecommons.org/licenses/by-nc/4.0/">Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) License</ext-link>, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p></license></permissions><abstract><p>In contrast to some other neurodegenerative diseases, little is known about ventilatory dysfunction in Parkinson’s disease (PD). To assess the spectrum of ventilation disorders in PD, we searched for and reviewed studies of dyspnea, lung volumes, respiratory muscle function, sleep breathing disorders and the response to hypoxemia in PD. Among the studies, we identified some limitations: (i) small study populations (mainly composed of patients with advanced PD), (ii) the absence of long-term follow-up and (iii) the absence of functional evaluations under “off-drug” conditions. Although there are many reports of abnormal spirometry data in PD (mainly related to impairment of the inspiratory muscles), little is known about hypoventilation in PD. We conclude that ventilatory dysfunction in PD has been poorly studied and little is known about its frequency and clinical relevance. Hence, there is a need to characterize the different phenotypes of ventilation disorders in PD, study their relationships with disease progression and assess their prognostic value.</p></abstract><kwd-group><label>Keywords</label><kwd>Parkinson’s disease</kwd><kwd>pathophysiology</kwd><kwd>ventilatory function</kwd><kwd>review</kwd></kwd-group></article-meta></front><floats-group><fig id="jpd-6-jpd160804-g001" orientation="portrait" position="float"><label>Fig.1</label><caption><p>A flow-volume loop in a PD patient (personal observation). Ordinate: Flow (L/s), Abscissa: Volume (L). Ventilatory flutter is predominant during inspiration (black arrow).</p></caption><graphic xlink:href="jpd-6-jpd160804-g001"></graphic></fig><table-wrap id="jpd-6-jpd160804-t001" orientation="portrait" position="float"><label>Table 1</label><caption><p>Summary of the literature data on dyspnea in PD. HY: Hoehn and Yahr, DBS: Deep brain stimulation. VIM: Ventrale intermediate nucleus of the thalamus, NA: Not available</p></caption><table frame="hsides" rules="groups"><colgroup span="1"><col align="justify" span="1"></col></colgroup><thead valign="top"><tr><td rowspan="1" colspan="1">Study</td><td rowspan="1" colspan="1">Number of patients</td><td rowspan="1" colspan="1">Disease duration (year)</td><td rowspan="1" colspan="1">Clinical scores</td><td rowspan="1" colspan="1">Control group</td><td rowspan="1" colspan="1">Misperception of dyspnea</td><td rowspan="1" colspan="1">Main results</td></tr></thead><tbody><tr><td rowspan="1" colspan="1">[<xref rid="ref016" ref-type="bibr">16</xref>]</td><td align="center" rowspan="1" colspan="1">25</td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1">HY 2–3</td><td rowspan="1" colspan="1">Yes</td><td rowspan="1" colspan="1">Yes</td><td rowspan="1" colspan="1">Impaired perception of dyspnea</td></tr><tr><td rowspan="1" colspan="1">[<xref rid="ref016" ref-type="bibr">14</xref>]</td><td align="center" rowspan="1" colspan="1">50</td><td rowspan="1" colspan="1">12.7 ± 5.4</td><td rowspan="1" colspan="1">UPDRS III 44.4 ± 13.4“on drug”</td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1">90% of patients with dyspnea on “off drug” condition</td></tr><tr><td rowspan="1" colspan="1">[<xref rid="ref015" ref-type="bibr">15</xref>]</td><td align="center" rowspan="1" colspan="1">20</td><td rowspan="1" colspan="1">7.5 ± 1.1</td><td rowspan="1" colspan="1">HY 2–3</td><td rowspan="1" colspan="1">Yes</td><td rowspan="1" colspan="1">Yes</td><td rowspan="1" colspan="1">No link between reduction in dyspnea and increase in lung volumes</td></tr><tr><td rowspan="1" colspan="1">[<xref rid="ref023" ref-type="bibr">23</xref>]</td><td align="center" rowspan="1" colspan="1">13</td><td rowspan="1" colspan="1">Patients withDBS</td><td rowspan="1" colspan="1">NA</td><td rowspan="1" colspan="1">Yes (VIM)</td><td rowspan="1" colspan="1">Yes</td><td rowspan="1" colspan="1">link between DBS and dyspnea</td></tr></tbody></table></table-wrap><table-wrap id="jpd-6-jpd160804-t002" orientation="portrait" position="float"><label>Table 2</label><caption><p>Summary of the literature data on pulmonary function and PD. HY: Hoehn and Yahr, NS: Not
