Proteome-wide characterization of signalling interactions in the hippocampal CA4/DG subfield of patients with Alzheimer’s disease
Identifieur interne : 001739 ( Ncbi/Merge ); précédent : 001738; suivant : 001740Proteome-wide characterization of signalling interactions in the hippocampal CA4/DG subfield of patients with Alzheimer’s disease
Auteurs : Jae Ho Kim [Corée du Sud] ; Julien Franck [France] ; Taewook Kang [Corée du Sud] ; Helmut Heinsen [Allemagne] ; Rivka Ravid [Pays-Bas] ; Isidro Ferrer [Espagne] ; Mi Hee Cheon [Corée du Sud] ; Joo-Yong Lee [Corée du Sud] ; Jong Shin Yoo [Corée du Sud] ; Harry W. Steinbusch [Pays-Bas] ; Michel Salzet [France] ; Isabelle Fournier [France] ; Young Mok Park [Corée du Sud]Source :
- Scientific Reports [ 2045-2322 ] ; 2015.
Abstract
Alzheimer’s disease (AD) is the most common form of dementia; however, mechanisms and biomarkers remain unclear. Here, we examined hippocampal CA4 and dentate gyrus subfields, which are less studied in the context of AD pathology, in post-mortem AD and control tissue to identify possible biomarkers. We performed mass spectrometry-based proteomic analysis combined with label-free quantification for identification of differentially expressed proteins. We identified 4,328 proteins, of which 113 showed more than 2-fold higher or lower expression in AD hippocampi than in control tissues. Five proteins were identified as putative AD biomarkers (MDH2, PCLO, TRRAP, YWHAZ, and MUC19 isoform 5) and were cross-validated by immunoblotting, selected reaction monitoring, and MALDI imaging. We also used a bioinformatics approach to examine upstream signalling interactions of the 113 regulated proteins. Five upstream signalling (IGF1, BDNF, ZAP70, MYC, and cyclosporin A) factors showed novel interactions in AD hippocampi. Taken together, these results demonstrate a novel platform that may provide new strategies for the early detection of AD and thus its diagnosis.
Url:
DOI: 10.1038/srep11138
PubMed: 26059363
PubMed Central: 4462342
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<front><div type="abstract" xml:lang="en"><p>Alzheimer’s disease (AD) is the most common form of dementia; however, mechanisms and biomarkers remain unclear. Here, we examined hippocampal CA4 and dentate gyrus subfields, which are less studied in the context of AD pathology, in post-mortem AD and control tissue to identify possible biomarkers. We performed mass spectrometry-based proteomic analysis combined with label-free quantification for identification of differentially expressed proteins. We identified 4,328 proteins, of which 113 showed more than 2-fold higher or lower expression in AD hippocampi than in control tissues. Five proteins were identified as putative AD biomarkers (MDH2, PCLO, TRRAP, YWHAZ, and MUC19 isoform 5) and were cross-validated by immunoblotting, selected reaction monitoring, and MALDI imaging. We also used a bioinformatics approach to examine upstream signalling interactions of the 113 regulated proteins. Five upstream signalling (IGF1, BDNF, ZAP70, MYC, and cyclosporin A) factors showed novel interactions in AD hippocampi. Taken together, these results demonstrate a novel platform that may provide new strategies for the early detection of AD and thus its diagnosis.</p>
</div>
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<author><name sortKey="Sparks, D L" uniqKey="Sparks D">D. L. Sparks</name>
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<author><name sortKey="Price, D A" uniqKey="Price D">D. A. Price</name>
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<biblStruct><analytic><author><name sortKey="Del Valle, J" uniqKey="Del Valle J">J. del Valle</name>
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<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Sci Rep</journal-id>
<journal-id journal-id-type="iso-abbrev">Sci Rep</journal-id>
<journal-title-group><journal-title>Scientific Reports</journal-title>
</journal-title-group>
<issn pub-type="epub">2045-2322</issn>
<publisher><publisher-name>Nature Publishing Group</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">26059363</article-id>
<article-id pub-id-type="pmc">4462342</article-id>
<article-id pub-id-type="pii">srep11138</article-id>
<article-id pub-id-type="doi">10.1038/srep11138</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Proteome-wide characterization of signalling interactions in the hippocampal CA4/DG subfield of patients with Alzheimer’s disease</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Ho Kim</surname>
<given-names>Jae</given-names>
</name>
<xref ref-type="aff" rid="a1">1</xref>
<xref ref-type="aff" rid="a2">2</xref>
<xref ref-type="author-notes" rid="n1">*</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Franck</surname>
<given-names>Julien</given-names>
</name>
<xref ref-type="aff" rid="a3">3</xref>
<xref ref-type="author-notes" rid="n1">*</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kang</surname>
<given-names>Taewook</given-names>
</name>
<xref ref-type="aff" rid="a1">1</xref>
<xref ref-type="aff" rid="a2">2</xref>
<xref ref-type="aff" rid="a4">4</xref>
<xref ref-type="author-notes" rid="n1">*</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Heinsen</surname>
<given-names>Helmut</given-names>
</name>
<xref ref-type="aff" rid="a5">5</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ravid</surname>
<given-names>Rivka</given-names>
</name>
<xref ref-type="aff" rid="a6">6</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ferrer</surname>
<given-names>Isidro</given-names>
</name>
<xref ref-type="aff" rid="a7">7</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hee Cheon</surname>
<given-names>Mi</given-names>
</name>
<xref ref-type="aff" rid="a2">2</xref>
<xref ref-type="aff" rid="a4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lee</surname>
<given-names>Joo-Yong</given-names>
</name>
<xref ref-type="aff" rid="a4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Shin Yoo</surname>
<given-names>Jong</given-names>
</name>
<xref ref-type="aff" rid="a2">2</xref>
<xref ref-type="aff" rid="a4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Steinbusch</surname>
<given-names>Harry W</given-names>
</name>
<xref ref-type="aff" rid="a8">8</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Salzet</surname>
<given-names>Michel</given-names>
</name>
<xref ref-type="aff" rid="a3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Fournier</surname>
<given-names>Isabelle</given-names>
</name>
<xref ref-type="corresp" rid="c1">a</xref>
<xref ref-type="aff" rid="a3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Mok Park</surname>
<given-names>Young</given-names>
</name>
<xref ref-type="corresp" rid="c2">b</xref>
<xref ref-type="aff" rid="a1">1</xref>
<xref ref-type="aff" rid="a2">2</xref>
<xref ref-type="aff" rid="a4">4</xref>
</contrib>
<aff id="a1"><label>1</label>
<institution>Center for Cognition and Sociality, Institute for Basic Science</institution>
, Daejeon 305-811,<country>Republic of Korea</country>
</aff>
<aff id="a2"><label>2</label>
<institution>Mass Spectrometry Research Center, Korea Basic Science Institute, 804-1 Yangcheong-ri, Ochang-eup, Cheongwon-gun</institution>
, Chungbuk 363-883,<country>Republic of Korea</country>
</aff>
<aff id="a3"><label>3</label>
<institution>Inserm U-1192, Laboratoire de Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM), Université de Lille 1, Cité Scientifique</institution>
, 59655 Villeneuve D’Ascq,<country>France</country>
</aff>
<aff id="a4"><label>4</label>
<institution>Graduate School of Analytical Science and Technology, Chungnam National University,</institution>
Daejeon 305-764,<country>Republic of Korea</country>
</aff>
<aff id="a5"><label>5</label>
<institution>Department of Psychiatry, Morphological Brain Research Unit, University of Würzburg</institution>
, Würzburg,<country>Germany</country>
</aff>
<aff id="a6"><label>6</label>
<institution>Brain Bank Consultants</institution>
, Amsterdam,<country>The Netherlands</country>
</aff>
<aff id="a7"><label>7</label>
<institution>Institut de Neuropatologia, Servei Anatomia Patologica, IDIBELL-Hospital Universitari de Bellvitge, Universitat de Barcelona</institution>
,<country>Spain</country>
</aff>
<aff id="a8"><label>8</label>
<institution>School for Mental Health and Neuroscience, Department of Translational Neuroscience, Maastricht University</institution>
, Maastricht,<country>The Netherlands</country>
</aff>
</contrib-group>
<author-notes><corresp id="c1"><label>a</label>
<email>isabelle.fournier@univ-lille1.fr</email>
</corresp>
<corresp id="c2"><label>b</label>
<email>ympark@kbsi.re.kr</email>
</corresp>
<fn id="n1"><label>*</label>
<p>These authors contributed equally to this work.</p>
</fn>
</author-notes>
<pub-date pub-type="epub"><day>10</day>
<month>06</month>
<year>2015</year>
</pub-date>
<pub-date pub-type="collection"><year>2015</year>
</pub-date>
<volume>5</volume>
<elocation-id>11138</elocation-id>
<history><date date-type="received"><day>19</day>
<month>12</month>
<year>2014</year>
</date>
<date date-type="accepted"><day>27</day>
<month>04</month>
<year>2015</year>
</date>
</history>
<permissions><copyright-statement>Copyright © 2015, Macmillan Publishers Limited</copyright-statement>
<copyright-year>2015</copyright-year>
<copyright-holder>Macmillan Publishers Limited</copyright-holder>
