A Movement Monitor Based on Magneto-Inertial Sensors for Non-Ambulant Patients with Duchenne Muscular Dystrophy: A Pilot Study in Controlled Environment
Identifieur interne : 001A42 ( Ncbi/Merge ); précédent : 001A41; suivant : 001A43A Movement Monitor Based on Magneto-Inertial Sensors for Non-Ambulant Patients with Duchenne Muscular Dystrophy: A Pilot Study in Controlled Environment
Auteurs : Anne-Gaëlle Le Moing [France] ; Andreea Mihaela Seferian [France] ; Amélie Moraux [France] ; Mélanie Annoussamy [France] ; Eric Dorveaux [France] ; Erwan Gasnier [France] ; Jean-Yves Hogrel [France] ; Thomas Voit [France] ; David Vissière [France] ; Laurent Servais [France]Source :
- PLoS ONE [ 1932-6203 ] ; 2016.
Abstract
Measurement of muscle strength and activity of upper limbs of non-ambulant patients with neuromuscular diseases is a major challenge. ActiMyo® is an innovative device that uses magneto-inertial sensors to record angular velocities and linear accelerations that can be used over long periods of time in the home environment. The device was designed to insure long-term stability and good signal to noise ratio, even for very weak movements. In order to determine relevant and pertinent clinical variables with potential for use as outcome measures in clinical trials or to guide therapy decisions, we performed a pilot study in non-ambulant neuromuscular patients. We report here data from seven Duchenne Muscular Dystrophy (DMD) patients (mean age 18.5 ± 5.5 years) collected in a clinical setting. Patients were assessed while wearing the device during performance of validated tasks (MoviPlate, Box and Block test and Minnesota test) and tasks mimicking daily living. The ActiMyo® sensors were placed on the wrists during all the tests. Software designed for use with the device computed several variables to qualify and quantify muscular activity in the non-ambulant subjects. Four variables representative of upper limb activity were studied: the rotation rate, the ratio of the vertical component in the overall acceleration, the hand elevation rate, and an estimate of the power of the upper limb. The correlations between clinical data and physical activity and the ActiMyo® movement parameters were analyzed. The mean of the rotation rate and mean of the elevation rate appeared promising since these variables had the best reliability scores and correlations with task scores. Parameters could be computed even in a patient with a Brooke functional score of 6. The variables chosen are good candidates as potential outcome measures in non-ambulant patients with Duchenne Muscular Dystrophy and use of the ActiMyo® is currently being explored in home environment.
Url:
DOI: 10.1371/journal.pone.0156696
PubMed: 27271157
PubMed Central: 4896626
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first="Laurent" last="Servais">Laurent Servais</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Institut de Myologie, Groupe Hospitalier de La Pitié Salpêtrière, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut de Myologie, Groupe Hospitalier de La Pitié Salpêtrière, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Measurement of muscle strength and activity of upper limbs of non-ambulant patients with neuromuscular diseases is a major challenge. ActiMyo<sup>®</sup> is an innovative device that uses magneto-inertial sensors to record angular velocities and linear accelerations that can be used over long periods of time in the home environment. The device was designed to insure long-term stability and good signal to noise ratio, even for very weak movements. In order to determine relevant and pertinent clinical variables with potential for use as outcome measures in clinical trials or to guide therapy decisions, we performed a pilot study in non-ambulant neuromuscular patients. We report here data from seven Duchenne Muscular Dystrophy (DMD) patients (mean age 18.5 ± 5.5 years) collected in a clinical setting. Patients were assessed while wearing the device during performance of validated tasks (MoviPlate, Box and Block test and Minnesota test) and tasks mimicking daily living. The ActiMyo<sup>®</sup> sensors were placed on the wrists during all the tests. Software designed for use with the device computed several variables to qualify and quantify muscular activity in the non-ambulant subjects. Four variables representative of upper limb activity were studied: the rotation rate, the ratio of the vertical component in the overall acceleration, the hand elevation rate, and an estimate of the power of the upper limb. The correlations between clinical data and physical activity and the ActiMyo<sup>®</sup> movement parameters were analyzed. The mean of the rotation rate and mean of the elevation rate appeared promising since these variables had the best reliability scores and correlations with task scores. Parameters could be computed even in a patient with a Brooke functional score of 6. The variables chosen are good candidates as potential outcome measures in non-ambulant patients with Duchenne Muscular Dystrophy and use of the ActiMyo<sup>®</sup> is currently being explored in home environment.