significant, UPDRS: Unified Parkinson’s Disease Rating Scale, MSA: Multiple system atrophy</p></caption><table frame="hsides" rules="groups"><colgroup span="1"><col align="justify" span="1"></col></colgroup><thead valign="top"><tr><td rowspan="1" colspan="1">Study</td><td rowspan="1" colspan="1">Number of patients</td><td rowspan="1" colspan="1">Disease duration (year)</td><td rowspan="1" colspan="1">Clinical scores</td><td rowspan="1" colspan="1">Control group</td><td rowspan="1" colspan="1">Spirometry</td><td rowspan="1" colspan="1">Dopasensitivity</td><td rowspan="1" colspan="1">Main results</td></tr></thead><tbody><tr><td rowspan="1" colspan="1">[<xref rid="ref037" ref-type="bibr">37</xref>]</td><td align="center" rowspan="1" colspan="1">31</td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1">obstruction</td><td rowspan="1" colspan="1">No</td><td rowspan="1" colspan="1">bronchoconstriction due to hyperactivity of the sympathetic system</td></tr><tr><td rowspan="1" colspan="1">[<xref rid="ref034" ref-type="bibr">34</xref>]</td><td align="center" rowspan="1" colspan="1">23</td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1">proximal obstruction</td></tr><tr><td rowspan="1" colspan="1">[<xref rid="ref036" ref-type="bibr">36</xref>]</td><td align="center" rowspan="1" colspan="1">6</td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1">obstruction</td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1">partial</td></tr><tr><td rowspan="1" colspan="1">[<xref rid="ref033" ref-type="bibr">33</xref>]</td><td align="center" rowspan="1" colspan="1">27</td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1">proximal obstruction</td></tr><tr><td rowspan="1" colspan="1">[<xref rid="ref032" ref-type="bibr">32</xref>]</td><td align="center" rowspan="1" colspan="1">31</td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1">12 HY3, 11 HY4, 8 HY5</td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1">obstruction</td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1">link with PD progression</td></tr><tr><td rowspan="1" colspan="1">[<xref rid="ref032" ref-type="bibr">32</xref>]</td><td align="center" rowspan="1" colspan="1">31</td><td rowspan="1" colspan="1">8</td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1">mixed</td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1">description of ventilatory flutter</td></tr><tr><td rowspan="1" colspan="1">[<xref rid="ref031" ref-type="bibr">31</xref>]</td><td align="center" rowspan="1" colspan="1">19</td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1">Yes</td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1">no impact of lung volumes on dysarthria</td></tr><tr><td rowspan="1" colspan="1">[<xref rid="ref028" ref-type="bibr">28</xref>]</td><td align="center" rowspan="1" colspan="1">63</td><td rowspan="1" colspan="1">5 ± 0.68</td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1">mixed</td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1">link with UPDRS III score</td></tr><tr><td rowspan="1" colspan="1">[<xref rid="ref030" ref-type="bibr">30</xref>]</td><td align="center" rowspan="1" colspan="1">58</td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1">mixed</td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1">link with clinical aspects of PD (bradykinesia, hypertonia, dorsal and cervical arthrosis)</td></tr><tr><td rowspan="1" colspan="1">[<xref rid="ref048" ref-type="bibr">48</xref>]</td><td align="center" rowspan="1" colspan="1">review</td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1">review</td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1">restriction associated with hypertonia, obstruction pulmonary syndrome associated with upper airway obstruction</td></tr><tr><td rowspan="1" colspan="1">[<xref rid="ref035" ref-type="bibr">35</xref>]</td><td align="center" rowspan="1" colspan="1">21</td><td rowspan="1" colspan="1">5 (mean)</td><td rowspan="1" colspan="1">HY 2–4</td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1">obstruction</td><td rowspan="1" colspan="1">Yes</td><td rowspan="1" colspan="1">lung volumes improved by L-DOPA</td></tr><tr><td rowspan="1" colspan="1">[<xref rid="ref027" ref-type="bibr">27</xref>]</td><td align="center" rowspan="1" colspan="1">40</td><td rowspan="1" colspan="1"> /</td><td rowspan="1" colspan="1">HY 1–3</td><td rowspan="1" colspan="1">Yes</td><td rowspan="1" colspan="1">restriction</td></tr><tr><td rowspan="1" colspan="1">[<xref rid="ref046" ref-type="bibr">46</xref>]</td><td align="center" rowspan="1" colspan="1">21</td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1">Yes</td><td