Goal-directed and habitual control in the basal ganglia: implications for Parkinson’s disease
Identifieur interne : 000C33 ( Ncbi/Merge ); précédent : 000C32; suivant : 000C34Goal-directed and habitual control in the basal ganglia: implications for Parkinson’s disease
Auteurs : Peter Redgrave [Royaume-Uni] ; Manuel Rodriguez [Espagne] ; Yoland Smith [États-Unis] ; Maria C. Rodriguez-Oroz [Espagne] ; Stephane Lehericy [France] ; Hagai Bergman [Israël] ; Yves Agid [France] ; Mahlon R. Delong [États-Unis] ; Jose A. Obeso [Espagne]Source :
- Nature reviews. Neuroscience [ 1471-003X ] ; 2010.
Abstract
Progressive loss of the ascending dopaminergic projection in the basal ganglia is a fundamental pathological feature of Parkinson’s disease. Studies in animals and humans have identified spatially segregated functional territories in the basal ganglia for the control of goal-directed and habitual actions. In patients with Parkinson’s disease the loss of dopamine is predominantly in the posterior putamen, a region of the basal ganglia associated with the control of habitual behaviour. These patients may therefore be forced into a progressive reliance on the goal-directed mode of action control that is mediated by comparatively preserved processing in the rostromedial striatum. Thus, many of their behavioural difficulties may reflect a loss of normal automatic control owing to distorting output signals from habitual control circuits, which impede the expression of goal-directed action.
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DOI: 10.1038/nrn2915
PubMed: 20944662
PubMed Central: 3124757
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Delong</name><affiliation wicri:level="1"><nlm:aff id="A5">Department of Neurology, Emory University School of Medicine, Atlanta, Georgia 30322, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Neurology, Emory University School of Medicine, Atlanta, Georgia 30322</wicri:regionArea><wicri:noRegion>Georgia 30322</wicri:noRegion></affiliation></author><author><name sortKey="Obeso, Jose A" sort="Obeso, Jose A" uniqKey="Obeso J" first="Jose A." last="Obeso">Jose A. 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Rodriguez-Oroz</name><affiliation wicri:level="2"><nlm:aff id="A3">Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Instituto Carlos III, Ministerio de Investigacion y Ciencias, 28038, Spain.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Espagne</country><wicri:regionArea>Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Instituto Carlos III, Ministerio de Investigacion y Ciencias, 28038</wicri:regionArea><placeName><region nuts="2" type="communauté">Communauté de Madrid</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A6">Movement Disorders Group, Neurosciences Division, CIMA and Department of Neurology and Neurosurgery, Clínica Universidad de Navarra, Pamplona, 31008, Spain.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Espagne</country><wicri:regionArea>Movement Disorders Group, Neurosciences Division, CIMA and Department of Neurology and Neurosurgery, Clínica Universidad de Navarra, Pamplona, 31008</wicri:regionArea><placeName><region nuts="2" type="communauté">Communauté forale de Navarre</region></placeName></affiliation></author><author><name sortKey="Lehericy, Stephane" sort="Lehericy, Stephane" uniqKey="Lehericy S" first="Stephane" last="Lehericy">Stephane Lehericy</name><affiliation wicri:level="4"><nlm:aff id="A7">Centre de NeuroImagerie de Recherche (CENIR), Institut du Cerveau et de la Moelle épinière (ICM), Universite Pierre et Marie Curie, Inserm U975, CNRS 7225, Groupe Hospitalier Pitié-Salpêtrière, 75013, Paris, France.