</p><p><bold><italic>Trial Registration</italic>:</bold> ClinicalTrials.gov NCT01611597</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Santoso, F" uniqKey="Santoso F">F Santoso</name></author><author><name sortKey="Redmond, Sj" uniqKey="Redmond S">SJ Redmond</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zimetbaum, P" uniqKey="Zimetbaum P">P Zimetbaum</name></author><author><name sortKey="Goldman, A" uniqKey="Goldman A">A Goldman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dash, D" uniqKey="Dash D">D Dash</name></author><author><name sortKey="Hernandez Ronquillo, L" uniqKey="Hernandez Ronquillo L">L 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<front><journal-meta><journal-id journal-id-type="nlm-ta">PLoS One</journal-id><journal-id journal-id-type="iso-abbrev">PLoS ONE</journal-id><journal-id journal-id-type="publisher-id">plos</journal-id><journal-id journal-id-type="pmc">plosone</journal-id><journal-title-group><journal-title>PLoS ONE</journal-title></journal-title-group><issn pub-type="epub">1932-6203</issn><publisher><publisher-name>Public Library of Science</publisher-name><publisher-loc>San Francisco, CA USA</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">27271157</article-id><article-id pub-id-type="pmc">4896626</article-id><article-id pub-id-type="doi">10.1371/journal.pone.0156696</article-id><article-id pub-id-type="publisher-id">PONE-D-16-01552</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Biology and Life Sciences</subject><subj-group><subject>Anatomy</subject><subj-group><subject>Musculoskeletal System</subject></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Medicine and Health Sciences</subject><subj-group><subject>Anatomy</subject><subj-group><subject>Musculoskeletal System</subject></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Physical Sciences</subject><subj-group><subject>Physics</subject><subj-group><subject>Classical Mechanics</subject><subj-group><subject>Acceleration</subject></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Biology and Life Sciences</subject><subj-group><subject>Anatomy</subject><subj-group><subject>Musculoskeletal System</subject><subj-group><subject>Limbs (Anatomy)</subject><subj-group><subject>Arms</subject><subj-group><subject>Hands</subject></subj-group></subj-group></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Medicine and Health Sciences</subject><subj-group><subject>Anatomy</subject><subj-group><subject>Musculoskeletal System</subject><subj-group><subject>Limbs (Anatomy)</subject><subj-group><subject>Arms</subject><subj-group><subject>Hands</subject></subj-group></subj-group></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Medicine and Health Sciences</subject><subj-group><subject>Neurology</subject><subj-group><subject>Muscular Dystrophies</subject><subj-group><subject>Duchenne Muscular Dystrophy</subject></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Medicine and Health Sciences</subject><subj-group><subject>Clinical Genetics</subject><subj-group><subject>X-Linked Traits</subject><subj-group><subject>Duchenne Muscular Dystrophy</subject></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Biology and Life Sciences</subject><subj-group><subject>Genetics</subject><subj-group><subject>Heredity</subject><subj-group><subject>Genetic Linkage</subject><subj-group><subject>Sex Linkage</subject><subj-group><subject>X-Linked Traits</subject><subj-group><subject>Duchenne Muscular Dystrophy</subject></subj-group></subj-group></subj-group></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Biology and Life Sciences</subject><subj-group><subject>Anatomy</subject><subj-group><subject>Musculoskeletal System</subject><subj-group><subject>Limbs (Anatomy)</subject><subj-group><subject>Arms</subject><subj-group><subject>Forearms</subject></subj-group></subj-group></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Medicine and Health Sciences</subject><subj-group><subject>Anatomy</subject><subj-group><subject>Musculoskeletal System</subject><subj-group><subject>Limbs (Anatomy)</subject><subj-group><subject>Arms</subject><subj-group><subject>Forearms</subject></subj-group></subj-group></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Biology and Life Sciences</subject><subj-group><subject>Anatomy</subject><subj-group><subject>Musculoskeletal System</subject><subj-group><subject>Limbs (Anatomy)</subject><subj-group><subject>Arms</subject><subj-group><subject>Wrist</subject></subj-group></subj-group></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Medicine and Health Sciences</subject><subj-group><subject>Anatomy</subject><subj-group><subject>Musculoskeletal System</subject><subj-group><subject>Limbs (Anatomy)</subject><subj-group><subject>Arms</subject><subj-group><subject>Wrist</subject></subj-group></subj-group></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Biology and Life Sciences</subject><subj-group><subject>Biomechanics</subject><subj-group><subject>Hand