A cross-sectional study on drug use in multiple system atrophy.
Identifieur interne : 001372 ( Ncbi/Merge ); précédent : 001371; suivant : 001373A cross-sectional study on drug use in multiple system atrophy.
Auteurs : María Ver Nica Rey [Argentine] ; Santiago Perez-Lloret ; Anne Pavy-Le Traon ; Wassilios G. Meissner ; Francois Tison ; Olivier RascolSource :
- CNS drugs [ 1179-1934 ] ; 2014.
Descripteurs français
- Wicri :
- geographic : France.
English descriptors
- KwdEn :
- Age Factors, Aged, Cross-Sectional Studies, Drug Interactions, Drug Therapy, Combination, Female, France (epidemiology), Humans, Male, Multiple System Atrophy (drug therapy), Multiple System Atrophy (epidemiology), Off-Label Use, Parkinson Disease (drug therapy), Parkinson Disease (epidemiology), Practice Patterns, Physicians', Registries, Severity of Illness Index.
- MESH :
- geographic , epidemiology : France.
- drug therapy : Multiple System Atrophy, Parkinson Disease.
- epidemiology : Multiple System Atrophy, Parkinson Disease.
- Age Factors, Aged, Cross-Sectional Studies, Drug Interactions, Drug Therapy, Combination, Female, Humans, Male, Off-Label Use, Practice Patterns, Physicians', Registries, Severity of Illness Index.
Abstract
Drug use has rarely been studied in multiple system atrophy (MSA) while such patients receive many treatments based on weak evidence.
DOI: 10.1007/s40263-014-0159-1
PubMed: 24683045
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">A cross-sectional study on drug use in multiple system atrophy.</title><author><name sortKey="Rey, Maria Ver Nica" sort="Rey, Maria Ver Nica" uniqKey="Rey M" first="María Ver Nica" last="Rey">María Ver Nica Rey</name><affiliation wicri:level="1"><nlm:affiliation>Departments of Clinical Pharmacology and Neurosciences, Faculty of Medicine, University Hospital and University of Toulouse 3, 37 Allées Jules Guesde, 31000, Toulouse, France, mverorey@yahoo.com.ar.</nlm:affiliation><country wicri:rule="url">Argentine</country><wicri:regionArea>Departments of Clinical Pharmacology and Neurosciences, Faculty of Medicine, University Hospital and University of Toulouse 3, 37 Allées Jules Guesde, 31000, Toulouse, France</wicri:regionArea><wicri:noRegion>France</wicri:noRegion></affiliation></author><author><name sortKey="Perez Lloret, Santiago" sort="Perez Lloret, Santiago" uniqKey="Perez Lloret S" first="Santiago" last="Perez-Lloret">Santiago Perez-Lloret</name></author><author><name sortKey="Pavy Le Traon, Anne" sort="Pavy Le Traon, Anne" uniqKey="Pavy Le Traon A" first="Anne" last="Pavy-Le Traon">Anne Pavy-Le Traon</name></author><author><name sortKey="Meissner, Wassilios G" sort="Meissner, Wassilios G" uniqKey="Meissner W" first="Wassilios G" last="Meissner">Wassilios G. Meissner</name></author><author><name sortKey="Tison, Francois" sort="Tison, Francois" uniqKey="Tison F" first="Francois" last="Tison">Francois Tison</name></author><author><name sortKey="Rascol, Olivier" sort="Rascol, Olivier" uniqKey="Rascol O" first="Olivier" last="Rascol">Olivier Rascol</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:24683045</idno><idno type="pmid">24683045</idno><idno type="doi">10.1007/s40263-014-0159-1</idno><idno type="wicri:Area/PubMed/Corpus">000567</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000567</idno><idno type="wicri:Area/PubMed/Curation">000549</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000549</idno><idno type="wicri:Area/PubMed/Checkpoint">000549</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000549</idno><idno type="wicri:Area/Ncbi/Merge">001372</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">A cross-sectional study on drug use in multiple system atrophy.</title><author><name sortKey="Rey, Maria Ver Nica" sort="Rey, Maria Ver Nica" uniqKey="Rey M" first="María Ver Nica" last="Rey">María Ver Nica Rey</name><affiliation wicri:level="1"><nlm:affiliation>Departments of Clinical Pharmacology and Neurosciences, Faculty of Medicine, University Hospital and University of Toulouse 3, 37 Allées Jules Guesde, 31000, Toulouse, France, mverorey@yahoo.com.ar.