rowspan="1" colspan="1">obstruction</td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1">abnormal agonist-antagonist muscle activity impacts on lungs volumes</td></tr><tr><td rowspan="1" colspan="1">[<xref rid="ref025" ref-type="bibr">25</xref>]</td><td align="center" rowspan="1" colspan="1">12</td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1">HY 3–5</td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1">restriction</td><td rowspan="1" colspan="1">NS</td><td rowspan="1" colspan="1">no obstructive syndrome, even in the “off-drug” condition</td></tr><tr><td rowspan="1" colspan="1">[<xref rid="ref029" ref-type="bibr">29</xref>]</td><td align="center" rowspan="1" colspan="1">53</td><td rowspan="1" colspan="1">2.8 in women, 3.2 in men</td><td rowspan="1" colspan="1">UPDRS 45 off, 14.6 on</td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1">restriction</td><td rowspan="1" colspan="1">partial</td><td rowspan="1" colspan="1">female patients had worse pulmonary function</td></tr><tr><td rowspan="1" colspan="1">[<xref rid="ref026" ref-type="bibr">26</xref>]</td><td align="center" rowspan="1" colspan="1">30</td><td rowspan="1" colspan="1">4.9 ± 3.1</td><td rowspan="1" colspan="1">UPDRS 32.4“on drug”</td><td rowspan="1" colspan="1">Yes (and MSA)</td><td rowspan="1" colspan="1">mixed</td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1">correlation with motor section of UPDRS</td></tr></tbody></table></table-wrap><table-wrap id="jpd-6-jpd160804-t003" orientation="portrait" position="float"><label>Table 3</label><caption><p>Summary of the literature data on respiratory muscle weakness and PD. HY: Hoehn and Yahr, inspi: Inspiratory muscles, expi: Expiratory muscles, NS: Not significant. UPDRS: Unified Parkinson’s Disease rating Scale</p></caption><table frame="hsides" rules="groups"><colgroup span="1"><col align="justify" span="1"></col></colgroup><thead valign="top"><tr><td rowspan="1" colspan="1">Study</td><td rowspan="1" colspan="1">Number of</td><td rowspan="1" colspan="1">Disease</td><td rowspan="1" colspan="1">Clinical</td><td rowspan="1" colspan="1">Control</td><td rowspan="1" colspan="1">Muscles</td><td rowspan="1" colspan="1">Dopasensitivity</td><td rowspan="1" colspan="1">main results</td></tr><tr><td rowspan="1" colspan="1">patients</td><td rowspan="1" colspan="1">duration (year)</td><td rowspan="1" colspan="1">scores</td><td rowspan="1" colspan="1">group</td></tr></thead><tbody><tr><td rowspan="1" colspan="1">[<xref rid="ref036" ref-type="bibr">36</xref>]</td><td align="center" rowspan="1" colspan="1">6</td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1">Inspi and expi</td><td rowspan="1" colspan="1">Yes</td></tr><tr><td rowspan="1" colspan="1">[<xref rid="ref040" ref-type="bibr">40</xref>]</td><td align="center" rowspan="1" colspan="1">9</td><td rowspan="1" colspan="1">2 to 14</td><td rowspan="1" colspan="1">HY 1–3</td><td rowspan="1" colspan="1">Yes</td></tr><tr><td rowspan="1" colspan="1">[<xref rid="ref042" ref-type="bibr">42</xref>]</td><td align="center" rowspan="1" colspan="1">10</td><td rowspan="1" colspan="1">6 to 20</td><td rowspan="1" colspan="1">HY 2–4</td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1">inspi</td><td rowspan="1" colspan="1">Yes(apomorphine)</td><td rowspan="1" colspan="1">due to lack of muscle coordination</td></tr><tr><td rowspan="1" colspan="1">[<xref rid="ref027" ref-type="bibr">27</xref>]</td><td align="center" rowspan="1" colspan="1">40</td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1">HY 1–3</td><td rowspan="1" colspan="1">Yes</td><td rowspan="1" colspan="1">normal</td></tr><tr><td rowspan="1" colspan="1">[<xref rid="ref039" ref-type="bibr">39</xref>]</td><td align="center" rowspan="1" colspan="1">66</td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1">HY 3–5</td><td rowspan="1" colspan="1">Yes</td><td rowspan="1" colspan="1">inspi and expi</td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1">abnormal response to mild hypoxia</td></tr><tr><td rowspan="1" colspan="1">[<xref rid="ref029" ref-type="bibr">29</xref>]</td><td align="center" rowspan="1" colspan="1">35</td><td rowspan="1" colspan="1"> 3</td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1">Yes</td><td rowspan="1" colspan="1">inspi and expi</td><td rowspan="1" colspan="1">Yes</td></tr><tr><td rowspan="1" colspan="1">[<xref rid="ref041" ref-type="bibr">41</xref>]</td><td