Spermidine protects against α-synuclein neurotoxicity
Identifieur interne : 001598 ( Ncbi/Merge ); précédent : 001597; suivant : 001599Spermidine protects against α-synuclein neurotoxicity
Auteurs : Sabrina Büttner [Autriche, Allemagne] ; Filomena Broeskamp [Autriche, Allemagne] ; Cornelia Sommer [Autriche, Allemagne] ; Maria Markaki [Grèce] ; Lukas Habernig [Autriche] ; Ali Alavian-Ghavanini [Autriche, Allemagne] ; Didac Carmona-Gutierrez [Autriche] ; Tobias Eisenberg [Autriche] ; Eva Michael [Allemagne] ; Guido Kroemer [France] ; Nektarios Tavernarakis [Grèce] ; Stephan J. Sigrist [Allemagne] ; Frank Madeo [Autriche]Source :
- Cell Cycle [ 1538-4101 ] ; 2014.
Abstract
As our society ages, neurodegenerative disorders like Parkinson`s disease (PD) are increasing in pandemic proportions. While mechanistic understanding of PD is advancing, a treatment with well tolerable drugs is still elusive. Here, we show that administration of the naturally occurring polyamine spermidine, which declines continuously during aging in various species, alleviates a series of PD-related degenerative processes in the fruit fly
Url:
DOI: 10.4161/15384101.2014.973309
PubMed: 25483063
PubMed Central: 4614020
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<affiliation><nlm:aff id="af0011"><institution>These authors contributed equally to this work.</institution>
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<author><name sortKey="Broeskamp, Filomena" sort="Broeskamp, Filomena" uniqKey="Broeskamp F" first="Filomena" last="Broeskamp">Filomena Broeskamp</name>
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</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0002"><institution>Institute for Biology/Genetics; Freie Universität Berlin</institution>
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</nlm:aff>
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<author><name sortKey="Sommer, Cornelia" sort="Sommer, Cornelia" uniqKey="Sommer C" first="Cornelia" last="Sommer">Cornelia Sommer</name>
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<author><name sortKey="Markaki, Maria" sort="Markaki, Maria" uniqKey="Markaki M" first="Maria" last="Markaki">Maria Markaki</name>
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<country xml:lang="fr">Grèce</country>
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<author><name sortKey="Habernig, Lukas" sort="Habernig, Lukas" uniqKey="Habernig L" first="Lukas" last="Habernig">Lukas Habernig</name>
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</nlm:aff>
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<author><name sortKey="Alavian Ghavanini, Ali" sort="Alavian Ghavanini, Ali" uniqKey="Alavian Ghavanini A" first="Ali" last="Alavian-Ghavanini">Ali Alavian-Ghavanini</name>
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</nlm:aff>
<country xml:lang="fr">Autriche</country>
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<author><name sortKey="Carmona Gutierrez, Didac" sort="Carmona Gutierrez, Didac" uniqKey="Carmona Gutierrez D" first="Didac" last="Carmona-Gutierrez">Didac Carmona-Gutierrez</name>
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<author><name sortKey="Eisenberg, Tobias" sort="Eisenberg, Tobias" uniqKey="Eisenberg T" first="Tobias" last="Eisenberg">Tobias Eisenberg</name>
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<author><name sortKey="Michael, Eva" sort="Michael, Eva" uniqKey="Michael E" first="Eva" last="Michael">Eva Michael</name>
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<country xml:lang="fr">Allemagne</country>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Spermidine protects against α-synuclein neurotoxicity </title>
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</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<affiliation><nlm:aff id="af0011"><institution>These authors contributed equally to this work.</institution>
</nlm:aff>
