Cognitive and affective theory of mind in dementia with Lewy bodies and Alzheimer’s disease
Identifieur interne : 001980 ( Ncbi/Merge ); précédent : 001979; suivant : 001981Cognitive and affective theory of mind in dementia with Lewy bodies and Alzheimer’s disease
Auteurs : Camille Heitz [France] ; Vincent Noblet [France] ; Clélie Phillipps [France] ; Benjamin Cretin [France] ; Natacha Vogt [France] ; Nathalie Philippi [France] ; Jennifer Kemp [France] ; Xavier De Petigny [France] ; Mathias Bilger [France] ; Catherine Demuynck [France] ; Catherine Martin-Hunyadi [France] ; Jean-Paul Armspach [France] ; Frédéric Blanc [France]Source :
- Alzheimer's Research & Therapy [ 1758-9193 ] ; 2016.
Abstract
Thirty-three patients with DLB (DLB group) and 15 patients with Alzheimer’s disease (AD group), all in the early stage of the disease, as well as 16 healthy elderly control subjects (HC group), were included in the study. After a global cognitive assessment, we used the Faux Pas Recognition (FPR) test, the Reading the Mind in the Eyes (RME) test and Ekman’s Facial Emotion Recognition test to assess cognitive and affective components of ToM. Patients underwent cerebral 3-T magnetic resonance imaging, and atrophy of grey matter was analysed using voxel-based morphometry. We performed a one-sample
The DLB group performed significantly worse than the HC group on the FPR test (
This study is the first one to show early impairments of ToM in DLB. The two cognitive and affective components both appear to be affected in this disease. Among patients with ToM difficulties, we found atrophy in brain regions classically involved in ToM, which reinforces the neuronal network of ToM. Further studies are now needed to better understand the neural basis of such impairment.
The online version of this article (doi:10.1186/s13195-016-0179-9) contains supplementary material, which is available to authorized users.
Url:
DOI: 10.1186/s13195-016-0179-9
PubMed: 26979460
PubMed Central: 4793654
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<author><name sortKey="Kemp, Jennifer" sort="Kemp, Jennifer" uniqKey="Kemp J" first="Jennifer" last="Kemp">Jennifer Kemp</name>
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<author><name sortKey="De Petigny, Xavier" sort="De Petigny, Xavier" uniqKey="De Petigny X" first="Xavier" last="De Petigny">Xavier De Petigny</name>
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<region type="old region">Alsace (région administrative)</region>
<settlement type="city">Strasbourg</settlement>
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<author><name sortKey="Martin Hunyadi, Catherine" sort="Martin Hunyadi, Catherine" uniqKey="Martin Hunyadi C" first="Catherine" last="Martin-Hunyadi">Catherine Martin-Hunyadi</name>
<affiliation wicri:level="3"><nlm:aff id="Aff3">Day Hospital, Memory Resources and Research Centre (CMRR), Department of Geriatrics, University Hospital of Strasbourg, Strasbourg, France</nlm:aff>
<country xml:lang="fr">France</country>
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<settlement type="city">Strasbourg</settlement>
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</author>
<author><name sortKey="Armspach, Jean Paul" sort="Armspach, Jean Paul" uniqKey="Armspach J" first="Jean-Paul" last="Armspach">Jean-Paul Armspach</name>
<affiliation wicri:level="3"><nlm:aff id="Aff2">ICube Laboratory, IMIS Team, University of Strasbourg, CNRS, FMTS, Strasbourg, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>ICube Laboratory, IMIS Team, University of Strasbourg, CNRS, FMTS, Strasbourg</wicri:regionArea>
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<region type="old region">Alsace (région administrative)</region>
<settlement type="city">Strasbourg</settlement>
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<author><name sortKey="Blanc, Frederic" sort="Blanc, Frederic" uniqKey="Blanc F" first="Frédéric" last="Blanc">Frédéric Blanc</name>