<license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/4.0/"><pmc-comment>author-paid</pmc-comment>
<license-p>This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</ext-link>
</license-p>
</license>
</permissions>
<abstract><p>Alzheimer’s disease (AD) is the most common form of dementia; however, mechanisms and biomarkers remain unclear. Here, we examined hippocampal CA4 and dentate gyrus subfields, which are less studied in the context of AD pathology, in post-mortem AD and control tissue to identify possible biomarkers. We performed mass spectrometry-based proteomic analysis combined with label-free quantification for identification of differentially expressed proteins. We identified 4,328 proteins, of which 113 showed more than 2-fold higher or lower expression in AD hippocampi than in control tissues. Five proteins were identified as putative AD biomarkers (MDH2, PCLO, TRRAP, YWHAZ, and MUC19 isoform 5) and were cross-validated by immunoblotting, selected reaction monitoring, and MALDI imaging. We also used a bioinformatics approach to examine upstream signalling interactions of the 113 regulated proteins. Five upstream signalling (IGF1, BDNF, ZAP70, MYC, and cyclosporin A) factors showed novel interactions in AD hippocampi. Taken together, these results demonstrate a novel platform that may provide new strategies for the early detection of AD and thus its diagnosis.</p>
</abstract>
</article-meta>
</front>
<floats-group><fig id="f1"><label>Figure 1</label>
<caption><title>Strategy for identifying putative biomarkers of AD.</title>
<p>(<bold>A</bold>
) Experimental scheme for analysis of regulated proteins from post-mortem AD tissues using mass spectrometry-based proteomic analysis with label-free quantification. (<bold>B</bold>
) Protein prioritization scheme for the selection of candidate proteins for verification.</p>
</caption>
<graphic xlink:href="srep11138-f1"></graphic>
</fig>
<fig id="f2"><label>Figure 2</label>
<caption><title>Venn diagrams summarizing proteins identified in human hippocampal tissue obtained from Alzheimer’s disease and control patients.</title>
<p>(<bold>A</bold>
) Overlap of proteins identified in all five control hippocampi, (<bold>B</bold>
) Overlap of proteins identified in all five AD hippocampi, (<bold>C</bold>
) Overlap of proteins identified by comparison between the CA4 and DG subfields and the entire hippocampus.</p>
</caption>
<graphic xlink:href="srep11138-f2"></graphic>
</fig>
<fig id="f3"><label>Figure 3</label>
<caption><p>(<bold>A)</bold>
Annotated optical image of a hippocampal section obtained from an Alzheimer’s disease patient stained with toluidine blue; Horn of Ammon (CA), dentate gryus (DG), and subiculum (S). (<bold>B</bold>
) MUC19 isoform 5 is highly expressed in AD hippocampal tissues. MALDI imaging mass spectrometry (MSI) data (MUC19; m/z 11,135 ± 0.05%). (<bold>C</bold>
) Spectral counting data for MUC19.</p>
</caption>
<graphic xlink:href="srep11138-f3"></graphic>
</fig>
<fig id="f4"><label>Figure 4</label>
<caption><title>Validation of proteins identified by nanoLC coupled with ESI ion-trap MS.</title>
<p>(<bold>A</bold>
) Western blot analysis of MDH2, PCLO, TRRAP, and YWHAZ. (<bold>B</bold>
) Spectral counting of PCLO, TRRAP, and YWHAZ. (<bold>C</bold>
) Comparison of individual protein amounts with the fragmentation ratio (endogenous light peak area/heavy standard peak area) in AD and control tissues as assessed by SRM.</p>
</caption>
<graphic xlink:href="srep11138-f4"></graphic>
</fig>
<fig id="f5"><label>Figure 5</label>
<caption><title>Analysis of regulated proteins using DAVID functional Gene Ontology.</title>
<p>(<bold>A</bold>
) Biological processes. (<bold>B</bold>
) Cellular components. (<bold>C</bold>
) Molecular functions (EASE score > 1.3, p < 0.05).</p>
</caption>
<graphic xlink:href="srep11138-f5"></graphic>
</fig>
<fig id="f6"><label>Figure 6</label>
<caption><title>Features of proteomic signalling interactions.</title>
<p>(<bold>A</bold>
) Signalling network for the relationship between the activation and/or inhibition of upstream regulators with downstream regulated proteins (<bold>B</bold>
) Interaction network for canonical neurological disease pathways including proteins that were up/downregulated in AD tissue.</p>
</caption>
<graphic xlink:href="srep11138-f6"></graphic>
</fig>
<table-wrap position="float" id="t1"><label>Table 1</label>
<caption><title>Upregulation and downregulation proteins list (Ratio ≥ 1.80 or p-value < 0.05*), SI = spectral index Asterisks indicate proteins with ratios that were significantly different from 1 (one-sample t-test, p < 0.05*).</title>
</caption>
<table frame="hsides" rules="groups" border="1"><colgroup><col align="center"></col>
<col align="center"></col>
<col align="center"></col>
<col align="center"></col>
<col align="center"></col>
<col align="center"></col>
<col align="center"></col>
<col align="center"></col>
<col align="center"></col>
<col align="center"></col>
<col align="center"></col>
<col align="center"></col>
<col align="center"></col>
<col align="center"></col>
<col align="center"></col>
<col align="center"></col>
<col align="center"></col>
</colgroup>
<thead valign="bottom"><tr><th align="center" valign="top" charoff="50"><bold>IPI</bold>
</th>
<th align="center" valign="top" charoff="50"><bold>GENE SYMBOL</bold>
</th>
<th align="center" valign="top" charoff="50"><bold>Sequencecoverage (%)</bold>
</th>
<th align="center" valign="top" charoff="50"><bold>No ofpeptide</bold>
</th>
<th align="center" valign="top" charoff="50"><bold>AD(SI)</bold>
</th>
<th align="center" valign="top" charoff="50"><bold>WT(SI)</bold>
</th>
<th align="center" valign="top" charoff="50"><bold>AverageFold Change (AD/WT)</bold>
</th>
<th align="center" valign="top" charoff="50"><bold>Adjustedp-value</bold>
</th>
<th align="center" valign="top" charoff="50"><bold>IPI</bold>
</th>
<th align="center" valign="top" charoff="50"><bold>GENESYMBOL</bold>
</th>
<th align="center" valign="top" charoff="50"><bold>Sequencecoverage (%)</bold>
</th>
<th align="center" valign="top" charoff="50"><bold>No ofpeptide</bold>
</th>
<th align="center" valign="top" charoff="50"><bold>AD(SI)</bold>
</th>
<th align="center" valign="top" charoff="50"><bold>WT(SI)</bold>
</th>
<th align="center" valign="top" charoff="50"><bold>AverageFold Change (AD/WT)</bold>
</th>
<th align="center" valign="top" charoff="50"><bold>Adjustedp-value</bold>
</th>
<td> </td>
</tr>
</thead>
<tbody valign="top"><tr><td colspan="17" align="center" valign="top" charoff="50"><bold>Upregulaton proteins</bold>
</td>
</tr>
<tr><td align="center" valign="top" charoff="50">IPI00470912</td>
<td align="center" valign="top" charoff="50">C2orf16*</td>
<td align="center" valign="top" charoff="50">9.0</td>
<td align="center" valign="top" charoff="50">12</td>
<td align="center" valign="top" charoff="50">7.53</td>
<td align="center" valign="top" charoff="50">0.00</td>
<td align="center" valign="top" charoff="50">n.a</td>
<td align="center" valign="top" charoff="50">0.00982</td>
<td align="center" valign="top" charoff="50">IPI01018212</td>
<td align="center" valign="top" charoff="50">PKM2</td>
<td align="center" valign="top" charoff="50">22.2</td>
<td align="center" valign="top" charoff="50">34</td>
<td align="center" valign="top" charoff="50">6.87</td>
<td align="center" valign="top" charoff="50">2.92</td>
<td align="center" valign="top" charoff="50">2.35</td>
<td align="center" valign="top" charoff="50">0.01708</td>
<td> </td>
</tr>
<tr><td align="center" valign="top" charoff="50">IPI00216864</td>
<td align="center" valign="top" charoff="50">PDZRN4*</td>
<td align="center" valign="top" charoff="50">9.5</td>
<td align="center" valign="top" charoff="50">16</td>
<td align="center" valign="top" charoff="50">5.28</td>
<td align="center" valign="top" charoff="50">0.00</td>
<td align="center" valign="top" charoff="50">n.a</td>
<td align="center" valign="top" charoff="50">0.00731</td>
<td align="center" valign="top" charoff="50">IPI00333696</td>
<td align="center" valign="top" charoff="50">HEATR5B</td>
<td align="center" valign="top" charoff="50">7.8</td>
<td align="center" valign="top" charoff="50">21</td>
<td align="center" valign="top" charoff="50">5.72</td>
<td align="center" valign="top" charoff="50">2.43</td>
<td align="center" valign="top" charoff="50">2.35</td>
<td align="center" valign="top" charoff="50">0.01892</td>
<td> </td>
</tr>
<tr><td align="center" valign="top" charoff="50">IPI00876841</td>
<td align="center" valign="top" charoff="50">ZSWIM8 *</td>
<td align="center" valign="top" charoff="50">4.6</td>
<td align="center" valign="top" charoff="50">9</td>
<td align="center" valign="top" charoff="50">4.23</td>
<td align="center" valign="top" charoff="50">0.25</td>
<td align="center" valign="top" charoff="50">16.72</td>
<td align="center" valign="top" charoff="50">0.01489</td>
<td align="center" valign="top" charoff="50">IPI00069084</td>
<td align="center" valign="top" charoff="50">TRRAP</td>
<td align="center" valign="top" charoff="50">2.3</td>
<td align="center" valign="top" charoff="50">18</td>
<td align="center" valign="top" charoff="50">3.73</td>
<td align="center" valign="top" charoff="50">1.64</td>
<td align="center" valign="top" charoff="50">2.28</td>
<td align="center" valign="top" charoff="50">0.01892</td>
<td> </td>
</tr>
<tr><td align="center" valign="top" charoff="50">IPI00219446</td>
<td align="center" valign="top" charoff="50">PEBP1*</td>