</nlm:affiliation><country wicri:rule="url">Argentine</country><wicri:regionArea>Departments of Clinical Pharmacology and Neurosciences, Faculty of Medicine, University Hospital and University of Toulouse 3, 37 Allées Jules Guesde, 31000, Toulouse, France</wicri:regionArea><wicri:noRegion>France</wicri:noRegion></affiliation></author><author><name sortKey="Perez Lloret, Santiago" sort="Perez Lloret, Santiago" uniqKey="Perez Lloret S" first="Santiago" last="Perez-Lloret">Santiago Perez-Lloret</name></author><author><name sortKey="Pavy Le Traon, Anne" sort="Pavy Le Traon, Anne" uniqKey="Pavy Le Traon A" first="Anne" last="Pavy-Le Traon">Anne Pavy-Le Traon</name></author><author><name sortKey="Meissner, Wassilios G" sort="Meissner, Wassilios G" uniqKey="Meissner W" first="Wassilios G" last="Meissner">Wassilios G. Meissner</name></author><author><name sortKey="Tison, Francois" sort="Tison, Francois" uniqKey="Tison F" first="Francois" last="Tison">Francois Tison</name></author><author><name sortKey="Rascol, Olivier" sort="Rascol, Olivier" uniqKey="Rascol O" first="Olivier" last="Rascol">Olivier Rascol</name></author></analytic><series><title level="j">CNS drugs</title><idno type="eISSN">1179-1934</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Age Factors</term><term>Aged</term><term>Cross-Sectional Studies</term><term>Drug Interactions</term><term>Drug Therapy, Combination</term><term>Female</term><term>France (epidemiology)</term><term>Humans</term><term>Male</term><term>Multiple System Atrophy (drug therapy)</term><term>Multiple System Atrophy (epidemiology)</term><term>Off-Label Use</term><term>Parkinson Disease (drug therapy)</term><term>Parkinson Disease (epidemiology)</term><term>Practice Patterns, Physicians'</term><term>Registries</term><term>Severity of Illness Index</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>France</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Multiple System Atrophy</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Multiple System Atrophy</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Age Factors</term><term>Aged</term><term>Cross-Sectional Studies</term><term>Drug Interactions</term><term>Drug Therapy, Combination</term><term>Female</term><term>Humans</term><term>Male</term><term>Off-Label Use</term><term>Practice Patterns, Physicians'</term><term>Registries</term><term>Severity of Illness Index</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>France</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Drug use has rarely been studied in multiple system atrophy (MSA) while such patients receive many treatments based on weak evidence.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">24683045</PMID><DateCreated><Year>2014</Year><Month>05</Month><Day>16</Day></DateCreated><DateCompleted><Year>2015</Year><Month>01</Month><Day>13</Day></DateCompleted><DateRevised><Year>2016</Year><Month>09</Month><Day>09</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1179-1934</ISSN><JournalIssue CitedMedium="Internet"><Volume>28</Volume><Issue>5</Issue><PubDate><Year>2014</Year><Month>May</Month></PubDate></JournalIssue><Title>CNS drugs</Title><ISOAbbreviation>CNS Drugs</ISOAbbreviation></Journal><ArticleTitle>A cross-sectional study on drug use in multiple system atrophy.</ArticleTitle><Pagination><MedlinePgn>483-90</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1007/s40263-014-0159-1</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Drug use has rarely been studied in multiple system atrophy (MSA) while such patients receive many treatments based on weak evidence.</AbstractText><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To analyze drug use from the database of the French MSA Reference Center, and to compare it with data from patients with Parkinson disease (PD).</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Medication of 147 MSA and 180 age- and sex-matched PD patients was analyzed. Motor and autonomic symptoms were explored in MSA patients by the SCOPA-Autonomic and Unified MSA Rating Scale (UMSARS).</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">MSA and PD patients received a mean of five different drugs. MSA patients were more frequently exposed to laxatives, antidiabetic medications, antihypotensives, muscarinic antagonists, alpha-adrenergic blockers, and antidepressants. Levodopa consumption was less in MSA-C (cerebellar) patients compared with MSA-P (parkinsonian) and PD patients. Dopamine agonists were more consumed by PD than MSA patients. MSA patients with more severe disability received more laxatives, anticoagulants, and antidepressants. MSA-P patients received more analgesics. "Probable" MSA patients received more antihypotensives and less alpha-adrenergic blockers. Patients with higher SCOPA-Autonomic scores were more frequently on antihypotensives or antidepressants. Drug associations leading to potential adverse interactions were uncommon (usually <5%).