Biology of gait control
Identifieur interne : 000D03 ( Ncbi/Merge ); précédent : 000D02; suivant : 000D04Biology of gait control
Auteurs : O. Beauchet ; C. Annweiler ; J. Verghese ; B. Fantino ; F. R. Herrmann ; G. AllaliSource :
- Neurology [ 0028-3878 ] ; 2011.
Abstract
Adverse neuromuscular events have been described in case of low serum 25-hydroxyvitamin D (25OHD) concentrations, suggesting that vitamin D may be involved in gait stability. The objective of this cross-sectional study was to examine the association between stride-to-stride variability of stride time (STV) and serum 25OHD concentration in adults aged 65 years and older.
STV and 25OHD concentration were assessed in 411 community-dwelling older adults (mean age 70.4 ± 1.8 years, 57.9% women). The following established 25OHD thresholds were used: severe 25OHD insufficiency <10 ng/mL, moderate 10–30 ng/mL, and normal >30 ng/mL. Age, number of drugs used per day, use of psychoactive drugs, depressive symptoms, cognitive decline, history of falls, distance visual acuity, lower limb proprioception, center of mass (CoM) motion, and walking speed were considered as potential confounders.
A total of 16.6% (n = 68) of subjects had severe 25OHD insufficiency, 70.3% (n = 289) moderate insufficiency, and 13.1% (n = 54) normal concentrations. In the full adjusted and the stepwise backward linear regression models, high STV (worse performance) was associated with severe 25OHD insufficiency (
Low serum 25OHD concentrations were associated with high STV reflecting a disturbed gait control. This association could be explained by a possible action of vitamin D on different components involved in gait control.
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DOI: 10.1212/WNL.0b013e318219fb08
PubMed: 21471466
PubMed Central: 3100089
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Allali</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">21471466</idno><idno type="pmc">3100089</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3100089</idno><idno type="RBID">PMC:3100089</idno><idno type="doi">10.1212/WNL.0b013e318219fb08</idno><date when="2011">2011</date><idno type="wicri:Area/Pmc/Corpus">000516</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000516</idno><idno type="wicri:Area/Pmc/Curation">000513</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000513</idno><idno type="wicri:Area/Pmc/Checkpoint">000706</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000706</idno><idno type="wicri:Area/Ncbi/Merge">000D03</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Biology of gait control</title><author><name sortKey="Beauchet, O" sort="Beauchet, O" uniqKey="Beauchet O" first="O." last="Beauchet">O. Beauchet</name></author><author><name sortKey="Annweiler, C" sort="Annweiler, C" uniqKey="Annweiler C" first="C." last="Annweiler">C. Annweiler</name></author><author><name sortKey="Verghese, J" sort="Verghese, J" uniqKey="Verghese J" first="J." last="Verghese">J. Verghese</name></author><author><name sortKey="Fantino, B" sort="Fantino, B" uniqKey="Fantino B" first="B." last="Fantino">B. Fantino</name></author><author><name sortKey="Herrmann, F R" sort="Herrmann, F R" uniqKey="Herrmann F" first="F. R." last="Herrmann">F. R. Herrmann</name></author><author><name sortKey="Allali, G" sort="Allali, G" uniqKey="Allali G" first="G." last="Allali">G. Allali</name></author></analytic><series><title level="j">Neurology</title><idno type="ISSN">0028-3878</idno><idno type="eISSN">1526-632X</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background:</title><p>Adverse neuromuscular events have been described in case of low serum 25-hydroxyvitamin D (25OHD) concentrations, suggesting that vitamin D may be involved in gait stability. The objective of this cross-sectional study was to examine the association between stride-to-stride variability of stride time (STV) and serum 25OHD concentration in adults aged 65 years and older.