<td align="center" valign="top" charoff="50">28.6</td>
<td align="center" valign="top" charoff="50">10</td>
<td align="center" valign="top" charoff="50">3.30</td>
<td align="center" valign="top" charoff="50">0.24</td>
<td align="center" valign="top" charoff="50">13.96</td>
<td align="center" valign="top" charoff="50">0.00040</td>
<td align="center" valign="top" charoff="50">IPI00943735</td>
<td align="center" valign="top" charoff="50">ANKRD36</td>
<td align="center" valign="top" charoff="50">6.3</td>
<td align="center" valign="top" charoff="50">10</td>
<td align="center" valign="top" charoff="50">3.15</td>
<td align="center" valign="top" charoff="50">1.38</td>
<td align="center" valign="top" charoff="50">2.28</td>
<td align="center" valign="top" charoff="50">0.01892</td>
<td> </td>
</tr>
<tr><td align="center" valign="top" charoff="50">IPI00871535</td>
<td align="center" valign="top" charoff="50">SPTAN1</td>
<td align="center" valign="top" charoff="50">3.0</td>
<td align="center" valign="top" charoff="50">13</td>
<td align="center" valign="top" charoff="50">9.35</td>
<td align="center" valign="top" charoff="50">1.01</td>
<td align="center" valign="top" charoff="50">9.24</td>
<td align="center" valign="top" charoff="50">0.01892</td>
<td align="center" valign="top" charoff="50">IPI00642259</td>
<td align="center" valign="top" charoff="50">DST</td>
<td align="center" valign="top" charoff="50">2.1</td>
<td align="center" valign="top" charoff="50">29</td>
<td align="center" valign="top" charoff="50">12.91</td>
<td align="center" valign="top" charoff="50">5.72</td>
<td align="center" valign="top" charoff="50">2.26</td>
<td align="center" valign="top" charoff="50">0.01899</td>
<td> </td>
</tr>
<tr><td align="center" valign="top" charoff="50">IPI00964552</td>
<td align="center" valign="top" charoff="50">COL12A1*</td>
<td align="center" valign="top" charoff="50">5.4</td>
<td align="center" valign="top" charoff="50">28</td>
<td align="center" valign="top" charoff="50">6.88</td>
<td align="center" valign="top" charoff="50">0.97</td>
<td align="center" valign="top" charoff="50">7.08</td>
<td align="center" valign="top" charoff="50">0.00444</td>
<td align="center" valign="top" charoff="50">IPI00218474</td>
<td align="center" valign="top" charoff="50">ENO3</td>
<td align="center" valign="top" charoff="50">14.7</td>
<td align="center" valign="top" charoff="50">14</td>
<td align="center" valign="top" charoff="50">2.17</td>
<td align="center" valign="top" charoff="50">0.98</td>
<td align="center" valign="top" charoff="50">2.21</td>
<td align="center" valign="top" charoff="50">0.01892</td>
<td> </td>
</tr>
<tr><td align="center" valign="top" charoff="50">IPI00084828</td>
<td align="center" valign="top" charoff="50">STXBP1*</td>
<td align="center" valign="top" charoff="50">11.8</td>
<td align="center" valign="top" charoff="50">9</td>
<td align="center" valign="top" charoff="50">3.78</td>
<td align="center" valign="top" charoff="50">0.57</td>
<td align="center" valign="top" charoff="50">6.67</td>
<td align="center" valign="top" charoff="50">0.01588</td>
<td align="center" valign="top" charoff="50">IPI00549725</td>
<td align="center" valign="top" charoff="50">PGAM1</td>
<td align="center" valign="top" charoff="50">17.5</td>
<td align="center" valign="top" charoff="50">9</td>
<td align="center" valign="top" charoff="50">3.78</td>
<td align="center" valign="top" charoff="50">1.74</td>
<td align="center" valign="top" charoff="50">2.17</td>
<td align="center" valign="top" charoff="50">0.01892</td>
<td> </td>
</tr>
<tr><td align="center" valign="top" charoff="50">IPI00413144</td>
<td align="center" valign="top" charoff="50">C15orf42</td>
<td align="center" valign="top" charoff="50">6.2</td>
<td align="center" valign="top" charoff="50">10</td>
<td align="center" valign="top" charoff="50">8.22</td>
<td align="center" valign="top" charoff="50">1.27</td>
<td align="center" valign="top" charoff="50">6.48</td>
<td align="center" valign="top" charoff="50">0.01766</td>
<td align="center" valign="top" charoff="50">IPI00291006</td>
<td align="center" valign="top" charoff="50">MDH2</td>
<td align="center" valign="top" charoff="50">27.9</td>
<td align="center" valign="top" charoff="50">25</td>
<td align="center" valign="top" charoff="50">11.18</td>
<td align="center" valign="top" charoff="50">5.21</td>
<td align="center" valign="top" charoff="50">2.15</td>
<td align="center" valign="top" charoff="50">0.01892</td>
<td> </td>
</tr>
<tr><td align="center" valign="top" charoff="50">IPI01014674</td>
<td align="center" valign="top" charoff="50">MUC19*</td>
<td align="center" valign="top" charoff="50">31.6</td>
<td align="center" valign="top" charoff="50">11</td>
<td align="center" valign="top" charoff="50">10.22</td>
<td align="center" valign="top" charoff="50">1.89</td>
<td align="center" valign="top" charoff="50">5.41</td>
<td align="center" valign="top" charoff="50">0.01349</td>
<td align="center" valign="top" charoff="50">IPI00414123</td>
<td align="center" valign="top" charoff="50">CRMP1</td>
<td align="center" valign="top" charoff="50">10.9</td>
<td align="center" valign="top" charoff="50">6</td>
<td align="center" valign="top" charoff="50">0.99</td>
<td align="center" valign="top" charoff="50">0.46</td>
<td align="center" valign="top" charoff="50">2.14</td>
<td align="center" valign="top" charoff="50">0.02350</td>
<td> </td>
</tr>
<tr><td align="center" valign="top" charoff="50">IPI00954159</td>
<td align="center" valign="top" charoff="50">AHCTF1P1</td>
<td align="center" valign="top" charoff="50">6.0</td>
<td align="center" valign="top" charoff="50">20</td>
<td align="center" valign="top" charoff="50">8.06</td>
<td align="center" valign="top" charoff="50">1.52</td>
<td align="center" valign="top" charoff="50">5.31</td>
<td align="center" valign="top" charoff="50">0.01856</td>
<td align="center" valign="top" charoff="50">IPI00025363</td>
<td align="center" valign="top" charoff="50">GFAP</td>
<td align="center" valign="top" charoff="50">61.1</td>
<td align="center" valign="top" charoff="50">195</td>
<td align="center" valign="top" charoff="50">38.93</td>
<td align="center" valign="top" charoff="50">18.50</td>
<td align="center" valign="top" charoff="50">2.10</td>
<td align="center" valign="top" charoff="50">0.01856</td>
<td> </td>
</tr>
<tr><td align="center" valign="top" charoff="50">IPI00382470</td>
<td align="center" valign="top" charoff="50">HSP90AA1</td>
<td align="center" valign="top" charoff="50">7.2</td>
<td align="center" valign="top" charoff="50">8</td>
<td align="center" valign="top" charoff="50">5.18</td>
<td align="center" valign="top" charoff="50">1.01</td>
<td align="center" valign="top" charoff="50">5.11</td>
<td align="center" valign="top" charoff="50">0.01892</td>
<td align="center" valign="top" charoff="50">IPI00550232</td>
<td align="center" valign="top" charoff="50">XIRP2</td>
<td align="center" valign="top" charoff="50">3.6</td>
<td align="center" valign="top" charoff="50">18</td>
<td align="center" valign="top" charoff="50">6.33</td>
<td align="center" valign="top" charoff="50">3.09</td>
<td align="center" valign="top" charoff="50">2.05</td>
<td align="center" valign="top" charoff="50">0.01892</td>
<td> </td>
</tr>
<tr><td align="center" valign="top" charoff="50">IPI00169383</td>
<td align="center" valign="top" charoff="50">PGK1</td>
<td align="center" valign="top" charoff="50">14.9</td>
<td align="center" valign="top" charoff="50">4</td>
<td align="center" valign="top" charoff="50">3.22</td>
<td align="center" valign="top" charoff="50">0.67</td>
<td align="center" valign="top" charoff="50">4.79</td>
<td align="center" valign="top" charoff="50">0.01839</td>
<td align="center" valign="top" charoff="50">IPI00045512</td>
<td align="center" valign="top" charoff="50">HMCN1</td>
<td align="center" valign="top" charoff="50">3.2</td>
<td align="center" valign="top" charoff="50">30</td>
<td align="center" valign="top" charoff="50">6.90</td>
<td align="center" valign="top" charoff="50">3.39</td>
<td align="center" valign="top" charoff="50">2.04</td>
<td align="center" valign="top" charoff="50">0.01892</td>
<td> </td>
</tr>
<tr><td align="center" valign="top" charoff="50">IPI00879193</td>
<td align="center" valign="top" charoff="50">TTC28</td>
<td align="center" valign="top" charoff="50">5.1</td>
<td align="center" valign="top" charoff="50">13</td>
<td align="center" valign="top" charoff="50">6.89</td>
<td align="center" valign="top" charoff="50">1.46</td>
<td align="center" valign="top" charoff="50">4.73</td>
<td align="center" valign="top" charoff="50">0.01856</td>
<td align="center" valign="top" charoff="50">IPI00006091</td>
<td align="center" valign="top" charoff="50">DMD</td>
<td align="center" valign="top" charoff="50">3.3</td>
<td align="center" valign="top" charoff="50">9</td>
<td align="center" valign="top" charoff="50">5.55</td>
<td align="center" valign="top" charoff="50">2.73</td>
<td align="center" valign="top" charoff="50">2.03</td>
<td align="center" valign="top" charoff="50">0.01899</td>
<td> </td>
</tr>
<tr><td align="center" valign="top" charoff="50">IPI00007188</td>
<td align="center" valign="top" charoff="50">SLC25A5</td>
<td align="center" valign="top" charoff="50">18.6</td>
<td align="center" valign="top" charoff="50">5</td>
<td align="center" valign="top" charoff="50">1.00</td>
<td align="center" valign="top" charoff="50">0.22</td>
<td align="center" valign="top" charoff="50">4.57</td>
