Assessment of metabolic changes in the striatum of a rat model of parkinsonism: an in vivo (1)H MRS study.
Identifieur interne : 000943 ( Ncbi/Merge ); précédent : 000942; suivant : 000944Assessment of metabolic changes in the striatum of a rat model of parkinsonism: an in vivo (1)H MRS study.
Auteurs : N. Kickler [France] ; E. Lacombe ; C. Chassain ; F. Durif ; A. Krainik ; R. Farion ; P. Provent ; C. Segebarth ; C. Rémy ; M. SavastaSource :
- NMR in biomedicine [ 0952-3480 ] ; 2009.
English descriptors
- KwdEn :
- MESH :
- chemical : Protons.
- metabolism : Corpus Striatum, Parkinson Disease.
- methods : Magnetic Resonance Spectroscopy.
- Animals, Disease Models, Animal, Humans, Male, Rats, Rats, Sprague-Dawley.
Abstract
Degeneration of the dopaminergic neurons of the substantia nigra pars compacta in Parkinson's disease induces an abnormal activation of the glutamatergic neurotransmission system within the basal ganglia network and related structures. The aim of this study was to use proton MRS to show metabolic changes in the striatum of 6-hydroxydopamine-lesioned rats, a rodent animal model of Parkinson's disease. Animals were examined before and after extensive lesioning of the nigral dopaminergic neurons and after acute administration of L-3,4-dihydroxyphenylalanine. No significant alterations in glutamate concentrations, assessed by the MR signal dominated by glutamate with minor contributions from glutamine and gamma-aminobutyric acid, could be measured. The total choline/total creatine ratio was found to be reduced in the striatum of the ipsilateral hemisphere.
DOI: 10.1002/nbm.1305
PubMed: 19130495
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Kickler</name><affiliation wicri:level="3"><nlm:affiliation>INSERM U836, Grenoble Institut des Neurosciences, BP 170, F-38042 Grenoble Cedex 9, France. Nils.Kickler@epfl.ch</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM U836, Grenoble Institut des Neurosciences, BP 170, F-38042 Grenoble Cedex 9</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="Lacombe, E" sort="Lacombe, E" uniqKey="Lacombe E" first="E" last="Lacombe">E. Lacombe</name></author><author><name sortKey="Chassain, C" sort="Chassain, C" uniqKey="Chassain C" first="C" last="Chassain">C. Chassain</name></author><author><name sortKey="Durif, F" sort="Durif, F" uniqKey="Durif F" first="F" last="Durif">F. Durif</name></author><author><name sortKey="Krainik, A" sort="Krainik, A" uniqKey="Krainik A" first="A" last="Krainik">A. Krainik</name></author><author><name sortKey="Farion, R" sort="Farion, R" uniqKey="Farion R" first="R" last="Farion">R. Farion</name></author><author><name sortKey="Provent, P" sort="Provent, P" uniqKey="Provent P" first="P" last="Provent">P. Provent</name></author><author><name sortKey="Segebarth, C" sort="Segebarth, C" uniqKey="Segebarth C" first="C" last="Segebarth">C. Segebarth</name></author><author><name sortKey="Remy, C" sort="Remy, C" uniqKey="Remy C" first="C" last="Rémy">C. Rémy</name></author><author><name sortKey="Savasta, M" sort="Savasta, M" uniqKey="Savasta M" first="M" last="Savasta">M. Savasta</name></author></analytic><series><title level="j">NMR in biomedicine</title><idno type="ISSN">0952-3480</idno><imprint><date when="2009" type="published">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Corpus Striatum (metabolism)</term><term>Disease Models, Animal</term><term>Humans</term><term>Magnetic Resonance Spectroscopy (methods)</term><term>Male</term><term>Parkinson Disease (metabolism)</term><term>Protons</term><term>Rats</term><term>Rats, Sprague-Dawley</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Protons</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Corpus Striatum</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Magnetic Resonance Spectroscopy</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Disease Models, Animal</term><term>Humans</term><term>Male</term><term>Rats</term><term>Rats, Sprague-Dawley</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Degeneration