<affiliation wicri:level="3"><nlm:aff id="Aff1">Neuropsychology Unit, Memory Resource and Research Centre (CMRR), Department of Neurology, University Hospital of Strasbourg, Strasbourg, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Neuropsychology Unit, Memory Resource and Research Centre (CMRR), Department of Neurology, University Hospital of Strasbourg, Strasbourg</wicri:regionArea>
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<settlement type="city">Strasbourg</settlement>
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<affiliation wicri:level="3"><nlm:aff id="Aff2">ICube Laboratory, IMIS Team, University of Strasbourg, CNRS, FMTS, Strasbourg, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>ICube Laboratory, IMIS Team, University of Strasbourg, CNRS, FMTS, Strasbourg</wicri:regionArea>
<placeName><region type="region">Grand Est</region>
<region type="old region">Alsace (région administrative)</region>
<settlement type="city">Strasbourg</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="Aff3">Day Hospital, Memory Resources and Research Centre (CMRR), Department of Geriatrics, University Hospital of Strasbourg, Strasbourg, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Day Hospital, Memory Resources and Research Centre (CMRR), Department of Geriatrics, University Hospital of Strasbourg, Strasbourg</wicri:regionArea>
<placeName><region type="region">Grand Est</region>
<region type="old region">Alsace (région administrative)</region>
<settlement type="city">Strasbourg</settlement>
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</analytic>
<series><title level="j">Alzheimer's Research & Therapy</title>
<idno type="eISSN">1758-9193</idno>
<imprint><date when="2016">2016</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
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<profileDesc><textClass></textClass>
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</teiHeader>
<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p><italic>Theory of mind</italic>
(ToM) refers to the ability to attribute mental states, thoughts (cognitive component) or feelings (affective component) to others. This function has been studied in many neurodegenerative diseases; however, to our knowledge, no studies investigating ToM in dementia with Lewy bodies (DLB) have been published. The aim of our study was to assess ToM in patients with DLB and to search for neural correlates of potential deficits.</p>
</sec>
<sec><title>Methods</title>
<p>Thirty-three patients with DLB (DLB group) and 15 patients with Alzheimer’s disease (AD group), all in the early stage of the disease, as well as 16 healthy elderly control subjects (HC group), were included in the study. After a global cognitive assessment, we used the Faux Pas Recognition (FPR) test, the Reading the Mind in the Eyes (RME) test and Ekman’s Facial Emotion Recognition test to assess cognitive and affective components of ToM. Patients underwent cerebral 3-T magnetic resonance imaging, and atrophy of grey matter was analysed using voxel-based morphometry. We performed a one-sample <italic>t</italic>
test to investigate the correlation between each ToM score and grey matter volume and a two-sample <italic>t</italic>
test to compare patients with DLB impaired with those non-impaired for each test.</p>
</sec>
<sec><title>Results</title>
<p>The DLB group performed significantly worse than the HC group on the FPR test (<italic>P</italic>
= 0.033) and the RME test (<italic>P</italic>
= 0.015). There was no significant difference between the AD group and the HC group or between the DLB group and the AD group. Some brain regions were associated with ToM impairments. The prefrontal cortex, with the inferior frontal cortex and the orbitofrontal cortex, was the main region, but we also found correlations with the temporoparietal junction, the precuneus, the fusiform gyrus and the insula.</p>
</sec>
<sec><title>Conclusions</title>