<td align="center" valign="top" charoff="50">0.01856</td>
<td align="center" valign="top" charoff="50">IPI00215715</td>
<td align="center" valign="top" charoff="50">CAMK2A</td>
<td align="center" valign="top" charoff="50">13.5</td>
<td align="center" valign="top" charoff="50">14</td>
<td align="center" valign="top" charoff="50">4.42</td>
<td align="center" valign="top" charoff="50">2.18</td>
<td align="center" valign="top" charoff="50">2.03</td>
<td align="center" valign="top" charoff="50">0.01892</td>
<td> </td>
</tr>
<tr><td align="center" valign="top" charoff="50">IPI00884904</td>
<td align="center" valign="top" charoff="50">AHNAK2</td>
<td align="center" valign="top" charoff="50">3.4</td>
<td align="center" valign="top" charoff="50">15</td>
<td align="center" valign="top" charoff="50">10.25</td>
<td align="center" valign="top" charoff="50">2.79</td>
<td align="center" valign="top" charoff="50">3.67</td>
<td align="center" valign="top" charoff="50">0.01892</td>
<td align="center" valign="top" charoff="50">IPI00930130</td>
<td align="center" valign="top" charoff="50">TUBB6</td>
<td align="center" valign="top" charoff="50">48.0</td>
<td align="center" valign="top" charoff="50">107</td>
<td align="center" valign="top" charoff="50">1.92</td>
<td align="center" valign="top" charoff="50">0.95</td>
<td align="center" valign="top" charoff="50">2.02</td>
<td align="center" valign="top" charoff="50">0.01892</td>
<td> </td>
</tr>
<tr><td align="center" valign="top" charoff="50">IPI01011955</td>
<td align="center" valign="top" charoff="50">MKI67</td>
<td align="center" valign="top" charoff="50">7.2</td>
<td align="center" valign="top" charoff="50">21</td>
<td align="center" valign="top" charoff="50">5.33</td>
<td align="center" valign="top" charoff="50">1.53</td>
<td align="center" valign="top" charoff="50">3.49</td>
<td align="center" valign="top" charoff="50">0.01892</td>
<td align="center" valign="top" charoff="50">IPI00419908</td>
<td align="center" valign="top" charoff="50">GPR179</td>
<td align="center" valign="top" charoff="50">4.9</td>
<td align="center" valign="top" charoff="50">9</td>
<td align="center" valign="top" charoff="50">4.24</td>
<td align="center" valign="top" charoff="50">2.10</td>
<td align="center" valign="top" charoff="50">2.02</td>
<td align="center" valign="top" charoff="50">0.02350</td>
<td> </td>
</tr>
<tr><td align="center" valign="top" charoff="50">IPI00218658</td>
<td align="center" valign="top" charoff="50">ITPR1</td>
<td align="center" valign="top" charoff="50">5.8</td>
<td align="center" valign="top" charoff="50">13</td>
<td align="center" valign="top" charoff="50">4.20</td>
<td align="center" valign="top" charoff="50">1.27</td>
<td align="center" valign="top" charoff="50">3.31</td>
<td align="center" valign="top" charoff="50">0.01856</td>
<td align="center" valign="top" charoff="50">IPI00171636</td>
<td align="center" valign="top" charoff="50">NAV1</td>
<td align="center" valign="top" charoff="50">5.8</td>
<td align="center" valign="top" charoff="50">10</td>
<td align="center" valign="top" charoff="50">3.76</td>
<td align="center" valign="top" charoff="50">1.92</td>
<td align="center" valign="top" charoff="50">1.95</td>
<td align="center" valign="top" charoff="50">0.01892</td>
<td> </td>
</tr>
<tr><td align="center" valign="top" charoff="50">IPI00328089</td>
<td align="center" valign="top" charoff="50">HIVEP3*</td>
<td align="center" valign="top" charoff="50">6.4</td>
<td align="center" valign="top" charoff="50">17</td>
<td align="center" valign="top" charoff="50">8.16</td>
<td align="center" valign="top" charoff="50">2.53</td>
<td align="center" valign="top" charoff="50">3.22</td>
<td align="center" valign="top" charoff="50">0.01203</td>
<td align="center" valign="top" charoff="50">IPI01015973</td>
<td align="center" valign="top" charoff="50">MUC16</td>
<td align="center" valign="top" charoff="50">8.6</td>
<td align="center" valign="top" charoff="50">233</td>
<td align="center" valign="top" charoff="50">7.47</td>
<td align="center" valign="top" charoff="50">3.87</td>
<td align="center" valign="top" charoff="50">1.93</td>
<td align="center" valign="top" charoff="50">0.01892</td>
<td> </td>
</tr>
<tr><td align="center" valign="top" charoff="50">IPI00413173</td>
<td align="center" valign="top" charoff="50">MKI67</td>
<td align="center" valign="top" charoff="50">3.4</td>
<td align="center" valign="top" charoff="50">10</td>
<td align="center" valign="top" charoff="50">10.05</td>
<td align="center" valign="top" charoff="50">3.52</td>
<td align="center" valign="top" charoff="50">2.85</td>
<td align="center" valign="top" charoff="50">0.01856</td>
<td align="center" valign="top" charoff="50">IPI00004233</td>
<td align="center" valign="top" charoff="50">MKI67</td>
<td align="center" valign="top" charoff="50">7.2</td>
<td align="center" valign="top" charoff="50">21</td>
<td align="center" valign="top" charoff="50">9.39</td>
<td align="center" valign="top" charoff="50">4.93</td>
<td align="center" valign="top" charoff="50">1.90</td>
<td align="center" valign="top" charoff="50">0.02167</td>
<td> </td>
</tr>
<tr><td align="center" valign="top" charoff="50">IPI00411656</td>
<td align="center" valign="top" charoff="50">PCLO*</td>
<td align="center" valign="top" charoff="50">3.2</td>
<td align="center" valign="top" charoff="50">26</td>
<td align="center" valign="top" charoff="50">16.37</td>
<td align="center" valign="top" charoff="50">5.81</td>
<td align="center" valign="top" charoff="50">2.82</td>
<td align="center" valign="top" charoff="50">0.01588</td>
<td align="center" valign="top" charoff="50">IPI00925013</td>
<td align="center" valign="top" charoff="50">MLL3*</td>
<td align="center" valign="top" charoff="50">12.5</td>
<td align="center" valign="top" charoff="50">26</td>
<td align="center" valign="top" charoff="50">8.01</td>
<td align="center" valign="top" charoff="50">4.25</td>
<td align="center" valign="top" charoff="50">1.89</td>
<td align="center" valign="top" charoff="50">0.01689</td>
<td> </td>
</tr>
<tr><td align="center" valign="top" charoff="50">IPI00740909</td>
<td align="center" valign="top" charoff="50">ALMS1</td>
<td align="center" valign="top" charoff="50">4.5</td>
<td align="center" valign="top" charoff="50">21</td>
<td align="center" valign="top" charoff="50">6.37</td>
<td align="center" valign="top" charoff="50">2.28</td>
<td align="center" valign="top" charoff="50">2.80</td>
<td align="center" valign="top" charoff="50">0.01856</td>
<td align="center" valign="top" charoff="50">IPI00218621</td>
<td align="center" valign="top" charoff="50">SON</td>
<td align="center" valign="top" charoff="50">7.6</td>
<td align="center" valign="top" charoff="50">98</td>
<td align="center" valign="top" charoff="50">7.24</td>
<td align="center" valign="top" charoff="50">3.86</td>
<td align="center" valign="top" charoff="50">1.87</td>
<td align="center" valign="top" charoff="50">0.02078</td>
<td> </td>
</tr>
<tr><td align="center" valign="top" charoff="50">IPI00398002</td>
<td align="center" valign="top" charoff="50">PLEC</td>
<td align="center" valign="top" charoff="50">4.1</td>
<td align="center" valign="top" charoff="50">28</td>
<td align="center" valign="top" charoff="50">7.85</td>
<td align="center" valign="top" charoff="50">3.00</td>
<td align="center" valign="top" charoff="50">2.61</td>
<td align="center" valign="top" charoff="50">0.01892</td>
<td align="center" valign="top" charoff="50">IPI00329573</td>
<td align="center" valign="top" charoff="50">COL12A1</td>
<td align="center" valign="top" charoff="50">7.2</td>
<td align="center" valign="top" charoff="50">30</td>
<td align="center" valign="top" charoff="50">5.12</td>
<td align="center" valign="top" charoff="50">2.79</td>
<td align="center" valign="top" charoff="50">1.84</td>
<td align="center" valign="top" charoff="50">0.01932</td>
<td> </td>
</tr>
<tr><td align="center" valign="top" charoff="50">IPI00789624</td>
<td align="center" valign="top" charoff="50">PCLO</td>
<td align="center" valign="top" charoff="50">6.7</td>
<td align="center" valign="top" charoff="50">40</td>
<td align="center" valign="top" charoff="50">13.14</td>
<td align="center" valign="top" charoff="50">5.08</td>
<td align="center" valign="top" charoff="50">2.59</td>
<td align="center" valign="top" charoff="50">0.01839</td>
<td align="center" valign="top" charoff="50">IPI00797574</td>
<td align="center" valign="top" charoff="50">BOD1L</td>
<td align="center" valign="top" charoff="50">5.9</td>
<td align="center" valign="top" charoff="50">23</td>
<td align="center" valign="top" charoff="50">11.54</td>
<td align="center" valign="top" charoff="50">6.38</td>
<td align="center" valign="top" charoff="50">1.81</td>
<td align="center" valign="top" charoff="50">0.01856</td>
<td> </td>
</tr>
<tr><td align="center" valign="top" charoff="50">IPI00749231</td>
<td align="center" valign="top" charoff="50">GPR98</td>
<td align="center" valign="top" charoff="50">3.5</td>
<td align="center" valign="top" charoff="50">17</td>
<td align="center" valign="top" charoff="50">3.19</td>
<td align="center" valign="top" charoff="50">1.24</td>
<td align="center" valign="top" charoff="50">2.58</td>
<td align="center" valign="top" charoff="50">0.01892</td>
<td align="center" valign="top" charoff="50">IPI00021907</td>
<td align="center" valign="top" charoff="50">MBP</td>
<td align="center" valign="top" charoff="50">32.2</td>
<td align="center" valign="top" charoff="50">41</td>
