Proton MR Spectroscopy for Diagnosis and Evaluation of Treatment Efficacy in Parkinson Disease.
Identifieur interne : 001782 ( Ncbi/Merge ); précédent : 001781; suivant : 001783Proton MR Spectroscopy for Diagnosis and Evaluation of Treatment Efficacy in Parkinson Disease.
Auteurs : Leslie Mazuel [France] ; Carine Chassain [France] ; Betty Jean [France] ; Bruno Pereira [France] ; Aurélie Cladière [France] ; Claudine Speziale [France] ; Franck Durif [France]Source :
- Radiology [ 1527-1315 ] ; 2016.
English descriptors
- KwdEn :
- MESH :
- chemical , therapeutic use : Antiparkinson Agents.
- diagnosis : Parkinson Disease.
- drug therapy : Parkinson Disease.
- methods : Magnetic Resonance Spectroscopy.
- Aged, Case-Control Studies, Female, Humans, Male, Middle Aged, Prospective Studies, Protons, Reproducibility of Results, Treatment Outcome.
Abstract
To assess the neurochemical profile in the putamen of patients with parkinsonian syndromes undergoing L-3,4-dihydroxyphenylalanine (L-DOPA) treatment (drug-on) or after withdrawal of L-DOPA medication (drug-off) compared with healthy volunteers to identify dopaminergic therapy-sensitive biomarkers of Parkinson disease.
DOI: 10.1148/radiol.2015142764
PubMed: 26237591
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Proton MR Spectroscopy for Diagnosis and Evaluation of Treatment Efficacy in Parkinson Disease.</title><author><name sortKey="Mazuel, Leslie" sort="Mazuel, Leslie" uniqKey="Mazuel L" first="Leslie" last="Mazuel">Leslie Mazuel</name><affiliation wicri:level="3"><nlm:affiliation>From the Department of UFR Medicine, Auvergne University, EA7280, Clermont-Ferrand, France (L.M., F.D.); Center for Magnetic Resonance Imaging (C.C., B.J., A.C., C.S.) and Department of Neurology (B.P., F.D.), CHU Gabriel Montpied, 58 rue Montalembert, 63000 Clermont-Ferrand, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>From the Department of UFR Medicine, Auvergne University, EA7280, Clermont-Ferrand, France (L.M., F.D.); Center for Magnetic Resonance Imaging (C.C., B.J., A.C., C.S.) and Department of Neurology (B.P., F.D.), CHU Gabriel Montpied, 58 rue Montalembert, 63000 Clermont-Ferrand</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Auvergne (région administrative)</region><settlement type="city">Clermont-Ferrand</settlement></placeName></affiliation></author><author><name sortKey="Chassain, Carine" sort="Chassain, Carine" uniqKey="Chassain C" first="Carine" last="Chassain">Carine Chassain</name><affiliation wicri:level="3"><nlm:affiliation>From the Department of UFR Medicine, Auvergne University, EA7280, Clermont-Ferrand, France (L.M., F.D.); Center for Magnetic Resonance Imaging (C.C., B.J., A.C., C.S.) and Department of Neurology (B.P., F.D.), CHU Gabriel Montpied, 58 rue Montalembert, 63000 Clermont-Ferrand, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>From the Department of UFR Medicine, Auvergne University, EA7280, Clermont-Ferrand, France (L.M., F.D.); Center for Magnetic Resonance Imaging (C.C., B.J., A.C., C.S.) and Department of Neurology (B.P., F.D.), CHU Gabriel Montpied, 58 rue Montalembert, 63000 Clermont-Ferrand</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Auvergne (région administrative)</region><settlement type="city">Clermont-Ferrand</settlement></placeName></affiliation></author><author><name sortKey="Jean, Betty" sort="Jean, Betty" uniqKey="Jean B" first="Betty" last="Jean">Betty Jean</name><affiliation wicri:level="3"><nlm:affiliation>From the Department of UFR Medicine, Auvergne University, EA7280, Clermont-Ferrand, France (L.M., F.D.); Center for Magnetic Resonance Imaging (C.C., B.J., A.C., C.S.) and Department of Neurology (B.P., F.D.), CHU Gabriel Montpied, 58 rue Montalembert, 63000 Clermont-Ferrand, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>From the Department of UFR Medicine, Auvergne University, EA7280, Clermont-Ferrand, France (L.M., F.D.); Center for Magnetic Resonance Imaging (C.C., B.J., A.C., C.S.) and Department of Neurology (B.P., F.D.), CHU Gabriel Montpied, 58 rue Montalembert, 63000 Clermont-Ferrand</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Auvergne (région administrative)</region><settlement type="city">Clermont-Ferrand</settlement></placeName></affiliation></author><author><name