<p>This study is the first one to show early impairments of ToM in DLB. The two cognitive and affective components both appear to be affected in this disease. Among patients with ToM difficulties, we found atrophy in brain regions classically involved in ToM, which reinforces the neuronal network of ToM. Further studies are now needed to better understand the neural basis of such impairment.</p>
</sec>
<sec><title>Electronic supplementary material</title>
<p>The online version of this article (doi:10.1186/s13195-016-0179-9) contains supplementary material, which is available to authorized users.</p>
</sec>
</div>
</front>
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<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Alzheimers Res Ther</journal-id>
<journal-id journal-id-type="iso-abbrev">Alzheimers Res Ther</journal-id>
<journal-title-group><journal-title>Alzheimer's Research & Therapy</journal-title>
</journal-title-group>
<issn pub-type="epub">1758-9193</issn>
<publisher><publisher-name>BioMed Central</publisher-name>
<publisher-loc>London</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">26979460</article-id>
<article-id pub-id-type="pmc">4793654</article-id>
<article-id pub-id-type="publisher-id">179</article-id>
<article-id pub-id-type="doi">10.1186/s13195-016-0179-9</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Research</subject>
</subj-group>
</article-categories>
<title-group><article-title>Cognitive and affective theory of mind in dementia with Lewy bodies and Alzheimer’s disease</article-title>
</title-group>
<contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Heitz</surname>
<given-names>Camille</given-names>
</name>
<address><phone>+33-38812638</phone>
<email>camille.heitz@chru-strasbourg.fr</email>
</address>
<xref ref-type="aff" rid="Aff1"></xref>
<xref ref-type="aff" rid="Aff2"></xref>
<xref ref-type="aff" rid="Aff3"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Noblet</surname>
<given-names>Vincent</given-names>
</name>
<address><email>vincent.noblet@unistra.fr</email>
</address>
<xref ref-type="aff" rid="Aff2"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Phillipps</surname>
<given-names>Clélie</given-names>
</name>
<address><email>clelie.phillipps@chru-strasbourg.fr</email>
</address>
<xref ref-type="aff" rid="Aff1"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Cretin</surname>
<given-names>Benjamin</given-names>
</name>
<address><email>benjamin.cretin@chru-strasbourg.fr</email>
</address>
<xref ref-type="aff" rid="Aff1"></xref>
<xref ref-type="aff" rid="Aff2"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Vogt</surname>
<given-names>Natacha</given-names>
</name>
<address><email>natacha.vogt@chru-strasbourg.fr</email>
</address>
<xref ref-type="aff" rid="Aff1"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Philippi</surname>
<given-names>Nathalie</given-names>
</name>
<address><email>nathalie.philippi@chru-strasbourg.fr</email>
</address>
<xref ref-type="aff" rid="Aff1"></xref>
<xref ref-type="aff" rid="Aff2"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kemp</surname>
<given-names>Jennifer</given-names>
</name>
<address><email>jennifer.kemp@chru-strasbourg.fr</email>
</address>
<xref ref-type="aff" rid="Aff1"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>de Petigny</surname>
<given-names>Xavier</given-names>
</name>
<address><email>xavier.depetigny@chru-strasbourg.fr</email>
</address>
<xref ref-type="aff" rid="Aff3"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Bilger</surname>
<given-names>Mathias</given-names>
</name>
<address><email>mathias.bilger@chru-strasbourg.fr</email>
</address>
<xref ref-type="aff" rid="Aff1"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Demuynck</surname>
<given-names>Catherine</given-names>
</name>
<address><email>catherine.demuynck@chru-strasbourg.fr</email>
</address>
<xref ref-type="aff" rid="Aff3"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Martin-Hunyadi</surname>
<given-names>Catherine</given-names>