<td align="center" valign="top" charoff="50">5.19</td>
<td align="center" valign="top" charoff="50">2.88</td>
<td align="center" valign="top" charoff="50">1.80</td>
<td align="center" valign="top" charoff="50">0.02579</td>
<td> </td>
</tr>
<tr><td align="center" valign="top" charoff="50">IPI00289776</td>
<td align="center" valign="top" charoff="50">MYCBP2</td>
<td align="center" valign="top" charoff="50">4.2</td>
<td align="center" valign="top" charoff="50">18</td>
<td align="center" valign="top" charoff="50">13.60</td>
<td align="center" valign="top" charoff="50">5.49</td>
<td align="center" valign="top" charoff="50">2.48</td>
<td align="center" valign="top" charoff="50">0.01892</td>
<td align="center" valign="top" charoff="50"> </td>
<td align="center" valign="top" charoff="50"> </td>
<td align="center" valign="top" charoff="50"> </td>
<td align="center" valign="top" charoff="50"> </td>
<td align="center" valign="top" charoff="50"> </td>
<td align="center" valign="top" charoff="50"> </td>
<td align="center" valign="top" charoff="50"> </td>
<td align="center" valign="top" charoff="50"> </td>
<td> </td>
</tr>
<tr><td align="center" valign="top" charoff="50">IPI00169307</td>
<td align="center" valign="top" charoff="50">ARHGAP21*</td>
<td align="center" valign="top" charoff="50">6.3</td>
<td align="center" valign="top" charoff="50">27</td>
<td align="center" valign="top" charoff="50">7.77</td>
<td align="center" valign="top" charoff="50">3.17</td>
<td align="center" valign="top" charoff="50">2.45</td>
<td align="center" valign="top" charoff="50">0.01489</td>
<td align="center" valign="top" charoff="50"> </td>
<td align="center" valign="top" charoff="50"> </td>
<td align="center" valign="top" charoff="50"> </td>
<td align="center" valign="top" charoff="50"> </td>
<td align="center" valign="top" charoff="50"> </td>
<td align="center" valign="top" charoff="50"> </td>
<td align="center" valign="top" charoff="50"> </td>
<td align="center" valign="top" charoff="50"> </td>
<td> </td>
</tr>
<tr><td align="center" valign="top" charoff="50">IPI00854820</td>
<td align="center" valign="top" charoff="50">PPRC1</td>
<td align="center" valign="top" charoff="50">6.6</td>
<td align="center" valign="top" charoff="50">14</td>
<td align="center" valign="top" charoff="50">2.86</td>
<td align="center" valign="top" charoff="50">1.18</td>
<td align="center" valign="top" charoff="50">2.42</td>
<td align="center" valign="top" charoff="50">0.01892</td>
<td align="center" valign="top" charoff="50"> </td>
<td align="center" valign="top" charoff="50"> </td>
<td align="center" valign="top" charoff="50"> </td>
<td align="center" valign="top" charoff="50"> </td>
<td align="center" valign="top" charoff="50"> </td>
<td align="center" valign="top" charoff="50"> </td>
<td align="center" valign="top" charoff="50"> </td>
<td align="center" valign="top" charoff="50"> </td>
<td> </td>
</tr>
<tr><td align="center" valign="top" charoff="50">IPI00215631</td>
<td align="center" valign="top" charoff="50">VCAN</td>
<td align="center" valign="top" charoff="50">4.0</td>
<td align="center" valign="top" charoff="50">21</td>
<td align="center" valign="top" charoff="50">4.29</td>
<td align="center" valign="top" charoff="50">1.79</td>
<td align="center" valign="top" charoff="50">2.39</td>
<td align="center" valign="top" charoff="50">0.01892</td>
<td align="center" valign="top" charoff="50"> </td>
<td align="center" valign="top" charoff="50"> </td>
<td align="center" valign="top" charoff="50"> </td>
<td align="center" valign="top" charoff="50"> </td>
<td align="center" valign="top" charoff="50"> </td>
<td align="center" valign="top" charoff="50"> </td>
<td align="center" valign="top" charoff="50"> </td>
<td align="center" valign="top" charoff="50"> </td>
<td> </td>
</tr>
<tr><td align="center" valign="top" charoff="50">IPI00102752</td>
<td align="center" valign="top" charoff="50">RBM15</td>
<td align="center" valign="top" charoff="50">7.6</td>
<td align="center" valign="top" charoff="50">20</td>
<td align="center" valign="top" charoff="50">4.99</td>
<td align="center" valign="top" charoff="50">8.89</td>
<td align="center" valign="top" charoff="50">0.56</td>
<td align="center" valign="top" charoff="50">0.01892</td>
<td align="center" valign="top" charoff="50">IPI00788168</td>
<td align="center" valign="top" charoff="50">MAST4</td>
<td align="center" valign="top" charoff="50">3.5</td>
<td align="center" valign="top" charoff="50">8</td>
<td align="center" valign="top" charoff="50">1.23</td>
<td align="center" valign="top" charoff="50">3.12</td>
<td align="center" valign="top" charoff="50">0.39</td>
<td align="center" valign="top" charoff="50">0.01892</td>
<td> </td>
</tr>
<tr><td align="center" valign="top" charoff="50">IPI00014845</td>
<td align="center" valign="top" charoff="50">DNAH8</td>
<td align="center" valign="top" charoff="50">3.9</td>
<td align="center" valign="top" charoff="50">29</td>
<td align="center" valign="top" charoff="50">2.63</td>
<td align="center" valign="top" charoff="50">4.73</td>
<td align="center" valign="top" charoff="50">0.56</td>
<td align="center" valign="top" charoff="50">0.01892</td>
<td align="center" valign="top" charoff="50">IPI00908811</td>
<td align="center" valign="top" charoff="50">CKB</td>
<td align="center" valign="top" charoff="50">32.3</td>
<td align="center" valign="top" charoff="50">26</td>
<td align="center" valign="top" charoff="50">1.05</td>
<td align="center" valign="top" charoff="50">2.69</td>
<td align="center" valign="top" charoff="50">0.39</td>
<td align="center" valign="top" charoff="50">0.01892</td>
<td> </td>
</tr>
<tr><td align="center" valign="top" charoff="50">IPI00217051</td>
<td align="center" valign="top" charoff="50">NAV3</td>
<td align="center" valign="top" charoff="50">11.7</td>
<td align="center" valign="top" charoff="50">33</td>
<td align="center" valign="top" charoff="50">8.65</td>
<td align="center" valign="top" charoff="50">15.58</td>
<td align="center" valign="top" charoff="50">0.56</td>
<td align="center" valign="top" charoff="50">0.01892</td>
<td align="center" valign="top" charoff="50">IPI00006451</td>
<td align="center" valign="top" charoff="50">NSF</td>
<td align="center" valign="top" charoff="50">5.0</td>
<td align="center" valign="top" charoff="50">4</td>
<td align="center" valign="top" charoff="50">1.01</td>
<td align="center" valign="top" charoff="50">2.58</td>
<td align="center" valign="top" charoff="50">0.39</td>
<td align="center" valign="top" charoff="50">0.01892</td>
<td> </td>
</tr>
<tr><td align="center" valign="top" charoff="50">IPI00044608</td>
<td align="center" valign="top" charoff="50">PLIN4</td>
<td align="center" valign="top" charoff="50">17.2</td>
<td align="center" valign="top" charoff="50">30</td>
<td align="center" valign="top" charoff="50">7.38</td>
<td align="center" valign="top" charoff="50">13.38</td>
<td align="center" valign="top" charoff="50">0.55</td>
<td align="center" valign="top" charoff="50">0.01892</td>
<td align="center" valign="top" charoff="50">IPI00031411</td>
<td align="center" valign="top" charoff="50">FAT1</td>
<td align="center" valign="top" charoff="50">3.0</td>
<td align="center" valign="top" charoff="50">17</td>
<td align="center" valign="top" charoff="50">2.66</td>
<td align="center" valign="top" charoff="50">7.08</td>
<td align="center" valign="top" charoff="50">0.38</td>
<td align="center" valign="top" charoff="50">0.01892</td>
<td> </td>
</tr>
<tr><td align="center" valign="top" charoff="50">IPI00854629</td>
<td align="center" valign="top" charoff="50">OBSCN</td>
<td align="center" valign="top" charoff="50">2.3</td>
<td align="center" valign="top" charoff="50">33</td>
<td align="center" valign="top" charoff="50">3.83</td>
<td align="center" valign="top" charoff="50">6.97</td>
<td align="center" valign="top" charoff="50">0.55</td>
<td align="center" valign="top" charoff="50">0.01892</td>
<td align="center" valign="top" charoff="50">IPI00983524</td>
<td align="center" valign="top" charoff="50">MBP</td>
<td align="center" valign="top" charoff="50">58.6</td>
<td align="center" valign="top" charoff="50">59</td>
<td align="center" valign="top" charoff="50">0.62</td>
<td align="center" valign="top" charoff="50">1.76</td>
<td align="center" valign="top" charoff="50">0.35</td>
<td align="center" valign="top" charoff="50">0.01856</td>
<td> </td>
</tr>
<tr><td align="center" valign="top" charoff="50">IPI00221325</td>
<td align="center" valign="top" charoff="50">RANBP2</td>
<td align="center" valign="top" charoff="50">5.3</td>
<td align="center" valign="top" charoff="50">14</td>
<td align="center" valign="top" charoff="50">3.98</td>
<td align="center" valign="top" charoff="50">7.24</td>
<td align="center" valign="top" charoff="50">0.55</td>
<td align="center" valign="top" charoff="50">0.02154</td>
<td align="center" valign="top" charoff="50">IPI00445401</td>
<td align="center" valign="top" charoff="50">HUWE1*</td>
<td align="center" valign="top" charoff="50">5.6</td>
<td align="center" valign="top" charoff="50">27</td>
<td align="center" valign="top" charoff="50">2.39</td>
<td align="center" valign="top" charoff="50">6.99</td>
<td align="center" valign="top" charoff="50">0.34</td>
<td align="center" valign="top" charoff="50">0.01203</td>
<td> </td>
</tr>
<tr><td align="center" valign="top" charoff="50">IPI00868928</td>
<td align="center" valign="top" charoff="50">KIF26B</td>