Strength</subject></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Physical Sciences</subject><subj-group><subject>Physics</subject><subj-group><subject>Classical Mechanics</subject><subj-group><subject>Motion</subject><subj-group><subject>Inertia</subject></subj-group></subj-group></subj-group></subj-group></subj-group></article-categories><title-group><article-title>A Movement Monitor Based on Magneto-Inertial Sensors for Non-Ambulant Patients with Duchenne Muscular Dystrophy: A Pilot Study in Controlled Environment</article-title><alt-title alt-title-type="running-head">Evaluation of Non-Ambulant DMD Patients with Magneto-Inertial Device</alt-title></title-group><contrib-group><contrib contrib-type="author" equal-contrib="yes"><name><surname>Le Moing</surname><given-names>Anne-Gaëlle</given-names></name><xref ref-type="aff" rid="aff001"><sup>1</sup></xref><xref ref-type="aff" rid="aff002"><sup>2</sup></xref></contrib><contrib contrib-type="author" equal-contrib="yes"><name><surname>Seferian</surname><given-names>Andreea Mihaela</given-names></name><xref ref-type="aff" rid="aff001"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Moraux</surname><given-names>Amélie</given-names></name><xref ref-type="aff" rid="aff001"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Annoussamy</surname><given-names>Mélanie</given-names></name><xref ref-type="aff" rid="aff001"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Dorveaux</surname><given-names>Eric</given-names></name><xref ref-type="aff" rid="aff003"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Gasnier</surname><given-names>Erwan</given-names></name><xref ref-type="aff" rid="aff001"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Hogrel</surname><given-names>Jean-Yves</given-names></name><xref ref-type="aff" rid="aff001"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Voit</surname><given-names>Thomas</given-names></name><xref ref-type="aff" rid="aff001"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Vissière</surname><given-names>David</given-names></name><xref ref-type="aff" rid="aff003"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Servais</surname><given-names>Laurent</given-names></name><xref ref-type="aff" rid="aff001"><sup>1</sup></xref><xref ref-type="corresp" rid="cor001">*</xref></contrib></contrib-group><aff id="aff001"><label>1</label><addr-line>Institut de Myologie, Groupe Hospitalier de La Pitié Salpêtrière, Paris, France</addr-line></aff><aff id="aff002"><label>2</label><addr-line>Service de Neurologie Pédiatrique, Groupe de Recherches sur l'Analyse Multimodale de la Fonction Cérébrale, Centre Hospitalier Universitaire Amiens—Picardie, Amiens, France</addr-line></aff><aff id="aff003"><label>3</label><addr-line>SYSNAV, Vernon, France</addr-line></aff><contrib-group><contrib contrib-type="editor"><name><surname>Mallela</surname><given-names>Krishna</given-names></name><role>Editor</role><xref ref-type="aff" rid="edit1"></xref></contrib></contrib-group><aff id="edit1"><addr-line>University of Colorado Anschutz Medical Campus, UNITED STATES</addr-line></aff><author-notes><fn fn-type="conflict" id="coi001"><p><bold>Competing Interests: </bold>JYH is inventor of the MyoGrip. JYH and AM are co-inventors of the MyoPinch. JYH, LS, and TV are co-inventors of the MoviPlate. DV, LS, JYH, and AM are co-inventors of the ActiMyo®. We declare the following patents/patent applications (Vissière, David; Servais, Laurent. Actimyo—Couple contra-gravitaire. France. Brevet FR 1650652. 27 Janvier 2016). Eric Dorveaux and David Vissière are employed by the commercial company SYSNAV. There are no further patents, products in development or marketed products to declare. This does not alter our adherence to all the PLOS ONE policies on sharing data and materials.</p></fn><fn fn-type="con" id="contrib001"><p>Conceived and designed the experiments: AGLM AMS AM EG JYH TV LS. Performed the experiments: AGLM AMS AM. Analyzed the data: AGLM AMS AM MA EG JYH LS. Contributed reagents/materials/analysis tools: AM ED DV. Wrote the paper: AGLM AMS AM MA JYH LS.</p></fn><corresp id="cor001">* E-mail: <email>l.servais@institut-myologie.org</email></corresp></author-notes><pub-date pub-type="epub"><day>7</day><month>6</month><year>2016</year></pub-date><pub-date pub-type="collection"><year>2016</year></pub-date><volume>11</volume><issue>6</issue><elocation-id>e0156696</elocation-id><history><date date-type="received"><day>27</day><month>1</month><year>2016</year></date><date date-type="accepted"><day>18</day><month>5</month><year>2016</year></date></history><permissions><copyright-statement>© 2016 Le Moing et al</copyright-statement><copyright-year>2016</copyright-year><copyright-holder>Le Moing et al</copyright-holder><license xlink:href="http://creativecommons.org/licenses/by/4.0/"><license-p>This is an open access article distributed under the terms of the <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution License</ext-link>, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</license-p></license></permissions><self-uri