</name>
<address><email>catherine.hunyadi@chru-strasbourg.fr</email>
</address>
<xref ref-type="aff" rid="Aff3"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Armspach</surname>
<given-names>Jean-Paul</given-names>
</name>
<address><email>jparmspach@unistra.fr</email>
</address>
<xref ref-type="aff" rid="Aff2"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Blanc</surname>
<given-names>Frédéric</given-names>
</name>
<address><email>frederic.blanc@chru-strasbourg.fr</email>
</address>
<xref ref-type="aff" rid="Aff1"></xref>
<xref ref-type="aff" rid="Aff2"></xref>
<xref ref-type="aff" rid="Aff3"></xref>
</contrib>
<aff id="Aff1"><label></label>
Neuropsychology Unit, Memory Resource and Research Centre (CMRR), Department of Neurology, University Hospital of Strasbourg, Strasbourg, France</aff>
<aff id="Aff2"><label></label>
ICube Laboratory, IMIS Team, University of Strasbourg, CNRS, FMTS, Strasbourg, France</aff>
<aff id="Aff3"><label></label>
Day Hospital, Memory Resources and Research Centre (CMRR), Department of Geriatrics, University Hospital of Strasbourg, Strasbourg, France</aff>
</contrib-group>
<pub-date pub-type="epub"><day>16</day>
<month>3</month>
<year>2016</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>16</day>
<month>3</month>
<year>2016</year>
</pub-date>
<pub-date pub-type="collection"><year>2016</year>
</pub-date>
<volume>8</volume>
<elocation-id>10</elocation-id>
<history><date date-type="received"><day>22</day>
<month>11</month>
<year>2015</year>
</date>
<date date-type="accepted"><day>29</day>
<month>1</month>
<year>2016</year>
</date>
</history>
<permissions><copyright-statement>© Heitz et al. 2016</copyright-statement>
<license license-type="OpenAccess"><license-p><bold>Open Access</bold>
This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</ext-link>
), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/publicdomain/zero/1.0/">http://creativecommons.org/publicdomain/zero/1.0/</ext-link>
) applies to the data made available in this article, unless otherwise stated.</license-p>
</license>
</permissions>
<abstract id="Abs1"><sec><title>Background</title>
<p><italic>Theory of mind</italic>
(ToM) refers to the ability to attribute mental states, thoughts (cognitive component) or feelings (affective component) to others. This function has been studied in many neurodegenerative diseases; however, to our knowledge, no studies investigating ToM in dementia with Lewy bodies (DLB) have been published. The aim of our study was to assess ToM in patients with DLB and to search for neural correlates of potential deficits.</p>
</sec>
<sec><title>Methods</title>
<p>Thirty-three patients with DLB (DLB group) and 15 patients with Alzheimer’s disease (AD group), all in the early stage of the disease, as well as 16 healthy elderly control subjects (HC group), were included in the study. After a global cognitive assessment, we used the Faux Pas Recognition (FPR) test, the Reading the Mind in the Eyes (RME) test and Ekman’s Facial Emotion Recognition test to assess cognitive and affective components of ToM. Patients underwent cerebral 3-T magnetic resonance imaging, and atrophy of grey matter was analysed using voxel-based morphometry. We performed a one-sample <italic>t</italic>
test to investigate the correlation between each ToM score and grey matter volume and a two-sample <italic>t</italic>
test to compare patients with DLB impaired with those non-impaired for each test.</p>
</sec>
<sec><title>Results</title>
<p>The DLB group performed significantly worse than the HC group on the FPR test (<italic>P</italic>
= 0.033) and the RME test (<italic>P</italic>
= 0.015). There was no significant difference between the AD group and the HC group or between the DLB group and the AD group. Some brain regions were associated with ToM impairments. The prefrontal cortex, with the inferior frontal cortex and the orbitofrontal cortex, was the main region, but we also found correlations with the temporoparietal junction, the precuneus, the fusiform gyrus and the insula.</p>