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<author><name sortKey="Broeskamp, Filomena" sort="Broeskamp, Filomena" uniqKey="Broeskamp F" first="Filomena" last="Broeskamp">Filomena Broeskamp</name>
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<affiliation wicri:level="1"><nlm:aff id="af0002"><institution>Institute for Biology/Genetics; Freie Universität Berlin</institution>
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</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<affiliation><nlm:aff id="af0011"><institution>These authors contributed equally to this work.</institution>
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<author><name sortKey="Sommer, Cornelia" sort="Sommer, Cornelia" uniqKey="Sommer C" first="Cornelia" last="Sommer">Cornelia Sommer</name>
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</nlm:aff>
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<affiliation wicri:level="1"><nlm:aff id="af0002"><institution>Institute for Biology/Genetics; Freie Universität Berlin</institution>
; Berlin,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Markaki, Maria" sort="Markaki, Maria" uniqKey="Markaki M" first="Maria" last="Markaki">Maria Markaki</name>
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; Heraklion, Crete,<country>Greece</country>
</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Habernig, Lukas" sort="Habernig, Lukas" uniqKey="Habernig L" first="Lukas" last="Habernig">Lukas Habernig</name>
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; Graz,<country>Austria</country>
</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
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<author><name sortKey="Alavian Ghavanini, Ali" sort="Alavian Ghavanini, Ali" uniqKey="Alavian Ghavanini A" first="Ali" last="Alavian-Ghavanini">Ali Alavian-Ghavanini</name>
<affiliation wicri:level="1"><nlm:aff id="af0001"><institution>Institute of Molecular Biosciences; University of Graz</institution>
; Graz,<country>Austria</country>
</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0002"><institution>Institute for Biology/Genetics; Freie Universität Berlin</institution>
; Berlin,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0004"><institution>Institute of Molecular Biology and Biochemistry; Center for Molecular Medicine; Medical University of Graz</institution>
; Graz,<country>Austria</country>
</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Carmona Gutierrez, Didac" sort="Carmona Gutierrez, Didac" uniqKey="Carmona Gutierrez D" first="Didac" last="Carmona-Gutierrez">Didac Carmona-Gutierrez</name>
<affiliation wicri:level="1"><nlm:aff id="af0001"><institution>Institute of Molecular Biosciences; University of Graz</institution>
; Graz,<country>Austria</country>
</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Eisenberg, Tobias" sort="Eisenberg, Tobias" uniqKey="Eisenberg T" first="Tobias" last="Eisenberg">Tobias Eisenberg</name>
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; Graz,<country>Austria</country>
</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Michael, Eva" sort="Michael, Eva" uniqKey="Michael E" first="Eva" last="Michael">Eva Michael</name>
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; Berlin,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Kroemer, Guido" sort="Kroemer, Guido" uniqKey="Kroemer G" first="Guido" last="Kroemer">Guido Kroemer</name>
<affiliation wicri:level="1"><nlm:aff id="af0005"><institution>INSERM</institution>
, U848; Villejuif,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0006"><institution>Metabolomics Platform; Institut Gustave Roussy</institution>
; Villejuif,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0007"><institution>Centre de Recherche des Cordeliers</institution>
; Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0008"><institution>Pôle de Biologie; Hôpital Européen Georges Pompidou</institution>
; AP-HP; Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0009"><institution>Université Paris Descartes; Sorbonne Paris Cité</institution>
; Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Tavernarakis, Nektarios" sort="Tavernarakis, Nektarios" uniqKey="Tavernarakis N" first="Nektarios" last="Tavernarakis">Nektarios Tavernarakis</name>
<affiliation wicri:level="1"><nlm:aff id="af0003"><institution>Institute of Molecular Biology and Biotechnology; Foundation for Research and Technology-Hellas</institution>
; Heraklion, Crete,<country>Greece</country>
</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0010"><institution>Department of Basic Sciences, Faculty of Medicine, University of Crete</institution>
; Heraklion, Crete,<country>Greece</country>
</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Sigrist, Stephan J" sort="Sigrist, Stephan J" uniqKey="Sigrist S" first="Stephan J" last="Sigrist">Stephan J. Sigrist</name>
<affiliation wicri:level="1"><nlm:aff id="af0002"><institution>Institute for Biology/Genetics; Freie Universität Berlin</institution>
; Berlin,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Madeo, Frank" sort="Madeo, Frank" uniqKey="Madeo F" first="Frank" last="Madeo">Frank Madeo</name>
<affiliation wicri:level="1"><nlm:aff id="af0001"><institution>Institute of Molecular Biosciences; University of Graz</institution>
; Graz,<country>Austria</country>
</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
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<series><title level="j">Cell Cycle</title>
<idno type="ISSN">1538-4101</idno>
<idno type="eISSN">1551-4005</idno>
<imprint><date when="2014">2014</date>
</imprint>
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<front><div type="abstract" xml:lang="en"><p>As our society ages, neurodegenerative disorders like Parkinson`s disease (PD) are increasing in pandemic proportions. While mechanistic understanding of PD is advancing, a treatment with well tolerable drugs is still elusive. Here, we show that administration of the naturally occurring polyamine spermidine, which declines continuously during aging in various species, alleviates a series of PD-related degenerative processes in the fruit fly <italic>Drosophila melanogaster</italic>
and the nematode <italic>Caenorhabditis elegans</italic>
, two established model systems for PD pathology. In the fruit fly, simple feeding with spermidine inhibited loss of climbing activity and early organismal death upon heterologous expression of human α-synuclein, which is thought to be the principal toxic trigger of PD. In this line, administration of spermidine rescued α-synuclein-induced loss of dopaminergic neurons, a hallmark of PD, in nematodes. Alleviation of PD-related neurodegeneration by spermidine was accompanied by induction of autophagy, suggesting that this cytoprotective process may be responsible for the beneficial effects of spermidine administration.</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Bove, J" uniqKey="Bove J">J Bové</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Garcia Arencibia, M" uniqKey="Garcia Arencibia M">M García-Arencibia</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lin, Mt" uniqKey="Lin M">MT Lin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wong, E" uniqKey="Wong E">E Wong</name>
</author>
</analytic>
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</back>
</TEI>
<pmc article-type="report"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Cell Cycle</journal-id>
<journal-id journal-id-type="iso-abbrev">Cell Cycle</journal-id>
<journal-id journal-id-type="pmc">KCCY</journal-id>
<journal-title-group><journal-title>Cell Cycle</journal-title>
</journal-title-group>
<issn pub-type="ppub">1538-4101</issn>
<issn pub-type="epub">1551-4005</issn>
<publisher><publisher-name>Taylor & Francis</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">25483063</article-id>
<article-id pub-id-type="pmc">4614020</article-id>
<article-id pub-id-type="publisher-id">973309</article-id>