</p></sec><sec><title>Methods:</title><p>STV and 25OHD concentration were assessed in 411 community-dwelling older adults (mean age 70.4 ± 1.8 years, 57.9% women). The following established 25OHD thresholds were used: severe 25OHD insufficiency <10 ng/mL, moderate 10–30 ng/mL, and normal >30 ng/mL. Age, number of drugs used per day, use of psychoactive drugs, depressive symptoms, cognitive decline, history of falls, distance visual acuity, lower limb proprioception, center of mass (CoM) motion, and walking speed were considered as potential confounders.</p></sec><sec><title>Results:</title><p>A total of 16.6% (n = 68) of subjects had severe 25OHD insufficiency, 70.3% (n = 289) moderate insufficiency, and 13.1% (n = 54) normal concentrations. In the full adjusted and the stepwise backward linear regression models, high STV (worse performance) was associated with severe 25OHD insufficiency (<italic>p</italic> = 0.028 and <italic>p</italic> = 0.044, respectively), high CoM motion (<italic>p</italic> = 0.031 and <italic>p</italic> = 0.014, respectively), and low lower limb proprioception score (<italic>p</italic> = 0.017 and <italic>p</italic> = 0.008, respectively). The stepwise backward regression model also showed that high STV was associated with female gender (<italic>p</italic> = 0.041).</p></sec><sec><title>Conclusions:</title><p>Low serum 25OHD concentrations were associated with high STV reflecting a disturbed gait control. This association could be explained by a possible action of vitamin D on different components involved in gait control.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Neurology</journal-id><journal-id journal-id-type="hwp">neurology</journal-id><journal-id journal-id-type="publisher-id">neur</journal-id><journal-id journal-id-type="pmc">neurology</journal-id><journal-id journal-id-type="publisher-id">WNL</journal-id><journal-title-group><journal-title>Neurology</journal-title></journal-title-group><issn pub-type="ppub">0028-3878</issn><issn pub-type="epub">1526-632X</issn><publisher><publisher-name>Lippincott Williams & Wilkins</publisher-name><publisher-loc>Hagerstown, MD</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">21471466</article-id><article-id pub-id-type="pmc">3100089</article-id><article-id pub-id-type="publisher-id">WNL202560</article-id><article-id pub-id-type="doi">10.1212/WNL.0b013e318219fb08</article-id><article-categories><subj-group subj-group-type="hwp-journal-coll"><subject>52</subject><subject>163</subject><subject>310</subject></subj-group><subj-group subj-group-type="heading"><subject>Articles</subject></subj-group></article-categories><title-group><article-title>Biology of gait control</article-title><subtitle>Vitamin D involvement</subtitle></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Beauchet</surname><given-names>O.</given-names></name><degrees>MD, PhD</degrees></contrib><contrib contrib-type="author"><name><surname>Annweiler</surname><given-names>C.</given-names></name><degrees>MD, MS</degrees></contrib><contrib contrib-type="author"><name><surname>Verghese</surname><given-names>J.</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><name><surname>Fantino</surname><given-names>B.</given-names></name><degrees>MD, PhD</degrees></contrib><contrib contrib-type="author"><name><surname>Herrmann</surname><given-names>F.R.</given-names></name><degrees>MD, MPH</degrees></contrib><contrib contrib-type="author"><name><surname>Allali</surname><given-names>G.</given-names></name><degrees>MD, PhD</degrees></contrib><aff>From the UPRES EA 2646 (O.B., C.A., B.F.), University of Angers, UNAM, Angers; Department of Internal Medicine and Geriatrics (O.B., C.A., B.F.), Angers University Hospital, Angers; Angers University Memory Center (O.B., C.A., B.F.), Angers, France; Department of Neurology (J.V.), Albert Einstein College of Medicine, Yeshiva University, New York, NY; and Departments of Rehabilitation and Geriatrics (F.R.H.) and Neurology (G.A.), Geneva University Hospitals and University of Geneva, Geneva, Switzerland.</aff></contrib-group><author-notes><corresp>Address correspondence and reprint requests to Dr. Olivier Beauchet,