</sec>
<sec><title>Conclusions</title>
<p>This study is the first one to show early impairments of ToM in DLB. The two cognitive and affective components both appear to be affected in this disease. Among patients with ToM difficulties, we found atrophy in brain regions classically involved in ToM, which reinforces the neuronal network of ToM. Further studies are now needed to better understand the neural basis of such impairment.</p>
</sec>
<sec><title>Electronic supplementary material</title>
<p>The online version of this article (doi:10.1186/s13195-016-0179-9) contains supplementary material, which is available to authorized users.</p>
</sec>
</abstract>
<kwd-group xml:lang="en"><title>Keywords</title>
<kwd>Theory of mind</kwd>
<kwd>Dementia with Lewy bodies</kwd>
<kwd>Alzheimer’s disease</kwd>
<kwd>Brain volume</kwd>
<kwd>Neural correlates</kwd>
</kwd-group>
<custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name>
<meta-value>© The Author(s) 2016</meta-value>
</custom-meta>
</custom-meta-group>
</article-meta>
</front>
</pmc>
<affiliations><list><country><li>France</li>
</country>
<region><li>Alsace (région administrative)</li>
<li>Grand Est</li>
</region>
<settlement><li>Strasbourg</li>
</settlement>
</list>
<tree><country name="France"><region name="Grand Est"><name sortKey="Heitz, Camille" sort="Heitz, Camille" uniqKey="Heitz C" first="Camille" last="Heitz">Camille Heitz</name>
</region>
<name sortKey="Armspach, Jean Paul" sort="Armspach, Jean Paul" uniqKey="Armspach J" first="Jean-Paul" last="Armspach">Jean-Paul Armspach</name>
<name sortKey="Bilger, Mathias" sort="Bilger, Mathias" uniqKey="Bilger M" first="Mathias" last="Bilger">Mathias Bilger</name>
<name sortKey="Blanc, Frederic" sort="Blanc, Frederic" uniqKey="Blanc F" first="Frédéric" last="Blanc">Frédéric Blanc</name>
<name sortKey="Blanc, Frederic" sort="Blanc, Frederic" uniqKey="Blanc F" first="Frédéric" last="Blanc">Frédéric Blanc</name>
<name sortKey="Blanc, Frederic" sort="Blanc, Frederic" uniqKey="Blanc F" first="Frédéric" last="Blanc">Frédéric Blanc</name>
<name sortKey="Cretin, Benjamin" sort="Cretin, Benjamin" uniqKey="Cretin B" first="Benjamin" last="Cretin">Benjamin Cretin</name>
<name sortKey="Cretin, Benjamin" sort="Cretin, Benjamin" uniqKey="Cretin B" first="Benjamin" last="Cretin">Benjamin Cretin</name>
<name sortKey="De Petigny, Xavier" sort="De Petigny, Xavier" uniqKey="De Petigny X" first="Xavier" last="De Petigny">Xavier De Petigny</name>
<name sortKey="Demuynck, Catherine" sort="Demuynck, Catherine" uniqKey="Demuynck C" first="Catherine" last="Demuynck">Catherine Demuynck</name>
<name sortKey="Heitz, Camille" sort="Heitz, Camille" uniqKey="Heitz C" first="Camille" last="Heitz">Camille Heitz</name>
<name sortKey="Heitz, Camille" sort="Heitz, Camille" uniqKey="Heitz C" first="Camille" last="Heitz">Camille Heitz</name>
<name sortKey="Kemp, Jennifer" sort="Kemp, Jennifer" uniqKey="Kemp J" first="Jennifer" last="Kemp">Jennifer Kemp</name>
<name sortKey="Martin Hunyadi, Catherine" sort="Martin Hunyadi, Catherine" uniqKey="Martin Hunyadi C" first="Catherine" last="Martin-Hunyadi">Catherine Martin-Hunyadi</name>
<name sortKey="Noblet, Vincent" sort="Noblet, Vincent" uniqKey="Noblet V" first="Vincent" last="Noblet">Vincent Noblet</name>
<name sortKey="Philippi, Nathalie" sort="Philippi, Nathalie" uniqKey="Philippi N" first="Nathalie" last="Philippi">Nathalie Philippi</name>
<name sortKey="Philippi, Nathalie" sort="Philippi, Nathalie" uniqKey="Philippi N" first="Nathalie" last="Philippi">Nathalie Philippi</name>
<name sortKey="Phillipps, Clelie" sort="Phillipps, Clelie" uniqKey="Phillipps C" first="Clélie" last="Phillipps">Clélie Phillipps</name>
<name sortKey="Vogt, Natacha" sort="Vogt, Natacha" uniqKey="Vogt N" first="Natacha" last="Vogt">Natacha Vogt</name>
</country>
</tree>
</affiliations>
</record>
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