sortKey="Pereira, Bruno" sort="Pereira, Bruno" uniqKey="Pereira B" first="Bruno" last="Pereira">Bruno Pereira</name><affiliation wicri:level="3"><nlm:affiliation>From the Department of UFR Medicine, Auvergne University, EA7280, Clermont-Ferrand, France (L.M., F.D.); Center for Magnetic Resonance Imaging (C.C., B.J., A.C., C.S.) and Department of Neurology (B.P., F.D.), CHU Gabriel Montpied, 58 rue Montalembert, 63000 Clermont-Ferrand, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>From the Department of UFR Medicine, Auvergne University, EA7280, Clermont-Ferrand, France (L.M., F.D.); Center for Magnetic Resonance Imaging (C.C., B.J., A.C., C.S.) and Department of Neurology (B.P., F.D.), CHU Gabriel Montpied, 58 rue Montalembert, 63000 Clermont-Ferrand</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Auvergne (région administrative)</region><settlement type="city">Clermont-Ferrand</settlement></placeName></affiliation></author><author><name sortKey="Cladiere, Aurelie" sort="Cladiere, Aurelie" uniqKey="Cladiere A" first="Aurélie" last="Cladière">Aurélie Cladière</name><affiliation wicri:level="3"><nlm:affiliation>From the Department of UFR Medicine, Auvergne University, EA7280, Clermont-Ferrand, France (L.M., F.D.); Center for Magnetic Resonance Imaging (C.C., B.J., A.C., C.S.) and Department of Neurology (B.P., F.D.), CHU Gabriel Montpied, 58 rue Montalembert, 63000 Clermont-Ferrand, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>From the Department of UFR Medicine, Auvergne University, EA7280, Clermont-Ferrand, France (L.M., F.D.); Center for Magnetic Resonance Imaging (C.C., B.J., A.C., C.S.) and Department of Neurology (B.P., F.D.), CHU Gabriel Montpied, 58 rue Montalembert, 63000 Clermont-Ferrand</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Auvergne (région administrative)</region><settlement type="city">Clermont-Ferrand</settlement></placeName></affiliation></author><author><name sortKey="Speziale, Claudine" sort="Speziale, Claudine" uniqKey="Speziale C" first="Claudine" last="Speziale">Claudine Speziale</name><affiliation wicri:level="3"><nlm:affiliation>From the Department of UFR Medicine, Auvergne University, EA7280, Clermont-Ferrand, France (L.M., F.D.); Center for Magnetic Resonance Imaging (C.C., B.J., A.C., C.S.) and Department of Neurology (B.P., F.D.), CHU Gabriel Montpied, 58 rue Montalembert, 63000 Clermont-Ferrand, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>From the Department of UFR Medicine, Auvergne University, EA7280, Clermont-Ferrand, France (L.M., F.D.); Center for Magnetic Resonance Imaging (C.C., B.J., A.C., C.S.) and Department of Neurology (B.P., F.D.), CHU Gabriel Montpied, 58 rue Montalembert, 63000 Clermont-Ferrand</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Auvergne (région administrative)</region><settlement type="city">Clermont-Ferrand</settlement></placeName></affiliation></author><author><name sortKey="Durif, Franck" sort="Durif, Franck" uniqKey="Durif F" first="Franck" last="Durif">Franck Durif</name><affiliation wicri:level="3"><nlm:affiliation>From the Department of UFR Medicine, Auvergne University, EA7280, Clermont-Ferrand, France (L.M., F.D.); Center for Magnetic Resonance Imaging (C.C., B.J., A.C., C.S.) and Department of Neurology (B.P., F.D.), CHU Gabriel Montpied, 58 rue Montalembert, 63000 Clermont-Ferrand, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>From the Department of UFR Medicine, Auvergne University, EA7280, Clermont-Ferrand, France (L.M., F.D.); Center for Magnetic Resonance Imaging (C.C., B.J., A.C., C.S.) and Department of Neurology (B.P., F.D.), CHU Gabriel Montpied, 58 rue Montalembert, 63000 Clermont-Ferrand</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Auvergne (région administrative)</region><settlement type="city">Clermont-Ferrand</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:26237591</idno><idno type="pmid">26237591</idno><idno type="doi">10.1148/radiol.2015142764</idno><idno type="wicri:Area/PubMed/Corpus">000199</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000199</idno><idno type="wicri:Area/PubMed/Curation">000199</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000199</idno><idno type="wicri:Area/PubMed/Checkpoint">000199</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000199</idno><idno type="wicri:Area/Ncbi/Merge">001782</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Proton MR Spectroscopy for Diagnosis and Evaluation of Treatment Efficacy in Parkinson Disease.