of the dopaminergic neurons of the substantia nigra pars compacta in Parkinson's disease induces an abnormal activation of the glutamatergic neurotransmission system within the basal ganglia network and related structures. The aim of this study was to use proton MRS to show metabolic changes in the striatum of 6-hydroxydopamine-lesioned rats, a rodent animal model of Parkinson's disease. Animals were examined before and after extensive lesioning of the nigral dopaminergic neurons and after acute administration of L-3,4-dihydroxyphenylalanine. No significant alterations in glutamate concentrations, assessed by the MR signal dominated by glutamate with minor contributions from glutamine and gamma-aminobutyric acid, could be measured. The total choline/total creatine ratio was found to be reduced in the striatum of the ipsilateral hemisphere.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">19130495</PMID><DateCreated><Year>2009</Year><Month>02</Month><Day>09</Day></DateCreated><DateCompleted><Year>2009</Year><Month>04</Month><Day>16</Day></DateCompleted><DateRevised><Year>2015</Year><Month>11</Month><Day>19</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0952-3480</ISSN><JournalIssue CitedMedium="Print"><Volume>22</Volume><Issue>2</Issue><PubDate><Year>2009</Year><Month>Feb</Month></PubDate></JournalIssue><Title>NMR in biomedicine</Title><ISOAbbreviation>NMR Biomed</ISOAbbreviation></Journal><ArticleTitle>Assessment of metabolic changes in the striatum of a rat model of parkinsonism: an in vivo (1)H MRS study.</ArticleTitle><Pagination><MedlinePgn>207-12</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/nbm.1305</ELocationID><Abstract><AbstractText>Degeneration of the dopaminergic neurons of the substantia nigra pars compacta in Parkinson's disease induces an abnormal activation of the glutamatergic neurotransmission system within the basal ganglia network and related structures. The aim of this study was to use proton MRS to show metabolic changes in the striatum of 6-hydroxydopamine-lesioned rats, a rodent animal model of Parkinson's disease. Animals were examined before and after extensive lesioning of the nigral dopaminergic neurons and after acute administration of L-3,4-dihydroxyphenylalanine. No significant alterations in glutamate concentrations, assessed by the MR signal dominated by glutamate with minor contributions from glutamine and gamma-aminobutyric acid, could be measured. The total choline/total creatine ratio was found to be reduced in the striatum of the ipsilateral hemisphere.</AbstractText><CopyrightInformation>Copyright (c) 2008 John Wiley & Sons, Ltd.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Kickler</LastName><ForeName>N</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>INSERM U836, Grenoble Institut des Neurosciences, BP 170, F-38042 Grenoble Cedex 9, France. 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Chassain</name><name sortKey="Durif, F" sort="Durif, F" uniqKey="Durif F" first="F" last="Durif">F. Durif</name><name sortKey="Farion, R" sort="Farion, R" uniqKey="Farion R" first="R" last="Farion">R. Farion</name><name sortKey="Krainik, A" sort="Krainik, A" uniqKey="Krainik A" first="A" last="Krainik">A. Krainik</name><name sortKey="Lacombe, E" sort="Lacombe, E" uniqKey="Lacombe E" first="E" last="Lacombe">E. Lacombe</name><name sortKey="Provent, P" sort="Provent, P" uniqKey="Provent P" first="P" last="Provent">P. Provent</name><name sortKey="Remy, C" sort="Remy, C" uniqKey="Remy C" first="C" last="Rémy">C. Rémy</name><name sortKey="Savasta, M" sort="Savasta, M" uniqKey="Savasta M" first="M" last="Savasta">M. Savasta</name><name sortKey="Segebarth, C" sort="Segebarth, C" uniqKey="Segebarth C" first="C" last="Segebarth">C. Segebarth</name></noCountry><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Kickler, N" sort="Kickler, N" uniqKey="Kickler N" first="N" last="Kickler">N. Kickler</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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