</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>Centre de NeuroImagerie de Recherche (CENIR), Institut du Cerveau et de la Moelle épinière (ICM), Universite Pierre et Marie Curie, Inserm U975, CNRS 7225, Groupe Hospitalier Pitié-Salpêtrière, 75013, Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName><orgName type="university">Université Pierre-et-Marie-Curie</orgName></affiliation></author><author><name sortKey="Bergman, Hagai" sort="Bergman, Hagai" uniqKey="Bergman H" first="Hagai" last="Bergman">Hagai Bergman</name><affiliation wicri:level="1"><nlm:aff id="A8">Hebrew University, Hadassah Medical School, Jerusalem 91120, Israel.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Israël</country><wicri:regionArea>Hebrew University, Hadassah Medical School, Jerusalem 91120</wicri:regionArea><wicri:noRegion>Jerusalem 91120</wicri:noRegion></affiliation></author><author><name sortKey="Agid, Yves" sort="Agid, Yves" uniqKey="Agid Y" first="Yves" last="Agid">Yves Agid</name><affiliation wicri:level="3"><nlm:aff id="A9">Institut du Cerveau et de la Moelle épinière (ICM), 75013, Paris, France.</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>Institut du Cerveau et de la Moelle épinière (ICM), 75013, Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName><placeName><settlement type="city">Paris</settlement><region type="region" nuts="2">Île-de-France</region></placeName><orgName type="hospital" n="4">Hôpital de la Salpêtrière</orgName></affiliation></author><author><name sortKey="Delong, Mahlon R" sort="Delong, Mahlon R" uniqKey="Delong M" first="Mahlon R." last="Delong">Mahlon R. Delong</name><affiliation wicri:level="1"><nlm:aff id="A5">Department of Neurology, Emory University School of Medicine, Atlanta, Georgia 30322, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Neurology, Emory University School of Medicine, Atlanta, Georgia 30322</wicri:regionArea><wicri:noRegion>Georgia 30322</wicri:noRegion></affiliation></author><author><name sortKey="Obeso, Jose A" sort="Obeso, Jose A" uniqKey="Obeso J" first="Jose A." last="Obeso">Jose A. Obeso</name><affiliation wicri:level="2"><nlm:aff id="A3">Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Instituto Carlos III, Ministerio de Investigacion y Ciencias, 28038, Spain.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Espagne</country><wicri:regionArea>Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Instituto Carlos III, Ministerio de Investigacion y Ciencias, 28038</wicri:regionArea><placeName><region nuts="2" type="communauté">Communauté de Madrid</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A6">Movement Disorders Group, Neurosciences Division, CIMA and Department of Neurology and Neurosurgery, Clínica Universidad de Navarra, Pamplona, 31008, Spain.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Espagne</country><wicri:regionArea>Movement Disorders Group, Neurosciences Division, CIMA and Department of Neurology and Neurosurgery, Clínica Universidad de Navarra, Pamplona, 31008</wicri:regionArea><placeName><region nuts="2" type="communauté">Communauté forale de Navarre</region></placeName></affiliation></author></analytic><series><title level="j">Nature reviews. Neuroscience</title><idno type="ISSN">1471-003X</idno><idno type="eISSN">1471-0048</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Progressive loss of the ascending dopaminergic projection in the basal ganglia is a fundamental pathological feature of Parkinson’s disease. Studies in animals and humans have identified spatially segregated functional territories in the basal ganglia for the control of goal-directed and habitual actions. In patients with Parkinson’s disease the loss of dopamine is predominantly in the posterior putamen, a region of the basal ganglia associated with the control of habitual behaviour. These patients may therefore be forced into a progressive reliance on the goal-directed mode of action control that is mediated by comparatively preserved processing in the rostromedial striatum. Thus, many of their behavioural difficulties may reflect a loss of normal automatic control owing to distorting output signals from habitual control circuits, which impede the expression of goal-directed action.