<article-id pub-id-type="doi">10.4161/15384101.2014.973309</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Report</subject>
</subj-group>
</article-categories>
<title-group><article-title>Spermidine protects against α-synuclein neurotoxicity </article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Büttner</surname>
<given-names>Sabrina</given-names>
</name>
<xref ref-type="aff" rid="af0001"><sup>1</sup>
</xref>
<xref ref-type="aff" rid="af0002"><sup>2</sup>
</xref>
<xref ref-type="aff" rid="af0011"><sup>†</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Broeskamp</surname>
<given-names>Filomena</given-names>
</name>
<xref ref-type="aff" rid="af0001"><sup>1</sup>
</xref>
<xref ref-type="aff" rid="af0002"><sup>2</sup>
</xref>
<xref ref-type="aff" rid="af0011"><sup>†</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Sommer</surname>
<given-names>Cornelia</given-names>
</name>
<xref ref-type="aff" rid="af0001"><sup>1</sup>
</xref>
<xref ref-type="aff" rid="af0002"><sup>2</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Markaki</surname>
<given-names>Maria</given-names>
</name>
<xref ref-type="aff" rid="af0003"><sup>3</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Habernig</surname>
<given-names>Lukas</given-names>
</name>
<xref ref-type="aff" rid="af0001"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Alavian-Ghavanini</surname>
<given-names>Ali</given-names>
</name>
<xref ref-type="aff" rid="af0001"><sup>1</sup>
</xref>
<xref ref-type="aff" rid="af0002"><sup>2</sup>
</xref>
<xref ref-type="aff" rid="af0004"><sup>4</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Carmona-Gutierrez</surname>
<given-names>Didac</given-names>
</name>
<xref ref-type="aff" rid="af0001"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Eisenberg</surname>
<given-names>Tobias</given-names>
</name>
<xref ref-type="aff" rid="af0001"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Michael</surname>
<given-names>Eva</given-names>
</name>
<xref ref-type="aff" rid="af0002"><sup>2</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kroemer</surname>
<given-names>Guido</given-names>
</name>
<xref ref-type="aff" rid="af0005"><sup>5</sup>
</xref>
<xref ref-type="aff" rid="af0006"><sup>6</sup>
</xref>
<xref ref-type="aff" rid="af0007"><sup>7</sup>
</xref>
<xref ref-type="aff" rid="af0008"><sup>8</sup>
</xref>
<xref ref-type="aff" rid="af0009"><sup>9</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Tavernarakis</surname>
<given-names>Nektarios</given-names>
</name>
<xref ref-type="aff" rid="af0003"><sup>3</sup>
</xref>
<xref ref-type="aff" rid="af0010"><sup>10</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Sigrist</surname>
<given-names>Stephan J</given-names>
</name>
<xref ref-type="aff" rid="af0002"><sup>2</sup>
</xref>
<xref ref-type="corresp" rid="an0001"><sup>*</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Madeo</surname>
<given-names>Frank</given-names>
</name>
<xref ref-type="aff" rid="af0001"><sup>1</sup>
</xref>
<xref ref-type="corresp" rid="an0001"><sup>*</sup>
</xref>
</contrib>
<aff id="af0001"><label>1</label>
<institution>Institute of Molecular Biosciences; University of Graz</institution>
; Graz,<country>Austria</country>
</aff>
<aff id="af0002"><label>2</label>
<institution>Institute for Biology/Genetics; Freie Universität Berlin</institution>
; Berlin,<country>Germany</country>
</aff>
<aff id="af0003"><label>3</label>
<institution>Institute of Molecular Biology and Biotechnology; Foundation for Research and Technology-Hellas</institution>
; Heraklion, Crete,<country>Greece</country>
</aff>
<aff id="af0004"><label>4</label>
<institution>Institute of Molecular Biology and Biochemistry; Center for Molecular Medicine; Medical University of Graz</institution>
; Graz,<country>Austria</country>
</aff>
<aff id="af0005"><label>5</label>
<institution>INSERM</institution>
, U848; Villejuif,<country>France</country>
</aff>
<aff id="af0006"><label>6</label>