</title><author><name sortKey="Mazuel, Leslie" sort="Mazuel, Leslie" uniqKey="Mazuel L" first="Leslie" last="Mazuel">Leslie Mazuel</name><affiliation wicri:level="3"><nlm:affiliation>From the Department of UFR Medicine, Auvergne University, EA7280, Clermont-Ferrand, France (L.M., F.D.); Center for Magnetic Resonance Imaging (C.C., B.J., A.C., C.S.) and Department of Neurology (B.P., F.D.), CHU Gabriel Montpied, 58 rue Montalembert, 63000 Clermont-Ferrand, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>From the Department of UFR Medicine, Auvergne University, EA7280, Clermont-Ferrand, France (L.M., F.D.); Center for Magnetic Resonance Imaging (C.C., B.J., A.C., C.S.) and Department of Neurology (B.P., F.D.), CHU Gabriel Montpied, 58 rue Montalembert, 63000 Clermont-Ferrand</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Auvergne (région administrative)</region><settlement type="city">Clermont-Ferrand</settlement></placeName></affiliation></author><author><name sortKey="Chassain, Carine" sort="Chassain, Carine" uniqKey="Chassain C" first="Carine" last="Chassain">Carine Chassain</name><affiliation wicri:level="3"><nlm:affiliation>From the Department of UFR Medicine, Auvergne University, EA7280, Clermont-Ferrand, France (L.M., F.D.); Center for Magnetic Resonance Imaging (C.C., B.J., A.C., C.S.) and Department of Neurology (B.P., F.D.), CHU Gabriel Montpied, 58 rue Montalembert, 63000 Clermont-Ferrand, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>From the Department of UFR Medicine, Auvergne University, EA7280, Clermont-Ferrand, France (L.M., F.D.); Center for Magnetic Resonance Imaging (C.C., B.J., A.C., C.S.) and Department of Neurology (B.P., F.D.), CHU Gabriel Montpied, 58 rue Montalembert, 63000 Clermont-Ferrand</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Auvergne (région administrative)</region><settlement type="city">Clermont-Ferrand</settlement></placeName></affiliation></author><author><name sortKey="Jean, Betty" sort="Jean, Betty" uniqKey="Jean B" first="Betty" last="Jean">Betty Jean</name><affiliation wicri:level="3"><nlm:affiliation>From the Department of UFR Medicine, Auvergne University, EA7280, Clermont-Ferrand, France (L.M., F.D.); Center for Magnetic Resonance Imaging (C.C., B.J., A.C., C.S.) and Department of Neurology (B.P., F.D.), CHU Gabriel Montpied, 58 rue Montalembert, 63000 Clermont-Ferrand, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>From the Department of UFR Medicine, Auvergne University, EA7280, Clermont-Ferrand, France (L.M., F.D.); Center for Magnetic Resonance Imaging (C.C., B.J., A.C., C.S.) and Department of Neurology (B.P., F.D.), CHU Gabriel Montpied, 58 rue Montalembert, 63000 Clermont-Ferrand</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Auvergne (région administrative)</region><settlement type="city">Clermont-Ferrand</settlement></placeName></affiliation></author><author><name sortKey="Pereira, Bruno" sort="Pereira, Bruno" uniqKey="Pereira B" first="Bruno" last="Pereira">Bruno Pereira</name><affiliation wicri:level="3"><nlm:affiliation>From the Department of UFR Medicine, Auvergne University, EA7280, Clermont-Ferrand, France (L.M., F.D.); Center for Magnetic Resonance Imaging (C.C., B.J., A.C., C.S.) and Department of Neurology (B.P., F.D.), CHU Gabriel Montpied, 58 rue Montalembert, 63000 Clermont-Ferrand, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>From the Department of UFR Medicine, Auvergne University, EA7280, Clermont-Ferrand, France (L.M., F.D.); Center for Magnetic Resonance Imaging (C.C., B.J., A.C., C.S.) and Department of Neurology (B.P., F.D.), CHU Gabriel Montpied, 58 rue Montalembert, 63000 Clermont-Ferrand</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Auvergne (région administrative)</region><settlement type="city">Clermont-Ferrand</settlement></placeName></affiliation></author><author><name sortKey="Cladiere, Aurelie" sort="Cladiere, Aurelie" uniqKey="Cladiere A" first="Aurélie" last="Cladière">Aurélie Cladière</name><affiliation wicri:level="3"><nlm:affiliation>From the Department of UFR Medicine, Auvergne