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">100962781</journal-id><journal-id journal-id-type="pubmed-jr-id">22270</journal-id><journal-id journal-id-type="nlm-ta">Nat Rev Neurosci</journal-id><journal-id journal-id-type="iso-abbrev">Nat. Rev. Neurosci.</journal-id><journal-title-group><journal-title>Nature reviews. Neuroscience</journal-title></journal-title-group><issn pub-type="ppub">1471-003X</issn><issn pub-type="epub">1471-0048</issn></journal-meta><article-meta><article-id pub-id-type="pmid">20944662</article-id><article-id pub-id-type="pmc">3124757</article-id><article-id pub-id-type="doi">10.1038/nrn2915</article-id><article-id pub-id-type="manuscript">UKMS35698</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Goal-directed and habitual control in the basal ganglia: implications for Parkinson’s disease</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Redgrave</surname><given-names>Peter</given-names></name><xref ref-type="aff" rid="A1">*</xref></contrib><contrib contrib-type="author"><name><surname>Rodriguez</surname><given-names>Manuel</given-names></name><xref ref-type="aff" rid="A2">‡</xref><xref ref-type="aff" rid="A3">§</xref></contrib><contrib contrib-type="author"><name><surname>Smith</surname><given-names>Yoland</given-names></name><xref ref-type="aff" rid="A4">||</xref><xref ref-type="aff" rid="A5">¶</xref></contrib><contrib contrib-type="author"><name><surname>Rodriguez-Oroz</surname><given-names>Maria C.</given-names></name><xref ref-type="aff" rid="A3">§</xref><xref ref-type="aff" rid="A6">#</xref></contrib><contrib contrib-type="author"><name><surname>Lehericy</surname><given-names>Stephane</given-names></name><xref ref-type="aff" rid="A7">**</xref></contrib><contrib contrib-type="author"><name><surname>Bergman</surname><given-names>Hagai</given-names></name><xref ref-type="aff" rid="A8">‡‡</xref></contrib><contrib contrib-type="author"><name><surname>Agid</surname><given-names>Yves</given-names></name><xref ref-type="aff" rid="A9">§§</xref></contrib><contrib contrib-type="author"><name><surname>DeLong</surname><given-names>Mahlon R.</given-names></name><xref ref-type="aff" rid="A5">¶</xref></contrib><contrib contrib-type="author"><name><surname>Obeso</surname><given-names>Jose A.</given-names></name><xref ref-type="aff" rid="A3">§</xref><xref ref-type="aff" rid="A6">#</xref></contrib></contrib-group><aff id="A1"><label>*</label>Neuroscience Research Unit, Department of Psychology, University of Sheffield, S10 2TP, UK.</aff><aff id="A2"><label>‡</label>Department of Physiology, Medical School, University of La Laguna, Tenerife, 38201, Spain.</aff><aff id="A3"><label>§</label>Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Instituto Carlos III, Ministerio de Investigacion y Ciencias, 28038, Spain.</aff><aff id="A4"><label>||</label>Yerkes National Primate Research Center, Emory University, Atlanta, Georgia 30329, USA.</aff><aff id="A5"><label>¶</label>Department of Neurology, Emory University School of Medicine, Atlanta, Georgia 30322, USA.</aff><aff id="A6"><label>#</label>Movement Disorders Group, Neurosciences Division, CIMA and Department of Neurology and Neurosurgery, Clínica Universidad de Navarra, Pamplona, 31008, Spain.</aff><aff id="A7"><label>**</label>Centre de NeuroImagerie de Recherche (CENIR), Institut du Cerveau et de la Moelle épinière (ICM), Universite Pierre et Marie Curie, Inserm U975, CNRS 7225, Groupe Hospitalier Pitié-Salpêtrière, 75013, Paris, France.</aff><aff id="A8"><label>‡‡</label>Hebrew University, Hadassah Medical School, Jerusalem 91120, Israel.</aff><aff id="A9"><label>§§</label>Institut du Cerveau et de la Moelle épinière (ICM), 75013, Paris, France.