<td align="center" valign="top" charoff="50">5.5</td>
<td align="center" valign="top" charoff="50">19</td>
<td align="center" valign="top" charoff="50">3.45</td>
<td align="center" valign="top" charoff="50">6.39</td>
<td align="center" valign="top" charoff="50">0.54</td>
<td align="center" valign="top" charoff="50">0.01892</td>
<td align="center" valign="top" charoff="50">IPI00257508</td>
<td align="center" valign="top" charoff="50">DPYSL2*</td>
<td align="center" valign="top" charoff="50">23.3</td>
<td align="center" valign="top" charoff="50">27</td>
<td align="center" valign="top" charoff="50">3.22</td>
<td align="center" valign="top" charoff="50">10.01</td>
<td align="center" valign="top" charoff="50">0.32</td>
<td align="center" valign="top" charoff="50">0.01203</td>
<td> </td>
</tr>
<tr><td align="center" valign="top" charoff="50">IPI01018628</td>
<td align="center" valign="top" charoff="50">UTY</td>
<td align="center" valign="top" charoff="50">11.6</td>
<td align="center" valign="top" charoff="50">24</td>
<td align="center" valign="top" charoff="50">5.10</td>
<td align="center" valign="top" charoff="50">9.47</td>
<td align="center" valign="top" charoff="50">0.54</td>
<td align="center" valign="top" charoff="50">0.01892</td>
<td align="center" valign="top" charoff="50">IPI00021263</td>
<td align="center" valign="top" charoff="50">YWHAZ*</td>
<td align="center" valign="top" charoff="50">17.0</td>
<td align="center" valign="top" charoff="50">12</td>
<td align="center" valign="top" charoff="50">0.84</td>
<td align="center" valign="top" charoff="50">2.65</td>
<td align="center" valign="top" charoff="50">0.32</td>
<td align="center" valign="top" charoff="50">0.01489</td>
<td> </td>
</tr>
<tr><td align="center" valign="top" charoff="50">IPI00018352</td>
<td align="center" valign="top" charoff="50">UCHL1</td>
<td align="center" valign="top" charoff="50">19.2</td>
<td align="center" valign="top" charoff="50">10</td>
<td align="center" valign="top" charoff="50">1.77</td>
<td align="center" valign="top" charoff="50">3.30</td>
<td align="center" valign="top" charoff="50">0.53</td>
<td align="center" valign="top" charoff="50">0.01892</td>
<td align="center" valign="top" charoff="50">IPI00479743</td>
<td align="center" valign="top" charoff="50">POTEE</td>
<td align="center" valign="top" charoff="50">14.1</td>
<td align="center" valign="top" charoff="50">40</td>
<td align="center" valign="top" charoff="50">0.82</td>
<td align="center" valign="top" charoff="50">2.75</td>
<td align="center" valign="top" charoff="50">0.30</td>
<td align="center" valign="top" charoff="50">0.01892</td>
<td> </td>
</tr>
<tr><td align="center" valign="top" charoff="50">IPI00815697</td>
<td align="center" valign="top" charoff="50">NAV2</td>
<td align="center" valign="top" charoff="50">12.0</td>
<td align="center" valign="top" charoff="50">31</td>
<td align="center" valign="top" charoff="50">2.12</td>
<td align="center" valign="top" charoff="50">4.00</td>
<td align="center" valign="top" charoff="50">0.53</td>
<td align="center" valign="top" charoff="50">0.02549</td>
<td align="center" valign="top" charoff="50">IPI01019113</td>
<td align="center" valign="top" charoff="50">TUBB</td>
<td align="center" valign="top" charoff="50">49.6</td>
<td align="center" valign="top" charoff="50">155</td>
<td align="center" valign="top" charoff="50">0.23</td>
<td align="center" valign="top" charoff="50">0.79</td>
<td align="center" valign="top" charoff="50">0.30</td>
<td align="center" valign="top" charoff="50">0.01756</td>
<td> </td>
</tr>
<tr><td align="center" valign="top" charoff="50">IPI00003935</td>
<td align="center" valign="top" charoff="50">HIST2H2BE</td>
<td align="center" valign="top" charoff="50">19.0</td>
<td align="center" valign="top" charoff="50">9</td>
<td align="center" valign="top" charoff="50">1.27</td>
<td align="center" valign="top" charoff="50">2.39</td>
<td align="center" valign="top" charoff="50">0.53</td>
<td align="center" valign="top" charoff="50">0.01892</td>
<td align="center" valign="top" charoff="50">IPI00006510</td>
<td align="center" valign="top" charoff="50">TUBB1</td>
<td align="center" valign="top" charoff="50">11.7</td>
<td align="center" valign="top" charoff="50">11</td>
<td align="center" valign="top" charoff="50">0.29</td>
<td align="center" valign="top" charoff="50">0.99</td>
<td align="center" valign="top" charoff="50">0.30</td>
<td align="center" valign="top" charoff="50">0.01892</td>
<td> </td>
</tr>
<tr><td align="center" valign="top" charoff="50">IPI00008161</td>
<td align="center" valign="top" charoff="50">ATP12A</td>
<td align="center" valign="top" charoff="50">5.9</td>
<td align="center" valign="top" charoff="50">12</td>
<td align="center" valign="top" charoff="50">0.77</td>
<td align="center" valign="top" charoff="50">1.46</td>
<td align="center" valign="top" charoff="50">0.53</td>
<td align="center" valign="top" charoff="50">0.01892</td>
<td align="center" valign="top" charoff="50">IPI01019105</td>
<td align="center" valign="top" charoff="50">UTY</td>
<td align="center" valign="top" charoff="50">4.7</td>
<td align="center" valign="top" charoff="50">10</td>
<td align="center" valign="top" charoff="50">1.29</td>
<td align="center" valign="top" charoff="50">4.57</td>
<td align="center" valign="top" charoff="50">0.28</td>
<td align="center" valign="top" charoff="50">0.01892</td>
<td> </td>
</tr>
<tr><td align="center" valign="top" charoff="50">IPI00018511</td>
<td align="center" valign="top" charoff="50">TUBB4Q</td>
<td align="center" valign="top" charoff="50">11.7</td>
<td align="center" valign="top" charoff="50">12</td>
<td align="center" valign="top" charoff="50">0.51</td>
<td align="center" valign="top" charoff="50">0.98</td>
<td align="center" valign="top" charoff="50">0.52</td>
<td align="center" valign="top" charoff="50">0.01977</td>
<td align="center" valign="top" charoff="50">IPI00478021</td>
<td align="center" valign="top" charoff="50">DNAH8*</td>
<td align="center" valign="top" charoff="50">4.0</td>
<td align="center" valign="top" charoff="50">29</td>
<td align="center" valign="top" charoff="50">2.06</td>
<td align="center" valign="top" charoff="50">7.68</td>
<td align="center" valign="top" charoff="50">0.27</td>
<td align="center" valign="top" charoff="50">0.01676</td>
<td> </td>
</tr>
<tr><td align="center" valign="top" charoff="50">IPI00952742</td>
<td align="center" valign="top" charoff="50">SHANK2</td>
<td align="center" valign="top" charoff="50">4.6</td>
<td align="center" valign="top" charoff="50">14</td>
<td align="center" valign="top" charoff="50">2.05</td>
<td align="center" valign="top" charoff="50">4.00</td>
<td align="center" valign="top" charoff="50">0.51</td>
<td align="center" valign="top" charoff="50">0.01892</td>
<td align="center" valign="top" charoff="50">IPI00217002</td>
<td align="center" valign="top" charoff="50">KIAA2018</td>
<td align="center" valign="top" charoff="50">7.2</td>
<td align="center" valign="top" charoff="50">11</td>
<td align="center" valign="top" charoff="50">1.48</td>
<td align="center" valign="top" charoff="50">5.65</td>
<td align="center" valign="top" charoff="50">0.26</td>
<td align="center" valign="top" charoff="50">0.01856</td>
<td> </td>
</tr>
<tr><td align="center" valign="top" charoff="50">IPI00297593</td>
<td align="center" valign="top" charoff="50">USP34</td>
<td align="center" valign="top" charoff="50">4.0</td>
<td align="center" valign="top" charoff="50">25</td>
<td align="center" valign="top" charoff="50">3.75</td>
<td align="center" valign="top" charoff="50">7.30</td>
<td align="center" valign="top" charoff="50">0.51</td>
<td align="center" valign="top" charoff="50">0.01892</td>
<td align="center" valign="top" charoff="50">IPI00853390</td>
<td align="center" valign="top" charoff="50">GPR112*</td>
<td align="center" valign="top" charoff="50">5.8</td>
<td align="center" valign="top" charoff="50">34</td>
<td align="center" valign="top" charoff="50">1.84</td>
<td align="center" valign="top" charoff="50">7.91</td>
<td align="center" valign="top" charoff="50">0.23</td>
<td align="center" valign="top" charoff="50">0.00982</td>
<td> </td>
</tr>
<tr><td align="center" valign="top" charoff="50">IPI00306457</td>
<td align="center" valign="top" charoff="50">FNDC1</td>
<td align="center" valign="top" charoff="50">9.4</td>
<td align="center" valign="top" charoff="50">10</td>
<td align="center" valign="top" charoff="50">2.74</td>
<td align="center" valign="top" charoff="50">5.42</td>
<td align="center" valign="top" charoff="50">0.51</td>
<td align="center" valign="top" charoff="50">0.01892</td>
<td align="center" valign="top" charoff="50">IPI00443415</td>
<td align="center" valign="top" charoff="50">MCC*</td>
<td align="center" valign="top" charoff="50">5.5</td>
<td align="center" valign="top" charoff="50">9</td>
<td align="center" valign="top" charoff="50">0.99</td>
<td align="center" valign="top" charoff="50">4.32</td>
<td align="center" valign="top" charoff="50">0.23</td>
<td align="center" valign="top" charoff="50">0.01203</td>
<td> </td>
</tr>
<tr><td align="center" valign="top" charoff="50">IPI00019848</td>
<td align="center" valign="top" charoff="50">HCFC1</td>
<td align="center" valign="top" charoff="50">7.5</td>
<td align="center" valign="top" charoff="50">15</td>
<td align="center" valign="top" charoff="50">3.51</td>
<td align="center" valign="top" charoff="50">6.95</td>
<td align="center" valign="top" charoff="50">0.51</td>