align="center" rowspan="1" colspan="1">26</td><td rowspan="1" colspan="1">9.1 ± 0,3</td><td rowspan="1" colspan="1">UPDRS 43 “on drug”</td><td rowspan="1" colspan="1">Yes</td><td rowspan="1" colspan="1">inspi and expi</td><td rowspan="1" colspan="1">NS</td><td rowspan="1" colspan="1">respiratory muscle weakness in early-stage PD</td></tr><tr><td rowspan="1" colspan="1">[<xref rid="ref026" ref-type="bibr">26</xref>]</td><td align="center" rowspan="1" colspan="1">30</td><td rowspan="1" colspan="1">4.9 ± 3.1</td><td rowspan="1" colspan="1">UPDRS 32.4 “on drug”</td><td rowspan="1" colspan="1">Yes (and MSA)</td><td rowspan="1" colspan="1">inspi and expi</td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1">correlation with motor section of UPDRS</td></tr></tbody></table></table-wrap><table-wrap id="jpd-6-jpd160804-t004" orientation="portrait" position="float"><label>Table 4</label><caption><p>Summary of the literature data on dyspnea and PD. HY: Hoehn and Yahr</p></caption><table frame="hsides" rules="groups"><colgroup span="1"><col align="justify" span="1"></col></colgroup><thead valign="top"><tr><td rowspan="1" colspan="1">Study</td><td rowspan="1" colspan="1">Number of</td><td rowspan="1" colspan="1">Disease</td><td rowspan="1" colspan="1">Clinical</td><td rowspan="1" colspan="1">Control</td><td rowspan="1" colspan="1">Main results</td></tr><tr><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1">patients</td><td rowspan="1" colspan="1">duration (year)</td><td rowspan="1" colspan="1">scores</td><td rowspan="1" colspan="1">group</td></tr></thead><tbody><tr><td rowspan="1" colspan="1">[<xref rid="ref056" ref-type="bibr">56</xref>] (article in Russian)</td><td rowspan="1" colspan="1">7</td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1">abnormal response to hypoxemia</td></tr><tr><td rowspan="1" colspan="1">[<xref rid="ref057" ref-type="bibr">57</xref>]</td><td rowspan="1" colspan="1">19</td><td rowspan="1" colspan="1">5.7 ± 0.3</td><td rowspan="1" colspan="1">HY 3–5</td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1">reduced response to hypoxia</td></tr><tr><td rowspan="1" colspan="1">[<xref rid="ref058" ref-type="bibr">58</xref>]</td><td rowspan="1" colspan="1">12</td><td rowspan="1" colspan="1">9.3 ± 4.6</td><td rowspan="1" colspan="1">HY 1.5 ± 0.7</td><td rowspan="1" colspan="1">Yes</td><td rowspan="1" colspan="1">reduced response to hypoxia</td></tr></tbody></table></table-wrap></floats-group></pmc><affiliations><list><country><li>France</li></country><region><li>Hauts-de-France</li><li>Nord-Pas-de-Calais</li></region><settlement><li>Lille</li></settlement><orgName><li>Université Lille 2</li><li>Université Lille Nord de France</li></orgName></list><tree><country name="France"><noRegion><name sortKey="Baille, Guillaume" sort="Baille, Guillaume" uniqKey="Baille G" first="Guillaume" last="Baille">Guillaume Baille</name></noRegion><name sortKey="Charley, Christelle Monaca" sort="Charley, Christelle Monaca" uniqKey="Charley C" first="Christelle Monaca" last="Charley">Christelle Monaca Charley</name><name sortKey="De Jesus, Anna Maria" sort="De Jesus, Anna Maria" uniqKey="De Jesus A" first="Anna Maria" last="De Jesus">Anna Maria De Jesus</name><name sortKey="Defebvre, Luc" sort="Defebvre, Luc" uniqKey="Defebvre L" first="Luc" last="Defebvre">Luc Defebvre</name><name sortKey="Devos, David" sort="Devos, David" uniqKey="Devos D" first="David" last="Devos">David Devos</name><name sortKey="Dujardin, Kathy" sort="Dujardin, Kathy" uniqKey="Dujardin K" first="Kathy" last="Dujardin">Kathy Dujardin</name><name sortKey="Moreau, Caroline" sort="Moreau, Caroline" uniqKey="Moreau C" first="Caroline" last="Moreau">Caroline Moreau</name><name sortKey="Perez, Thierry" sort="Perez, Thierry" uniqKey="Perez T" first="Thierry" last="Perez">Thierry Perez</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/Ncbi/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001A53 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd -nk 001A53 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonFranceV1
|flux= Ncbi
|étape= Merge
|type= RBID
|clé= PMC:5008229
|texte= Ventilatory Dysfunction in Parkinson’s Disease
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/RBID.i -Sk "pubmed:27314755" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd \
| NlmPubMed2Wicri -a ParkinsonFranceV1
| This area was generated with Dilib version V0.6.29. |  |