</aff><author-notes><corresp id="CR1">Correspondence to P.R. and J.O. <email>P.Redgrave@sheffield.ac.uk</email>; <email>jobeso@unav.es</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>9</day><month>6</month><year>2011</year></pub-date><pub-date pub-type="epub"><day>14</day><month>10</month><year>2010</year></pub-date><pub-date pub-type="ppub"><month>11</month><year>2010</year></pub-date><pub-date pub-type="pmc-release"><day>28</day><month>6</month><year>2011</year></pub-date><volume>11</volume><issue>11</issue><fpage>760</fpage><lpage>772</lpage><permissions><copyright-statement>© 2010 Macmillan Publishers Limited. All rights reserved</copyright-statement><copyright-year>2010</copyright-year></permissions><abstract><p id="P1">Progressive loss of the ascending dopaminergic projection in the basal ganglia is a fundamental pathological feature of Parkinson’s disease. Studies in animals and humans have identified spatially segregated functional territories in the basal ganglia for the control of goal-directed and habitual actions. In patients with Parkinson’s disease the loss of dopamine is predominantly in the posterior putamen, a region of the basal ganglia associated with the control of habitual behaviour. These patients may therefore be forced into a progressive reliance on the goal-directed mode of action control that is mediated by comparatively preserved processing in the rostromedial striatum. Thus, many of their behavioural difficulties may reflect a loss of normal automatic control owing to distorting output signals from habitual control circuits, which impede the expression of goal-directed action.</p></abstract><funding-group><award-group><funding-source country="United Kingdom">Wellcome Trust : </funding-source><award-id>091409 || WT</award-id></award-group></funding-group></article-meta></front></pmc><affiliations><list><country><li>Espagne</li><li>France</li><li>Israël</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Canaries</li><li>Communauté de Madrid</li><li>Communauté forale de Navarre</li><li>Île-de-France</li></region><settlement><li>Paris</li></settlement><orgName><li>Hôpital de la Salpêtrière</li><li>Université Pierre-et-Marie-Curie</li></orgName></list><tree><country name="Royaume-Uni"><noRegion><name sortKey="Redgrave, Peter" sort="Redgrave, Peter" uniqKey="Redgrave P" first="Peter" last="Redgrave">Peter Redgrave</name></noRegion></country><country name="Espagne"><region name="Canaries"><name sortKey="Rodriguez, Manuel" sort="Rodriguez, Manuel" uniqKey="Rodriguez M" first="Manuel" last="Rodriguez">Manuel Rodriguez</name></region><name sortKey="Obeso, Jose A" sort="Obeso, Jose A" uniqKey="Obeso J" first="Jose A." last="Obeso">Jose A. Obeso</name><name sortKey="Obeso, Jose A" sort="Obeso, Jose A" uniqKey="Obeso J" first="Jose A." last="Obeso">Jose A. Obeso</name><name sortKey="Rodriguez Oroz, Maria C" sort="Rodriguez Oroz, Maria C" uniqKey="Rodriguez Oroz M" first="Maria C." last="Rodriguez-Oroz">Maria C. Rodriguez-Oroz</name><name sortKey="Rodriguez Oroz, Maria C" sort="Rodriguez Oroz, Maria C" uniqKey="Rodriguez Oroz M" first="Maria C." last="Rodriguez-Oroz">Maria C. Rodriguez-Oroz</name><name sortKey="Rodriguez, Manuel" sort="Rodriguez, Manuel" uniqKey="Rodriguez M" first="Manuel" last="Rodriguez">Manuel Rodriguez</name></country><country name="États-Unis"><noRegion><name sortKey="Smith, Yoland" sort="Smith, Yoland" uniqKey="Smith Y" first="Yoland" last="Smith">Yoland Smith</name></noRegion><name sortKey="Delong, Mahlon R" sort="Delong, Mahlon R" uniqKey="Delong M" first="Mahlon R." last="Delong">Mahlon R. Delong</name><name sortKey="Smith, Yoland" sort="Smith, Yoland" uniqKey="Smith Y" first="Yoland" last="Smith">Yoland Smith</name></country><country name="France"><region name="Île-de-France"><name sortKey="Lehericy, Stephane" sort="Lehericy, Stephane" uniqKey="Lehericy S" first="Stephane" last="Lehericy">Stephane Lehericy</name></region><name sortKey="Agid, Yves" sort="Agid, Yves" uniqKey="Agid Y" first="Yves" last="Agid">Yves Agid</name></country><country name="Israël"><noRegion><name sortKey="Bergman, Hagai" sort="Bergman, Hagai" uniqKey="Bergman H" first="Hagai" last="Bergman">Hagai Bergman</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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