<addr-line>Department of Internal Medicine and Geriatrics, Angers University Hospitals, 49933 Angers cedex 9, France</addr-line><email>olbeauchet@chu-angers.fr</email></corresp><fn fn-type="other"><p><italic>Study funding</italic>: Supported by the Swiss National Science Foundation (No. 33CM30–124115 to G.A.).</p></fn></author-notes><pub-date pub-type="ppub"><day>10</day><month>5</month><year>2011</year></pub-date><pub-date pub-type="epub"><day>6</day><month>4</month><year>2011</year></pub-date><pub-date pub-type="pmc-release"><day>10</day><month>5</month><year>2012</year></pub-date><pmc-comment> PMC Release delay is 12 months and 0 days and was based on the
<volume>76</volume><issue>19</issue><fpage>1617</fpage><lpage>1622</lpage><history><date date-type="received"><day>1</day><month>9</month><year>2010</year></date><date date-type="accepted"><day>17</day><month>12</month><year>2010</year></date></history><permissions><copyright-statement>Copyright © 2011 by AAN Enterprises, Inc.</copyright-statement><copyright-year>2011</copyright-year><copyright-holder>AAN Enterprises, Inc.</copyright-holder></permissions><self-uri xlink:title="pdf" xlink:type="simple" xlink:href="znl01911001617.pdf"></self-uri><abstract><sec><title>Background:</title><p>Adverse neuromuscular events have been described in case of low serum 25-hydroxyvitamin D (25OHD) concentrations, suggesting that vitamin D may be involved in gait stability. The objective of this cross-sectional study was to examine the association between stride-to-stride variability of stride time (STV) and serum 25OHD concentration in adults aged 65 years and older.</p></sec><sec><title>Methods:</title><p>STV and 25OHD concentration were assessed in 411 community-dwelling older adults (mean age 70.4 ± 1.8 years, 57.9% women). The following established 25OHD thresholds were used: severe 25OHD insufficiency <10 ng/mL, moderate 10–30 ng/mL, and normal >30 ng/mL. Age, number of drugs used per day, use of psychoactive drugs, depressive symptoms, cognitive decline, history of falls, distance visual acuity, lower limb proprioception, center of mass (CoM) motion, and walking speed were considered as potential confounders.</p></sec><sec><title>Results:</title><p>A total of 16.6% (n = 68) of subjects had severe 25OHD insufficiency, 70.3% (n = 289) moderate insufficiency, and 13.1% (n = 54) normal concentrations. In the full adjusted and the stepwise backward linear regression models, high STV (worse performance) was associated with severe 25OHD insufficiency (<italic>p</italic> = 0.028 and <italic>p</italic> = 0.044, respectively), high CoM motion (<italic>p</italic> = 0.031 and <italic>p</italic> = 0.014, respectively), and low lower limb proprioception score (<italic>p</italic> = 0.017 and <italic>p</italic> = 0.008, respectively). The stepwise backward regression model also showed that high STV was associated with female gender (<italic>p</italic> = 0.041).</p></sec><sec><title>Conclusions:</title><p>Low serum 25OHD concentrations were associated with high STV reflecting a disturbed gait control. This association could be explained by a possible action of vitamin D on different components involved in gait control.</p></sec></abstract><custom-meta-group><custom-meta><meta-name>special-property</meta-name><meta-value>pap</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc><affiliations><list></list><tree><noCountry><name sortKey="Allali, G" sort="Allali, G" uniqKey="Allali G" first="G." last="Allali">G. Allali</name><name sortKey="Annweiler, C" sort="Annweiler, C" uniqKey="Annweiler C" first="C." last="Annweiler">C. Annweiler</name><name sortKey="Beauchet, O" sort="Beauchet, O" uniqKey="Beauchet O" first="O." last="Beauchet">O. Beauchet</name><name sortKey="Fantino, B" sort="Fantino, B" uniqKey="Fantino B" first="B." last="Fantino">B. Fantino</name><name sortKey="Herrmann, F R" sort="Herrmann, F R" uniqKey="Herrmann F" first="F. R." last="Herrmann">F. R. Herrmann</name><name sortKey="Verghese, J" sort="Verghese, J" uniqKey="Verghese J" first="J." last="Verghese">J. Verghese</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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