<institution>Metabolomics Platform; Institut Gustave Roussy</institution>
; Villejuif,<country>France</country>
</aff>
<aff id="af0007"><label>7</label>
<institution>Centre de Recherche des Cordeliers</institution>
; Paris,<country>France</country>
</aff>
<aff id="af0008"><label>8</label>
<institution>Pôle de Biologie; Hôpital Européen Georges Pompidou</institution>
; AP-HP; Paris,<country>France</country>
</aff>
<aff id="af0009"><label>9</label>
<institution>Université Paris Descartes; Sorbonne Paris Cité</institution>
; Paris,<country>France</country>
</aff>
<aff id="af0010"><label>10</label>
<institution>Department of Basic Sciences, Faculty of Medicine, University of Crete</institution>
; Heraklion, Crete,<country>Greece</country>
</aff>
<aff id="af0011"><label>†</label>
<institution>These authors contributed equally to this work.</institution>
</aff>
</contrib-group>
<author-notes><corresp id="an0001"><label>*</label>
<addr-line>Correspondence to: Frank Madeo</addr-line>
; Email: <email xlink:href="frank.madeo@uni-graz.at">frank.madeo@uni-graz.at</email>
; Stephan J Sigrist; Email: <email xlink:href="stephan.sigrist@fu-berlin.de">stephan.sigrist@fu-berlin.de</email>
</corresp>
</author-notes>
<pub-date pub-type="collection"><day>15</day>
<month>12</month>
<year>2014</year>
</pub-date>
<pub-date pub-type="epub"><day>31</day>
<month>10</month>
<year>2014</year>
</pub-date>
<volume>13</volume>
<issue>24</issue>
<fpage seq="19">3903</fpage>
<lpage>3908</lpage>
<history><date date-type="received"><day>29</day>
<month>7</month>
<year>2014</year>
</date>
<date date-type="rev-recd"><day>24</day>
<month>9</month>
<year>2014</year>
</date>
<date date-type="accepted"><day>30</day>
<month>9</month>
<year>2014</year>
</date>
</history>
<permissions><copyright-statement>© 2014 The Author(s). Published with license by Taylor & Francis Group, LLC</copyright-statement>
<copyright-statement content-type="description">© Sabrina Büttner, Filomena Broeskamp, Cornelia Sommer, Maria Markaki, Lukas Habernig, Ali Alavian-Ghavanini, Didac Carmona-Gutierrez, Tobias Eisenberg, Eva Michael, Guido Kroemer, Nektarios Tavernarakis, Stephan J Sigrist, and Frank Madeo</copyright-statement>
<copyright-year>2014</copyright-year>
<copyright-holder>The Author(s)</copyright-holder>
<license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc/3.0/"><license-p>This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by-nc/3.0/">http://creativecommons.org/licenses/by-nc/3.0/</ext-link>
), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.</license-p>
</license>
</permissions>
<self-uri content-type="pdf" xlink:href="kccy-13-24-973309.pdf"></self-uri>
<abstract><p>As our society ages, neurodegenerative disorders like Parkinson`s disease (PD) are increasing in pandemic proportions. While mechanistic understanding of PD is advancing, a treatment with well tolerable drugs is still elusive. Here, we show that administration of the naturally occurring polyamine spermidine, which declines continuously during aging in various species, alleviates a series of PD-related degenerative processes in the fruit fly <italic>Drosophila melanogaster</italic>
and the nematode <italic>Caenorhabditis elegans</italic>
, two established model systems for PD pathology. In the fruit fly, simple feeding with spermidine inhibited loss of climbing activity and early organismal death upon heterologous expression of human α-synuclein, which is thought to be the principal toxic trigger of PD. In this line, administration of spermidine rescued α-synuclein-induced loss of dopaminergic neurons, a hallmark of PD, in nematodes. Alleviation of PD-related neurodegeneration by spermidine was accompanied by induction of autophagy, suggesting that this cytoprotective process may be responsible for the beneficial effects of spermidine administration.</p>
</abstract>
<kwd-group kwd-group-type="author"><title>Keywords</title>
<kwd>autophagy</kwd>
<kwd>aging</kwd>
<kwd>α-synuclein</kwd>