content-type="pdf" xlink:href="pone.0156696.pdf"></self-uri><abstract><p>Measurement of muscle strength and activity of upper limbs of non-ambulant patients with neuromuscular diseases is a major challenge. ActiMyo<sup>®</sup> is an innovative device that uses magneto-inertial sensors to record angular velocities and linear accelerations that can be used over long periods of time in the home environment. The device was designed to insure long-term stability and good signal to noise ratio, even for very weak movements. In order to determine relevant and pertinent clinical variables with potential for use as outcome measures in clinical trials or to guide therapy decisions, we performed a pilot study in non-ambulant neuromuscular patients. We report here data from seven Duchenne Muscular Dystrophy (DMD) patients (mean age 18.5 ± 5.5 years) collected in a clinical setting. Patients were assessed while wearing the device during performance of validated tasks (MoviPlate, Box and Block test and Minnesota test) and tasks mimicking daily living. The ActiMyo<sup>®</sup> sensors were placed on the wrists during all the tests. Software designed for use with the device computed several variables to qualify and quantify muscular activity in the non-ambulant subjects. Four variables representative of upper limb activity were studied: the rotation rate, the ratio of the vertical component in the overall acceleration, the hand elevation rate, and an estimate of the power of the upper limb. The correlations between clinical data and physical activity and the ActiMyo<sup>®</sup> movement parameters were analyzed. The mean of the rotation rate and mean of the elevation rate appeared promising since these variables had the best reliability scores and correlations with task scores. Parameters could be computed even in a patient with a Brooke functional score of 6. The variables chosen are good candidates as potential outcome measures in non-ambulant patients with Duchenne Muscular Dystrophy and use of the ActiMyo<sup>®</sup> is currently being explored in home environment.</p><p><bold><italic>Trial Registration</italic>:</bold> ClinicalTrials.gov NCT01611597</p></abstract><funding-group><funding-statement>The PreActi study was entirely funded by Institute of Myology, AIM. Eric Dorveaux and David Vissière are employed by the commercial company SYSNAV. SYSNAV provided support in the form of salaries for authors ED and DV and provided the prototype used for the study and the operating system on a collaboration agreement, but did not have any additional role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section.</funding-statement></funding-group><counts><fig-count count="4"></fig-count><table-count count="5"></table-count><page-count count="17"></page-count></counts><custom-meta-group><custom-meta id="data-availability"><meta-name>Data Availability</meta-name><meta-value>All relevant data are within the paper and its Supporting Information files.</meta-value></custom-meta></custom-meta-group></article-meta><notes><title>Data Availability</title><p>All relevant data are within the paper and its Supporting Information files.</p></notes></front></pmc><affiliations><list><country><li>France</li></country><region><li>Hauts-de-France</li><li>Picardie</li><li>Île-de-France</li></region><settlement><li>Amiens</li><li>Paris</li></settlement></list><tree><country name="France"><region name="Île-de-France"><name sortKey="Le Moing, Anne Gaelle" sort="Le Moing, Anne Gaelle" uniqKey="Le Moing A" first="Anne-Gaëlle" last="Le Moing">Anne-Gaëlle Le Moing</name></region><name sortKey="Annoussamy, Melanie" sort="Annoussamy, Melanie" uniqKey="Annoussamy M" first="Mélanie" last="Annoussamy">Mélanie Annoussamy</name><name sortKey="Dorveaux, Eric" sort="Dorveaux, Eric" uniqKey="Dorveaux E" first="Eric" last="Dorveaux">Eric Dorveaux</name><name sortKey="Gasnier, Erwan" sort="Gasnier, Erwan" uniqKey="Gasnier E" first="Erwan" last="Gasnier">Erwan Gasnier</name><name sortKey="Hogrel, Jean Yves" sort="Hogrel, Jean Yves" uniqKey="Hogrel J" first="Jean-Yves" last="Hogrel">Jean-Yves Hogrel</name><name sortKey="Le Moing, Anne Gaelle" sort="Le Moing, Anne Gaelle" uniqKey="Le Moing A" first="Anne-Gaëlle" last="Le Moing">Anne-Gaëlle Le Moing</name><name sortKey="Moraux, Amelie" sort="Moraux, Amelie" uniqKey="Moraux A" first="Amélie" last="Moraux">Amélie Moraux</name><name sortKey="Seferian, Andreea Mihaela" sort="Seferian, Andreea Mihaela" uniqKey="Seferian A" first="Andreea Mihaela" last="Seferian">Andreea Mihaela Seferian</name><name sortKey="Servais, Laurent" sort="Servais, Laurent" uniqKey="Servais L" first="Laurent" last="Servais">Laurent Servais</name><name sortKey="Vissiere, David" sort="Vissiere, David" uniqKey="Vissiere D" first="David" last="Vissière">David Vissière</name><name sortKey="Voit, Thomas" sort="Voit, Thomas" uniqKey="Voit T" first="Thomas" last="Voit">Thomas Voit</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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