University, EA7280, Clermont-Ferrand, France (L.M., F.D.); Center for Magnetic Resonance Imaging (C.C., B.J., A.C., C.S.) and Department of Neurology (B.P., F.D.), CHU Gabriel Montpied, 58 rue Montalembert, 63000 Clermont-Ferrand, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>From the Department of UFR Medicine, Auvergne University, EA7280, Clermont-Ferrand, France (L.M., F.D.); Center for Magnetic Resonance Imaging (C.C., B.J., A.C., C.S.) and Department of Neurology (B.P., F.D.), CHU Gabriel Montpied, 58 rue Montalembert, 63000 Clermont-Ferrand</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Auvergne (région administrative)</region><settlement type="city">Clermont-Ferrand</settlement></placeName></affiliation></author><author><name sortKey="Speziale, Claudine" sort="Speziale, Claudine" uniqKey="Speziale C" first="Claudine" last="Speziale">Claudine Speziale</name><affiliation wicri:level="3"><nlm:affiliation>From the Department of UFR Medicine, Auvergne University, EA7280, Clermont-Ferrand, France (L.M., F.D.); Center for Magnetic Resonance Imaging (C.C., B.J., A.C., C.S.) and Department of Neurology (B.P., F.D.), CHU Gabriel Montpied, 58 rue Montalembert, 63000 Clermont-Ferrand, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>From the Department of UFR Medicine, Auvergne University, EA7280, Clermont-Ferrand, France (L.M., F.D.); Center for Magnetic Resonance Imaging (C.C., B.J., A.C., C.S.) and Department of Neurology (B.P., F.D.), CHU Gabriel Montpied, 58 rue Montalembert, 63000 Clermont-Ferrand</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Auvergne (région administrative)</region><settlement type="city">Clermont-Ferrand</settlement></placeName></affiliation></author><author><name sortKey="Durif, Franck" sort="Durif, Franck" uniqKey="Durif F" first="Franck" last="Durif">Franck Durif</name><affiliation wicri:level="3"><nlm:affiliation>From the Department of UFR Medicine, Auvergne University, EA7280, Clermont-Ferrand, France (L.M., F.D.); Center for Magnetic Resonance Imaging (C.C., B.J., A.C., C.S.) and Department of Neurology (B.P., F.D.), CHU Gabriel Montpied, 58 rue Montalembert, 63000 Clermont-Ferrand, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>From the Department of UFR Medicine, Auvergne University, EA7280, Clermont-Ferrand, France (L.M., F.D.); Center for Magnetic Resonance Imaging (C.C., B.J., A.C., C.S.) and Department of Neurology (B.P., F.D.), CHU Gabriel Montpied, 58 rue Montalembert, 63000 Clermont-Ferrand</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Auvergne (région administrative)</region><settlement type="city">Clermont-Ferrand</settlement></placeName></affiliation></author></analytic><series><title level="j">Radiology</title><idno type="eISSN">1527-1315</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Antiparkinson Agents (therapeutic use)</term><term>Case-Control Studies</term><term>Female</term><term>Humans</term><term>Magnetic Resonance Spectroscopy (methods)</term><term>Male</term><term>Middle Aged</term><term>Parkinson Disease (diagnosis)</term><term>Parkinson Disease (drug therapy)</term><term>Prospective Studies</term><term>Protons</term><term>Reproducibility of Results</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiparkinson Agents</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Magnetic Resonance Spectroscopy</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Case-Control Studies</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Prospective Studies</term><term>Protons</term><term>Reproducibility of Results</term><term>Treatment Outcome</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To assess the neurochemical profile in the putamen of patients with parkinsonian syndromes undergoing L-3,4-dihydroxyphenylalanine (L-DOPA) treatment (drug-on) or after withdrawal of L-DOPA medication (drug-off) compared with healthy volunteers to identify dopaminergic therapy-sensitive biomarkers of Parkinson disease.