<kwd>dopaminergic neuron loss</kwd>
<kwd>motor dysfunction</kwd>
<kwd>neurodegeneration</kwd>
<kwd>Parkinson's disease</kwd>
<kwd>Spermidine</kwd>
</kwd-group>
<counts><fig-count count="2"></fig-count>
<table-count count="0"></table-count>
<ref-count count="60"></ref-count>
<page-count count="6"></page-count>
</counts>
</article-meta>
</front>
</pmc>
<affiliations><list><country><li>Allemagne</li>
<li>Autriche</li>
<li>France</li>
<li>Grèce</li>
</country>
</list>
<tree><country name="Autriche"><noRegion><name sortKey="Buttner, Sabrina" sort="Buttner, Sabrina" uniqKey="Buttner S" first="Sabrina" last="Büttner">Sabrina Büttner</name>
</noRegion>
<name sortKey="Alavian Ghavanini, Ali" sort="Alavian Ghavanini, Ali" uniqKey="Alavian Ghavanini A" first="Ali" last="Alavian-Ghavanini">Ali Alavian-Ghavanini</name>
<name sortKey="Alavian Ghavanini, Ali" sort="Alavian Ghavanini, Ali" uniqKey="Alavian Ghavanini A" first="Ali" last="Alavian-Ghavanini">Ali Alavian-Ghavanini</name>
<name sortKey="Broeskamp, Filomena" sort="Broeskamp, Filomena" uniqKey="Broeskamp F" first="Filomena" last="Broeskamp">Filomena Broeskamp</name>
<name sortKey="Carmona Gutierrez, Didac" sort="Carmona Gutierrez, Didac" uniqKey="Carmona Gutierrez D" first="Didac" last="Carmona-Gutierrez">Didac Carmona-Gutierrez</name>
<name sortKey="Eisenberg, Tobias" sort="Eisenberg, Tobias" uniqKey="Eisenberg T" first="Tobias" last="Eisenberg">Tobias Eisenberg</name>
<name sortKey="Habernig, Lukas" sort="Habernig, Lukas" uniqKey="Habernig L" first="Lukas" last="Habernig">Lukas Habernig</name>
<name sortKey="Madeo, Frank" sort="Madeo, Frank" uniqKey="Madeo F" first="Frank" last="Madeo">Frank Madeo</name>
<name sortKey="Sommer, Cornelia" sort="Sommer, Cornelia" uniqKey="Sommer C" first="Cornelia" last="Sommer">Cornelia Sommer</name>
</country>
<country name="Allemagne"><noRegion><name sortKey="Buttner, Sabrina" sort="Buttner, Sabrina" uniqKey="Buttner S" first="Sabrina" last="Büttner">Sabrina Büttner</name>
</noRegion>
<name sortKey="Alavian Ghavanini, Ali" sort="Alavian Ghavanini, Ali" uniqKey="Alavian Ghavanini A" first="Ali" last="Alavian-Ghavanini">Ali Alavian-Ghavanini</name>
<name sortKey="Broeskamp, Filomena" sort="Broeskamp, Filomena" uniqKey="Broeskamp F" first="Filomena" last="Broeskamp">Filomena Broeskamp</name>
<name sortKey="Michael, Eva" sort="Michael, Eva" uniqKey="Michael E" first="Eva" last="Michael">Eva Michael</name>
<name sortKey="Sigrist, Stephan J" sort="Sigrist, Stephan J" uniqKey="Sigrist S" first="Stephan J" last="Sigrist">Stephan J. Sigrist</name>
<name sortKey="Sommer, Cornelia" sort="Sommer, Cornelia" uniqKey="Sommer C" first="Cornelia" last="Sommer">Cornelia Sommer</name>
</country>
<country name="Grèce"><noRegion><name sortKey="Markaki, Maria" sort="Markaki, Maria" uniqKey="Markaki M" first="Maria" last="Markaki">Maria Markaki</name>
</noRegion>
<name sortKey="Tavernarakis, Nektarios" sort="Tavernarakis, Nektarios" uniqKey="Tavernarakis N" first="Nektarios" last="Tavernarakis">Nektarios Tavernarakis</name>
<name sortKey="Tavernarakis, Nektarios" sort="Tavernarakis, Nektarios" uniqKey="Tavernarakis N" first="Nektarios" last="Tavernarakis">Nektarios Tavernarakis</name>
</country>
<country name="France"><noRegion><name sortKey="Kroemer, Guido" sort="Kroemer, Guido" uniqKey="Kroemer G" first="Guido" last="Kroemer">Guido Kroemer</name>
</noRegion>
<name sortKey="Kroemer, Guido" sort="Kroemer, Guido" uniqKey="Kroemer G" first="Guido" last="Kroemer">Guido Kroemer</name>
<name sortKey="Kroemer, Guido" sort="Kroemer, Guido" uniqKey="Kroemer G" first="Guido" last="Kroemer">Guido Kroemer</name>
<name sortKey="Kroemer, Guido" sort="Kroemer, Guido" uniqKey="Kroemer G" first="Guido" last="Kroemer">Guido Kroemer</name>
<name sortKey="Kroemer, Guido" sort="Kroemer, Guido" uniqKey="Kroemer G" first="Guido" last="Kroemer">Guido Kroemer</name>
</country>
</tree>
</affiliations>
</record>
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