</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Some differences in drug use between MSA and PD patients were observed and expected, including those used for the relief of parkinsonian motor symptoms, autonomic dysfunction, and depression. Many of these drugs are frequently used in MSA in the absence of well-established, positive, benefit-risk evaluations, thus calling for better assessments. The reason why other medications, including anti-diabetic medications, were more consumed by MSA patients remains unclear and deserves further exploration.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Rey</LastName><ForeName>María Verónica</ForeName><Initials>MV</Initials><AffiliationInfo><Affiliation>Departments of Clinical Pharmacology and Neurosciences, Faculty of Medicine, University Hospital and University of Toulouse 3, 37 Allées Jules Guesde, 31000, Toulouse, France, mverorey@yahoo.com.ar.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Perez-Lloret</LastName><ForeName>Santiago</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Pavy-Le Traon</LastName><ForeName>Anne</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Meissner</LastName><ForeName>Wassilios G</ForeName><Initials>WG</Initials></Author><Author ValidYN="Y"><LastName>Tison</LastName><ForeName>Francois</ForeName><Initials>F</Initials></Author><Author ValidYN="Y"><LastName>Rascol</LastName><ForeName>Olivier</ForeName><Initials>O</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>New Zealand</Country><MedlineTA>CNS Drugs</MedlineTA><NlmUniqueID>9431220</NlmUniqueID><ISSNLinking>1172-7047</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000367" MajorTopicYN="N">Age Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003430" MajorTopicYN="N">Cross-Sectional Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004347" MajorTopicYN="N">Drug Interactions</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004359" MajorTopicYN="N">Drug Therapy, Combination</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005602" MajorTopicYN="N" Type="Geographic">France</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019578" MajorTopicYN="N">Multiple System Atrophy</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D056687" MajorTopicYN="N">Off-Label Use</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010818" MajorTopicYN="N">Practice Patterns, Physicians'</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012042" MajorTopicYN="N">Registries</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012720" MajorTopicYN="N">Severity of Illness Index</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2014</Year><Month>4</Month><Day>1</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2014</Year><Month>4</Month><Day>1</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>1</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">24683045</ArticleId><ArticleId IdType="doi">10.1007/s40263-014-0159-1</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Argentine</li></country></list><tree><noCountry><name sortKey="Meissner, Wassilios G" sort="Meissner, Wassilios G" uniqKey="Meissner W" first="Wassilios G" last="Meissner">Wassilios G. Meissner</name><name sortKey="Pavy Le Traon, Anne" sort="Pavy Le Traon, Anne" uniqKey="Pavy Le Traon A" first="Anne" last="Pavy-Le Traon">Anne Pavy-Le Traon</name><name sortKey="Perez Lloret, Santiago" sort="Perez Lloret, Santiago" uniqKey="Perez Lloret S" first="Santiago" last="Perez-Lloret">Santiago Perez-Lloret</name><name sortKey="Rascol, Olivier" sort="Rascol, Olivier" uniqKey="Rascol O" first="Olivier" last="Rascol">Olivier Rascol</name><name sortKey="Tison, Francois" sort="Tison, Francois" uniqKey="Tison F" first="Francois" last="Tison">Francois Tison</name></noCountry><country name="Argentine"><noRegion><name sortKey="Rey, Maria Ver Nica" sort="Rey, Maria Ver Nica" uniqKey="Rey M" first="María Ver Nica" last="Rey">María Ver Nica Rey</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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