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26237591</PMID><DateCreated><Year>2016</Year><Month>01</Month><Day>21</Day></DateCreated><DateCompleted><Year>2016</Year><Month>05</Month><Day>31</Day></DateCompleted><DateRevised><Year>2016</Year><Month>01</Month><Day>21</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1527-1315</ISSN><JournalIssue CitedMedium="Internet"><Volume>278</Volume><Issue>2</Issue><PubDate><Year>2016</Year><Month>Feb</Month></PubDate></JournalIssue><Title>Radiology</Title><ISOAbbreviation>Radiology</ISOAbbreviation></Journal><ArticleTitle>Proton MR Spectroscopy for Diagnosis and Evaluation of Treatment Efficacy in Parkinson Disease.</ArticleTitle><Pagination><MedlinePgn>505-13</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1148/radiol.2015142764</ELocationID><Abstract><AbstractText Label="PURPOSE" NlmCategory="OBJECTIVE">To assess the neurochemical profile in the putamen of patients with parkinsonian syndromes undergoing L-3,4-dihydroxyphenylalanine (L-DOPA) treatment (drug-on) or after withdrawal of L-DOPA medication (drug-off) compared with healthy volunteers to identify dopaminergic therapy-sensitive biomarkers of Parkinson disease.</AbstractText><AbstractText Label="MATERIALS AND METHODS" NlmCategory="METHODS">The local institutional review board approved the study, and all participants gave informed consent. A short echo-time (29 msec) single-voxel (1-cm(3)) proton (hydrogen 1 [(1)H]) magnetic resonance (MR) spectroscopic approach was used at 3 T to explore the metabolic profile in the putamen of patients with Parkinson disease. Spectra obtained from 20 healthy volunteers were blindly compared with spectra obtained from 20 patients with parkinsonian syndromes in drug-on and drug-off conditions in a randomized permuted block study to assess the accuracy of diagnostic biomarkers for Parkinson disease and efficacy of L-DOPA therapy. The statistical tests were two sided, with a type-I error set at α of .05. Random-effects models were used to compare healthy subjects and patients with parkinsonian syndromes in drug-on or drug-off conditions.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Measured concentrations of putaminal total N-acetylaspartate (tNAA) (8.1 ± 0.2 vs 9.4 ± 0.4; P < .01), total creatine (tCr) (7.5 ± 0.2 vs 8.3 ± 0.3; P < .01), and myo-inositol (m-Ins) (3.8 ± 0.3 vs 5.6 ± 0.4; P < .001) were significantly lower in patients with parkinsonian syndromes in drug-off condition than in healthy volunteers. Moreover, L-DOPA therapy restored tNAA (9.1 ± 0.4 vs 8.1 ± 0.2; P < .01) and tCr (8.1 ± 0.3 vs 7.5 ± 0.2; P < .01) levels, whereas m-Ins levels remained unchanged. The combined glutamate and glutamine and choline showed no changes in drug-off or drug-on condition compared with those in control subjects.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">tNAA, tCr, and m-Ins were identified as putative biomarkers of Parkinson disease in the putamen of patients. tNAA and tCr levels are responsive to L-DOPA therapy.</AbstractText><CopyrightInformation>© RSNA, 2015.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Mazuel</LastName><ForeName>Leslie</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>From the Department of UFR Medicine, Auvergne University, EA7280, Clermont-Ferrand, France (L.M., F.D.); Center for Magnetic Resonance Imaging (C.C., B.J., A.C., C.S.) and Department of Neurology (B.P., F.D.), CHU Gabriel Montpied, 58 rue Montalembert, 63000 Clermont-Ferrand, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chassain</LastName><ForeName>Carine</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>From the Department of UFR Medicine, Auvergne University, EA7280, Clermont-Ferrand, France (L.M., F.D.); Center for Magnetic Resonance Imaging (C.C., B.J., A.C., C.S.) and Department of Neurology (B.P., F.D.), CHU Gabriel Montpied, 58 rue Montalembert, 63000 Clermont-Ferrand, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jean</LastName><ForeName>Betty</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>From the Department of UFR Medicine, Auvergne University, EA7280, Clermont-Ferrand, France (L.M., F.D.); Center for Magnetic Resonance Imaging (C.C., B.J., A.C., C.S.) and Department of Neurology (B.P., F.D.), CHU Gabriel Montpied, 58 rue Montalembert, 63000 Clermont-Ferrand, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pereira</LastName><ForeName>Bruno</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>From the Department of UFR Medicine, Auvergne University, EA7280, Clermont-Ferrand, France (L.M., F.D.); Center for Magnetic Resonance Imaging (C.C., B.J., A.C., C.S.) and Department of Neurology (B.P., F.D.), CHU Gabriel Montpied, 58 rue Montalembert, 63000 Clermont-Ferrand, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cladière</LastName><ForeName>Aurélie</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>From the Department of UFR Medicine, Auvergne University, EA7280, Clermont-Ferrand, France (L.M., F.D.); Center for Magnetic Resonance Imaging (C.C., B.J., A.C., C.S.) and Department of Neurology (B.P., F.D.), CHU Gabriel Montpied, 58 rue Montalembert, 63000 Clermont-Ferrand, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Speziale</LastName><ForeName>Claudine</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>From the Department of UFR Medicine, Auvergne University, EA7280, Clermont-Ferrand, France (L.M., F.D.); Center for Magnetic Resonance Imaging (C.C., B.J., A.C., C.S.) and Department of Neurology (B.P., F.D.), CHU Gabriel Montpied, 58 rue Montalembert, 63000 Clermont-Ferrand, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Durif</LastName><ForeName>Franck</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>From the Department of UFR Medicine, Auvergne University, EA7280, Clermont-Ferrand, France (L.M., F.D.); Center for Magnetic Resonance Imaging (C.C., B.J., A.C., C.S.) and Department of Neurology (B.P., F.D.), CHU Gabriel Montpied, 58 rue Montalembert, 63000 Clermont-Ferrand, France.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>08</Month><Day>04</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Radiology</MedlineTA><NlmUniqueID>0401260</NlmUniqueID><ISSNLinking>0033-8419</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000978">Antiparkinson Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D011522">Protons</NameOfSubstance></Chemical></ChemicalList><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000978" MajorTopicYN="N">Antiparkinson Agents</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016022" MajorTopicYN="N">Case-Control Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009682" MajorTopicYN="N">Magnetic Resonance Spectroscopy</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="Y">diagnosis</QualifierName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011446" MajorTopicYN="N">Prospective Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011522" MajorTopicYN="N">Protons</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015203" MajorTopicYN="N">Reproducibility of Results</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016896" MajorTopicYN="N">Treatment Outcome</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>8</Month><Day>4</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>8</Month><Day>4</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>6</Month><Day>1</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">26237591</ArticleId><ArticleId IdType="doi">10.1148/radiol.2015142764</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>France</li></country><region><li>Auvergne (région administrative)</li><li>Auvergne-Rhône-Alpes</li></region><settlement><li>Clermont-Ferrand</li></settlement></list><tree><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Mazuel, Leslie" sort="Mazuel, Leslie" uniqKey="Mazuel L" first="Leslie" last="Mazuel">Leslie Mazuel</name></region><name sortKey="Chassain, Carine" sort="Chassain, Carine" uniqKey="Chassain C" first="Carine" last="Chassain">Carine Chassain</name><name sortKey="Cladiere, Aurelie" sort="Cladiere, Aurelie" uniqKey="Cladiere A" first="Aurélie" last="Cladière">Aurélie Cladière</name><name sortKey="Durif, Franck" sort="Durif, Franck" uniqKey="Durif F" first="Franck" last="Durif">Franck Durif</name><name sortKey="Jean, Betty" sort="Jean, Betty" uniqKey="Jean B" first="Betty" last="Jean">Betty Jean</name><name sortKey="Pereira, Bruno" sort="Pereira, Bruno" uniqKey="Pereira B" first="Bruno" last="Pereira">Bruno Pereira</name><name sortKey="Speziale, Claudine" sort="Speziale, Claudine" uniqKey="Speziale C" first="Claudine" last="Speziale">Claudine Speziale</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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|texte= Proton MR Spectroscopy for Diagnosis and Evaluation of Treatment Efficacy in Parkinson Disease.
}}
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