<td align="center" valign="top" charoff="50">0.02078</td>
<td align="center" valign="top" charoff="50">IPI00956686</td>
<td align="center" valign="top" charoff="50">ATXN7*</td>
<td align="center" valign="top" charoff="50">15.6</td>
<td align="center" valign="top" charoff="50">11</td>
<td align="center" valign="top" charoff="50">0.88</td>
<td align="center" valign="top" charoff="50">4.54</td>
<td align="center" valign="top" charoff="50">0.19</td>
<td align="center" valign="top" charoff="50">0.01203</td>
<td> </td>
</tr>
<tr><td align="center" valign="top" charoff="50">IPI00914628</td>
<td align="center" valign="top" charoff="50">USP24</td>
<td align="center" valign="top" charoff="50">4.5</td>
<td align="center" valign="top" charoff="50">9</td>
<td align="center" valign="top" charoff="50">1.76</td>
<td align="center" valign="top" charoff="50">3.48</td>
<td align="center" valign="top" charoff="50">0.50</td>
<td align="center" valign="top" charoff="50">0.02135</td>
<td align="center" valign="top" charoff="50">IPI00157790</td>
<td align="center" valign="top" charoff="50">KIAA0368</td>
<td align="center" valign="top" charoff="50">4.2</td>
<td align="center" valign="top" charoff="50">7</td>
<td align="center" valign="top" charoff="50">0.99</td>
<td align="center" valign="top" charoff="50">5.17</td>
<td align="center" valign="top" charoff="50">0.19</td>
<td align="center" valign="top" charoff="50">0.01856</td>
<td> </td>
</tr>
<tr><td align="center" valign="top" charoff="50">IPI00026320</td>
<td align="center" valign="top" charoff="50">UBR5</td>
<td align="center" valign="top" charoff="50">5.1</td>
<td align="center" valign="top" charoff="50">15</td>
<td align="center" valign="top" charoff="50">6.07</td>
<td align="center" valign="top" charoff="50">12.42</td>
<td align="center" valign="top" charoff="50">0.49</td>
<td align="center" valign="top" charoff="50">0.01892</td>
<td align="center" valign="top" charoff="50">IPI00220717</td>
<td align="center" valign="top" charoff="50">RBM15*</td>
<td align="center" valign="top" charoff="50">7.6</td>
<td align="center" valign="top" charoff="50">20</td>
<td align="center" valign="top" charoff="50">1.03</td>
<td align="center" valign="top" charoff="50">5.64</td>
<td align="center" valign="top" charoff="50">0.18</td>
<td align="center" valign="top" charoff="50">0.00731</td>
<td> </td>
</tr>
<tr><td align="center" valign="top" charoff="50">IPI00215877</td>
<td align="center" valign="top" charoff="50">APC</td>
<td align="center" valign="top" charoff="50">7.6</td>
<td align="center" valign="top" charoff="50">41</td>
<td align="center" valign="top" charoff="50">3.85</td>
<td align="center" valign="top" charoff="50">7.89</td>
<td align="center" valign="top" charoff="50">0.49</td>
<td align="center" valign="top" charoff="50">0.01892</td>
<td align="center" valign="top" charoff="50">IPI00795015</td>
<td align="center" valign="top" charoff="50">SACS*</td>
<td align="center" valign="top" charoff="50">1.9</td>
<td align="center" valign="top" charoff="50">15</td>
<td align="center" valign="top" charoff="50">0.99</td>
<td align="center" valign="top" charoff="50">5.78</td>
<td align="center" valign="top" charoff="50">0.17</td>
<td align="center" valign="top" charoff="50">0.00731</td>
<td> </td>
</tr>
<tr><td align="center" valign="top" charoff="50">IPI00946001</td>
<td align="center" valign="top" charoff="50">ONECUT2</td>
<td align="center" valign="top" charoff="50">26.8</td>
<td align="center" valign="top" charoff="50">15</td>
<td align="center" valign="top" charoff="50">3.48</td>
<td align="center" valign="top" charoff="50">7.17</td>
<td align="center" valign="top" charoff="50">0.49</td>
<td align="center" valign="top" charoff="50">0.01891</td>
<td align="center" valign="top" charoff="50">IPI00738216</td>
<td align="center" valign="top" charoff="50">KIAA0947*</td>
<td align="center" valign="top" charoff="50">7.1</td>
<td align="center" valign="top" charoff="50">15</td>
<td align="center" valign="top" charoff="50">0.62</td>
<td align="center" valign="top" charoff="50">3.82</td>
<td align="center" valign="top" charoff="50">0.16</td>
<td align="center" valign="top" charoff="50">0.01203</td>
<td> </td>
</tr>
<tr><td align="center" valign="top" charoff="50">IPI00298994</td>
<td align="center" valign="top" charoff="50">TLN1</td>
<td align="center" valign="top" charoff="50">6.9</td>
<td align="center" valign="top" charoff="50">18</td>
<td align="center" valign="top" charoff="50">4.76</td>
<td align="center" valign="top" charoff="50">9.93</td>
<td align="center" valign="top" charoff="50">0.48</td>
<td align="center" valign="top" charoff="50">0.01856</td>
<td align="center" valign="top" charoff="50">IPI00642705</td>
<td align="center" valign="top" charoff="50">ARID1A*</td>
<td align="center" valign="top" charoff="50">7.7</td>
<td align="center" valign="top" charoff="50">25</td>
<td align="center" valign="top" charoff="50">1.33</td>
<td align="center" valign="top" charoff="50">8.27</td>
<td align="center" valign="top" charoff="50">0.16</td>
<td align="center" valign="top" charoff="50">0.00731</td>
<td> </td>
</tr>
<tr><td align="center" valign="top" charoff="50">IPI00914890</td>
<td align="center" valign="top" charoff="50">MAST4</td>
<td align="center" valign="top" charoff="50">3.3</td>
<td align="center" valign="top" charoff="50">8</td>
<td align="center" valign="top" charoff="50">1.17</td>
<td align="center" valign="top" charoff="50">2.47</td>
<td align="center" valign="top" charoff="50">0.47</td>
<td align="center" valign="top" charoff="50">0.02154</td>
<td align="center" valign="top" charoff="50">IPI01014270</td>
<td align="center" valign="top" charoff="50">APOB</td>
<td align="center" valign="top" charoff="50">4.6</td>
<td align="center" valign="top" charoff="50">21</td>
<td align="center" valign="top" charoff="50">1.33</td>
<td align="center" valign="top" charoff="50">9.55</td>
<td align="center" valign="top" charoff="50">0.14</td>
<td align="center" valign="top" charoff="50">0.01856</td>
<td> </td>
</tr>
<tr><td align="center" valign="top" charoff="50">IPI00788188</td>
<td align="center" valign="top" charoff="50">DYNC2H1</td>
<td align="center" valign="top" charoff="50">5.4</td>
<td align="center" valign="top" charoff="50">24</td>
<td align="center" valign="top" charoff="50">2.83</td>
<td align="center" valign="top" charoff="50">6.05</td>
<td align="center" valign="top" charoff="50">0.47</td>
<td align="center" valign="top" charoff="50">0.01892</td>
<td align="center" valign="top" charoff="50">IPI00740545</td>
<td align="center" valign="top" charoff="50">POTEI*</td>
<td align="center" valign="top" charoff="50">11.2</td>
<td align="center" valign="top" charoff="50">26</td>
<td align="center" valign="top" charoff="50">0.21</td>
<td align="center" valign="top" charoff="50">1.54</td>
<td align="center" valign="top" charoff="50">0.14</td>
<td align="center" valign="top" charoff="50">0.00507</td>
<td> </td>
</tr>
<tr><td align="center" valign="top" charoff="50">IPI00007750</td>
<td align="center" valign="top" charoff="50">TUBA4A</td>
<td align="center" valign="top" charoff="50">37.4</td>
<td align="center" valign="top" charoff="50">56</td>
<td align="center" valign="top" charoff="50">0.55</td>
<td align="center" valign="top" charoff="50">1.19</td>
<td align="center" valign="top" charoff="50">0.46</td>
<td align="center" valign="top" charoff="50">0.01856</td>
<td align="center" valign="top" charoff="50">IPI00790327</td>
<td align="center" valign="top" charoff="50">ATP1A3*</td>
<td align="center" valign="top" charoff="50">8.7</td>
<td align="center" valign="top" charoff="50">27</td>
<td align="center" valign="top" charoff="50">0.40</td>
<td align="center" valign="top" charoff="50">4.10</td>
<td align="center" valign="top" charoff="50">0.10</td>
<td align="center" valign="top" charoff="50">0.01489</td>
<td> </td>
</tr>
<tr><td align="center" valign="top" charoff="50">IPI00026272</td>
<td align="center" valign="top" charoff="50">HIST1H2AE</td>
<td align="center" valign="top" charoff="50">21.8</td>
<td align="center" valign="top" charoff="50">6</td>
<td align="center" valign="top" charoff="50">0.76</td>
<td align="center" valign="top" charoff="50">1.67</td>
<td align="center" valign="top" charoff="50">0.46</td>
<td align="center" valign="top" charoff="50">0.01892</td>
<td align="center" valign="top" charoff="50">IPI00879810</td>
<td align="center" valign="top" charoff="50">SPTAN1</td>
<td align="center" valign="top" charoff="50">5.3</td>
<td align="center" valign="top" charoff="50">18</td>
<td align="center" valign="top" charoff="50">1.00</td>
<td align="center" valign="top" charoff="50">10.50</td>
<td align="center" valign="top" charoff="50">0.10</td>
<td align="center" valign="top" charoff="50">0.01892</td>
<td> </td>
</tr>
<tr><td align="center" valign="top" charoff="50">IPI00985241</td>
<td align="center" valign="top" charoff="50">MBP</td>
<td align="center" valign="top" charoff="50">67.5</td>
<td align="center" valign="top" charoff="50">59</td>
<td align="center" valign="top" charoff="50">1.00</td>
<td align="center" valign="top" charoff="50">2.21</td>
<td align="center" valign="top" charoff="50">0.45</td>
<td align="center" valign="top" charoff="50">0.01892</td>
<td align="center" valign="top" charoff="50">IPI00917728</td>
<td align="center" valign="top" charoff="50">NEB*</td>
<td align="center" valign="top" charoff="50">3.7</td>
<td align="center" valign="top" charoff="50">58</td>
<td align="center" valign="top" charoff="50">0.80</td>
<td align="center" valign="top" charoff="50">9.19</td>
<td align="center" valign="top" charoff="50">0.09</td>
<td align="center" valign="top" charoff="50">0.00549</td>
<td> </td>
</tr>
<tr><td align="center" valign="top" charoff="50">IPI00215628</td>
<td align="center" valign="top" charoff="50">VCAN</td>
<td align="center" valign="top" charoff="50">5.5</td>
<td align="center" valign="top" charoff="50">9</td>
<td align="center" valign="top" charoff="50">1.17</td>
<td align="center" valign="top" charoff="50">2.75</td>
<td align="center" valign="top" charoff="50">0.43</td>
<td align="center" valign="top" charoff="50">0.02109</td>
<td align="center" valign="top" charoff="50">IPI00871227</td>
<td align="center" valign="top" charoff="50">HMCN1*</td>
<td align="center" valign="top" charoff="50">3.1</td>
<td align="center" valign="top" charoff="50">15</td>
<td align="center" valign="top" charoff="50">0.29</td>
<td align="center" valign="top" charoff="50">4.56</td>
<td align="center" valign="top" charoff="50">0.06</td>
<td align="center" valign="top" charoff="50">0.01203</td>
<td> </td>
</tr>
<tr><td align="center" valign="top" charoff="50">IPI00643465</td>
<td align="center" valign="top" charoff="50">TACC2</td>
<td align="center" valign="top" charoff="50">3.2</td>
<td align="center" valign="top" charoff="50">7</td>
<td align="center" valign="top" charoff="50">1.17</td>
<td align="center" valign="top" charoff="50">2.76</td>
<td align="center" valign="top" charoff="50">0.42</td>
<td align="center" valign="top" charoff="50">0.01892</td>
<td align="center" valign="top" charoff="50">IPI00386035</td>
<td align="center" valign="top" charoff="50">FLG*</td>
<td align="center" valign="top" charoff="50">11.7</td>
<td align="center" valign="top" charoff="50">21</td>
<td align="center" valign="top" charoff="50">0.00</td>
<td align="center" valign="top" charoff="50">6.61</td>
<td align="center" valign="top" charoff="50">n.a</td>
<td align="center" valign="top" charoff="50">0.00731</td>
<td> </td>
</tr>
<tr><td align="center" valign="top" charoff="50">IPI00179298</td>
<td align="center" valign="top" charoff="50">HUWE1*</td>
<td align="center" valign="top" charoff="50">5.6</td>
<td align="center" valign="top" charoff="50">43</td>
<td align="center" valign="top" charoff="50">4.55</td>
<td align="center" valign="top" charoff="50">10.74</td>
<td align="center" valign="top" charoff="50">0.42</td>
<td align="center" valign="top" charoff="50">0.01708</td>
<td align="center" valign="top" charoff="50">IPI00012645</td>
<td align="center" valign="top" charoff="50">SPTBN2*</td>
<td align="center" valign="top" charoff="50">5.9</td>
<td align="center" valign="top" charoff="50">10</td>
<td align="center" valign="top" charoff="50">0.00</td>
<td align="center" valign="top" charoff="50">6.66</td>
<td align="center" valign="top" charoff="50">n.a</td>
<td align="center" valign="top" charoff="50">0.00741</td>
<td> </td>
</tr>
<tr><td align="center" valign="top" charoff="50">IPI00847978</td>
<td align="center" valign="top" charoff="50">FAT3</td>
<td align="center" valign="top" charoff="50">1.0</td>
<td align="center" valign="top" charoff="50">13</td>
<td align="center" valign="top" charoff="50">2.56</td>
<td align="center" valign="top" charoff="50">6.06</td>
<td align="center" valign="top" charoff="50">0.42</td>
<td align="center" valign="top" charoff="50">0.02078</td>
<td align="center" valign="top" charoff="50"> </td>
<td align="center" valign="top" charoff="50"> </td>
<td align="center" valign="top" charoff="50"> </td>
<td align="center" valign="top" charoff="50"> </td>
<td align="center" valign="top" charoff="50"> </td>
<td align="center" valign="top" charoff="50"> </td>
<td align="center" valign="top" charoff="50"> </td>
<td align="center" valign="top" charoff="50"> </td>
<td> </td>
</tr>
</tbody>
</table>
</table-wrap>
<table-wrap position="float" id="t2"><label>Table 2</label>
<caption><title>Annotated upstream regulators listed according to z-scores and p values.</title>
</caption>
<table frame="hsides" rules="groups" border="1"><colgroup><col align="center"></col>
<col align="center"></col>
<col align="center"></col>
<col align="center"></col>
<col align="center"></col>
</colgroup>
<thead valign="bottom"><tr><th align="center" valign="top" charoff="50"><bold>Upstream Regulator</bold>
</th>
<th align="center" valign="top" charoff="50"><bold>Molecule Type</bold>
</th>
<th align="center" valign="top" charoff="50"><bold>Activation z-score</bold>
</th>
<th align="center" valign="top" charoff="50"><bold>p-value</bold>
</th>
<th align="center" valign="top" charoff="50"><bold>Target molecules in regulated proteins</bold>
</th>
</tr>
</thead>
<tbody valign="top"><tr><td align="center" valign="top" charoff="50">ZAP70</td>
<td align="center" valign="top" charoff="50">Kinase</td>
<td align="center" valign="top" charoff="50">2.000</td>
<td align="center" valign="top" charoff="50">4.12E–06</td>
<td align="center" valign="top" charoff="50">HSP90AA1, ITPR1, MYCBP2, PLEC</td>
</tr>
<tr><td align="center" valign="top" charoff="50">IGF1</td>
<td align="center" valign="top" charoff="50">Growth factor</td>
<td align="center" valign="top" charoff="50">1.970</td>
<td align="center" valign="top" charoff="50">6.92E–03</td>
<td align="center" valign="top" charoff="50">DMD,GFAP, MBP, MKI67</td>
</tr>
<tr><td align="center" valign="top" charoff="50">BDNF</td>
<td align="center" valign="top" charoff="50">Growth factor</td>
<td align="center" valign="top" charoff="50">1.953</td>
<td align="center" valign="top" charoff="50">8.33E–04</td>
<td align="center" valign="top" charoff="50">GFAP, HSP90AA1, ITPR1, MBP</td>
</tr>
<tr><td align="center" valign="top" charoff="50">MYC</td>
<td align="center" valign="top" charoff="50">Transcription regulator</td>
<td align="center" valign="top" charoff="50">1.865</td>
<td align="center" valign="top" charoff="50">2.49E–03</td>
<td align="center" valign="top" charoff="50">HSP90AA1, MBP, MKI67, PGAM1, PGK1, PKM, SLC25A5</td>
</tr>
<tr><td align="center" valign="top" charoff="50">Cyclosporin A</td>
<td align="center" valign="top" charoff="50">Biologic drug</td>
<td align="center" valign="top" charoff="50">−1.982</td>
<td align="center" valign="top" charoff="50">7.61E–03</td>
<td align="center" valign="top" charoff="50">GFAP, HSP90AA1, ITPR1, MDH2</td>
</tr>
</tbody>
</table>
</table-wrap>
</floats-group>
</pmc>
<affiliations><list><country><li>Allemagne</li>
<li>Corée du Sud</li>
<li>Espagne</li>
<li>France</li>
<li>Pays-Bas</li>
</country>
</list>
<tree><country name="Corée du Sud"><noRegion><name sortKey="Ho Kim, Jae" sort="Ho Kim, Jae" uniqKey="Ho Kim J" first="Jae" last="Ho Kim">Jae Ho Kim</name>
</noRegion>
<name sortKey="Hee Cheon, Mi" sort="Hee Cheon, Mi" uniqKey="Hee Cheon M" first="Mi" last="Hee Cheon">Mi Hee Cheon</name>
<name sortKey="Hee Cheon, Mi" sort="Hee Cheon, Mi" uniqKey="Hee Cheon M" first="Mi" last="Hee Cheon">Mi Hee Cheon</name>
<name sortKey="Ho Kim, Jae" sort="Ho Kim, Jae" uniqKey="Ho Kim J" first="Jae" last="Ho Kim">Jae Ho Kim</name>
<name sortKey="Kang, Taewook" sort="Kang, Taewook" uniqKey="Kang T" first="Taewook" last="Kang">Taewook Kang</name>
<name sortKey="Kang, Taewook" sort="Kang, Taewook" uniqKey="Kang T" first="Taewook" last="Kang">Taewook Kang</name>
<name sortKey="Kang, Taewook" sort="Kang, Taewook" uniqKey="Kang T" first="Taewook" last="Kang">Taewook Kang</name>
<name sortKey="Lee, Joo Yong" sort="Lee, Joo Yong" uniqKey="Lee J" first="Joo-Yong" last="Lee">Joo-Yong Lee</name>
<name sortKey="Mok Park, Young" sort="Mok Park, Young" uniqKey="Mok Park Y" first="Young" last="Mok Park">Young Mok Park</name>
<name sortKey="Mok Park, Young" sort="Mok Park, Young" uniqKey="Mok Park Y" first="Young" last="Mok Park">Young Mok Park</name>
<name sortKey="Mok Park, Young" sort="Mok Park, Young" uniqKey="Mok Park Y" first="Young" last="Mok Park">Young Mok Park</name>
<name sortKey="Shin Yoo, Jong" sort="Shin Yoo, Jong" uniqKey="Shin Yoo J" first="Jong" last="Shin Yoo">Jong Shin Yoo</name>
<name sortKey="Shin Yoo, Jong" sort="Shin Yoo, Jong" uniqKey="Shin Yoo J" first="Jong" last="Shin Yoo">Jong Shin Yoo</name>
</country>
<country name="France"><noRegion><name sortKey="Franck, Julien" sort="Franck, Julien" uniqKey="Franck J" first="Julien" last="Franck">Julien Franck</name>
</noRegion>
<name sortKey="Fournier, Isabelle" sort="Fournier, Isabelle" uniqKey="Fournier I" first="Isabelle" last="Fournier">Isabelle Fournier</name>
<name sortKey="Salzet, Michel" sort="Salzet, Michel" uniqKey="Salzet M" first="Michel" last="Salzet">Michel Salzet</name>
</country>
<country name="Allemagne"><noRegion><name sortKey="Heinsen, Helmut" sort="Heinsen, Helmut" uniqKey="Heinsen H" first="Helmut" last="Heinsen">Helmut Heinsen</name>
</noRegion>
</country>
<country name="Pays-Bas"><noRegion><name sortKey="Ravid, Rivka" sort="Ravid, Rivka" uniqKey="Ravid R" first="Rivka" last="Ravid">Rivka Ravid</name>
</noRegion>
<name sortKey="Steinbusch, Harry W" sort="Steinbusch, Harry W" uniqKey="Steinbusch H" first="Harry W" last="Steinbusch">Harry W. Steinbusch</name>
</country>
<country name="Espagne"><noRegion><name sortKey="Ferrer, Isidro" sort="Ferrer, Isidro" uniqKey="Ferrer I" first="Isidro" last="Ferrer">Isidro Ferrer</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>
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